Review
Pharmacology & Pharmacy
Xiangjiang Wang, Xianjing Han, Chaozhou Li, Zhi Chen, Hao Huang, Jindong Chen, Chenshuo Wu, Taojian Fan, Tianzhong Li, Weichun Huang, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Abdullah Swelm. Wageh, Fei Zheng, G. Al-Sehemi, Guiqing Wang, Zhongjian Xie, Han Zhang
Summary: 2D materials are widely used in bone therapies due to their excellent physicochemical properties, showing versatile functions in treating different bone diseases. They can be applied in bone tissue engineering, joint lubrication, bone tumors, etc., with various mechanisms of action.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Physical
Xuwei Cui, Luqi Liu, Wenlong Dong, Yekai Zhou, Zhong Zhang
Summary: Bubbles in 2D materials play important roles in both the performance and mechanical property measurement of 2D material devices, and they can also serve as effective tools to tune the electronic and photonic performance of 2D materials.
Article
Chemistry, Physical
Wen-ou Bai, Ke Wu, Chunlei Wu, Ning Li, Yangqin Gao, Lei Ge
Summary: Photocatalytic water splitting is a green method to solve the energy shortage, and combining two-dimensional carbon nitride nano sheets with other semiconductors can effectively increase the surface area and improve the utilization of photogenerated charges. In this study, 2D-2D NiCo-LDH/g-C3N4 composites were synthesized using a simple hydrothermal method, and the hydrogen production rate was enhanced by 21 times. Density functional theory (DFT) calculations revealed the successful construction of an S-type heterojunction, achieving spatial separation of photogenerated electron-hole pairs with strong redox capability. This work emphasizes the creation of effective transport channels for photogenerated charge transfer and separation through efficient interfacial regulation strategy.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Engineering, Biomedical
Robert P. Accolla, Jia-Pu Liang, Taylor R. Lansberry, Irayme Labrada Miravet, Marlon Loaisiga, Baltasar Lopez Sardi, Cherie L. Stabler
Summary: An oxygen-generating composite material called OxySite is developed by encapsulating calcium peroxide (CaO2) within polydimethylsiloxane and formulating it into microbeads for tissue integration. Material parameters are modulated to study oxygen generation kinetics and cellular applications. In vitro and in vivo experiments demonstrate the improved metabolic activity and function of cells when coencapsulated with optimized OxySite microbeads.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biophysics
Upasana Ghimire, Rupesh Kandel, Sita Shrestha, Joon Yeon Moon, Se Rim Jang, Bishnu Kumar Shrestha, Chan Hee Park, Cheol Sang Kim
Summary: Fabricating bioartificial bone graft ceramics with properties similar to native stem-cell niches is challenging. Infections caused by microbial invasion are also a concern. In this study, biomimetic porous scaffolds were developed, which significantly improved biocompatibility, osteo-regeneration, mechanical strength, and antibacterial properties. These scaffolds showed superior performance compared to conventional scaffolds, making them promising for bone tissue regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Environmental
Satheesh kumar Balu, Swetha Andra, S. Chitra, Ramya Ramadoss, Y. Ravi Kumar, Manickam Selvaraj, Hamed A. Ghramh, Mohammed A. Assiri, Sakar Mohan
Summary: MXenes have gained significant importance in various applications in the fields of energy, environment, and healthcare. Their tunable surface chemistry and nano-dimensional layered features make them a versatile material with improved multifunctional properties compared to other two-dimensional materials. This review focuses on the synthesis processes, characterizations, and antimicrobial properties of MXenes, and elucidates their mechanisms of action against bacteria, fungi, and viruses. The future perspective of MXenes for biomedical applications is also discussed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Jack Maughan, Pedro J. Gouveia, Javier Gutierrez Gonzalez, Liam M. Leahy, Ian Woods, Cian O'Connor, Tara McGuire, James R. Garcia, Donagh G. O'Shea, Sarah F. McComish, Oran D. Kennedy, Maeve A. Caldwell, Adrian Dervan, Jonathan N. Coleman, Fergal J. O'Brien
Summary: This study reports the development of an electroconductive pristine graphene-based (pG) composite material for central nervous system applications, which balances conductivity, biocompatibility, and mechanical performance. The composite material showed no adverse effects on neuronal and glial cell growth, and enhanced neurite outgrowth and cellular morphology compared to controls. The versatility of the composite material was demonstrated through the fabrication of various conductive neural-interfacing structures.
APPLIED MATERIALS TODAY
(2022)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Wenxin Liu, Yingnan Zhu, Zhaofan Tao, Yuxiang Chen, Lei Zhang, Alideertu Dong
Summary: A black phosphorus-based conductive hydrogel (HA-DA@BP) was prepared by an amidation reaction coupled with a coordination of Fe3+-catechol. The hydrogel could undergo phase transition from sol phase to gel phase under electrical stimulus (ES). The release of black phosphorus (BP) under slight acidity conditions could achieve synergistic electrical antibacterial action and promote wound healing, indicating its potential application in skin tissue engineering.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Mireille M. J. P. E. Sthijns, Clemens A. van Blitterswijk, Vanessa L. S. LaPointe
Summary: This review proposed a novel strategy to generate tissue-specific ECM by releasing metabolic molecules through a synthetic material, which stimulates cells to form their own ECM. The approach is based on the modulation of ECM properties via cellular metabolism, targeting different levels of metabolism to achieve desired effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Bingcheng Yi, Qi Xu, Wei Liu
Summary: Cell-matrix interactions and substrate stiffness play critical roles in tissue repair and regeneration. This review provides an overview of recent progress in understanding the cellular responses mediated by substrate stiffness and the manipulation of scaffold stiffness. It aims to facilitate interdisciplinary knowledge transfer and the design of suitable biomaterials for tissue regeneration.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Abdalla Abdal-hay, Faheem A. Sheikh, Ahmed N. Shmroukh, Hamouda M. Mousa, Yu-Kyoung Kim, Saso Ivanovski
Summary: The fabrication of BGC nanoneedle-like structures on PA6 substrates via ion dissociation method showed excellent dispersion and promoted osteogenic differentiation, indicating potential for bone tissue regeneration.
MATERIALS & DESIGN
(2021)
Review
Chemistry, Multidisciplinary
Huijun Yu, Meng Dai, Jing Zhang, Wenhan Chen, Qiu Jin, Shuguang Wang, Zuoli He
Summary: This article provides an overview of different construction modes for regulating the interfaces and functional performance of 2D nanomaterials. It summarizes the key factors for enhancing the photocatalytic performance of 2D/2D heterostructures and discusses the importance of surface defects, cocatalysts, and surface modification. Perspectives and challenges for expanding the use of 2D/2D heterostructures in photocatalysis are also proposed.
Review
Chemistry, Physical
Zhenglong Li, Yaping Chen, Tianyi Ma, Yinzhu Jiang, Jian Chen, Hongge Pan, Wenping Sun
Summary: The exploration of highly active and low-cost electrocatalysts using 2D metal-free nanomaterials is crucial for sustainable and efficient energy conversion technologies. Surface engineering and interface engineering are key strategies for constructing advanced electrocatalysts based on these materials. Challenges and future directions of utilizing 2D metal-free nanomaterials in electrocatalysis are also discussed.
ADVANCED ENERGY MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Soroush Ahmadi, Ahmad Hivechi, S. Hajir Bahrami, Peiman B. Milan, Seyedeh Sara Ashraf
Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Physics, Applied
Joao Rodrigues, Justyna Grzonka, Joao Fernandes, Joao Santos, Oleksandr Bondarchuk, Paulo Ferreira, Pedro Alpuim, Andrea Capasso
Summary: Extended investigations on 2D transition metal dichalcogenides have revealed their potential applications in various technological fields. In this work, atomically thin MoSe2 was successfully grown using a chemical vapor deposition method and extensively characterized. The samples exhibited monolayer structure and crystallinity, with well-defined and intense photoluminescence.
