Review
Biochemistry & Molecular Biology
Qin Niu, Qiannan Sun, Rushui Bai, Yunfan Zhang, Zimeng Zhuang, Xin Zhang, Tianyi Xin, Si Chen, Bing Han
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide with current treatment models presenting limitations. Nanomaterial-based photothermal therapy (PTT) has attracted research attention as a promising alternative. This paper reviews the latest progress in applying biological nanomaterials for PTT in OSCC and discusses different categories of photothermal nanomaterials and drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Manxiu Huai, Mingliang Pei, Jiaxing Pan, Yun Zhu, Yingwen Chen, Peng Du, Yanming Duan, Huixiong Xu, Wensong Ge
Summary: A colon microenvironment-responsive hydrogel (AL/HA hydrogel) was developed and used to package IFX, creating a facile oral antibody delivery system for IBD treatment. The AL/HA hydrogel showed significant therapeutic effect on IBD and helped alleviate the drawbacks of IFX.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Nanoscience & Nanotechnology
Mingxin Cao, Enyu Shi, Hanping Wang, Lujia Mao, Qiqi Wu, Xinming Li, Yanjie Liang, Xiaoying Yang, Yinsong Wang, Changyi Li
Summary: Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the head and neck, and traditional treatment methods have limitations. Molecular targeted therapies offer solutions by maximizing anticancer efficacy and minimizing treatment toxicity. Receptor-mediated targeted delivery of anticancer therapeutics is the most promising approach.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Yu Guo, Xi He, Rui-Mo Zhao, Hui-Zhen Yang, Zheng Huang, Ji Zhang, Xiao-Qi Yu
Summary: This study designed and synthesized a series of ROS-responsive lipids based on the thioketal structure for the treatment of colitis. The experimental results showed that these lipids could effectively consume ROS in cells and reduce the expression levels of inflammatory factors. After PEGylation, the lipids aggregated effectively in the intestine during the treatment of mouse colitis and significantly relieved the inflammatory symptoms. This study sheds light on the synergistic treatment of colitis through anti-inflammatory siRNA delivery and ROS depletion strategies.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Biomaterials
Huan Zhao, Yurong Du, Lei Liu, Yabing Du, Kang Cui, Pu Yu, Li Li, Yanjie Zhu, Wei Jiang, Zhen Li, Hao Tang, Wang Ma
Summary: The study introduces a new method to improve the stability and resistance of probiotics by coating them with nanozyme coatings on their surface, enhancing colonization of intestinal microbiota, reducing inflammatory responses, and promoting intestinal epithelial barrier homeostasis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Pharmacology & Pharmacy
Asma Ghaemi, Masoume Vakili-Azghandi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: Gene therapy has the potential to prevent or treat various genetic or acquired diseases by regulating gene and protein expression. Effective delivery systems are needed to ensure successful gene therapy, and oral delivery approaches show promise in treating diseases such as inflammatory bowel disease and cancer. This review provides an update on the development of oral gene delivery techniques for gene therapy and vaccination purposes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Kolade Adebowale, Rick Liao, Vineeth Chandran Suja, Neha Kapate, Andrew Lu, Yongsheng Gao, Samir Mitragotri
Summary: Cell therapies have shown promise in treating previously incurable diseases, and the engineering of cell surfaces with various materials has emerged as a valuable tool to enhance their therapeutic performance. This review summarizes recent advances in decorating cell surfaces with nanoparticles, microparticles, and polymeric coatings, and highlights the benefits of surface modifications in protecting carrier cells, enhancing cell trafficking, and delivering therapeutic agents. While these technologies are still in the proof-of-concept stage, their promising efficacy from preclinical studies provides a strong foundation for future clinical translation, revolutionizing the field of cell therapies.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tianhe Huang, Guan Wang, Mohammad-Ali Shahbazi, Yuancheng Bai, Jingrui Zhang, Guobing Feng, Elham Asadian, Fatemeh Ghorbani-Bidkorpeh, Zhiyuang Yang, Yuanai Li, Qingqing Huo, Yingxin Liu, Dongfei Liu
Summary: A versatile surface decoration strategy has been developed to efficiently encapsulate water-soluble peptides and improve their pharmacokinetic features. By assembling peptide molecules into nanoparticles and decorating the surface with charged amino acid-grafted polymer layer, the phase transfer of peptide nanoparticles is controlled and the encapsulation efficiency is over 96%.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Bricard Mbituyimana, Manjila Adhikari, Fuyu Qi, Zhijun Shi, Lina Fu, Guang Yang
