Review
Medicine, General & Internal
Per-Johan Jakobsson, Luke Robertson, Janika Welzel, Mingshu Zhang, Yang Zhihua, Gao Kaixin, Huang Runyue, Wen Zehuai, Marina Korotkova, Ulf Goransson
Summary: Chinese medicine has a long tradition of use in the treatment and prevention of rheumatoid arthritis (RA). This article summarizes the background, mechanisms, and proposed clinical trial for using Chinese herbal medicine in the prevention of RA. RA is an autoimmune, inflammatory disease that primarily affects the joints and is associated with genetic variations and smoking.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Immunology
Yujiao Liang, Mengyao Liu, Yingxue Cheng, Xinchang Wang, Weijie Wang
Summary: This article mainly explores the relationship between Traditional Chinese Medicine (TCM) and gut microbiota in treating Rheumatoid arthritis (RA). It comprehensively summarizes the roles of gut microbiota in the onset and development of RA, and elucidates the mechanism of TCM in preventing and treating RA by influencing the microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ivo Ricardo de Seabra Rodrigues Dias, Hang Hong Lo, Kaixi Zhang, Betty Yuen Kwan Law, Ali Adnan Nasim, Sookja Kim Chung, Vincent Kam Wai Wong, Liang Liu
Summary: Rheumatoid arthritis is a chronic inflammatory autoimmune disease affecting approximately 0.5-1% of the population, requiring new treatment options. Endoplasmic reticulum stress has been associated with rheumatoid arthritis, cancer, and inflammatory pathologies, with some traditional Chinese medicines showing potential in modulating ER stress.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Integrative & Complementary Medicine
Liang-zhen You, Qian-qian Dai, Xiao-ying Zhong, Dong-dong Yu, He-rong Cui, Yi-fan Kong, Meng-zhu Zhao, Xin-yi Zhang, Qian-qian Xu, Zhi-yue Guan, Xu-xu Wei, Xue-cheng Zhang, Song-jie Han, Wen-jing Liu, Zhao Chen, Xiao-yu Zhang, Chen Zhao, Ying-hui Jin, Hong-cai Shang
Summary: This study evaluated the efficacy and safety of three traditional Chinese medicine drugs and three herbal formulas (3-drugs-3-formulas) in patients with COVID-19. The combination of 3-drugs-3-formulas was found to shorten the duration of symptoms, decrease hospitalization time, aggravation rate, and mortality, and increase the recovery rate of chest CT manifestations and total effectiveness. The 3-drugs-3-formulas can play an active role in treating all stages of COVID-19.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Review
Pharmacology & Pharmacy
Liqiong Yu, Shiling Li, Lili Pu, Chunhong Yang, Qian Shi, Qi Zhao, Shengbu Meniga, Yue Liu, Yi Zhang, Xianrong Lai
Summary: This review provides a comprehensive overview of medicinal plants with anti-rheumatoid arthritis (RA) activity in the traditional Tibetan medicine (TTM) system. It discusses the major bioactive components and treatment mechanisms, highlighting the importance of regulating pro-inflammatory cytokine expression in RA.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Zhenyu Zhao, Yanda Li, Liangyun Zhou, Xiuteng Zhou, Bowen Xie, Wenjin Zhang, Jiahui Sun
Summary: Traditional Chinese medicine (TCM) has shown significant effectiveness in preventing and treating COVID-19, with the ability to prevent iatrogenic infections and a high national participation rate in China. It is currently the best choice for the treatment and prevention of COVID-19 and is expected to be promoted globally.
Article
Medical Informatics
Yidi Cui, Bo Gao, Lihong Liu, Jing Liu, Yan Zhu
Summary: The research team constructed a large-scale intelligent retrieval system AMFormulaS using ontology, which efficiently retrieves and analyzes information on traditional Chinese medicine formulas and decoction pieces, providing support for scientific research and new drug development.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Review
Cell Biology
Wenhao Li, Lei Yu, Wenming Li, Gaoran Ge, Yong Ma, Long Xiao, Yusen Qiao, Wei Huang, Wenli Huang, Minggang Wei, Zhirong Wang, Jiaxiang Bai, Dechun Geng
Summary: This article summarizes the methods and effectiveness of both Western and Chinese medicine in the treatment of inflammatory arthritis, with a focus on the targets and mechanisms of action of Chinese medicine. The relationship between gut microbiota and Chinese medicine and the role of drug delivery systems in Chinese medicine use are also briefly discussed. This review provides updated and comprehensive insights into the clinical application of Chinese medicine for the treatment of inflammatory arthritis.
