Article
Nanoscience & Nanotechnology
Xinchen Wu, Olivia Gauntlett, Tengfei Zhang, Sanika Suvarnapathaki, Colleen McCarthy, Bin Wu, Gulden Camci-Unal
Summary: Scaffold-based bone regeneration using eggshell microparticles in protein-derived hydrogels significantly promotes bone regeneration by inducing osteogenic differentiation and supporting tissue infiltration over a 12-week period.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Horia Opris, Mihaela Baciut, Marioara Moldovan, Stanca Cuc, Ioan Petean, Daiana Opris, Simion Bran, Florin Gligor Onisor, Gabriel Armenea, Grigore Baciut
Summary: This study investigates the properties of eggshell membrane (ESM) and its potential application in tissue engineering. The results show that the non-uniform collagen arrangement of ESM limits its suitability as a guided bone regeneration membrane, but crosslinking techniques may enhance its properties for such applications.
Article
Dentistry, Oral Surgery & Medicine
Minh Khai Le Thieu, Havard Jostein Haugen, Javier Sanz-Esporrin, Mariano Sanz, Stale Petter Lyngstadaas, Anders Verket
Summary: In chronic non-contained bone defects treated with GBR, TiO2 blocks demonstrated the largest lateral volume augmentation but less new bone formation, while DBBM particles showed more mineralized bone in the grafted area but in smaller amounts. Empty controls had the most new lateral bone formation outward from the defect margins.
CLINICAL ORAL IMPLANTS RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yin-Zhe An, Franz-Josef Strauss, Jin-Young Park, Yu Qin Shen, Daniel Stefan Thoma, Jung-Seok Lee
Summary: The results of the study suggest that fixation of collagen membrane (CM) significantly enhances the expression of osteogenic factors, leading to more new bone formation, which is important in guiding bone regeneration.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
E. Aristodemou, M. Retzepi, E. Calciolari, N. Donos
Summary: This study evaluated the effect of membrane occlusiveness and experimental diabetes on early and late healing following guided bone regeneration. The results showed that the application of cell permeable membranes may mask the potentially adverse effect of experimental diabetes on bone regeneration.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Chemistry, Physical
Maoxia Wang, Xiaoqing Zhang, Yazhen Li, Anchun Mo
Summary: The study evaluated the impact of different GBR procedures on bone graft contour after wound closure in lateral ridge augmentation. Results showed that using i-PRF combined with a surgical template may contribute to achieving a better graft thickness.
Article
Dentistry, Oral Surgery & Medicine
Xiaoting Shen, Sijia Yang, Yangbo Xu, Wenting Qi, Fuming He
Summary: This study analyzed the marginal bone loss (Delta MBL) of tissue- or bone-level implants after simultaneous guided bone regeneration (GBR) and found that Delta MBL was similar for both types of implants, indicating desirable marginal bone stability.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Chemistry, Physical
Anton Friedmann, Stefan Fickl, Kai R. Fischer, Milad Dalloul, Werner Goetz, Frederic Kauffmann
Summary: This study compared the effects of different graft/membrane combinations on bone formation and found that collagen membranes with prolonged resorption/barrier profile combined with bone substitutes featuring different degradation profiles are sufficient to support new bone formation, and tacking strategy/membrane fixation is not necessary.
Article
Nanoscience & Nanotechnology
Yuwei Zhu, Bingyang Dai, Xu Li, Wei Liu, Jiangpeng Wang, Jiankun Xu, Shunxiang Xu, Xuan He, Shian Zhang, Quan Li, Ling Qin, To Ngai
Summary: The developed biphasic GBR membrane in this study can accelerate calvarial defect repair and has a favorable effect on bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Elena Canciani, Paola Stratico, Vincenzo Varasano, Claudia Dellavia, Chiara Sciarrini, Lucio Petrizzi, Lia Rimondini, Elena M. Varoni
Summary: This study evaluated the pre-clinical efficacy of a nano-HA/PGLA/dextran-based scaffold loaded with PLL and FN for bone regeneration in critical-size tibial defects using an ovine model. The scaffold showed promising results in promoting bone regeneration and had resorbable properties, suggesting its potential in treating large bone defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Young-Chang Ko, Jungwon Lee, Dongseob Lee, Yang-Jo Seol, Ki-Tae Koo, Yong-Moo Lee
Summary: This study aimed to compare the progression of experimental peri-implantitis between implants placed in pristine bone and guided bone regeneration (GBR) sites. The results showed no significant differences in marginal bone loss between the two groups during the progression of peri-implantitis. Histological, immunohistochemical, and polarized light microscopic analysis also revealed no significant differences between pristine bone and GBR sites. Therefore, previous hard tissue grafting at the implant sites does not affect the development of experimental peri-implantitis.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephane Durual, Leandra Schaub, Mustapha Mekki, Daniel Manoil, Carla P. Martinelli-Klay, Irena Sailer, Susanne S. Scherrer, Laurine Marger
Summary: The study demonstrated that saline treatment could improve the handling of DBBM-C and accelerate bone regeneration, resulting in higher quality tissue in vivo.
