Article
Cell Biology
Guozhi Xia, Bowen Qin, Chaoran Ma, Yaowu Zhu, Qiangsun Zheng
Summary: The study suggests that high-dose intravenous vitamin C (HIVC) can ameliorate myocardial injury in COVID-19 patients by alleviating hyperinflammation, particularly showing significant effects in severe cases.
Article
Pharmacology & Pharmacy
Bing Zhao, Min Liu, Ping Liu, Yibing Peng, Jun Huang, Mengjiao Li, Yihui Wang, LiLi Xu, Silei Sun, Xing Qi, Yun Ling, Jian Li, Wenhong Zhang, Enqiang Mao, Jieming Qu
Summary: The study suggests that high-dose intravenous vitamin C (HDIVC) may help limit the aggravation of COVID-19, including shortening the duration of systemic inflammatory response syndrome (SIRS), reducing SIRS occurrence, decreasing C-reactive protein levels, increasing CD4(+) T cell count, and improving coagulation function. Further randomized controlled trials are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Dengfeng Gao, Min Xu, Gang Wang, Jianrui Lv, Xiaorong Ma, Yonghong Guo, Dexin Zhang, Huiyun Yang, Wei Jiang, Fuxue Deng, Guozhi Xia, Ziwei Lu, Lv Lv, Shouping Gong
Summary: The study suggests that high-dose vitamin C may reduce mortality and improve oxygen support status in patients with Coronavirus disease 2019, without any adverse events.
Review
Nutrition & Dietetics
Lei Sun, Jia-Hao Zhao, Wen-Yi Fan, Bo Feng, Wen-Wen Liu, Rui-Qin Chen, Chuang Ban, Ao-Gui Dang, Miao Wang, Kang-Ting Luo, Guo-Yu Zhou, Fang-Fang Yu, Yue Ba
Summary: This meta-analysis explored the therapeutic effects of high-dose vitamin C supplementation for patients with COVID-19, and the results showed that it can alleviate inflammatory response and hinder the aggravation of the disease.
Article
Immunology
Ritesh Aggarwal, Arun Dewan, Ankita Pandey, Nikita Trehan, Muhammad Aamir Majid
Summary: This study evaluated the efficacy of intravenous immunoglobulin (IVIG) in severe and critical COVID-19 disease. The results showed that IVIG treatment can reduce the need for mechanical ventilation, decrease in-hospital mortality, and shorten ICU-length of stay. Early administration of IVIG, older age, obesity, and chronic respiratory disease were associated with better outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Saeidreza JamaliMoghadamSiahkali, Besharat Zarezade, Sogol Koolaji, SeyedAhmad SeyedAlinaghi, Abolfazl Zendehdel, Mohammad Tabarestani, Ehsan Sekhavati Moghadam, Ladan Abbasian, Seyed Ali Dehghan Manshadi, Mohamadreza Salehi, Malihe Hasannezhad, Sara Ghaderkhani, Mohsen Meidani, Faeze Salahshour, Fatemeh Jafari, Navid Manafi, Fereshteh Ghiasvand
Summary: The study found that there were no significantly better outcomes at discharge in patients with severe COVID-19 who received high-dose intravenous vitamin C (HDIVC) in addition to the main treatment regimen.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Biology
Guangling Guo, Qi Chen, Guoshi Luo, Zhongji Meng, Pan Lei, Ping Chen, Jeanne A. Drisko
Summary: High-dose IVC demonstrated unexpected clinical benefits in treating COVID-19 in two cancer patients presenting with complicated severe comorbidities where an unfavorable prognosis was anticipated.
Article
Critical Care Medicine
Jing Zhang, Xin Rao, Yiming Li, Yuan Zhu, Fang Liu, Guangling Guo, Guoshi Luo, Zhongji Meng, Daniel De Backer, Hui Xiang, Zhiyong Peng
Summary: In this trial, high-dose vitamin C infusion did not improve IMVFD28 for patients with severe COVID-19, but may have a potential benefit in oxygenation.