AGEING RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Sonja Stojanovic, Bojana Stamenkovic, Jovan Nedovic, Ivana Aleksic, Jelena Jovanovic, Jovana Cvetkovic, Jasmina Jocic, Miljana Sarac, Novica Dimic, Marija Andjelkovic Apostolovic, Milovan Stojanovic
Summary: This study analyzed the impact of disease-modifying antirheumatic drugs, vaccination status, and clinical and demographic characteristics on the hospitalization rate of COVID-19 patients with rheumatoid arthritis. The results showed that treatment with disease-modifying antirheumatic drugs, except for rituximab, did not increase the risk of hospitalization, while the use of tocilizumab proved to be protective. Age, hypertension, and rituximab therapy were identified as independent factors associated with the hospitalization of rheumatoid arthritis patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Pharmacology & Pharmacy
Zhi-Yu Li, Zhi-Jun Xie, Hai-Chang Li, Jian-Jian Wang, Xiang-Hui Wen, Shou-Yuan Wu, Jiao Chen, Juan-Juan Zhang, Lin Li, Qiang-Qiang Guo, Qiu-Ping Liu, Hui Lan, Yue-Peng Jiang, Dian-Ming Li, Xiao-Feng Xu, Si-Yue Song, Ming Zhang, Shan Fang, Wei-Dong Lai, Yi-Ni Gao, Feng-Qi Zhang, Wen-Qing Luo, Yu Lou, Wu Chen, Xia-Feng Zhang, Ke-Er Wang, Ming-Qian Zhou, Yuan-Fang He, An-Ran Xi, Yan Gao, Yi Zhang, Yao-Long Chen, Cheng-Ping Wen
Summary: This article introduces the development of guidelines for the integrated treatment of severe COVID-19 with TCM and western medicine, based on the WHO handbook, the GRADE system, and the RIGHT reporting items. The aim is to provide clinical guidance and decision basis for healthcare professionals.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Integrative & Complementary Medicine
Parva Namiranian, Omid Sadatpour, Sadegh Azimzadeh Jamalkandi, Mohammad Hossein Ayati, Mehrdad Karimi
Summary: This review suggests that complementary medicine holds potential for new drug discovery against coronavirus, but further research is required to determine the safety and efficacy of using these medicinal plants.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Zixin Shu, Kai Chang, Yana Zhou, Chaoan Peng, Xugui Li, Wei Cai, Li Wei, Qiguang Zheng, Haoyu Tian, Jianan Xia, Kuo Yang, Ning Wang, Jifen Liu, Xiaojun Min, Dengying Yan, Jing Sun, Huan Wu, Xiaomeng Li, Yi Zheng, Zecong Yu, Xi Lu, Yuxia Yang, Ting Jia, Jinghui Ji, Qunzheng Zou, Yinyan Wang, Minzhong Xiao, Qing Zhang, Yajuan Xiong, Feng Sun, Qiang Zhu, Xingxing Jiang, Guodong Wang, Sydney Chi-Wai Tang, Junhua Zhang, Xiuyang Li, Nevin Zhang, Boli Zhang, Xiaolin Tong, Baoyan Liu, Xuezhong Zhou, Kam Wa Chan, Xiaodong Li
Summary: The study evaluated the real-world effectiveness of add-on semi-individualized Chinese medicine (CM) in treating COVID-19 during the outbreak, and found that it significantly reduced mortality among COVID-19 patients, especially in severe/critical cases. Immune-modulating and anti-asthmatic CMs were commonly used, and the effects were dose-dependent.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Chuting Yang, Tingting Wang, Juan Chen, Jiajun He, Yuanhao Li, Chaowu Chen, Guotao Lu, Weiwei Chen
Summary: Traditional Chinese medicine has unique advantages in treating acute pancreatitis, improving the condition of patients by regulating inflammatory responses and enhancing immunity, thereby reducing mortality rates and financial burdens.
