Article
Pharmacology & Pharmacy
Kristeen Ye Wen Teo, Shipin Zhang, Jia Tong Loh, Ruenn Chai Lai, Hwee Weng Dennis Hey, Kong-Peng Lam, Sai Kiang Lim, Wei Seong Toh
Summary: MSC exosomes promote the polarization of M2-like macrophages through activation of the toll-like receptor signaling pathway and CD73-mediated adenosine production. The production of adenosine activates AKT/ERK-dependent signaling pathways via binding to adenosine receptors A(2A) and A(2B). These findings highlight the critical role of CD73 in mediating M2-like macrophage polarization by MSC exosomes, and have implications for predicting the immunomodulatory potency of MSC exosome preparations.
Article
Oncology
Daniel Baumann, Jennifer Drebant, Tanja Haegele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa
Summary: M2 macrophages are more sensitive to MEK inhibition-induced cell death, while activation of the p38 MAPK pathway in M1 macrophages renders them resistant to MEK inhibition-induced cell death. This indicates that MEK inhibitors can selectively eliminate M2 macrophages from the tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Cell Biology
Luise Mueller, Antje Tunger, Manja Wobus, Malte von Bonin, Russell Towers, Martin Bornhaeuser, Francesco Dazzi, Rebekka Wehner, Marc Schmitz
Summary: Mesenchymal stromal cells (MSCs) have the ability to regulate and inhibit the function of immune cells, playing a crucial role in the pathogenesis of inflammatory disorders and showing promise in the treatment of conditions such as acute graft-versus-host disease, graft rejection, and autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sathuwarman Raveenthiraraj, Griselda Awanis, Marcello Chieppa, Amy E. O'Connell, Anastasia Sobolewski
Summary: This study demonstrates the different effects of homeostatic and inflammatory macrophages on the colonic epithelium. Inflammatory macrophages reduce the numbers of goblet and tuft cells and increase the numbers of stem cells in the crypt, while homeostatic macrophages promote crypt cell proliferation through physical contact. The findings highlight the importance of understanding cellular interactions and immune cell subtypes in crypt cell biology during inflammation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Wenya Zhu, Qianqian Chen, Yi Li, Jun Wan, Jia Li, Shuai Tang
Summary: A modified MSC transplantation with overexpression of HIF-1 alpha is an effective treatment for IBD. HIF-MSCs attenuate colitis and restore immune balance through regulating macrophage polarization via PI3K-gamma. The findings suggest that HIF-MSC transplantation is a potential precision therapy for IBD.
Article
Oncology
Adrienne M. Parsons, Eric M. Darling
Summary: The study revealed the impact of time on adipose-derived stem/stromal cell (ASC) response to an inflammatory environment. Time played a role in the balance of pro- and anti-inflammatory ASC phenotypes, with IL-6 consistently present and IDO1 heterogeneously upregulated in later stages of sustained cytokine stimulation. Immune response of ASC remained constant for 96-168 hours after a pulse stimulus, and the presence of ASCs altered macrophage phenotype independent of ASC cytokine exposure time.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shaowei Kang, Bin Wang, Yanan Xie, Xu Cao, Mei Wang
Summary: M1 and M2 macrophages are crucial for cardiac healing post-MI, with M1 macrophages playing a critical role in promoting remodeling through activation of the EMT pathway.
Article
Neurosciences
Francesca Pischiutta, Enrico Caruso, Helena Cavaleiro, Antonio J. Salgado, David J. Loane, Elisa R. Zanier
Summary: Traumatic brain injury (TBI) patients require better neuroprotective/neuroreparative strategies. Mesenchymal stromal cells (MSCs) have shown promise in neuroprotection through paracrine mechanisms. Immunomodulation by MSC-derived secretome is a key mechanism for their therapeutic effects. Secretome promotes tissue repair and neurological recovery, but excessive neuroinflammatory response can worsen TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Review
Immunology
Ayman F. Refaie, Batoul L. Elbassiouny, Malgorzata Kloc, Omaima M. Sabek, Sherry M. Khater, Amani M. Ismail, Rania H. Mohamed, Mohamed A. Ghoneim
Summary: MSC-based therapy for T1DM shows promise, but there are conflicting views on their immunological profile. Research focuses on understanding the mechanisms of their immunomodulatory functions and exploring ways to enhance their effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
M. Bessa-Goncalves, C. Ribeiro-Machado, M. Costa, C. C. Ribeiro, J. N. Barbosa, M. A. Barbosa, S. G. Santos
Summary: This study demonstrated that the incorporation of 10mM of magnesium sulfate improved the mechanical properties of the fibrinogen scaffold and promoted macrophage polarization to M2 phenotype. In vivo experiments showed that FgMg10 scaffolds reduced inflammatory mediators and increased M2 macrophage polarization.
ACTA BIOMATERIALIA
(2023)
Article
Biology
Xiao Su, Xiaolei Li, Shiqing Wang, Xiaotong Xue, Rui Liu, Xiaojing Bai, Pixia Gong, Chao Feng, Lijuan Cao, Tingting Wang, Yayun Ding, Junjie Jiang, Yongjing Chen, Yufang Shi, Changshun Shao
Summary: This study found that Nestin-positive mesenchymal stromal cells (T-MSCs) mainly distribute in the medulla and cortical-medulla junction of the thymus, and possess immunosuppressive ability. Additionally, T-MSCs exhibit remarkable therapeutic efficacy in acute liver injury and inflammatory bowel disease (IBD).
Review
Biochemistry & Molecular Biology
Elham Abdollahi, Thomas P. Johnston, Zahra Ghaneifar, Parviz Vahedi, Pouya Goleij, Sara Azhdari, Abbas Shapouri Moghaddam
Summary: This review summarizes the impact of curcumin on macrophage polarization in various inflammatory diseases and explores the underlying molecular mechanisms. The findings suggest that curcumin can beneficially influence M1 and M2 macrophages, leading to improved inflammatory conditions such as cancer, autoimmune diseases, renal inflammation, stroke, atherosclerosis, and macrophage-driven pathogenesis.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Hengfang Zhang, Shuang Zhang, Xuan Dang, Lexun Lin, Liping Ren, Rong Song
Summary: Macrophages play a crucial role in the development of periodontitis and their phenotype is influenced by GPNMB protein. Overexpression of GPNMB in macrophages was found to enhance the secretion of anti-inflammatory factors and inhibit the secretion of pro-inflammatory factors.
Review
Cell Biology
Candice Bohaud, Rafael Contreras-Lopez, Jholy de la Cruz, Claudia Terraza-Aguirre, Mingxing Wei, Farida Djouad, Christian Jorgensen
Summary: Osteoarthritis is a multifaceted degenerative and inflammatory joint disorder, with current therapies often only providing short-term benefits without complete structural and functional reconstitution. Identifying novel therapeutic targets and strategies is crucial to achieve long-term clinical benefits for OA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)