Article
Biochemistry & Molecular Biology
Madhu Sharma, Naresh Mittapelly, Venkatesh Teja Banala, Sandeep Urandur, Shalini Gautam, Disha Marwaha, Nikhil Rai, Neha Singh, Ashutosh Gupta, Kalyan Mitra, Prabhat Ranjan Mishra
Summary: HR+/HER2- metastatic breast cancer is a common and dangerous condition in women. A novel MN system using HA-PVA-PVP microneedle array is developed to deliver RB for breast cancer treatment, reducing toxicity and improving efficacy.
Article
Nanoscience & Nanotechnology
Kiyohiro Toyofuku, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto
Summary: Nucleic acid drugs, such as antisense oligonucleotides (ASOs), have shown great potential as therapeutics for intractable diseases. However, their current administration via injection can negatively impact patient quality of life. This study introduces a transdermal delivery method using lipid-based ionic liquid surfactants, which enhance the skin permeation and intracellular delivery of ASOs. In vitro and in vivo experiments demonstrate the effectiveness of this approach in inhibiting tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Suliman Khan, Anwarul Hasan, Farnoosh Attar, Mohammad Mahdi Nejadi Babadaei, Hojjat Alizadeh Zeinabad, Majid Salehi, Morteza Alizadeh, Mahbub Hassan, Hossein Derakhshankhah, Michael R. Hamblin, Qian Bai, Majid Sharifi, Mojtaba Falahati, Timo L. M. ten Hagen
Summary: Microneedle arrays have attracted attention as cancer detection and treatment platforms, delivering active molecules through the skin and improving patient health. They enable controlled release of multiple drugs, optimizing treatment and preventing drug interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Tamer A. Ismail, Tamer M. Shehata, Dalia I. Mohamed, Heba S. Elsewedy, Wafaa E. Soliman
Summary: The study demonstrated that BRU-loaded ethosomal gel exhibited significant anticancer activity against A375 human melanoma cell lines, providing strong motivation for further investigation of BRU-loaded ethosomal gel as a prospective therapeutic strategy for melanoma treatment.
Review
Pharmacology & Pharmacy
Deepak Kulkarni, Fouad Damiri, Satish Rojekar, Mehrukh Zehravi, Sarker Ramproshad, Dipali Dhoke, Shubham Musale, Ashiya A. Mulani, Pranav Modak, Roshani Paradhi, Jyotsna Vitore, Md Habibur Rahman, Mohammed Berrada, Prabhanjan S. Giram, Simona Cavalu
Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.
Review
Biochemistry & Molecular Biology
Farzaneh Sabbagh, Ida Idayu Muhamad, Razieh Niazmand, Pritam Kumar Dikshit, Beom Soo Kim
Summary: This review focuses on the design of carriers for insulin delivery and various non-invasive mechanisms for insulin delivery. It also highlights the use of smart stimuli-responsive insulin delivery systems and different polymers as insulin carriers. The advantages, limitations, and effects of each non-invasive route on insulin delivery are discussed in detail.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Xiaona Cao, Guojun Chen
Summary: This review provides an overview of recent advances in microneedle technology for non-transdermal applications, with a particular focus on its applications in ocular, vascular, oral, mucosal, and cancer tissues. The improved design of microneedles has expanded their potential for non-transdermal applications.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Tae Hyeon Kim, Na Yeon Kim, Hee Uk Lee, Ji Wook Choi, Taewook Kang, Bong Geun Chung
Summary: Cancer is a leading cause of death worldwide, and conventional cancer therapy has limitations. To address these issues, a transdermal drug delivery system based on iontophoresis has been developed. Controlled by a smartphone application, this system significantly enhances drug permeation at the tumor site and reduces systemic side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Engineering, Biomedical
Dan Yang, Minglong Chen, Ying Sun, Yunpan Jin, Chao Lu, Xin Pan, Guilan Quan, Chuanbin Wu
Summary: This review discusses the emergence of versatile microneedles for transdermal delivery of various drugs, especially focusing on their application in treating different skin diseases such as superficial tumors, scars, psoriasis, herpes, acne, and alopecia. It also summarizes the promises and challenges of widespread translation of microneedles for transdermal drug delivery in dermatology.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Medicinal
Sani Sabo, Laura J. Waters
