Article
Cell & Tissue Engineering
Zhenyu Li, Qingxian Li, Kai Tong, Jiayong Zhu, Hui Wang, Biao Chen, Liaobin Chen
Summary: This study investigated the effect of rat bone marrow stromal cell-derived exosomes (BMSC-Exos) on tendon-bone healing after anterior cruciate ligament reconstruction (ACLR). The results showed that BMSC-Exos promoted the polarization of M1 macrophages to M2 macrophages via miR-23a-3p. This reduced the early inflammatory reaction at the tendon-bone interface and promoted early healing after ACLR.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, Yaoting Ji, Yufeng Zhang
Summary: Mitochondrial transfer from macrophages to mesenchymal stem cells regulates bone homeostasis, and abnormal transfer under osteoporotic conditions leads to metabolic remodeling in stem cells.
Article
Oncology
Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Wei Guo
Summary: In this study, it was found that macrophage-derived exosomal lncRNA LIFR-AS1 can promote osteosarcoma cell proliferation, invasion, and restrain cell apoptosis via the miR-29a/NFIA axis. LIFR-AS1 acts as a potential novel therapeutic target for osteosarcoma therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Materials Science, Biomaterials
Jinjin Wang, Yazheng Wang, Yi Li, Yide He, Wen Song, Qintao Wang, Yumei Zhang, Chenyang He
Summary: A comprehensive understanding of the communication between bone marrow mesenchymal stem cells (bm-MSCs) and macrophages in the peri-implant microenvironment is crucial for predicting implantation outcomes. Previous studies have revealed the indirect influence of Ti surface topography on the osteogenic differentiation of bm-MSCs through modulating macrophage polarization. However, it is unclear whether bm-MSCs can also exert an immunomodulatory role on macrophages under the influence of Ti surface topography. In this study, bm-MSCs inoculated on Ti with nanoporous topography were co-cultured with macrophages, and it was confirmed bidirectionally that bm-MSCs can induce immunomodulatory effects on macrophages through exosome-mediated paracrine actions, adversely affecting the osteogenic microenvironment around the implant.
REGENERATIVE BIOMATERIALS
(2023)
Article
Cell Biology
Linfang Li, Huiyan Zuo, Xiuqing Huang, Tao Shen, Weiqing Tang, Xiaoyi Zhang, Tong An, Lin Dou, Jian Li
Summary: The study found that exosomal miR-143-5p derived from bone marrow macrophages induces insulin resistance in hepatocytes by repressing MKP5. This discovery provides important insights into the molecular mechanisms underlying hepatic insulin resistance.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Wenhui Chen, Fan Zuo, Kaiwen Zhang, Tian Xia, Wei Lei, Zixiang Zhang, Lili Bao, Yiwen You
Summary: The molecular mechanism for metastasis in nasopharyngeal carcinoma (NPC) remains unclear. Research has shown that exosomes released by NPC cells can promote metastasis by inhibiting ferroptosis of macrophages, with targeting MIF being a potential treatment for reducing metastasis rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhiyuan Niu, Lei Wang, Xiaofeng Qin, Zhimin Ye, Bin Xie, Yongbin Hu
Summary: Silicosis is a serious occupational disease characterized by inflammation, fibroblast activation, and extracellular matrix deposition in the lung. Macrophage-derived exosomes have been found to play a role in the development of silicosis by transferring microRNAs (miRNAs). In this study, the researchers identified the up-regulation of miR-7219-3p in both macrophages and their exosomes after silica exposure, as well as in a silicotic mice model. They found that miR-7219-3p promoted fibroblast to myofibroblast trans-differentiation, cell proliferation, and migration. The target gene of miR-7219-3p, Spouty1 (SPRY1), was confirmed to modulate the Ras/ERK/MAPK signaling pathway, and manipulating SPRY1 expression affected fibroblast to myofibroblast trans-differentiation via this pathway. Inhibition of exosomal miR-7219-3p partially suppressed fibroblast to myofibroblast trans-differentiation and silica-induced pulmonary fibrosis. These findings suggest that exosomal miR-7219-3p could be a potential therapeutic target for silicosis.
