期刊
GLAND SURGERY
卷 10, 期 1, 页码 219-232出版社
AME PUBL CO
DOI: 10.21037/gs-20-582
关键词
Nonfunctional pancreatic neuroendocrine tumors (NF-PNETs); malignancy; observation; parenchyma-sparing pancreatectomy
类别
资金
- National Natural Sciences Foundation of China [81970543, 81570591]
- Research Unit Project of Chinese Academy of Medical Sciences [2019-I2M-5-030]
This study evaluated the risk of malignancy of small nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) and their outcomes following curative resection. It found that surgical resection may be considered for small tumors and parenchyma-sparing pancreatectomy can be an alternative for select cases.
Background: Small nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) <= 2 cm have variable biological features, and there is no gold standard treatment for their management. The present study aimed to evaluate the risk of malignancy of small NF-PNETs and their outcomes following curative resection. Methods: Patients with NF-PNETs undergoing surgical resection at the First Affiliated Hospital, College of Medicine, Zhejiang University, between 2012 and 2017 were included. Clinicopathological characteristics, perioperative results, and prognosis were retrospectively analyzed. Results: A total of 73 patients were identified, including 28 with small NF-PNETs and 45 large PNETs; 32.1% of NF-PNETs <= 2 cm underwent a parenchyma-sparing pancreas surgery, which was >6.7% in large NF-PNETs. No statistically significant differences in perioperative results, postoperative complications, and long-term outcomes were found between small tumors undergoing standard and parenchyma-sparing pancreatectomy. Eighteen small tumors (64.3%) developed a perioperative complication, with a clinically significant pancreatic fistula rate of 25%; however, only 2 patient needed reintervention. Small NF-PNETs in 3 patients were malignant. Multivariate logistic regression showed that grade >= 3 and lymphovascular invasion were independently related to malignancy in NF-PNETs. Conclusions: Small NF-PNETs (<= 2 cm) are not immune from potential malignancy. Surgical resection may be considered for small tumors and can provide favorable postoperative and long-term outcomes. Parenchyma-sparing pancreatectomy may be an alternative surgery for selected small local NF-PNETs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据