APPLIED PHYSICS LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Joao Fernandes, Siva Sankar Nemala, Giovanni De Bellis, Andrea Capasso
Summary: Liquid phase exfoliation (LPE) enables large-scale and cost-effective production of graphene materials, with applications in various fields. However, the use of current solvents poses health and environmental risks, highlighting the need for green solvents.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biophysics
Irene Palacio, Miguel Moreno, Almudena Nanez, Agnes Purwidyantri, Telma Domingues, Patricia D. Cabral, Jerome Borme, Marzia Marciello, Jesus Ignacio Mendieta-Moreno, Beatriz Torres-Vazquez, Jose Ignacio Martinez, Maria Francisca Lopez, Mar Garcia-Hernandez, Luis Vazquez, Pavel Jelinek, Pedro Alpuim, Carlos Briones, Jose Angel Martin-Gago
Summary: Biosensors based on covalently functionalized graphene have been developed for ultra-sensitive aptamer-based detection of hepatitis C virus core protein. The induced polarization at the graphene interface causes a net shift of the Dirac cone, enhancing the sensitivity for attomolar detection. This unexpected effect opens up possibilities for ultrasensitive and real-time diagnostics of various diseases using graphene-based functionalized platforms.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Ivo Colmiais, Vitor Silva, Jerome Borme, Pedro Alpuim, Paulo M. Mendes
Summary: Graphene has unique properties that are ideal for radiofrequency applications, but its characterization presents challenges due to its two-dimensional nature. This study evaluates the Thru-Reflect-Line calibration as a solution for extracting graphene's electrical characteristics, and identifies the necessary requirements for the calibration structures. The inclusion of thick metallic contacts, a low-loss substrate, and a short and thin contact is crucial for accurately characterizing graphene. Additionally, a backgate must be included to account for the dependence of graphene's properties on the applied polarization voltage.
Article
Chemistry, Multidisciplinary
Agnes Purwidyantri, Sarah Azinheiro, Aitor Garcia Roldan, Tereza Jaegerova, Adriana Vilaca, Rofer Machado, M. Fatima Cerqueria, Jerome Borme, Telma Domingues, Marco Martins, Pedro Alpuim, Marta Prado
Summary: Identifying grape varieties in wine and related products using DNA analysis is challenging due to their complexity and low DNA content. This study presents an integrated portable biosensor based on a monolayer graphene field-effect transistor array, which can distinguish closely related grapevine varieties and detect single-nucleotide polymorphisms. The biosensor operates at ultralow DNA concentrations with a high specificity and attomolar detection limit. It offers a promising way for decentralized analytical tools to track wine authenticity and contribute to the digitalization of the agro-food industry.
Article
Nanoscience & Nanotechnology
Viviana Sousa, Arka Sarkar, Oleg I. Lebedev, Christophe Candolfi, Bertrand Lenoir, Rodrigo Coelho, Antonio P. Goncalves, Eliana M. F. Vieira, Pedro Alpuim, Kirill Kovnir, Yury V. Kolen'ko
Summary: This study presents a simple and effective method for the preparation of solution-processed chalcogenide thermoelectric materials. By using colloidal synthesis and spark plasma sintering, phase-pure chalcogenides with distinct morphologies were obtained. The solution-processed PbTe, PbSe, and SnSe exhibited low thermal conductivity and moderate thermoelectric performance. The findings of this study provide a valuable approach for the design of efficient solution-processed chalcogenide thermoelectrics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Siva Nemala Sankar, Joao Fernandes, Marilia Barreiros dos Santos, Begona Espina, Pedro Alpuim, Ander Garcia Diez, Senentxu Lanceros-Mendez, Lalita Saini, Suvigya Kaushik, Gopinadhan Kalon, Andrea Capasso
Summary: In this study, an efficient and green strategy was proposed to fabricate mu m-thick, graphene-based laminates by liquid phase exfoliation and vacuum filtration. The membranes showed structural and mechanical stability during long-term operation in water, and exhibited size selection and anion-selectivity in ion transport studies. Additionally, the membranes demonstrated high rejection rates and antibacterial properties. Therefore, these green graphene-based membranes offer a viable option for future water management applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Rui M. R. Pinto, Siva Sankar Nemala, Mohammadmahdi Faraji, Joao Fernandes, Clara Ponte, Giovanni De Bellis, Aritz Retolaza, K. B. Vinayakumar, Andrea Capasso
Summary: Material jetting techniques allow selective deposition of droplets of materials in liquid or powder form by drop-on-demand printing. This study printed zero-dimensional multi-layer shell-structured fullerene material on polyethylene terephthalate substrates using drop-on-demand inkjet printing. The printed CNO structures showed high sensitivity to temperature and humidity, making them potential candidates for inkjet-printed technologies such as environmental and gas sensors.