Summary: Cell-based therapies are promising approaches for treating incurable diseases, but face barriers in clinical translation and commercialization. Microneedles have emerged as a potential solution for improving cell delivery and sampling. This review highlights the latest advancements in microneedles for cell-based therapies and their applications in various diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Anxin Wu, Chonghao Chen, Jing Lu, Jiayi Sun, Meng Xiao, Xuan Yue, Ping Zhou, Shiyi Zhao, Guofeng Zhong, Chi Huang, Yan Qu, Chen Zhang
Summary: This study developed oral colon-targeted adhesion core-shell nanoparticles using FA-Zein as the core and pectin as the shell to improve the bioavailability of glycyrrhizic acid and enhance its anti-inflammatory effects in specific parts of the intestine. The nanoparticles showed stability in the stomach and small intestine, and released GA in the colon with abundant flora. Targeting with folate-acid was confirmed in cell studies, and the NPs exhibited high adhesion on the colon in a mouse model of ulcerative colitis, reducing levels of MPO and TNF-alpha through decreasing macrophages and neutrophils.
Article
Nanoscience & Nanotechnology
Xiao Wang, Huan Gu, Huan Zhang, Jing Xian, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang
Summary: The study successfully loaded magnolol into core-shell zein-based nanoparticles with chondroitin sulfate coating and embedded them into hydrogel microspheres, forming a system named Mag@CS-Zein NPsinMPs. This drug delivery system exhibited good macrophage-targeting and sustained drug release capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Giulia Della Pelle, Nina Kostevsek
Summary: Gene therapy has the potential to be a significant advancement in 21st-century medicine. Using the body's cells as drug delivery systems offers a unique approach, with red blood cells as a potential candidate due to their abundance and potential cost-effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mingxiao Cui, Zhou Fang, Mengdi Song, Taidi Zhou, Yongjie Wang, Kehai Liu
Summary: This study constructed nano-drug delivery systems based on Phragmites rhizoma polysaccharide, which effectively alleviated ulcerative colitis, and explored the significant roles of the Phragmites rhizoma polysaccharide-based nanocarriers in the drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Hennie Marie Johnsen, Werner Filtvedt, Marianne Hiorth, Jo Klaveness
Summary: The medical use of hydrogen gas has gained attention in recent years. Researchers have investigated the use of silicon particles as nanocarriers to safely generate hydrogen. The results showed that cCVD silicon particles can efficiently generate hydrogen in physiological conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Environmental
Lin Zhu, Jie Yao, Gaofeng Ma, Ping Cao, Shiliang Wu, Zhaoying Li
Summary: Surface modifications of CeO2 with Fe2O3 and/or MoO3 can adjust SCR catalytic performance and SO2 resistance. Fe2O3 slightly improves low temperature SCR activity, while MoO3 significantly enhances NOx conversion. Different deactivation behaviors are observed at 250 degrees C for the four catalysts.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ying Liu, Mengmeng Zhang, Xinyue Wang, Fengmin Yang, Zhenping Cao, Lu Wang, Jinyao Liu
Summary: This article reports a method of treating cancer and protecting susceptible patients from lethal infections (such as COVID-19) by dressing bacteria with a hybrid immunoactive nanosurface. The dressed bacteria release immunoactivators to stimulate immune cells, promoting immune responses against tumors and viruses.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Juanjuan Li, Zhenzhen Fu, Yong Liu
Summary: Liquid metal nanoparticles functionalized with surfactant molecules are used to assemble a nanocomposite material with a liquid metal core and a zeolitic-imidazolate framework shell. The resulting supraparticles are incorporated into an alginate-based hydrogel, which displays physiologically responsive sol-gel transformation, stable photothermal performance, and controllable zinc ion release. The composite hydrogel serves as a dual functional antitumor and antibacterial biomedicine, completely eradicating tumor cells/bacteria after a single treatment with laser-activated composite hydrogel.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Medicinal
Kaikai Xue, Lu Wang, Jinyao Liu
Summary: Bacteria have been widely used as therapeutic agents for immunotherapy, but there are safety issues and poor treatment efficacy due to the dependence on dosage. Therefore, a promising strategy is to modify the surface of bacteria to carry additional immune modulators, which can reduce the bacterial dose and enhance immune responses. This paper introduces the immunomodulation mediated by bacteria and the mechanisms involved, and summarizes the applications of surface modification approaches in improving immune functions.
Article
Psychiatry
Jifeng Wang, Yuan Cao, Weiliang Hou, Dexi Bi, Fang Yin, Yaohui Gao, Dengfeng Huang, Yingying Li, Zhan Cao, Yinmei Yan, Jianhua Zhao, Dewu Kong, Xiaoqiong Lv, Linsheng Huang, Hui Zhong, Chunyan Wu, Qiyi Chen, Rong Yang, Qing Wei, Huanlong Qin
Summary: Autism spectrum disorder (ASD) is a complex behavioral disorder characterized by difficulties in social interaction, restricted verbal communication, and repetitive behaviors. Fecal microbiota transplantation (FMT) is a safe and efficient strategy to adjust gut microbiota dysbiosis and improve ASD-related behavioral symptoms, but its mechanism is still unknown. Understanding the impact of microbiota on ASD development is crucial for developing new therapeutic strategies.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Chemistry, Multidisciplinary
Haiyan Guo, Zhenping Cao, Juanjuan Li, Zhenzhen Fu, Sisi Lin, Lu Wang, Jinyao Liu
Summary: Photosensitizer-based therapy faces limitations such as weak and easily attenuated photosensitive effects, poor tumor penetration and retention, and the need for multiple irradiation. In this study, bacteria were engineered to express melanin and coated with synthetic photosensitizers, forming a ternary combination for photoacoustic imaging-guided photothermal therapy. The integrated bacteria exhibited stable triple photoacoustic and photothermal effects under monochromatic irradiation, and were able to preferentially colonize hypoxic tumor tissue and generate uniform imaging signals and sufficient heating upon laser irradiation. The results showed inhibited tumor growth and extended survival in different tumor-bearing mouse models, suggesting the potential of bacteria-based innovative photosensitizers for imaging-guided therapy.
Review
Pharmacology & Pharmacy
Guocheng Xie, Sisi Lin, Feng Wu, Jinyao Liu
Summary: The low bioavailability and side effects of conventional drugs for eye disease have led to the development of efficient drug delivery systems using nanomaterials. This review highlights the unique functions of nanomaterials for carrying and transporting ocular drugs, as well as various strategies to enhance their performance. The current applications and limitations of nanomaterial-based delivery systems in treating ocular diseases are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Juanjuan Li, Jiani Han, Wenqin Yu, Kaiyuan Wang, Zhu Liu, Yong Liu
Summary: A alginate-based aerogel dressing with photothermal bactericidal activity, hemostatic property, and free radical scavenging has been reported for wound disinfection and accelerated healing. The dressing is constructed by immersing a clean nail in a solution of sodium alginate and tannic acid, allowing for the distribution of metal-phenolic networks throughout the composite. This work provides a simple strategy for developing multifunctional biomaterials and biomedicine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Chao Pan, Lu Wang, Mengmeng Zhang, Juanjuan Li, Junqiu Liu, Jinyao Liu
Summary: Introduces a new immunization strategy called in situ polymerization-mediated antigen presentation (IPAP), which allows antigen-loaded nanovaccines to spontaneously form and efficiently anchor onto dendritic cells in vivo through co-deposition with dopamine. IPAP promotes antigen presentation by increasing cell uptake and reducing antigen degradation. It prolongs antigen duration and enhances accumulation in lymph nodes, resulting in strong antigen-specific immune responses. IPAP is applicable for different antigens and overcomes the disadvantages of complex preparation and purification processes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Yong Liu, Fei Yang, Zixin Pan, Zhenzhen Fu, Xiaoli Jiang, Zhenping Cao, Juanjuan Li, Hao Wang
Summary: Metallic materials have long been used as antibacterial agents, and gallium, an abiogenic metal, has shown pharmaceutical effects in developing unconventional anticancer and antibacterial drugs. Recent research has demonstrated the potential of gallium-based materials in creating safe, efficacious, multifunctional, and even smart bactericidal medicine. This study provides a comprehensive guide for the design, fabrication, and implementation of gallium-based materials.
Article
Oncology
Yutong Cui, Jiani Han, Hong Li, Xiang Ma, Yanqiong Tang, Yong Deng, Dayong Wang, Denggao Huang, Juanjuan Li, Zhu Liu
Summary: In this study, we fabricated fluorescence gold nanoclusters decorated gas vesicles for ultrasound-mediated enhanced cellular delivery and imaging. The gas vesicles showed improved stability and fluorescence ability compared to free gold nanoclusters. The flow cytometry assay and confocal images confirmed the enhanced cellular uptake and imaging efficiency of the gas vesicles under ultrasound impact.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Biomedical
Yunxiang Yan, Yong Liu, Juanjuan Li, Ye Li, Haoheng Wu, Hong Li, Xiang Ma, Yanqiong Tang, Yuan Tong, Kexian Yi, Quanfeng Liang, Zhu Liu
Summary: A molecular switch-integrated, photo-responsive nanoplatform based on hollow mesoporous silica nanospheres (HMSN) loaded with silver nanoparticles (Ag NPs), vancomycin (Van), and hemin (HAVH) is reported for bacteria elimination and abscess therapy. The molecular switch hemin can be released from HMSN upon near-infrared (NIR) light irradiation, triggering the release of pre-loaded Ag+ and Van, enabling photothermal-modulated drug release and synergistic photothermal-chemo therapy (PTT-CHT). This study presents a new strategy for antibacterial drug delivery with high controllability and extendibility, which may benefit the development of smart multifunctional nanomedicine for diseases not limited to bacterial infections.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Yuan Cao, Jifeng Wang, Weiliang Hou, Yanqiang Ding, Yefei Zhu, Jiayi Zheng, Qiongyi Huang, Zhan Cao, Ruting Xie, Qing Wei, Huanlong Qin
Summary: The gut microbiome is linked to the occurrence and development of colorectal cancer (CRC), and specific features of expressed T cell receptor (TCR) beta repertoires in CRC patients were identified. The relative abundance of certain microorganisms was consistently elevated in CRC patients compared to healthy individuals. The correlation between somatic mutations, TCR clonality, and microbial biomarkers in CRC was investigated, leading to the construction of a classifier for clinical detection of CRC based on the microbiome and TCR repertoires.
Review
Chemistry, Multidisciplinary
Sisi Lin, Feng Wu, Yifan Zhang, Huan Chen, Haiyan Guo, Yanmei Chen, Jinyao Liu
Summary: This article reviews the strategies for surface chemical modification of bacteria and the advanced functions achieved by modifying specific surface components, highlighting the applications of modified bacteria for bioimaging, diagnosis, and therapy.
CHEMICAL SOCIETY REVIEWS
(2023)