Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

Restoring light sensitivity using tunable near-infrared sensors

(2020) Dasha Nelidova et al.   SCIENCE

Towards optogenetic vision restoration with high resolution

(2020) Ulisse Ferrari et al.   PLoS Computational Biology

Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration

(2019) Michael Telias et al.   NEURON

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

(2019) Eloise Hudry et al.   NEURON

Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates

(2019) Paul-Henri Prévot et al.   Nature Biomedical Engineering

Retinal AAV8- RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery

(2018) Catherine Cukras et al.   MOLECULAR THERAPY

Safety of rAAV2/2- ND4 Gene Therapy for Leber Hereditary Optic Neuropathy

(2018) Catherine Vignal et al.   OPHTHALMOLOGY

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

(2017) Antoine Chaffiol et al.   MOLECULAR THERAPY

At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior

(2017) Nicole A. Repina et al.   Annual Review of Chemical and Biomolecular Engineering

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

(2016) Abhishek Sengupta et al.   EMBO Molecular Medicine

Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

(2016) Jean Bennett et al.   LANCET

Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial

(2016) Lyndon da Cruz et al.   OPHTHALMOLOGY

Maintaining ocular safety with light exposure, focusing on devices for optogenetic stimulation

(2016) Boyuan Yan et al.   VISION RESEARCH

Three-dimensional spatiotemporal focusing of holographic patterns

(2016) Oscar Hernandez et al.   Nature Communications

Representing vision and blindness

(2016) Patrick L. Ray et al.   Journal of Biomedical Semantics

Anatomical Identification of Extracellularly Recorded Cells in Large-Scale Multielectrode Recordings

(2015) P. H. Li et al.   JOURNAL OF NEUROSCIENCE

Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

(2015) Emilie Macé et al.   MOLECULAR THERAPY

Photovoltaic restoration of sight with high visual acuity

(2015) Henri Lorach et al.   NATURE MEDICINE

Subretinal Visual Implant Alpha IMS – Clinical trial interim report

(2015) Katarina Stingl et al.   VISION RESEARCH

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

(2013) D. Dalkara et al.   Science Translational Medicine

Interim Results from the International Trial of Second Sight's Visual Prosthesis

(2012) Mark S. Humayun et al.   OPHTHALMOLOGY

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

A QVGA 143 dB Dynamic Range Frame-Free PWM Image Sensor With Lossless Pixel-Level Video Compression and Time-Domain CDS

(2010) Christoph Posch et al.   IEEE JOURNAL OF SOLID-STATE CIRCUITS

Molecular basis of infrared detection by snakes

(2010) Elena O. Gracheva et al.   NATURE

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Optobionic vision—a new genetically enhanced light on retinal prosthesis

(2009) Patrick Degenaar et al.   Journal of Neural Engineering

Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE