Review
Nutrition & Dietetics
Chien-Ning Hsu, Chih-Yao Hou, Wei-Hsuan Hsu, You-Lin Tain
Summary: Research has shown a link between early gut microbiota and cardiovascular diseases, leading to targeted therapies such as probiotics, prebiotics, and postbiotics. Reprogramming interventions targeting the gut microbiota have shown promise in preventing cardiovascular diseases. Further studies will be needed to fully implement these findings into practice.
Article
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Julie Y. H. Chan, Chien-Te Lee, You-Lin Tain
Summary: Resveratrol has been shown to protect adult offspring from hypertension programmed by prenatal exposure to ADMA and TMAO, potentially through regulation of gut microbiota, fecal butyrate levels, modulation of the renin-angiotensin system, and the nitric oxide pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, Chih-Yao Hou, You-Lin Tain
Summary: This review highlights the link between cardiovascular and renal programming with developmental origins of CVD and kidney disease, discussing the positive influence of resveratrol on these diseases and its role as a reprogramming agent in animal studies. Further research is needed to clarify the reprogramming effects of resveratrol before clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: This review discusses the innovative use of animal models in studying the mechanisms behind developmental origins of hypertension. Research has found that early maternal stress can alter the gut microbiota, leading to adverse outcomes in offspring. Dysbiosis of the gut microbiota is involved in the developmental origins of hypertension, while targeted therapy for the gut microbiota can prevent hypertension in later life.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The developmental origins of health and disease theory suggests that many adult-onset diseases can originate in early life. Oxidative stress plays a crucial role in renal programming, and perinatal use of antioxidants can reverse programming processes and prevent adult-onset diseases.
Article
Biochemistry & Molecular Biology
Chien-Ning Hsu, Julie Y. H. Chan, Kay L. H. Wu, Hong-Ren Yu, Wei-Chia Lee, Chih-Yao Hou, You-Lin Tain
Summary: The study found that high-fructose diet and minocycline treatment, both individually and combined, resulted in elevated blood pressure in adult male offspring, with no synergistic effect between the two. Different groups showed distinct enterotypes. Minocycline treatment increased the F/B ratio but decreased the abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment led to lower levels of plasma acetic acid and butyric acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress plays a crucial role in the developmental origins of hypertension, as early-life oxidative stress leads to developmental programming in key blood pressure-controlled organs and subsequently results in hypertension in adulthood. Antioxidant therapy has the potential to lower blood pressure and serves as a novel preventive strategy for hypertension with developmental origins.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Hypertension is a significant global disease burden and can originate in early life. Melatonin, a hormone with multifaceted biological functions, plays important roles in pregnancy, fetal development, and blood pressure regulation. Early melatonin therapy as a reprogramming strategy can protect against the early life origins of hypertension.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Polyphenols, a group of plant chemicals, have antihypertensive effects. Early use of polyphenols can prevent the development of hypertension, although the understanding of this is limited. This review provides a summary of the chemistry and biological function of polyphenols, as well as the epidemiological and experimental evidence supporting the early-life origins of hypertension. Animal data on the use of specific polyphenols as an early-life intervention to protect offspring against hypertension in adulthood are discussed, along with underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang
Summary: Cardiovascular diseases (CVDs) are highly prevalent worldwide, and the balance of intestinal microecology plays a crucial role in their occurrence and development. Trimethylamine N-oxide (TMAO), a metabolite produced by gut microbiota from dietary choline and L-carnitine, has been found to inhibit cholesterol metabolism, induce platelet aggregation, and promote atherosclerosis. This review provides insights into the biological and chemical characteristics of TMAO, as well as its impact on various CVDs, including atherosclerosis, heart failure, hypertension, arrhythmia, and coronary artery disease. Understanding the mechanism of TMAO in promoting CVDs may contribute to the development of targeted therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chien-Ning Hsu, Hung-Wei Yang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, You-Lin Tain
Summary: Melatonin therapy can prevent hypertension and attenuate kidney injury in male rats with chronic kidney disease, by mediating gut microbiota-derived metabolites and the nitric oxide pathway. The protective effects of melatonin are associated with restoration of gut microbiota alterations and prevention of increased uremic toxins levels. Melatonin sex-specifically protects young rats against hypertension and kidney injury induced by chronic kidney disease.
Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Article
Nutrition & Dietetics
Manman Lu, Yuhui Yang, Yuncong Xu, Xiaoyue Wang, Bo Li, Guowei Le, Yanli Xie
Summary: Dietary methionine restriction (MR) can reduce plasma trimethylamine-N-oxide (TMAO) levels by manipulating gut microbiota in mice. MR decreases the ability of gut microbiota to produce trimethylamine (TMA), reduces TMA levels and expression of choline TMA-lyase (CutC) in the intestine, and increases the abundance of SCFA-producing bacteria.
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: The gut-kidney interaction and gut microbiota-targeted therapies have gained increasing attention in the research of chronic kidney disease (CKD). Understanding the impact of early-life gut microbiome on CKD and the development of early interventions are crucial for reducing CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Chien-Ning Hsu, You-Lin Tain
Summary: Animal models are essential for investigating the causal relationship between early-life exposure and the developmental programming of hypertension, providing insights into how early interventions can reprogram disease processes and prevent hypertension.
Article
Food Science & Technology
Chih-Yao Hou, Chia-Min Lin, Anil Kumar Patel, Chengdi Dong, Ming-Kuei Shih, Chang-Wei Hsieh, Yu-Lin Hung, Ping-Hsiu Huang
Summary: This study aims to determine the potential of using incinerated eggshell powder and alkaline electrolyzed oxidized (EO) water for pidan production instead of harmful NaOH. The results showed that pidan produced using incinerated eggshell powder solution and alkaline EO water had similar physicochemical and sensory qualities to the commercial product.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Biotechnology & Applied Microbiology
Chien-Ning Hsu, Ya-Ting Lin, Yu-Hsu Chen, Tsung-Yu Tseng, Hsing-Fen Tsai, Shinn-Gwo Hong, Chao-Ling Yao
Summary: The study successfully immobilized fibronectin on a bio-based and aligned poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) film through chemical modification, and demonstrated its potential as a scaffold for vascular tissue engineering. The fibronectin-fixed PHBV films showed excellent cell biocompatibility, promoting rapid proliferation and correct cell functions of endothelial progenitor cells (EPCs).
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2023)
Article
Food Science & Technology
Yen-Tso Lai, Chih-Yao Hou, Shin-Ping Lin, Yi-Chen Lo, Chien-Hao Chen, Chang-Wei Hsieh, Hui-Wen Lin, Kuan-Chen Cheng
Summary: This study investigated nontraditional inoculation strategies using aroma-producing yeast strains for Kyoho wine fermentation and conducted instrumental analysis and sensory evaluation. The results showed that mixed culture could promote the formation of esters and glycerol and reduce the content of ethanol in wine. Sensory analysis suggested that the sequential inoculation treatment of three yeast strains was associated with floral, red fruity, and tropical fruity aroma attributes.
JOURNAL OF FOOD SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Oxidative stress occurs when the production of reactive oxygen or nitrogen species exceeds the capacity of antioxidant systems. It has a significant impact on kidney development and can lead to kidney disease in adulthood. Evaluating biomarkers allows us to assess oxidative stress in fetuses and neonates. Animal models have provided valuable insights into the mechanisms of renal programming related to oxidative stress and interventions to prevent kidney disease. This comprehensive review examines the effects of perinatal oxidative stress on renal programming, the role of antioxidant strategies in kidney disease prevention, and the challenges in translating findings from animal models to clinical practice.
Article
Chemistry, Medicinal
Ting-Chun Liu, Chien-Ning Hsu, Wen-Chin Lee, Shih-Wei Wang, Chiang-Chi Huang, Yueh-Ting Lee, Chung-Ming Fu, Jin-Bor Chen, Lung-Chih Li
Summary: Osteoporosis and cardiovascular disease are correlated with increased morbidity and mortality in elderly women. This study compared mortality rate and cardiovascular events between denosumab and raloxifene in osteoporotic women. The results showed that denosumab is superior to raloxifene in lowering risks of all-cause mortality and certain ischemic strokes.
Article
Pediatrics
You-Lin Tain, Chien-Ning Hsu
Summary: The disruption of gut microbiota composition and structure, known as dysbiosis, plays a crucial role in the development of kidney diseases. Understanding the connection between dysbiotic gut microbiota and pediatric renal diseases is important for the prevention and treatment of these conditions. This review explores the link between dysbiotic gut microbiota and various pediatric renal diseases and discusses potential gut microbiota-targeted therapies.