Article
Cell & Tissue Engineering
Brent Allan, Rui Ruan, Euphemie Landao-Bassonga, Nicholas Gillman, Tao Wang, Junjie Gao, Yonghua Ruan, Yuan Xu, Clair Lee, Mithran Goonewardene, Minghao Zheng
Summary: Treatment of cortical bone defects is a clinical challenge. In this study, a new type I collagen membrane for guided bone regeneration (GBR) has been clinically translated. The collagen membrane acts in an osteoconductive manner to facilitate cortical bone regeneration and improve cortical bone repair significantly, both in preclinical animal study and clinical trial. CelGro collagen membrane shows promise for GBR in both dental and orthopedic applications.
TISSUE ENGINEERING PART A
(2021)
Article
Biochemistry & Molecular Biology
Ronja Finze, Markus Laubach, Mairim Russo Serafini, Ulrich Kneser, Flavia Medeiros Savi
Summary: Large-volume bone defect regeneration is a complex and time-consuming process with multiple interdependent regeneration phases. Scaffold-guided bone regeneration has shown efficacy in both preclinical and clinical studies. Immunohistochemistry analysis provides valuable insights into the complex bone regeneration processes.
Article
Materials Science, Biomaterials
Dalia Acharjee, Santanu Mandal, Sujan Krishna Samanta, Mangal Roy, Biswanath Kundu, Sukumar Roy, Piyali Basak, Samit K. K. Nandi
Summary: In this study, a titanium-doped hydroxyapatite scaffold was produced from natural eggshell and laboratory-grade reagents to compare the efficacy of natural and synthetic resources of hydroxyapatite materials on new bone regeneration. The results showed that the titanium-doped biosourced hydroxyapatite scaffold had good biocompatibility and new bone-forming ability, indicating its potential use as a bone grafting material in orthopedic surgery.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Medicine, Research & Experimental
Raluca Petea-Balea, Manuela Lenghel, Horatiu Rotar, Cristian Dinu, Simion Bran, Onisor Florin, Rares Roman, Simona Senila, Csaba Csutak, Ciurea Anca
Summary: Ultrasound is the first-line imaging technique, but may not fully assess the extent of vascular anomalies in some cases. Magnetic resonance imaging with DCE-MRI allows accurate evaluation of the extent and anatomical relationship of vascular anomalies, as well as providing hemodynamic characterization, aiding in therapy selection and prognosis assessment.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Olga Medvedev, Mihaela Hedesiu, Anca Ciurea, Manuela Lenghel, Horatiu Rotar, Cristian Dinu, Rares Roman, Dragos Termure, Csaba Csutak
Summary: This article reviews the literature on perineural spread in head-and-neck tumors, summarizes important information for diagnostic imaging, and discusses the pathogenesis, clinical signs, prognostic importance, and technical considerations for computer tomography and magnetic resonance imaging. The anatomical pathways of the cranial nerves and main checkpoints are also synthesized, emphasizing the significance of perineural spread as important clues for differential diagnosis.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Polymer Science
Florin Onisor, Simion Bran, Ileana Mitre, Alexandru Mester, Andrada Voina-Tonea, Gabriel Armencea, Mihaela Baciut
Summary: This study systematically reviewed the literature on the use of polymers as bone substitutes for the treatment of periodontal infrabony defects. The results showed that polymer-based bone substitutes may be a useful alternative in treating infrabony defects with favorable outcomes.
Article
Health Care Sciences & Services
Cristian Dinu, Tiberiu Tamas, Gabriela Agrigoroaei, Sebastian Stoia, Horia Opris, Simion Bran, Gabriel Armencea, Avram Manea
Summary: Orbital fractures are a common result of facial trauma, and proper orbital reconstruction is important to prevent complications. This study evaluated the soft tissue of the orbit after posttraumatic reconstruction of orbital wall fractures. The findings showed varying degrees of fat and muscular tissue loss in all cases of reconstructed orbital fractures, providing guidance for primary or secondary soft tissue augmentation in orbital reconstruction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Sorana Muresanu, Oana Almasan, Mihaela Hedesiu, Laura Diosan, Cristian Dinu, Reinhilde Jacobs
Summary: This study provides a comprehensive review of the literature on the use of artificial intelligence (AI) in dental and maxillofacial cone beam computed tomography (CBCT), with the aim of assisting future researchers and dental professionals. The study found that AI models, particularly deep learning models, are commonly used in this field. The applications of AI have the potential to improve oral healthcare quality, promote personalized dentistry, and expedite dental procedures.