Article
Chemistry, Analytical
Mbaye Dieng, Siva Sankar, Pingping Ni, Ileana Florea, Pedro Alpuim, Andrea Capasso, Abderrahim Yassar, Fatima Zahra Bouanis
Summary: Large-scale production of solution-processable graphene nanosheets (GNSs) has opened up possibilities for their use as gas sensors. This study demonstrates the fabrication of functional gas sensors using a scalable deposition method and non-covalent functionalization of GNS films with Co-porphyrin and Fe-phthalocyanines. The chemiresistive sensor response of the functionalized GNSs towards low concentrations of nitrogen dioxide (NO2) was significantly improved compared to pristine GNSs.
Article
Electrochemistry
Beatrice Ricciardi, Barbara Mecheri, Williane da Silva Freitas, Valerio C. A. Ficca, Ernesto Placidi, Irene Gatto, Alessandra Carbone, Andrea Capasso, Alessandra D'Epifanio
Summary: High-performance platinum group metal-free (PGM-free) electrocatalysts were prepared from porous organic polymers (POPs) precursors with highly-porous structures and adjustable surface area. The effect of Fe content on the material's structure, surface chemistry, and electrocatalytic activity toward the oxygen reduction reaction (ORR) was elucidated through electrochemical and spectroscopical characterization. The Fe-N-C catalysts with different iron contents showed promising ORR activity, with further advancement prospects for fuel cell applications.
Article
Chemistry, Analytical
Rabiaa Elkarous, Afrah Bardaoui, Jerome Borme, Nabil Sghaier, Pedro Alpuim, Diogo M. F. Santos, Radhouane Chtourou
Summary: This study proposes a high-performance asymmetric gold/graphene/platinum photodetector that operates without bias. It incorporates interdigitated metallic contacts to enhance the separation and collection of photocarriers. By utilizing chemical vapor deposition and electron-beam lithography, three devices with different dimensions were fabricated and evaluated for their photoresponsivities at different wavelengths. The 100 μm device exhibited the highest photoresponsivity of 358 A/W at 400 nm illumination. These findings demonstrate the potential of the proposed design to increase the active area, improve light absorption, and achieve efficient separation and collection of photogenerated carriers, making it highly relevant for optoelectronic applications.
Article
Physics, Applied
Min Jung Kim, Gabriel Moreira, Nicola Lisi, Namwon Kim, Wooyoung Shim, Gwan-Hyoung Lee, Andrea Capasso
Summary: This study reports a solvent-free transfer technique for monolayer graphene using cyclododecane (CDD) as a supporting coating, which can efficiently transfer graphene to a desired substrate without the need for post-transfer cleaning treatment. This technique paves the way for the widespread adoption of graphene in various applications.
APPLIED PHYSICS LETTERS
(2023)
Proceedings Paper
Engineering, Manufacturing
Rui M. R. Pinto, Siva Sankar Nemala, Mohammadmahdi Faraji, Andrea Capasso, K. B. Vinayakumar
Summary: Flexible and printed electronics can benefit from the use of novel 2D and nano-materials to achieve specific chemical, mechanical, and electrical functionalities. In this study, carbon nano onions (CNO) were successfully deposited on flexible polymer substrates using piezoelectric drop-on-demand inkjet printing. The printing conditions for the low-viscosity ethanol-based CNO suspensions were optimized to ensure high resolution and line continuity. The printed CNO devices showed good electrical properties and are suitable for various applications such as temperature compensation, humidity sensing, and gas sensing.
2022 IEEE INTERNATIONAL CONFERENCE ON FLEXIBLE AND PRINTABLE SENSORS AND SYSTEMS (IEEE FLEPS 2022)
(2022)