Article
Multidisciplinary Sciences
Zofia Dubicka, Maria Gajewska, Wojciech Kozlowski, Valeria Mikhalevich
Summary: Morphology is crucial for understanding the evolution and classification of foraminifera, with Paleozoic taxa showing diverse test wall microstructures that challenge traditional high-rank classification. Fusulinata, traditionally considered a unified group, may in fact consist of multiple taxonomic groups needing revision.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Susrut Akkineni, Gregory S. Doerk, Chenyang Shi, Biao Jin, Shuai Zhang, Stefan Habelitz, James J. De Yoreo
Summary: The study demonstrates how the supramolecular structures of matrix proteins can be synthetically directed into predetermined patterns while retaining their functionality. They used block copolymer lamellar patterns to direct the assembly of peptide nanoribbons, which template calcium phosphate nucleation by creating a low-energy interface. The results show that the patterned nanoribbons maintain their structure and function, and successfully direct the formation of calcium phosphate with high fidelity.
Article
Chemistry, Multidisciplinary
Juan Xu, Xingzhong Zhu, Lihui Xu, Caixia Kan, Daning Shi
Summary: Hard template-directed growth methods are effective for synthesizing Ag nanostructures with precise size control, while soft template methods are flexible for synthesizing Ag nanostructures with various morphologies. However, the strong confinement effect of the hard template limits the diversity of Ag nanostructures and neglects the role of the soft template.
Article
Materials Science, Ceramics
Debojit Paul, Gopal Das
Summary: In this study, organic molecules were used as templates to synthesize and stabilize the least stable crystalline phase of CaCO3, vaterite. While curcumin successfully stabilized the vaterite phase, quercetin did not, leading to an interesting observation of dumbbell-shaped calcite crystals. Various parameters such as template concentration, sequence of addition, temperature, and ionic strength were investigated to understand the influence on the phase, morphology, and size of the particles during the biomineralization process.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Marc Robin, Chakib Djediat, Arnaud Bardouil, Niki Baccile, Camille Chareyron, Ivo Zizak, Peter Fratzl, Mohamed Selmane, Bernard Haye, Isabelle Genois, Jean-Marc Krafft, Guylene Costentin, Thierry Azais, Franck Artzner, Marie-Madeleine Giraud-Guille, Paul Zaslansky, Nadine Nassif
Summary: This study demonstrates that the non-fibrillar osteoid in sheep is organized in a liquid-crystal cholesteric geometry. The acidic domains promote the formation of fibrillar plywood textures of collagen, which are important for bone maturation.
Article
Multidisciplinary Sciences
Dimitra Athanasiadou, Nadeen Meshry, Naara G. Monteiro, Ana C. Ervolino-Silva, Ryan Lee Chan, Christopher A. McCulloch, Roberta Okamoto, Karina M. M. Carneiro
Summary: DNA-based biomaterials have potential as biodegradable scaffolds for bone repair due to their ability to bind Ca2+ and promote HAP growth. This study describes the design and synthesis of DNA hydrogels, their interactions with osteogenic cell lines, and their promotion of new bone formation in rat calvarial wounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Xiaoyong Yue, Liguang Xu, Hengwei Lin, Chuanlai Xu, Si Li
Summary: In this study, Pt and Pt-Au bimetal-doped chiral nanostructures with different morphologies and compositions were constructed using L-/D-arginine and mono-sulfonate tetraphenyl porphyrin assemblies as chiral templates. The shape and composition of these chiral nanostructures can be finely regulated by adjusting the pH, ionic strength, and reaction time. These chiral nanostructures exhibit superior enantioselective photocatalytic ability under visible light, providing a new strategy for the photocatalytic conversion of chiral organics.
Article
Materials Science, Multidisciplinary
Ruth Fabiola Balderas-Valadez, Alessandro Nagel, Yuya Kanehira, Ilko Bald, Claudia Pacholski
Summary: The homogeneous and ordered coverage of substrate surfaces with nanostructures is achieved by using colloidal arrays, which allows for the fabrication of highly ordered nanostructure arrays on large areas.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Stefanie Tjaberings, Markus Heidelmann, Steffen Franzka, Andre H. Groeschel
Summary: ABC triblock terpolymers can form nanostructures with complex shapes, multiple compartments, and localized chemistry, making them promising soft templates for organic/inorganic hybrids. By selectively loading microdomains in multicompartment nanofibers (MCNFs), nanoscale multimetallic hybrid materials can be obtained. Various hybrid MCNFs with different metal compositions were created by loading FeCl3, PdCl2, H2PtCl6, AgNO3, CuCl2, or ZnCl2 onto PS-b-PB-b-PT MCNFs and postmodifying them. The loading order was found to be crucial for successful creation of multimetallic nanostructures. These structures hold potential applications in energy, photocatalysis, and electrocatalysis.
