期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.601738
关键词
nerve; neurogenesis; cancer; perineural invasion; neurotrophins
资金
- Chronic Non-communicable Diseases Prevention and Control of National Ministry of Science and Technology [2016YFC1303804]
- Jilin Provincial Key Laboratory of Biological Therapy [20170622011JC]
- Jilin Provincial Science and Technology Department [20180101009JC, 20190303146SF]
- Scientific and Technological Research of Jilin Provincial Education Department [JJKH20190023KJ]
- Jilin Province Finance Department [2018SCZWSZX-010]
Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis. Perineural invasion, a process by which cancer cells invade the surrounding nerves, provides an alternative route for metastasis and generation of tumor-related pain. Moreover, central and sympathetic nervous system dysfunctions and psychological stress-induced hormone network disorders may influence the malignant progression of cancer through multiple mechanisms. This reciprocal interaction between nerves and cancer cells provides novel insights into the cellular and molecular bases of tumorigenesis. In addition, they point to the potential utility of anti-neurogenic therapies. This review describes the evolving cross-talk between nerves and cancer cells, thus uncovers potential therapeutic targets for cancer.
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