期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/jpm11010060
关键词
air pollution; biomarker; exposure; human; lung cancer; miRNA
资金
- Ministry of Education, Youth and Sports of the Czech Republic project Healthy Aging in Industrial Environment HAIE [CZ.02.1.01/0.0/0.0/16_019/0000798]
- European Union (European Structural and Investment funds
- Operation Programme Research, Development and Education)
- Ministry of Education, Youth and Sports of the Czech Republic (Research Infrastructures NanoEnviCZ) [LM2018124]
- Ministry of Education, Youth and Sports of the Czech Republic (EATRIS-CZ) [LM2018133]
- EU
- Ministry of Education, Youth and Sports of the Czech Republic as a JPND 2020 project ADAIR [8F20008]
- Czech Science Foundation [18-02079S]
Small non-coding RNA molecules (miRNAs) are important in the epigenetic regulation of gene expression and have been proposed as biomarkers for human cancers. Environmental pollutants, including airborne contaminants, can affect miRNA levels. A total of 25 miRNAs, including miR-222, miR-21, miR-126-3p, miR-155, and miR-425, were identified as potential biomarkers for lung cancer in populations exposed to air pollution.
Small non-coding RNA molecules (miRNAs) play an important role in the epigenetic regulation of gene expression. As these molecules have been repeatedly implicated in human cancers, they have been suggested as biomarkers of the disease. Additionally, miRNA levels have been shown to be affected by environmental pollutants, including airborne contaminants. In this review, we searched the current literature for miRNAs involved in lung cancer, as well as miRNAs deregulated as a result of exposure to air pollutants. We then performed a synthesis of the data and identified those molecules commonly deregulated under both conditions. We detected a total of 25 miRNAs meeting the criteria, among them, miR-222, miR-21, miR-126-3p, miR-155 and miR-425 being the most prominent. We propose these miRNAs as biomarkers of choice for the identification of human populations exposed to air pollution with a significant risk of developing lung cancer.
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