Review
Environmental Sciences
Horia Opris, Mihaela Baciut, Simion Bran, Florin Onisor, Oana Almasan, Avram Manea, Tiberiu Tamas, Sebastian Stoia, Armencea Gabriel, Grigore Baciut, Bogdan Crisan, Mihaela Hedesiu, Liana Crisan, Ioan Barbur, Daiana Opris, Cristian Dinu
Summary: This study evaluated the relationship between the hyoid and cervical posture and symptoms in patients with temporomandibular joint disorder (TMD). It found a possible association between hyoid and cervical posture and TMD, but more clinical trials are needed to draw definitive conclusions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Oana Almasan, Mihaela Hedesiu, Mihaela Baciut, Smaranda Buduru, Cristian Dinu
Summary: This study aimed to conduct a systematic review on temporomandibular joint (TMJ) psoriatic arthritis (PsA). A total of 23 publications with 151 TMJ PsA patients were included. Clinical symptoms of TMJ PsA included TMJ pain and sounds, limited range of jaw movements, preauricular swelling, malocclusion, headache, tinnitus, neck stiffness, and altered dietary function. Evaluation of TMJ included MRI, CT, and ultrasonography. Conservative therapy showed significant improvement in TMJ function.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Environmental Sciences
Cristian Dinu, Avram Manea, Denisa Tomoiaga, Mihaela Baciut, Oana Almasan, Andrei Otto Mitre, Ioan Barbur, Mihaela Hedesiu, Gabriel Armencea, Horia Opris, Sebastian Stoia, Tiberiu Tamas, Grigore Baciut, Florin Onisor, Simion Bran
Summary: This study evaluated and categorized the postoperative recovery symptoms of patients undergoing bimaxillary orthognathic surgery. The most common symptoms correlated with the healing process were edema, hematoma, trismus, pain, and anesthesia/hypoesthesia. Edema peaked 48-72 hours postoperatively, mouth opening amplitude decreased during the first two weeks, and patients experienced persistent anesthesia/hypoesthesia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Sebastian Stoia, Manuela Lenghel, Cristian Dinu, Tiberiu Tamas, Simion Bran, Mihaela Baciut, Emil Botan, Daniel Leucuta, Gabriel Armencea, Florin Onisor, Grigore Baciut
Summary: This study aimed to determine the value of multiparametric MRI in the preoperative differential diagnosis of parotid tumors. The results showed significant differences in T2WI and ADC in the differentiation of benign and malignant tumors. Multiparametric MRI had a sensitivity, specificity, and accuracy of 81.8%, 88.6%, and 92.3%, respectively. The combination of multiparametric and conventional MRI improved the preoperative differential diagnosis of parotid gland tumors.
Article
Biochemistry & Molecular Biology
Rares-Mario Borsa, Valentin Toma, Anca Onaciu, Cristian-Silviu Moldovan, Radu Marginean, Diana Cenariu, Gabriela-Fabiola Stiufiuc, Cristian-Mihail Dinu, Simion Bran, Horia-Octavian Opris, Sergiu Vacaras, Florin Onisor-Gligor, Dorin Sentea, Mihaela-Felicia Baciut, Cristina-Adela Iuga, Rares-Ionut Stiufiuc
Summary: Cancer remains a major challenge in medical practice. Oral cancer, in particular, has a significant impact due to its visibility, leading to social stigma and increased anxiety. New early diagnosis methods are needed to improve treatment efficiency and patients' quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ioan Barbur, Horia Opris, Horatiu Alexandru Colosi, Mihaela Baciut, Daiana Opris, Stanca Cuc, Ioan Petean, Marioara Moldovan, Cristian Mihail Dinu, Grigore Baciut
Summary: The mechanical properties of polymethylmethacrylate (PMMA) and graphene-based PMMA with Zn and Ag were compared in this study. Scanning electron microscopy was used to analyze the samples before and after the mechanical test. The compression behavior, flexural properties, tensile strength, and shape of the PMMA variants were investigated and compared. The results showed no statistical difference in the mechanical properties of the samples, but the graphene-based PMMA displayed similar performance to commercially available PMMA and showed potential for future clinical use.
Article
Biochemistry & Molecular Biology
Horia Opris, Mihaela Baciut, Marioara Moldovan, Stanca Cuc, Ioan Petean, Daiana Opris, Simion Bran, Florin Gligor Onisor, Gabriel Armenea, Grigore Baciut
Summary: This study investigates the properties of eggshell membrane (ESM) and its potential application in tissue engineering. The results show that the non-uniform collagen arrangement of ESM limits its suitability as a guided bone regeneration membrane, but crosslinking techniques may enhance its properties for such applications.
Article
Biochemistry & Molecular Biology
Ioan Barbur, Horia Opris, Bogdan Crisan, Stanca Cuc, Horatiu Alexandru Colosi, Mihaela Baciut, Daiana Opris, Doina Prodan, Marioara Moldovan, Liana Crisan, Cristian Dinu, Grigore Baciut
Summary: Dental 3D printing technologies have revolutionized orthodontic occlusal splint manufacturing, and they have been widely used in various dental fields. This study assessed the mechanical properties of 3D-printed materials and compared them with conventional PMMA. The results showed that 3D-printed materials are a promising alternative in clinical practice.
Article
Mathematics, Applied
Cristian Dinu, Daniela Danciulescu, Alexandru Tugui
Summary: In this work, improved versions of the Ky-Fan inequality for functions on time scales are presented, with the use of weights that can simultaneously take negative and positive values. It also explores the potential applications of these models in the economic context, as Economics offers numerous opportunities for time scales applications. Time scales not only unify discrete and continuous mathematics, but also provide a unified approach to discrete and continuous methods in economic studies.
CARPATHIAN JOURNAL OF MATHEMATICS
(2021)
