期刊
COMPLEMENTARY MEDICINE RESEARCH
卷 28, 期 5, 页码 435-445出版社
KARGER
DOI: 10.1159/000513701
关键词
Moxibustion; Systematic review; Essential hypertension
资金
- National Natural Science Foundation of China [81590955]
- Science and Technology Project of the Department of Education of Jiangxi Province [GJJ180696]
- Teaching Reform Project of Colleges and Universities in Jiangxi province [JXJG-19-12-14]
- Education Science 13th Five-year Plan Project of Jiangxi Province [20YB148]
- National Key R&D Program of China [2017YFC1700406]
This study suggests that moxibustion may have a positive effect on reducing blood pressure and improving the response to hypotensive treatment. However, the effects of moxibustion on typical hypertension symptoms and long-term safety remain uncertain and require further investigation.
Introduction: This systematic review aims to update the evidence for moxibustion for essential hypertension. Methods: Randomized controlled trials (RCTs) comparing moxibustion versus lifestyle intervention or moxibustion plus antihypertensive drugs versus antihypertensive drugs alone were searched in 9 databases up to March 29, 2020. In meta-analyses, mean difference (MD) and proportional odds ratio (pOR) with 95% confidence intervals (CIs) was pooled for continuous and ordinal outcomes, respectively. Results: Eighteen RCTs were included, involving 1,460 patients. Moxibustion decreased systolic (MD -7.85 mm Hg, 95% CI -9.69 to -6.00, p < 0.00001, I-2 = 46%) and diastolic (MD -4.09 mm Hg, 95% CI -5.45 to -2.73, p < 0.0001, I-2 = 56%) blood pressures and improved the response to hypotensive treatment (pOR 2.37, 95% CI 1.49-3.75, p = 0.0003, I-2 = 57%) significantly more than did the control treatment. Moxibustion also significantly relieved headache and dizziness but the effects changed to be statistically nonsignificant after excluding RCTs with a high risk of bias. Moxibustion did not significantly relieve insomnia and anxiety. No adverse events were reported. Conclusions: Based on the current low to moderate quality evidence, our study suggests that moxibustion may have effects on reducing blood pressure. The effects of moxibustion on typical hypertension symptoms and the long-term safety of moxibustion remain uncertain.
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