Article
Food Science & Technology
Chih-Yao Hou, Sulfath Hakkim Hazeena, Pin-Xian Li, Shu-Ling Hsieh, Chang-Wei Hsieh, Min-Hung Chen, Ming-Kuei Shih, Meng-Chieh Yu, Yu-Shen Liang
Summary: This study aimed to extend the storage life of atemoya fruit by applying D-limonene nanoemulsion coating, reduce spoilage, and facilitate market expansion. The results showed that 0.25% D-limonene nanoemulsion inhibited browning and reduced physiological metabolisms. Higher concentrations of D-limonene caused damage to the peel cells.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Medicine, General & Internal
Heng-Ching Liao, Fang-Ju Lin, Chien-Ning Hsu, Susan Shur -Fen Gau, Chi-Chuan Wang
Summary: This study examined the use of methylphenidate and atomoxetine in patients diagnosed with attention deficit hyperactivity disorder (ADHD) in Taiwan between 2004 and 2017. The study investigated the initial treatment for ADHD, the time between diagnosis and prescription, and medication-switching patterns. The majority of patients (98.2%) received methylphenidate, while atomoxetine use increased over time. The study also found that the prevalence of pharmacotherapy for ADHD was relatively low.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Nutrition & Dietetics
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Hong-Tai Tzeng, Wei-Chia Lee, Kay L. H. Wu, Hong-Ren Yu, Julie Y. H. Chan, Chien-Ning Hsu
Summary: Maternal nutrition plays a crucial role in adult disease development. Excessive fructose intake by mothers contributes to hypertension in their offspring. New evidence suggests a connection between early-life gut microbiota and later hypertension. This study aimed to investigate if maternal supplementation of butyrate or propionate can prevent hypertension in offspring exposed to a high-fructose diet.
Review
Biochemistry & Molecular Biology
Chih-Jen Chen, Ming-Chou Cheng, Chien-Ning Hsu, You-Lin Tain
Summary: Hydrogen sulfide (H2S) plays a crucial role in kidney health and disease through dysregulated signaling and interactions with various mechanisms. Interventions such as sulfur-containing amino acids, N-acetylcysteine, H2S donors, and organosulfur compounds during gestation and lactation have shown promising results in improving renal outcomes. However, more research is needed to translate these findings into clinical practice.
Article
Public, Environmental & Occupational Health
Lung-Chih Li, You-Lin Tain, Hsiao-Ching Kuo, Chien-Ning Hsu
Summary: A cohort study in Taiwan found that pediatric and young adult patients on dialysis had a higher risk of cardiovascular disease and mortality compared to adult patients. Non-atherosclerotic cardiovascular disease was more prevalent in younger patients within the first 6 months of dialysis initiation, while atherosclerotic cardiovascular disease risk was higher in adults after 6 months.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Green & Sustainable Science & Technology
Chia -Min Lin, Samuel Herianto, Chang-Wei Hsieh, Ming-Kuei Shih, Jhih-Ying Ciou, Jing-Chung Huang, Tsu-Tung Liu, Hsiu-Ling Chen, Chih-Yao Hou
Summary: In this study, a soaking treatment using ozone-microbubble (OMB) water was demonstrated as an effective disinfection method for jumbo squid. Soaking squids with OMB for 3 minutes (OMB3) was found to reduce microbial contaminants and maintain squid qualities, compared to the control treatment (RO5). The OMB3 treatment also minimized pigment release and color change in the squid throughout storage periods.
JOURNAL OF CLEANER PRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Nitric oxide (NO) is a gaseous signaling molecule that plays a crucial role in protecting the kidneys. NO can be generated through different pathways, either dependent or independent of NO synthase (NOS). Deficiency of NO is closely associated with chronic kidney disease (CKD). Adverse intrauterine conditions can impact kidney development, increase the risk of CKD, but early reprogramming treatments have the potential to mitigate this risk. This review highlights the relationship between NOS/NO research and renal programming and reprogramming, and suggests potential strategies targeting NO for preventing and treating renal programming.
Article
Biochemistry & Molecular Biology
You-Lin Tain, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: This study aimed to investigate the protective effects of sodium thiosulfate (STS) in a rat model of maternal CKD-induced hypertension. The results showed that STS treatment could enhance H2S and NO signaling pathways, alter gut microbiota, and protect offspring from maternal CKD-primed hypertension. This suggests that early-life interventions targeting reactive sulfur species (RSS) have potential preventive and therapeutic benefits for CKD-induced hypertension.