ANNALS OF INTENSIVE CARE
(2021)
Article
Biochemistry & Molecular Biology
Fabienne Jaun, Maria Boesing, Giorgia Luethi-Corridori, Kristin Abig, Nando Bloch, Stephanie Giezendanner, Victoria Grillmayr, Philippe Haas, Anne B. Leuppi-Taegtmeyer, Juergen Muser, Andrea Raess, Philipp Schuetz, Michael Brandle, Joerg D. Leuppi
Summary: The role of vitamin D in the COVID-19 pandemic has been controversial, and the effectiveness of vitamin D-3 supplementation in COVID-19 patients remains inconclusive. This study conducted a randomized, placebo-controlled double-blind trial on hospitalized COVID-19 patients to compare the effect of high-dose vitamin D-3 supplementation on length of hospital stay. The results showed that vitamin D-3 supplementation did not significantly shorten the hospital stay.
Article
Pharmacology & Pharmacy
Ayman M. Al-Qaaneh, Fuad H. Al-Ghamdi, Sayed AbdulAzeez, J. Francis Borgio
Summary: This study aimed to evaluate predictors of mortality and the clinical effectiveness of tocilizumab in COVID-19 patients. The results showed strong correlations between ICU admission, patient age, and the number of tocilizumab doses administered with COVID-19 mortality. Additionally, early administration of tocilizumab and longer hospital length of stay were found to reduce COVID-19 mortalities. Overdosing on tocilizumab may lead to adverse reactions and an increased incidence of infection.
Article
Medicine, General & Internal
Andrea L. Hess, Alexandra Halalau, Jonathan J. Dokter, Tania S. Paydawy, Patrick Karabon, Aveh Bastani, Rebecca E. Baker, Abdalla Kara Balla, Stephen A. Galens
Summary: This study evaluated the efficacy and safety of high-dose intravenous vitamin C (HDIVC) in severe COVID-19 patients. The results showed that patients who received HDIVC had a longer time to death, as well as lower rates of mechanical ventilation and cardiac arrest. Therefore, HDIVC may be an effective treatment in reducing the occurrence of mechanical ventilation and cardiac arrest in severe COVID-19 patients.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Mohamad Fleifel, Jonathan Mina, Tony Haykal, Rana Asmar, Ghida El Hout, Ranime Harb, Hani Dimassi, Jacques Mokhbat, Anna Farra, Rola Husni-Samaha
Summary: This study retrospectively analyzed the treatment of COVID-19 inpatients and found that patients receiving high dose vitamin C intravenous injection often experienced dyspnea and desaturation, and were more likely to require oxygen therapy. In comparison, patients treated with remdesivir were more likely to be discharged after clinical improvement. The study concludes that further research is needed to establish local guidelines for the treatment of COVID-19.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Medicine, General & Internal
Rimesh Pal, Sant Ram, Deepy Zohmangaihi, Indranil Biswas, Vikas Suri, Laxmi N. Yaddanapudi, Pankaj Malhotra, Shiv L. Soni, Goverdhan D. Puri, Ashish Bhalla, Sanjay K. Bhadada
Summary: The study compared serum calcium and phosphate levels in patients with non-severe COVID-19 to a healthy adult cohort, finding that the patients had significantly lower levels of both calcium and phosphate compared to the controls.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Suma Thomas, Divyang Patel, Barbara Bittel, Kathy Wolski, Qiuqing Wang, Anirudh Kumar, Zachary J. Il'Giovine, Reena Mehra, Carla McWilliams, Steve E. Nissen, Milind Y. Desai
Summary: This study found that treatment with high-dose zinc gluconate, ascorbic acid, or a combination of the two supplements did not significantly decrease the duration of symptoms in ambulatory patients diagnosed with SARS-CoV-2 infection compared to standard care.
Article
Infectious Diseases
Ronen Arbel, Alon Peretz, Ruslan Sergienko, Michael Friger, Tanya Beckenstein, Hadar Duskin-Bitan, Shlomit Yaron, Ariel Hammerman, Natalya Bilenko, Doron Netzer
Summary: A population-based cohort study in Israel from September 2022 to January 2023 found that older adults who received a bivalent mRNA booster vaccine had significantly lower rates of hospitalization due to COVID-19 compared to those who did not receive the booster.
LANCET INFECTIOUS DISEASES
(2023)