Article
Immunology
Hui Yu, Lei Qin, Yunzhi Peng, Wenhui Bai, Zhanli Wang
Summary: The study revealed that exosomes released from hypertrophic cardiomyocytes induced inflammatory responses in macrophages through miR-155, activating various signaling pathways, which may play a crucial role in the development of cardiac hypertrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhen Chen, Hao Wu, Weiyang Fan, Jiashuo Zhang, Yue Yao, Weiwei Su, Yonggang Wang, Peibo Li
Summary: Extracellular vesicles play a role in maintaining lung homeostasis in cigarette smoke-induced lung diseases. Previous studies have shown that cigarette smoke extract-treated extracellular vesicles promote macrophage polarization, leading to the development of inflammatory responses. This study found that naringenin and cigarette smoke extract co-treated extracellular vesicles significantly inhibit macrophage polarization and the secretion of inflammatory factors. Furthermore, naringenin downregulates miR-21-3p in extracellular vesicles, which targets the PTEN/AKT cascade in macrophages and suppresses M1 macrophage polarization. It also decreases PARP1 expression in extracellular vesicles, potentially suppressing M1 macrophage polarization. These findings provide new pharmacological references for naringenin in the treatment of cigarette smoke-induced lung inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yen-Chieh Chuang, Shu-Yu Wu, Yu-Chuan Huang, Chung-Kan Peng, Shih-En Tang, Kun-Lun Huang
Summary: In this study, the role of aquaporins (AQPs) in macrophage polarization was investigated. The AQP inhibitor mercury chloride (HgCl2) was found to restrict cell volume change, suppress the p38 MAPK/NF kappa B pathway, promote autophagy, and influence macrophage M1 polarization.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Jixian Liu, Ruixing Luo, Junbin Wang, Xinyu Luan, Da Wu, Hua Chen, Qinghua Hou, Guangxian Mao, Xiaoqiang Li
Summary: The study identified that tumor cell-derived exosomal miR-770 inhibited M2 macrophage polarization via targeting MAP3K1, thus suppressing the invasion and growth of NSCLC cells. This provides a new strategy for the treatment of NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiaqi Wu, Xiaoyu Ma, Yu Lu, Tao Zhang, Zuoqin Du, Jin Xu, Jingcan You, Ni Chen, Xin Deng, Jianbo Wu
Summary: Pueraria lobata exerts anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization.
Article
Cardiac & Cardiovascular Systems
Giana J. Schena, Emma K. Murray, Alycia N. Hildebrand, Alaina L. Headrick, Yijun Yang, Keith A. Koch, Hajime Kubo, Deborah Eaton, Jaslyn Johnson, Remus Berretta, Sadia Mohsin, Raj Kishore, Timothy A. McKinsey, John W. Elrod, Steven R. Houser
Summary: Heart failure is a leading cause of death in the United States, and there is currently no cure for it. Treatment with cortical bone stem cells (CBSC) has shown beneficial effects in post-myocardial infarction and post-ischemia-reperfusion (I/R) models. Exosomes derived from CBSCs may partially contribute to these effects by reducing scar size and improving cardiac function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Article
Endocrinology & Metabolism
Changjun Li, Weishan Wang, Liang Xie, Xianghang Luo, Xu Cao, Mei Wan
Article
Medicine, Research & Experimental
Chang-Jun Li, Peng Cheng, Meng-Ke Liang, Yu-Si Chen, Qiong Lu, Jin-Yu Wang, Zhu-Ying Xia, Hou-De Zhou, Xu Cao, Hui Xie, Er-Yuan Liao, Xiang-Hang Luo
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Multidisciplinary Sciences
Changjun Li, Gehua Zhen, Yu Chai, Liang Xie, Janet L. Crane, Emily Farber, Charles R. Farber, Xianghang Luo, Peisong Gao, Xu Cao, Mei Wan
NATURE COMMUNICATIONS
(2016)
Article
Multidisciplinary Sciences
Mi Yang, Chang-Jun Li, Xi Sun, Qi Guo, Ye Xiao, Tian Su, Man-Li Tu, Hui Peng, Qiong Lu, Qing Liu, Hong-Bo He, Tie-Jian Jiang, Min-Xiang Lei, Mei Wan, Xu Cao, Xiang-Hang Luo
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Changjun Li, Yu Chai, Lei Wang, Bo Gao, Hao Chen, Peisong Gao, Feng-Quan Zhou, Xianghang Luo, Janet L. Crane, Bin Yu, Xu Cao, Mei Wan
NATURE COMMUNICATIONS
(2017)
Article
Endocrinology & Metabolism
Changjun Li, Qiujuan Xing, Bing Yu, Hui Xie, Weishan Wang, Chenhui Shi, Janet L. Crane, Xu Cao, Mei Wan
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Cell & Tissue Engineering
Weishan Wang, Changjun Li, Lijuan Pang, Chenhui Shi, Fengjing Guo, Anmin Chen, Xu Cao, Mei Wan
STEM CELLS AND DEVELOPMENT
(2014)
Article
Medicine, Research & Experimental
Chang-Jun Li, Ye Xiao, Mi Yang, Tian Su, Xi Sun, Qi Guo, Yan Huang, Xiang-Hang Luo
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Review
Cell Biology
Jing Hou, Chen He, Wenzhen He, Mi Yang, Xianghang Luo, Changjun Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Cell Biology
Chen He, Wenzhen He, Jing Hou, Kaixuan Chen, Mei Huang, Mi Yang, Xianghang Luo, Changjun Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Cell Biology
Yili Xu, Mei Huang, Wenzhen He, Chen He, Kaixuan Chen, Jing Hou, Min Huang, Yurui Jiao, Ran Liu, Nanyu Zou, Ling Liu, Changjun Li
Summary: In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Yurui Jiao, Jiake Xu, Chao Liang, Changjun Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Changjun Li, Bart O. Williams, Xu Cao, Mei Wan