Article
Chemistry, Multidisciplinary
Marek Ondrus, Veronika Sykorova, Michal Hocek
Summary: This new alternative involves enzymatic synthesis of single-stranded hypermodified oligodeoxyribonucleotides by reverse transcription from RNA templates catalyzed by DNA polymerases, followed by digestion of RNA by RNases. The resulting hypermodified oligonucleotides could have applications in the selection of aptamers or other functional macromolecules.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Junhua Zhao, Qin Hu, Yinlin Lei, Chuanhua Gao, Pinjie Zhang, Bo Zhou, Gongjun Zhang, Weijie Song, Xiaoge Lou, Xiaoli Zhou
Summary: A novel three-phase reaction system was used to synthesize ultralong HAPNWs, with the study also investigating the influence of raw materials and initial pH on the nanowire structure. The formation mechanism of HAPNWs was proposed, and the HAPNWs/carbon composite adsorbent showed unique adsorption properties for methyl orange removal.
Article
Engineering, Environmental
Peipei Wang, Mingshu Xiao, Hao Pei, Hang Xing, Shi-Hua Luo, Chia-Kuang Tsung, Li Li
Summary: In this study, metal organic framework (MOF)-biomineralized DNA nanospheres were developed as chemodynamic therapy (CDT) agents with tumor-activable cascade reactions for boosting intracellular H2O2 concentration, achieving remarkable antitumor outcome. The CDT agent utilizes tumor acid-induced dissociation to release Fe2+/Fe3+ for Fenton reaction and GOx for catalyzing glucose into H2O2, synergistically elevating ROS level in tumor cells to induce ferroptosis. This strategy provides a promising approach for developing CDT agents with improved therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Xiong Liang, Zehang Liu, Jianan Fu, Heting Zhang, Jinbiao Huang, Shuai Ren, Zhenxuan Zhang, Qing Chen, Yong Xiao, Wenqing Ruan, Jiang Ma
Summary: A hierarchical nanoporous platinum-based metallic glass has been developed as an efficient and robust catalyst for oxygen reduction reaction (ORR). It exhibits super hydrophilicity and long-term stability through self-renewal surface, making it a promising material for electrochemical energy conversion and storage devices.
Article
Chemistry, Multidisciplinary
Haiping Wu, Shun Huang, Ying Zhu, Jia Li, Xiaoxiao Pang, Yongyao Tang, Siqiao Li, Ping Ji, Shijia Ding, Wei Cheng, Wenyang Li
Summary: A multifaceted bone microenvironment amendment, Mineralized zippered G4-Hemin DNAzyme hydrogel (MDH), is proposed to improve osteogenic capacity and promote bone defect repair in osteoporotic patients. The MDH, synthesized through a rolling circle amplification DNA hydrogel system, allows the introduction of zippered G4-Hemin DNAzyme with excellent enzyme-like activity and ROS scavenging ability. An autonomous mineralization system is created by ingeniously utilizing the DNA amplification by-product pyrophosphate as a phosphorus source, addressing the stability challenge of DNA hydrogel bio-application. In vitro and in vivo studies demonstrate that MDH effectively improves oxidative stress, restores mitochondrial membrane potential balance, and enhances osteogenic capacity.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Rawan Alsharedeh, Nid'a Alshraiedeh, Alaa A. Aljabali, Murtaza M. Tambuwala
Summary: This review discusses the feasibility of using magnetotactic bacteria and their organelles, magnetosomes, as nanocarriers in cancer treatment. Evidence suggests that they can be used to deliver various anticancer medicines and genetic materials. The unique properties of magnetite crystals make them suitable for use in biotechnology and nanomedicine.
CURRENT DRUG DELIVERY
(2023)
Article
Chemistry, Multidisciplinary
Dimitra Athanasiadou, Alexander L. Danesi, Liana Umbrio, James Holcroft, Bernhard Ganss, Karina M. M. Carneiro
Summary: The study investigates the synthesis of modified amelogenin by inserting the mineralizing AMTN-derived motif SSEEL both internally and at its C-terminus. C-terminus modified amelogenin promoted hydroxyapatite formation, while internal incorporation of the motif initially resulted in amorphous calcium phosphate formation. This research provides new insights for mineralized tissue regeneration using recombinamer proteins.
