Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

Sequence-based determinants and prediction of fuzzy interactions in protein complexes

(2020) Marton Miskei et al.   JOURNAL OF MOLECULAR BIOLOGY

Templated folding of intrinsically disordered proteins

(2020) Angelo Toto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence-based prediction of protein binding mode landscapes

(2020) Attila Horvath et al.   PLoS Computational Biology

Mapping the transition state for a binding reaction between ancient intrinsically disordered proteins

(2020) Elin Karlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classifying the Binding Modes of Disordered Proteins

(2020) Monika Fuxreiter   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Surveying biomolecular frustration at atomic resolution

(2020) Mingchen Chen et al.   Nature Communications

How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein?

(2018) Daniela Bonetti et al.   BIOPHYSICAL JOURNAL

Frustration, function and folding

(2018) Diego U Ferreiro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fuzziness in Protein Interactions—A Historical Perspective

(2018) Monika Fuxreiter   JOURNAL OF MOLECULAR BIOLOGY

Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy

(2018) Elise Delaforge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

(2018) Lisa M. Tuttle et al.   Cell Reports

A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins

(2018) Elin Karlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins

(2018) Per Jemth et al.   Science Advances

Fuzziness enables context dependence of protein interactions

(2017) Marton Miskei et al.   FEBS LETTERS

Simultaneous quantification of protein order and disorder

(2017) Pietro Sormanni et al.   Nature Chemical Biology

Theory, simulations, and experiments show that proteins fold by multiple pathways

(2017) William A. Eaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unique Domain Forms a Fuzzy Intramolecular Complex in Src Family Kinases

(2017) Miguel Arbesú et al.   STRUCTURE

Emergence and evolution of an interaction between intrinsically disordered proteins

(2017) Greta Hultqvist et al.   eLife

FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies

(2016) Marton Miskei et al.   NUCLEIC ACIDS RESEARCH

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

(2016) Angelo Toto et al.   Scientific Reports

A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1

(2016) Mauris C. Nnamani et al.   Cell Reports

Frustration Sculpts the Early Stages of Protein Folding

(2015) Eva Di Silvio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Short linear motifs – ex nihilo evolution of protein regulation

(2015) Norman E. Davey et al.   Cell Communication and Signaling

Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein

(2015) Gergő Gógl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of hierarchical protein dynamics

(2015) J. R. Lewandowski et al.   SCIENCE

Structural origin of slow diffusion in protein folding

(2015) H. S. Chung et al.   SCIENCE

Native Contact Density and Nonnative Hydrophobic Effects in the Folding of Bacterial Immunity Proteins

(2015) Tao Chen et al.   PLoS Computational Biology

Compensatory Adaptations of Structural Dynamics in an Intrinsically Disordered Protein Complex

(2014) Dennis Kurzbach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Conserved nucleation sites reinforce the significance of Phi value analysis in protein-folding studies

(2014) Stefano Gianni et al.   IUBMB LIFE

A Frustrated Binding Interface for Intrinsically Disordered Proteins

(2014) Per Jemth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

(2014) Stefano Gianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

(2014) F. Morcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb

(2014) Angelo Toto et al.   PROTEIN SCIENCE

Frustration in biomolecules

(2014) Diego U. Ferreiro et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Interaction of Nonstructural Protein 5A of the Hepatitis C Virus with Src Homology 3 Domains Using Noncanonical Binding Sites

(2013) Melanie Schwarten et al.   BIOCHEMISTRY

Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system

(2013) R. Giri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native contacts determine protein folding mechanisms in atomistic simulations

(2013) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition between native topology and nonnative interactions in simple and complex folding kinetics of natural and designed proteins

(2010) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

(2008) N. Calosci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA