Article
Cell Biology
Huafu Li, Chunming Wang, Linxiang Lan, Axel Behrens, Mona Tomaschko, Josue Ruiz, Qiao Su, Guangying Zhao, Cheng Yuan, Xing Xiao, Bo Li, Leping Yan, Wang Wu, Wuguo Li, Junzong Chen, Yulong He, Changhua Zhang
Summary: EMT plays a crucial role in the aggressiveness and metastasis of gastric cancer, especially in the infiltration of NK cells into tumor cells. Vinculin expression is closely related to cancer aggressiveness and distant metastasis, affecting patient survival prognosis. Additionally, VCL can influence EMT and tumor immunity by regulating EPCAM gene expression.
Article
Oncology
Hongxin Cao, Shuang Quan, Lu Zhang, Yunzhen Chen, Guangjun Jiao
Summary: Osteosarcoma patients with high BMPR2 expression levels have poor prognosis and the immune infiltration, metastasis, and prognosis can be considered as biomarkers.
Article
Oncology
Kan Hu, Yugui Zhang, Jun Rong, Wensheng Deng, Benping Xiao
Summary: TCLlnc1 is overexpressed in gastric cancer tissues and plasma. Plasma TCLlnc1 is closely correlated with TCLlnc1 in gastric cancer tissues and has a good diagnostic value for early-stage gastric cancer. Increased accumulation of TCLlnc1 is closely correlated with distant recurrence and poor survival.
Article
Oncology
Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan, Qiuyuan Wen
Summary: In this study, the association between phosphorylated S6 (p-S6) protein expression and lymph node metastasis (LNM) in non-small cell lung cancer (NSCLC) was investigated. The results showed that p-S6 expression was increased in NSCLC with LNM and was also associated with poor prognosis.
Article
Genetics & Heredity
Guoshun Zhang, Hua Shang, Bin Liu, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: ATP2A1 is a potential prognostic biomarker in colorectal cancer, with high expression associated with significantly lower overall survival rates. Inhibiting the autophagy process by ATP2A1 can significantly suppress the proliferation of colorectal cancer cells.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Hao Zhang, Jialin He, Ziyu Dai, Zeyu Wang, Xisong Liang, Fengqiong He, Zhiwei Xia, Songshan Feng, Hui Cao, Liyang Zhang, Quan Cheng
Summary: The study indicates that PDIA5 is highly expressed in gliomas, associated with aggressive tumors and poor clinical outcomes, positively correlated with immune infiltrating cells and immune-related pathways, and patients with high PDIA5 expression benefit from immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Shu-lan Chen, Jun Li, Jin-gao Li, Xiao-ting Pan, Hong-wen Wu, Fei Xu
Summary: This study found that high pre-treatment LAR levels were significantly associated with poor prognosis in patients with nasopharyngeal carcinoma (NPC), particularly in terms of distant metastasis-free survival (DMFS). LAR can serve as a predictive biomarker for NPC patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Oncology
Jinqin Qian, Cong Huang, Zhenpeng Zhu, Yuhui He, Yang Wang, Ninghan Feng, Shiming He, Xuesong Li, Liqun Zhou, Cuijian Zhang, Yanqing Gong
Summary: This study reveals the significant role of NFE2L3 in bladder cancer and suggests its potential as a valuable clinical prognostic biomarker and therapeutic target. NFE2L3 overexpression is associated with progression and metastasis of bladder cancer, and several mechanisms are involved.
Article
Cell Biology
Haizhou Liu, Zihan Zhang, Yi Huang, Wene Wei, Shufang Ning, Jilin Li, Xinqiang Liang, Kaisheng Liu, Litu Zhang
Summary: The study demonstrated the association of pre-treatment plasma HSP90AA1 with the risk of breast cancer onset and metastasis, showing that combining with other markers could conveniently predict patients' risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Retraction
Biochemistry & Molecular Biology
Mingming Zhang, Pei Liu, Famei Xu, Yuanlong He, Xiangjun Xie, Xiangjun Jiang
Summary: The article on Vinculin promoting gastric cancer proliferation and migration has been retracted due to flaws and inconsistencies, and the conclusions were deemed invalid by the editors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Pathology
Hideaki Mita, Hiroto Katoh, Daisuke Komura, Miwako Kakiuchi, Hiroyuki Abe, Hirofumi Rokutan, Koichi Yagi, Sachiyo Nomura, Tetsuo Ushiku, Yasuyuki Seto, Shumpei Ishikawa
Summary: In this study, immunohistochemical analysis of 342 gastric cancer cases revealed that approximately half of the samples showed aberrant expression of CDH11 in gastric cancer cells. The aberrant expression of CDH11 was statistically associated with bone metastasis, as well as liver and distant lymph node metastasis. Therefore, aberrant CDH11 expression in gastric cancer cells can serve as a predictive biomarker for distant metastasis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Raquel Blazquez, Martin Andreas Proescholdt, Marlene Klauser, Karl-Michael Schebesch, Christian Doenitz, Daniel Heudobler, Lena Stange, Markus J. Riemenschneider, Elisabeth Bumes, Katharina Rosengarth, Andreas Schicho, Nils-Ole Schmidt, Alexander Brawanski, Tobias Pukrop, Christina Wendl
Summary: The aim of this study was to identify specific magnetic resonance imaging (MRI) patterns at the macro-metastasis/brain parenchyma interface (MMPI) in patients with brain metastases (BM) and to correlate these patterns with patient outcome. The results showed that patients with a breakout pattern had a highly aggressive clinical course, indicating a need for more aggressive treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lu Deng, Dandan Wang, Shouzhen Chen, Weiguo Hu, Ru Zhang
Summary: The study found that EPYC expression in ovarian cancer increases with disease progression, and interfering with EPYC expression can weaken the migration, invasion, and proliferation abilities of SKOV3 cells. EPYC is mainly involved in ECM organization and signal transduction pathways such as PI3K/Akt and focal adhesion, and may interact with proteins like PLCG2 and CRK.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Chengsi Ren, Anran Gao, Chengshi Fu, Xiangyun Teng, Jianzhang Wang, Shaofang Lu, Jiahui Gao, Jinfeng Huang, Dongdong Liu, Jianhua Xu
Summary: A signature containing CD74 and TSPAN7 genes was developed to predict the risk of distant metastasis in breast cancer patients. This signature is related to immune cell infiltration and can serve as an independent predictive factor. An individualized prediction model based on this signature was constructed, which effectively predicts the metastatic risk in breast cancer patients.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Guiyuan Wang, Yulin Cen, Celi Wang, Wei Xiang, Shenjie Li, Yang Ming, Ligang Chen, Jie Zhou
Summary: The study found that RECQL1 is over-expressed in low-grade glioma (LGG), and high RECQL1 expression is associated with poor prognosis and tumor immune infiltration in LGG patients. The results provide potential novel biomarkers and therapeutic targets for the treatment of LGG patients.
TRANSLATIONAL CANCER RESEARCH
(2022)
