期刊
BIOMOLECULES
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom11010079
关键词
mangiferin; cancer; molecular mechanisms; polymer systems; drug delivery
资金
- Government of the Russian Federation [08-08]
Mangiferin, a natural C-glucosylxantone, has potential for treating various diseases with its antioxidant, anti-inflammatory, anti-cancer properties and lack of toxicity. Despite low oral bioavailability, polymer systems have been developed to improve solubility and biological action.
For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.
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