Review
Pharmacology & Pharmacy
Xiunan Wei, Xiaohui Leng, Gongyi Li, Ruting Wang, Lili Chi, Dajuan Sun
Summary: Inflammatory bowel disease (IBD) can progress into colitis-associated colorectal cancer (CAC) through the inflammation-cancer sequence. Although the mechanism of carcinogenesis in IBD has not been fully elucidated, recent research suggests that CAC may have a distinct pathogenesis pattern. Traditional Chinese Medicine (TCM) formulas have shown potential in the prevention and treatment of CAC, but there is a need for further review and high-quality research. TCM formulas regulate various biological processes in CAC and engage several major signal transduction pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Xiaomin Kang, De Jin, Linlin Jiang, Yuqing Zhang, Yuehong Zhang, Xuedong An, Liyun Duan, Cunqing Yang, Rongrong Zhou, Yingying Duan, Yuting Sun, Fengmei Lian
Summary: This study systematically reviewed the efficacy of traditional Chinese medicine (TCM) for COVID-19 and discussed its possible mechanisms. The included studies showed that TCM could reduce the proportion of patients progressing to severe cases and the mortality rate of severe or critical patients. Additionally, TCM could relieve clinical symptoms, shorten hospital stay, and improve laboratory indicators.
Article
Plant Sciences
Qina Huang, Rusong Xu, Yan Zhang, Zongxiong Yan, Hongwei Chen, Guosheng Shao
Summary: Salicylic acid (SA) application can alleviate the toxic effects of cadmium (Cd) on plants by increasing nutrient accumulation, enhancing the activity of antioxidative defense system, and reducing lipid peroxidation. SA application can also improve Cd tolerance by modulating the expression of Cd stress tolerance genes and affecting manganese (Mn) accumulation. Furthermore, SA application can regulate the expression of iron (Fe) related genes to reduce the response to Cd exposure.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Applied
Yulin Wu, Jun Liu, Huili Hao, Lianmei Hu, Xiaoyong Zhang, Lianxiang Luo, Jincheng Zeng, Wei Zhang, Io Nam Wong, Riming Huang
Summary: Investigation on Caulerpa chemnitzia polysaccharides led to the discovery of a new polysaccharide (CCP) with immunomodulatory effects, potentially acting through the activation of NF-kappa B signaling pathway and arachidonic acid metabolism pathway.
Article
Computer Science, Software Engineering
Wenjie Chen, Zimiao Xie, Pengxin Yuan, Ruolin Wang, Hongwei Chen, Bo Xiao
Summary: In this paper, an intelligent guide system based on a smartphone is proposed. Videos of tactile paving captured by the phone camera are processed and analyzed, and guide messages are sent to the user in the form of sound or vibration. A fine-tuned MobileNet model is used for feature extraction, and Single Shot MultiBox Detector (SSD) is employed for TWSI detection. The user's position is determined using the Score Voting algorithm, and corresponding guide information is provided. The system achieves high accuracy and real-time performance, and can replace bumpy tactile paving with flat stickers or paint with TWSI patterns.
JOURNAL OF SYSTEMS AND SOFTWARE
(2023)
Article
Computer Science, Artificial Intelligence
Mao-Lun Chiang, Hui-Ching Hsieh, Ting-Yi Chang, Tzu-Ling Lin, Hong-Wei Chen
Summary: In the era of Internet of Things, mobile edge computing (MEC) networks provide computing and storage services near the radio access network to reduce overload and network delays. It can collaborate with third parties to develop various services. However, proper handling of replica generation and deployment is necessary to avoid compromising the benefits of MEC and consider achieving better load balancing and resource utilization.
Article
Chemistry, Analytical
Hui-Xia Zhang, Jian-Feng Qin, Jian-Feng Sun, Yu Pan, Tong-Meng Yan, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang
Summary: Despite the challenges posed by macromolecular nucleic acids, a recent labeling method using N-(tert-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) has shown promise in the profiling and characterization of DNA and RNA. This method offers advantages such as strong retention, predictable MS2 data, and avoidance of harmful reagents. It has been successfully applied to the analysis of tRNA, including the detection of modified bases and the discovery of new modifications. The ease of access and simplicity of this method make it a valuable tool for researchers.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qing-Hua Liu, Yu-Dong Zhang, Zhang-Wen Ma, Zheng-Ming Qian, Zhi-Hong Jiang, Wei Zhang, Liang Wang
Summary: Ophiocordyceps sinensis is a valuable medicinal fungus used in traditional Chinese medicine, with polysaccharides as key constituents. This study confirmed that the polysaccharides extracted from the cultivated fungus were mostly glycogen.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Virology
Hongwei Chen, Haoyang Zhang, Simin Wen, Xuehao Xiu, Danming You, Huiying Zhao, Dayan Wang, Yuedong Yang, Yuelong Shu
Summary: Currently, there is a lack of systematic exploration on the clinical factors influencing immune responses to influenza vaccines. The mechanism of low responsiveness to influenza vaccination (LRIV) is complex and not well understood. In this study, we combined our in-house genome-wide association studies (GWAS) analysis of LRIV with the GWAS summary of 10 blood-based biomarkers to investigate the genetics shared between LRIV and blood-based biomarkers using Mendelian randomization (MR). The results suggest a potential causal relationship between genetically instrumented LRIV and decreased eosinophil count.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Hongbing Jiang, Astha Joshi, Tianyu Gan, Andrew B. Janowski, Chika Fujii, Traci L. Bricker, Tamarand L. Darling, Houda H. Harastani, Kuljeet Seehra, Hongwei Chen, Stephen Tahan, Ana Jung, Binita Febles, Joshua A. Blatter, Scott A. Handley, Bijal A. Parikh, David Wang, Adrianus C. M. Boon
Summary: A study shows that the s2m element in the RNA of the SARS-CoV-2 virus does not affect its growth and spread.
