Natural Product Synthesis through the Lens of Informatics

Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists

(2020) Benjamin J. Huffman et al.   Nature Chemistry

Synthesis of (−)-Picrotoxinin by Late-Stage Strong Bond Activation

(2020) Steven W. M. Crossley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (−)-Bilobalide

(2020) Robert M. Demoret et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates

(2019) Tucker Huffman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes

(2019) Kevin Hung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products in the “Marketplace”: Interfacing Synthesis and Biology

(2019) Benjamin J. Huffman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry

(2019) Seb Caille et al.   JOURNAL OF ORGANIC CHEMISTRY

Sesquiterpene Cyclizations inside the Hexameric Resorcinarene Capsule: Total Synthesis of δ-Selinene and Mechanistic Studies

(2019) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Concise asymmetric synthesis of (−)-bilobalide

(2019) Meghan A. Baker et al.   NATURE

Recent achievements and current trajectories of diversity-oriented synthesis

(2019) Christopher J Gerry et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanism of Action of the Cytotoxic Asmarine Alkaloids

(2018) Michael J. Lambrecht et al.   ACS Chemical Biology

Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies

(2018) Jeffrey M. Witkin et al.   BIOCHEMICAL PHARMACOLOGY

A review of salvinorin analogs and their kappa -opioid receptor activity

(2018) Jeremy J. Roach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

(2018) Tao Che et al.   CELL

Towards the generalized iterative synthesis of small molecules

(2018) Jonathan W. Lehmann et al.   Nature Reviews Chemistry

The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer

(2018) Samantha A. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Contemporary Synthetic Strategies toward seco-Prezizaane Sesquiterpenes from Illicium Species

(2018) Matthew L. Condakes et al.   JOURNAL OF ORGANIC CHEMISTRY

The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry–Biology Interface

(2017) Dale L. Boger   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of (−)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation

(2017) Masaki Ohtawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

(2017) Jeremy J. Roach et al.   ACS Central Science

Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells

(2016) Masaki Shoji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins

(2016) Steven W. M. Crossley et al.   CHEMICAL REVIEWS

An Additive Definition of Molecular Complexity

(2016) Thomas Böttcher   Journal of Chemical Information and Modeling

Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class

(2016) Hai-Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurite outgrowth enhancement by jiadifenolide: possible targets

(2016) R. A. Shenvi   NATURAL PRODUCT REPORTS

GABA Signaling and Neuroactive Steroids in Adrenal Medullary Chromaffin Cells

(2016) Keita Harada et al.   Frontiers in Cellular Neuroscience

Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore

(2016) Norihiro Tada et al.   ACS Central Science

Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

(2015) Renato A. Bauer   DRUG DISCOVERY TODAY

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Syntheses and biological studies of marine terpenoids derived from inorganic cyanide

(2015) Martin J. Schnermann et al.   NATURAL PRODUCT REPORTS

An eight-step gram-scale synthesis of (−)-jiadifenolide

(2015) Hai-Hua Lu et al.   Nature Chemistry

Biology-Oriented Synthesis: Harnessing the Power of Evolution

(2014) Hilde van Hattum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol

(2014) Kotaro Iwasaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Method of Continuous Variations: Applications of Job Plots to the Study of Molecular Associations in Organometallic Chemistry

(2013) Joseph S. Renny et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines

(2013) Sergey V. Pronin et al.   NATURE

3D Molecular Descriptors Important for Clinical Success

(2012) David C. Kombo et al.   Journal of Chemical Information and Modeling

A Stereoselective Hydroamination Transform To Access Polysubstituted Indolizidines

(2012) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a Potent Antimalarial Amphilectene

(2012) Sergey V. Pronin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization

(2012) Sergey V. Pronin et al.   Nature Chemistry

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

(2011) Minoru Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic Studies of the Lithium Enolate of 4-Fluoroacetophenone: Rapid-Injection NMR Study of Enolate Formation, Dynamics, and Aldol Reactivity

(2011) Kristopher J. Kolonko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Heterodimerization: Stereocontrolled Assembly via Solvent-Caged Unsymmetrical Diazene Fragmentation

(2011) Mohammad Movassaghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuropharmacology of the Naturally Occurring  -Opioid Hallucinogen Salvinorin A

(2011) C. W. Cunningham et al.   PHARMACOLOGICAL REVIEWS

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

(2010) Sivaraman Dandapani et al.   Nature Chemical Biology

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles

(2010) P. A. Clemons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Pentacyclicseco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties fromIllicium jiadifengpi

(2009) Miwa Kubo et al.   ORGANIC LETTERS

Reaction of Isonitriles with Carboxylic Acids in a Cavitand: Observation of Elusive Isoimide Intermediates

(2008) Per Restorp et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of the Hallucinogenic Neoclerodane Diterpenoid Salvinorin A

(2008) Masato Nozawa et al.   ORGANIC LETTERS

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH