期刊
BIOMOLECULES
卷 10, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/biom10121690
关键词
oviduct; embryo; oviductal fluid; OVGP1
资金
- Fundacion Seneca-Agencia de Ciencia y Tecnologia de la Region de Murcia Ayudas a la realizacion de proyectos para el desarrollo de investigacion cientifica y tecnica por grupos competitivos 2018 [20887/PI/18]
- (MCINN/AEI/FEDER, UE) from the Ministry of Economy and Competitiveness (Spain) [PGC2018-094781-B-I00]
The oviduct plays important roles in reproductive events: sperm reservoir formation, final gamete maturation, fertilization and early embryo development. It is well known that the oviductal environment affects gametes and embryos and, ultimately, the health of offspring, so that in vivo embryos are better in terms of morphology, cryotolerance, pregnancy rates or epigenetic profile than those obtained in vitro. The deciphering of embryo-maternal interaction in the oviduct may provide a better understanding of the embryo needs during the periconception period to improve reproductive efficiency. Here, we perform a comparative analysis among species of oviductal gene expression related to embryonic development during its journey through the oviduct, as described to date. Cross-talk communication between the oviduct environment and embryo will be studied by analyses of the secreted or exosomal proteins of the oviduct and the presence of receptors in the membrane of the embryo blastomeres. Finally, we review the data that are available to date on the expression and characterization of the most abundant protein in the oviduct, oviductin (OVGP1), highlighting its fundamental role in fertilization and embryonic development.
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