JOURNAL OF VIROLOGY
(2023)
Article
Environmental Sciences
Yashuai Pu, Yiping Li, Liqin Zhu, Yu Cheng, Linda A. Nuamah, Haikuo Zhang, Hongwei Chen, Guanchao Du, Ling Wang, Congqing Song
Summary: Constructed wetlands in a subtropical monsoon climate area of eastern China were seasonally assessed for six years. The study found that the removal efficiency of pollutants varied significantly among different seasons. By optimizing controllable operating parameters, efficient and sustainable long-term operation of constructed wetlands can be achieved.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Energy & Fuels
Hongwei Chen, Junzhi Zhuang, Gang Zhou, Yuwei Wang, Zhenglong Sun, Yoash Levron
Summary: This paper proposes an emergency load shedding method based on data-driven strategies and deep reinforcement learning. The traditional event-driven load shedding strategy faces the risk of mismatching in high renewable energy penetrated power systems. In order to address this challenge, the proposed method transforms the emergency load shedding strategy into a Markov Decision Process and optimizes it using deep reinforcement learning.
Article
Virology
Haoyang Zhang, Zhenxing Lu, Fan Yang, Hongwei Chen, Le Zhang, Huiying Zhao, Yongkun Chen
Summary: After adjusting China's zero-COVID policy, there has been a significant increase in COVID-19 cases. A survey was conducted to investigate self-perceived symptoms and their association with vaccination status during this outbreak. The survey included 552 individuals, and infected individuals displayed various symptoms associated with different factors, with fatigue, phlegm, and cough being the three most common.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Analytical
Hongwei Chen, Hailin Zhou, Yunxiao Liang, Zongsheng Huang, Shanyi Yang, Xuancheng Wang, Zhiyong She, Zhijuan Wei, Qisong Zhang
Summary: Colorectal advanced adenoma (CAA) is a precancerous lesion of colorectal cancer (CRC), and early diagnosis is important. This study is the first to explore the biomarkers and mechanism of CAA-CRC sequence using serum lipidomics. 10 differential lipids, including PC 44:5, PC 35:6e, and SM d40:3, showed good discriminant ability for CAA and CRC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, General & Internal
Chen Hongwei
Summary: This study aimed to evaluate the impact of home quarantine during the COVID-19 pandemic on parents' stress and children's anxiety and depression. The results showed that the quarantine event caused by the pandemic was directly related to the anxiety and depression scores in children, and higher stress levels in parents predicted higher anxiety and depression scores in children.
IRANIAN RED CRESCENT MEDICAL JOURNAL
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Ronghao Li, Yi Wang, Jiahui Huang, Lei Tang, HongWei Chen
Summary: This study proposes a Fabry-Perot antenna (FPA) with broadband RCS reduction by loading a broadband Low-RCS metasurface. The loading of this metasurface not only achieves broadband RCS reduction from 6.2-30GHz, extending the reduced bandwidth, but also increases the gain of the FPA to 19.6dBi.
2022 CROSS STRAIT RADIO SCIENCE & WIRELESS TECHNOLOGY CONFERENCE, CSRSWTC
(2022)
Article
Metallurgy & Metallurgical Engineering
Haitao Zhao, Shuize Wang, Junheng Gao, Jianjun Qi, Ru Su, Hongqi Zhang, Hongwei Chen, Zhiqiang Tian, Lijuan Bai
Summary: This research carefully characterizes the V-shaped cracks on the surface of drawn welding wires and thoroughly discusses their underlying mechanism. It is found that the V-shaped cracks often appear in pairs with opposite directions. The formation of these cracks is attributed to the deterioration of local lubrication during the wire drawing process, leading to the austenitization of the wire surface and subsequent formation of martensite.
METALLURGICAL RESEARCH & TECHNOLOGY
(2022)