PD-1 siRNA-Encapsulated Solid Lipid Nanoparticles Downregulate PD-1 Expression by Macrophages and Inhibit Tumor Growth

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Enhancing PD-1 Gene Silence in T Lymphocytes by Comparing the Delivery Performance of Two Inorganic Nanoparticle Platforms

(2019) Yanheng Wu et al.   Nanomaterials

PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide

(2019) Tiesuo Zhao et al.   Cell Death & Disease

Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes

(2019) Yanheng Wu et al.   Nanomedicine

PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy

(2019) Arash Salmaninejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy

(2019) Gulsah Erel-Akbaba et al.   ACS Nano

The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer

(2019) Jiajing Cai et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade

(2019) Amy L. Shergold et al.   PHARMACOLOGICAL RESEARCH

Immunosuppressive B cells expressing PD-1/PD-L1 in solid tumors: A mini review

(2019) Xiaowen Sun et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics

(2019) Jayesh A. Kulkarni et al.   ACCOUNTS OF CHEMICAL RESEARCH

The Acidic Tumor Microenvironment as a Driver of Cancer

(2019) Ebbe Boedtkjer et al.   Annual Review of Physiology

Combination of attenuated Salmonella carrying PD‐1 siRNA with nifuroxazide for colon cancer therapy

(2019) Tiesuo Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PLGA Nanoparticles Codelivering siRNAs against Programmed Cell Death Protein-1 and Its Ligand Gene for Suppression of Colon Tumor Growth

(2019) Seo Young Kwak et al.   MOLECULAR PHARMACEUTICS

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Receptor Occupancy Imaging Studies in Oncology Drug Development

(2018) Ingrid J. G. Burvenich et al.   AAPS Journal

Macrophages as a potential tumor-microenvironment target for noninvasive imaging of early response to anticancer therapy

(2018) Qizhen Cao et al.   BIOMATERIALS

The siRNA-mediated downregulation of PD-1 alone or simultaneously with CTLA-4 shows enhanced in vitro CAR-T-cell functionality for further clinical development towards the potential use in immunotherapy of melanoma

(2018) Bianca Simon et al.   EXPERIMENTAL DERMATOLOGY

Lipid nanoparticles with minimum burst release of TNF-α siRNA show strong activity against rheumatoid arthritis unresponsive to methotrexate

(2018) Abdulaziz M. Aldayel et al.   JOURNAL OF CONTROLLED RELEASE

Inhibitors of the PD-1 Pathway in Tumor Therapy

(2018) Martin W. LaFleur et al.   JOURNAL OF IMMUNOLOGY

Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

(2018) Maarten A. Ligtenberg et al.   MOLECULAR THERAPY

Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

(2018) Pooja Dhupkar et al.   Cancer Medicine

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

The roles of PD-1/PD-L1 and its signalling pathway in gastrointestinal tract cancers

(2018) Chunguo Cui et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

(2018) Francesca R. Mariotti et al.   OncoImmunology

Gene therapy using bacterial vectors

(2017) Peter Celec   Frontiers in Bioscience-Landmark

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Immunotherapy: Macrophages hijack anti-PD-1 therapy

(2017) David Killock   Nature Reviews Clinical Oncology

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

(2015) Sonja Kleffel et al.   CELL

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ

(2014) Jens HW Pahl et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The effect of the acid-sensitivity of 4-(N)-stearoyl gemcitabine-loaded micelles on drug resistance caused by RRM1 overexpression

(2012) Saijie Zhu et al.   BIOMATERIALS

MRI of Tumor-Associated Macrophages with Clinically Applicable Iron Oxide Nanoparticles

(2011) H. E. Daldrup-Link et al.   CLINICAL CANCER RESEARCH