Summary: This study discusses the use of PDMS as a sustainable alternative to skin for pharmaceutical analysis, enhancing the ability to predict permeability for hydrophilic and hydrophobic drugs. Optimizations and limitations related to transdermal drug delivery research are documented and reviewed.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Neha Tiwari, Ernesto Rafael Osorio-Blanco, Ana Sonzogni, David Esporrin-Ubieto, Huiyi Wang, Marcelo Calderon
Summary: Nanosized carrier systems offer a promising alternative for improving skin penetration of therapeutic molecules with minimal damage to the skin's natural barrier. The use of nanoparticles for delivering drugs, genetic material, and vaccines into the skin is discussed, along with the importance of nanotoxicology studies and recent clinical developments in shedding light on their potential for market translation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Geonwoo Kang, Minkyung Kim, Huisuk Yang, Jiwoo Shin, Jeeho Sim, Hyeri Ahn, Mingyu Jang, Youseong Kim, Hye Su Min, Hyungil Jung
Summary: A latch applicator, consisting of simple plastic parts and operated by thumb force, was developed for efficient and cost-effective administration of dissolving microneedles (DMN). The optimized latch applicator demonstrated successful insertion of the drug-loaded DMN into the skin and showed higher antibody production compared to intramuscular injection in an immunization test. This latch applicator has the potential to greatly improve drug delivery, including vaccines, with its effective DMN insertion and competitive price.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Noriyuki Uchida, Masayoshi Yanagi, Hiroki Hamada
Summary: A transdermal drug delivery system (TDDS) provides drug absorption via the skin and could replace conventional oral and blood administration. However, designing efficient TDDS is challenging due to the barrier properties of the skin, and methods using physical and chemical stimuli may cause inflammation and tissue damage. New TDDS with nanocarriers have emerged to minimize skin damage with the advancement of nanotechnology.
Article
Chemistry, Multidisciplinary
Geonwoo Kang, Minkyung Kim, Huisuk Yang, Jiwoo Shin, Jeeho Sim, Hyeri Ahn, Mingyu Jang, Youseong Kim, Hye Su Min, Hyungil Jung
Summary: In this article, a novel applicator is developed to efficiently insert dissolving microneedle patches into the skin with optimized force and velocity. This applicator is cost-competitive and easy to use with thumb-force operation. The study shows that the microneedle and applicator system can generate significantly higher antibody levels compared to intramuscular injection when using a model antigen.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Sakshi Priya, Yashika Tomar, Vaibhavi Meghraj Desai, Gautam Singhvi
Summary: For decades, scientists have been focusing on finding effective long-term or disease-modifying treatments for skin disorders. Conventional drug delivery systems have shown poor efficacy and associated side effects, leading to challenges in patient adherence. Dissolving microneedles have gained attention for their advantages in breaching skin barriers with minimal discomfort and easy application, making them a potential novel drug delivery strategy for the long-term treatment of skin disorders.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Biochemistry & Molecular Biology
Tariq Mehmood, Sana Hanif, Faiza Azhar, Ijaz Ali, Ahmed Alafnan, Talib Hussain, Afrasim Moin, Mubarak A. Alamri, Muhammad Ali Syed
Summary: In this study, a reversed-phased high-pressure liquid chromatography (RP-HPLC) method was proposed for the estimation of lignocaine hydrochloride (LIG), hydrocortisone (HYD), and Ketoprofen (KET) in a gel formulation. The method was found to be accurate, precise, and specific in identifying the drugs. The proposed method showed low limits of detection (LOD) and quantification (LOQ) for LIG, HYD, and KET. The study also evaluated the greenness score of the method and found it to be environmentally friendly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Syed Mohd Danish Rizvi, Talib Hussain, Farhan Alshammari, Hana Sonbol, Nabeel Ahmad, Syed Shah Mohammed Faiyaz, Mohammad Amjad Kamal, El-Sayed Khafagy, Afrasim Moin, Amr Selim Abu Lila
Summary: Infections caused by resistant bacterial pathogens have become more complicated for clinicians worldwide. Researchers have developed gold nanoparticles (AuNPs) that efficiently deliver cephalosporin antibiotics to resistant clinical pathogens. The synthesized AuNPs showed high stability and were effective against resistant strains of E. coli and K. pneumoniae. This study suggests that investing in a nano-antibiotic strategy may be a better approach to overcome resistance.
Article
Genetics & Heredity
Misbahuddin M. Rafeeq, Hussam Aly Sayed Murad, Najumuddin, Samee Ullah, Zaheer Ahmed, Qamre Alam, Muhammad Bilal, Alaa Hamed M. Habib, Ziaullah Sain, Muhammad Jawad Khan, Muhammad Umair
Summary: A novel nonsense variant in the TBX2 gene was identified, which may result in loss of protein function or nonsense-mediated decay (NMD). This study expands the mutation spectrum in the TBX2 gene and facilitates the diagnosis and genetic counseling of related features in affected families.
FRONTIERS IN GENETICS
(2023)
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Article
Cell Biology
Misbahuddin M. Rafeeq, Alaa Hamed Habib, Alaa F. Nahhas, Najat Binothman, Majidah Aljadani, Jawaher Almulhim, Ziaullah M. Sain, Mohammad Zubair Alam, Norah A. Alturki, Qamre Alam, Manish Manish, Rajnish Kumar Singh
Summary: In this study, the expression pattern of KSHV-encoded protease was investigated under physiologically allowed and chemically induced reactivation conditions. The results showed a direct and proportionate relationship between ORF17 expression and reactivation time. An inhibitor of ORF17, 1-oleoyl-2-hydroxy-sn-glycero-3-phospho-(1 ' -myo-inositol), was identified through virtual screening and demonstrated significant reduction in the production of Kaposi's sarcoma associated herpesvirus in vitro experiments and induced reactivation conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Gehad Subaiea, Syed Mohd Danish Rizvi, Hemant Kumar Singh Yadav, Turki Al Hagbani, Marwa Helmy Abdallah, El-Sayed Khafagy, Hosahalli Veerabhadrappa Gangadharappa, Talib Hussain, Amr Selim Abu Lila
Summary: Lung cancer is the most fatal type of cancer worldwide. Combining different chemotherapeutics has been shown to be effective in managing cancer. Ganetespib (GAN) is a potent hsp90 inhibitor with enhanced properties compared to its predecessors. This study investigated the combination of GAN and methotrexate (MTX) in lung carcinomas and found that the GAN/MTX combination had significant cytotoxic effects on A549 cells by modulating the NF-kB/p65 signaling pathway.
Article
Chemistry, Analytical
Mazin Zamzami, Samer Alamoudi, Abrar Ahmad, Hani Choudhry, Mohammad Imran Khan, Salman Hosawi, Gulam Rabbani, El-Sayed Shalaan, Bassim Arkook
Summary: This study presents an electrochemical method for directly identifying unlabeled Gram-negative bacteria without the need for additional substances. The design of the electrode geometry plays a crucial role in the detection sensitivity of Gram-negative bacteria. The aim is to find the most suitable electrode geometry to detect and quantify bacterial cells in normal saline solutions.
Review
Biology
Amr S. Abu Lila, Azza A. H. Rajab, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Wael A. H. Hegazy
Summary: Urinary tract infections are a common health care facility-associated infection, and bacteria can survive hostile environments by forming biofilms which provide protection and increase gene transfer. Understanding the role of biofilm formation in recurrent UTIs and finding strategies to eradicate biofilms are crucial for preventing this growing public health concern.
Article
Pharmacology & Pharmacy
Maram Suresh Gupta, Tegginamath Pramod Kumar, Dinesh Reddy, Kamla Pathak, Devegowda Vishakante Gowda, A. V. Naresh Babu, Alhussain H. Aodah, El-Sayed Khafagy, Hadil Faris Alotaibi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussin
Summary: Iron deficiency is a major health problem, especially during pregnancy. This study developed and characterized pullulan-based iron-loaded orodispersible films (i-ODFs) which showed good physicochemical properties, excellent disintegration time, and optimal stability at specified storage conditions.
Article
Infectious Diseases
Amr Selim Abu Lila, Tareq Nafea Alharby, Jowaher Alanazi, Muteb Alanazi, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Abdullah Ali Al Balushi, Wael A. H. Hegazy
Summary: This study investigates the prevalence and genetic basis of antibiotic resistance to macrolides, lincosamides, and streptogramins (MLS) in Enterococci and the correlation between MLS resistance and biocide resistance. The results show high resistance rates to MLS antibiotics, with constitutive resistance being the most prevalent phenotype. The erythromycin ribosome methylase (erm) genes, particularly ermB, were the most detected MLS resistance-encoding genes. The study also reveals a significant correlation between MLS resistance and reduced susceptibility to biocides, with efflux genes playing a crucial role in developing cross-resistance to both MLS antibiotics and biocides.
Article
Biochemistry & Molecular Biology
Mohammad Imran Khan, Hani Choudhry, Sadaf Jahan, Irfan A. A. Rather
Summary: With the increasing prevalence of multi-drug-resistant fungal infections, especially in developing countries, the development of new strategies and drugs to overcome drug resistance in fungal pathogens is crucial. This study investigated the potential of human neutrophil peptide (HNP) as a treatment for Candida infections. Results showed that HNP alone and in combination with fluconazole (FLC) exhibited antifungal activity against both susceptible and resistant C. albicans isolates. Furthermore, HNP inhibited biofilm formation and the activity of drug efflux pumps and their genes. These findings suggest that HNP could be used as a monotherapy or in combination with FLC to treat azole-resistant C. albicans.
Article
Engineering, Chemical
Turki Al Hagbani, Afrasim Moin, Talib Hussain, N. Vishal Gupta, Farhan Alshammari, Syed Mohd Danish Rizvi, Sheshagiri Dixit
Summary: The study investigated the potential of anti-tubercular pyrrole derivatives as candidates for cancer treatment using computational and experimental methods. The most potent derivatives C8 and C18 were identified and further analyzed through molecular simulation and cell-based assays. Results showed that C8 exhibited better stability and lower IC50 values compared to C18, and it induced significant cell cycle arrest and apoptosis in A549 cells. These findings suggest that C8 could be a promising repurposed candidate for lung cancer treatment. However, further in vivo assessment is needed for clinical translation.
Article
Biochemistry & Molecular Biology
Danish Iqbal, Mohammed Alsaweed, Qazi Mohammad Sajid Jamal, Mohammad Rehan Asad, Syed Mohd Danish Rizvi, Moattar Raza Rizvi, Hind Muteb Albadrani, Munerah Hamed, Sadaf Jahan, Hadeel Alyenbaawi
Summary: Neurodegenerative disorders, such as Alzheimer's disease, have a negative impact on the economy and psychological well-being. This study uses computational screening to identify potential multi-target inhibitors for Alzheimer's disease by analyzing fungal metabolites. The compound Bisacremine-C shows promising activity against GSK-3 beta, the NMDA receptor, and BACE-1, making it a potential candidate for further experimental validation and clinical trials.
