期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.607209
关键词
tumor-associated macrophages; pancreatic ductal adenocarcinoma; polarization; reprogramming; origin
资金
- National Natural Science Foundation of China [81673023, 81872501, 81502068]
- Beijing Natural Science Foundation of China [7172177]
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy that can only be cured by surgery in its early stages, but recurrence remains a high possibility. Tumor-associated macrophages (TAMs) play a crucial role in PDAC development, promoting tumor behaviors such as tumorigenesis and metastasis.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only cured by surgical resection in its early stage, but there remains a relatively high possibility of recurrence. The development of PDAC is closely associated with the tumor microenvironment. Tumor-associated macrophages (TAMs) are one of the most abundant immune cell populations in the pancreatic tumor stroma. TAMs are inclined to M2 deviation in the tumor microenvironment, which promotes and supports tumor behaviors, including tumorigenesis, immune escape, metastasis, and chemotherapeutic resistance. Herein, we comprehensively reviewed the latest researches on the origin, polarization, functions, and reprogramming of TAMs in PDAC.
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