Article
Nanoscience & Nanotechnology
Alexander L. Danesi, Dimitra Athanasiadou, Abdulmateen O. Aderinto, Prakash Rasie, Leo Y. T. Chou, Karina M. M. Carneiro
Summary: The study demonstrates that DNA nanostructures can promote site-specific calcium phosphate formation under mineralizing conditions, resulting in amorphous calcium phosphate or hydroxyapatite. This finding sheds light on the mechanisms of crystal nucleation and growth in mineralized tissues, providing insights for mineralized tissue regeneration strategies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Alexander L. Danesi, Dimitra Athanasiadou, Ahmad Mansouri, Alina Phen, Mehrnoosh Neshatian, James Holcroft, Johan Bonde, Bernhard Ganss, Karina M. M. Carneiro
Summary: Biomineralization is a crucial process in which organisms produce mineralized tissues, such as teeth, bones, and shells, composed of hierarchically organized hydroxyapatite crystals. Developing protein-based materials as artificial scaffolds for guiding hydroxyapatite growth is an attractive goal for designing ordered nanomaterials and tissue regeneration. Uniaxial hydroxyapatite growth on a nanoengineered amelogenin scaffold combined with amelotin may provide insights into the molecular mechanism of hydroxyapatite formation and mineralized tissue formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Andrew Y. Wang, Nuno M. Coelho, Pamma D. Arora, Yongqiang Wang, Denise Eymael, Chenfan Ji, Qin Wang, Wilson Lee, Jessica Xu, Andras Kapus, Karina M. M. Carneiro, Christopher A. McCulloch
Summary: Fibrosis is characterized by excessive deposition of densely packed collagen fibrils, which hampers organ structure and function. A key player in collagen-rich lesions is the discoidin domain receptor 1 (DDR1), which is associated with increased collagen compaction through Ca2+-dependent nonmuscle myosin IIA (NMIIA). This study reveals a functional relationship between DDR1 and the transient receptor potential vanilloid type 4 (TRPV4) channel, showing that DDR1 regulates Ca2+ influx through TRPV4 to promote critical processes involved in collagen compaction and alignment in fibrotic lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Y. Bai, J. Bonde, K. M. M. Carneiro, Y. Zhang, W. Li, S. Habelitz
Summary: The development of the complex fibrous architecture of human enamel involves the observed amelogenin nanoribbons in in vitro experiments; protein structures matching the nanoribbons were found in enamel lacking the enzyme KLK4; similar structures were described as early as the 1960s, although researchers were unaware of their true function at the time.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Arwa Bafail, Karina Midori Mori Carneiro, Anil Kishen, Anuradha Prakki
Summary: The study evaluated the effect of Odanacatib inhibitor treatment on lipopolysaccharide (LPS) contamination-induced dentin degradation mediated by cathepsin-K. Results showed that LPS contamination significantly increased the release rates of telopeptides from dentin matrix, while Odanacatib treatment significantly reduced the telopeptide release rates in LPS-contaminated dentin.
Article
Multidisciplinary Sciences
Dimitra Athanasiadou, Nadeen Meshry, Naara G. Monteiro, Ana C. Ervolino-Silva, Ryan Lee Chan, Christopher A. McCulloch, Roberta Okamoto, Karina M. M. Carneiro
Summary: DNA-based biomaterials have potential as biodegradable scaffolds for bone repair due to their ability to bind Ca2+ and promote HAP growth. This study describes the design and synthesis of DNA hydrogels, their interactions with osteogenic cell lines, and their promotion of new bone formation in rat calvarial wounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cardiac & Cardiovascular Systems
Nikolaos Anousakis-Vlachochristou, Dimitra Athanasiadou, Karina M. M. Carneiro, Konstantinos Toutouzas
Summary: This study reviews the alterations of structural native extracellular matrix proteins involved in the development of calcific aortic valve stenosis (CAVS) and highlights its link to deregulated biomechanical function.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nikolaos Anousakis-Vlachochristou, Dimitra Athanasiadou, Manolis Mavroidis, Antigoni Miliou, Manousos Makridakis, Loukas Kaklamanis, Stamatis Adamopoulos, Antonia Vlahou, Dennis V. Cokkinos, Karina Carneiro, Konstantinos P. Toutouzas
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
