Engineering approaches for studying immune-tumor cell interactions and immunotherapy

Use of ex vivo patient derived tumor organotypic spheroids to identify combination therapies for HER2mutant non small cell lung cancer

(2020) Elena Ivanova et al.   CLINICAL CANCER RESEARCH

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

(2020) Steven Lohard et al.   Nature Communications

The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation

(2020) Mark F. Coughlin et al.   Advanced Healthcare Materials

The future of cancer immunotherapy: microenvironment-targeting combinations

(2020) Yonina R. Murciano-Goroff et al.   CELL RESEARCH

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies

(2020) Florent Petitprez et al.   Frontiers in Immunology

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

(2020) Raju K. Vaddepally et al.   Cancers

Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model

(2020) Kristina Haase et al.   ADVANCED FUNCTIONAL MATERIALS

Engineering CAR-T Cells for Next-Generation Cancer Therapy

(2020) Mihe Hong et al.   CANCER CELL

T-cell activation is modulated by the 3D mechanical microenvironment

(2020) Fatemeh S. Majedi et al.   BIOMATERIALS

Tumor-Derived cGAMP Regulates Activation of the Vasculature

(2020) Marco Campisi et al.   Frontiers in Immunology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model

(2019) Yuta Ando et al.   Advanced Healthcare Materials

Microfluidic three-dimensional biomimetic tumor model for studying breast cancer cell migration and invasion in the presence of interstitial flow

(2019) Chao Song et al.   CHINESE CHEMICAL LETTERS

Three‐dimensional microfluidic tumor–macrophage system for breast cancer cell invasion

(2019) Shengli Mi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic Model for Evaluation of Immune Checkpoint Inhibitors in Human Tumors

(2019) Ashley L. Beckwith et al.   Advanced Healthcare Materials

Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment

(2019) Hyunho Kim et al.   Advanced Science

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Reconfigurable open microfluidics for studying the spatiotemporal dynamics of paracrine signalling

(2019) Jiaquan Yu et al.   Nature Biomedical Engineering

Microfluidic-Based Immunomodulation of Immune Cells Using Upconversion Nanoparticles in Simulated Blood Vessel–Tumor System

(2019) Dulani Chandima Wimalachandra et al.   ACS Applied Materials & Interfaces

An engineered tumor-on-a-chip device with breast cancer-immune cell interactions for assessing T-cell recruitment

(2019) Aereas Aung et al.   CANCER RESEARCH

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

(2019) Jessica L. Ritter et al.   CANCER RESEARCH

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Conditional Reprogramming for Patient-Derived Cancer Models and Next-Generation Living Biobanks

(2019) Palechor-Ceron et al.   Cells

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

(2018) Amy Cochrane et al.   ADVANCED DRUG DELIVERY REVIEWS

A novel 3D heterotypic spheroid model for studying extracellular vesicle-mediated tumour and immune cell communication

(2018) Lilite Sadovska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

(2018) A. Boussommier-Calleja et al.   BIOMATERIALS

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

(2018) Xin Cui et al.   BIOMATERIALS

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

(2018) Susan Tsai et al.   BMC CANCER

Co-culture of tumor spheroids and monocytes in a collagen matrix-embedded microfluidic device to study the migration of breast cancer cells

(2018) Tianying Yuan et al.   CHINESE CHEMICAL LETTERS

Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation

(2018) Chinky Shiu Chen Liu et al.   JOURNAL OF IMMUNOLOGY

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

(2018) N. Moore et al.   LAB ON A CHIP

Interstitial Flow Promotes Macrophage Polarization toward an M2 Phenotype

(2018) Ran Li et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanogenetics for the remote and noninvasive control of cancer immunotherapy

(2018) Yijia Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cells, basophils and eosinophils: From allergy to cancer

(2018) A. Rigoni et al.   SEMINARS IN IMMUNOLOGY

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity

(2018) Hilary Sherman et al.   Frontiers in Immunology

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

(2018) Sharon Wei Ling Lee et al.   Frontiers in Immunology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

(2018) Jose M. Ayuso et al.   OncoImmunology

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

(2017) Aaron M. Goodman et al.   MOLECULAR CANCER THERAPEUTICS

Improving T Cell Expansion with a Soft Touch

(2017) Lester H. Lambert et al.   NANO LETTERS

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

(2017) Niklas K. Finnberg et al.   Oncotarget

Organs on chip approach: a tool to evaluate cancer -immune cells interactions

(2017) Elena Biselli et al.   Scientific Reports

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade

(2017) Dirk Zboralski et al.   Cancer Immunology Research

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

(2017) Stefania Parlato et al.   Scientific Reports

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

(2016) Sylvia Herter et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways

(2016) Ran Li et al.   CANCER RESEARCH

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

(2016) Kengo Nozaki et al.   JOURNAL OF GASTROENTEROLOGY

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

RECIST — learning from the past to build the future

(2016) Saskia Litière et al.   Nature Reviews Clinical Oncology

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

(2016) T T Vellinga et al.   ONCOGENE

Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling

(2016) Steven G. Allen et al.   Scientific Reports

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

(2015) Ariane Giannattasio et al.   BMC CANCER

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Impact of the spheroid model complexity on drug response

(2015) Oliver Ingo Hoffmann et al.   JOURNAL OF BIOTECHNOLOGY

Establishment of a heterotypic 3D culture system to evaluate the interaction of TREG lymphocytes and NK cells with breast cancer

(2015) Tanya N. Augustine et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Ultrasonic three-dimensional on-chip cell culture for dynamic studies of tumor immune surveillance by natural killer cells

(2015) Athanasia E. Christakou et al.   LAB ON A CHIP

Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment

(2015) Yang Zhao et al.   Oncotarget

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

(2015) Jing Bai et al.   Oncotarget

A multidisciplinary study usingin vivotumor models and microfluidic cell-on-chip approach to explore the cross-talk between cancer and immune cells

(2014) Fabrizio Mattei et al.   Journal of Immunotoxicology

Cancer-driven dynamics of immune cells in a microfluidic environment

(2014) Elena Agliari et al.   Scientific Reports

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Harnessing the antitumor potential of macrophages for cancer immunotherapy

(2014) Kristen B Long et al.   OncoImmunology

Three-Dimensional Scaffolds to Evaluate Tumor Associated Fibroblast-Mediated Suppression of Breast Tumor Specific T Cells

(2013) Vy Phan-Lai et al.   BIOMACROMOLECULES

Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells

(2013) Bhaskar Mitra et al.   RSC Advances

Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion

(2012) Sung Kyu Kim et al.   ANALYST

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

(2012) Brian F. Zamarron et al.   International Journal of Biological Sciences

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

Patient-derived tumour xenografts as models for oncology drug development

(2012) John J. Tentler et al.   Nature Reviews Clinical Oncology

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D Porous Chitosan-Alginate Scaffolds: A New Matrix for Studying Prostate Cancer Cell-Lymphocyte Interactions In Vitro

(2012) Stephen J. Florczyk et al.   Advanced Healthcare Materials

Microfluidic device to study cell transmigration under physiological shear stress conditions

(2011) Dorota Kwasny et al.   BIOMEDICAL MICRODEVICES

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   Integrative Biology

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

The Incidence of Cancer in a Population-Based Cohort of Canadian Heart Transplant Recipients

(2010) Y. Jiang et al.   AMERICAN JOURNAL OF TRANSPLANTATION