Review
Pharmacology & Pharmacy
Chaithanya Ganji, Batoul Farran
Summary: This review focuses on dysregulated genes associated with epigenetic mechanisms in pancreatic cancer progression and resistance, as well as current clinical trials for epigenetic drugs. Combining epigenetic drugs with targeted therapies might represent a promising approach for treating pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Article
Cell Biology
Fang Zhang, Mert Icyuz, Andrzej Bartke, Liou Y. Sun
Summary: The study showed that GH intervention during early life significantly altered histone H3 markers in Ames dwarf mice, resulting in tissue-specific changes in H3 lysine methylation and acetylation. These findings indicate an important epigenetic mechanism by which hormonal signals during early life can influence aging and longevity in mammals.
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biology
Honglian Zhang, Ying Liu, Yali Xie, Yunji Zhu, Jingwen Liu, Falong Lu
Summary: DNA methylation and H3K27me3 are two chromatin modifications, and it is found that H3K27me3 can negatively regulate DNA methylation by inhibiting the methylation process. Loss of H3K27me3 leads to increased methylation at previously marked H3K27me3 sites, and genome-wide analysis shows the absence of H3 ubiquitination at H3K27me3 marked nucleosomes. In addition, loss of H3K27me3 modification induces an increase in H3K18 ubiquitination at the corresponding hyper-methylated loci. Importantly, it is demonstrated that H3K27me3 directly inhibits UHRF1-mediated H3 ubiquitination on nucleosomes.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhiming Li, Xinzong Zhang, Shiming Xie, Xingping Liu, Caifeng Fei, Xunbin Huang, Yunge Tang, Li-quan Zhou
Summary: This study reveals the important role of Nuclear receptor binding SET domain protein 2 (Nsd2) in spermatogenesis. The loss of Nsd2 leads to apoptosis and abnormal development of spermatogenic cells, as well as dysregulation of genes and histone modifications. Furthermore, Nsd2 deficiency results in the retention of histones and increased protamine proteins in spermatozoa. These findings uncover the involvement of Nsd2 in chromatin remodeling during spermatogenesis and provide insights into the molecular mechanisms of epigenetic abnormalities affecting male reproductive health.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nofar Harpaz, Tamir Mittelman, Olga Beresh, Ofir Griess, Noa Furth, Tomer-Meir Salame, Roni Oren, Liat Fellus-Alyagor, Alon Harmelin, Sanda Alexandrescu, Joana Graca Marques, Mariella G. Filbin, Guy Ron, Efrat Shema
Summary: This study adapted CyTOF to analyze histone modifications in DIPG tumor cells and identified two epigenetically distinct subpopulations. These subpopulations were consistent across different tumor lines, and showed differences in proliferation capacity and expression of stem cell and differentiation markers. The study also demonstrated potential interactions between histone modifications and epigenetic alterations during the cell cycle.
Article
Biochemistry & Molecular Biology
Eleanor Glancy, Cheng Wang, Ellen Tuck, Evan Healy, Simona Amato, Hannah K. Neikes, Andrea Mariani, Marlena Mucha, Michiel Vermeulen, Diego Pasini, Adrian P. Bracken
Summary: Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition and recruits cPRC1 for repression of developmental genes. PRC2 forms two subcomplexes, PRC2.1 and PRC2.2, which have distinct roles in recruiting different forms of cPRC1. PRC2.1 catalyzes H3K27me3 and recruits CBX2/4-cPRC1, while PRC2.2 recruits CBX7-cPRC1 through its accessory protein JARID2.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Song, Julia A. VanBuskirk, Shannath L. Merbs
Summary: This study reveals an important role of epigenetic regulation in controlling opsin expression, and demonstrates this through experiments using epigenetic modifiers in cell cultures and mouse retinal explants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bibiana Torok, Csilla Lea Fazekas, Adrienn Szabo, Dora Zelena
Summary: Vasopressin, acting through V2, V1a, and V1b receptors, regulates kidney water resorption, blood pressure, stress-axis, social behavior, and memory. Its implication in depression and schizophrenia may involve epigenetic changes such as DNA methylation, histone modification, and micro RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Liya Bai, Haitao Sun, Wenxue Jiang, Liping Yang, Gongyan Liu, Xueyan Zhao, Hongmei Hu, Jianying Wang, Shuxia Gao
Summary: Our study investigated the expression pattern, methylation, and histone H3 acetylation status of Wnt10b during the SHF cycle in Angora rabbits. We found that Wnt10b plays a critical role in cyclic transition of SHFs, with methylation of CpG5 site negatively correlated with Wnt10b expression, and histone H3 acetylation likely involved in upregulating Wnt10b transcription in SHFs. Additionally, potential binding to transcription factors ZF57 and HDBP was predicted within the CpG5 site.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Genetics & Heredity
Federico Tessadori, Karen Duran, Karen Knapp, Matthias Fellner, Sarah Smithson, Ana Beleza Meireles, Mariet W. Elting, Quinten Waisfisz, Anne O'Donnell-Luria, Catherine Nowak, Jessica Douglas, Anne Ronan, Theresa Brunet, Urania Kotzaeridou, Shayna Svihovec, Margarita S. Saenz, Isabelle Thiffault, Florencia Del Viso, Patrick Devine, Shannon Rego, Jessica Tenney, Arie van Haeringen, Claudia A. L. Ruivenkamp, Saskia Koene, Stephen P. Robertson, Charulata Deshpande, Rolph Pfundt, Nienke Verbeek, Jiddeke M. van de Kamp, Janneke M. M. Weiss, Anna Ruiz, Elisabeth Gabau, Ehud Banne, Alexander Pepler, Armand Bottani, Sacha Laurent, Michel Guipponi, Emilia Bijlsma, Ange-Line Bruel, Arthur Sorlin, Mary Willis, Zoe Powis, Thomas Smol, Catherine Vincent-Delorme, Diana Baralle, Estelle Colin, Nicole Revencu, Eduardo Calpena, Andrew O. M. Wilkie, Maya Chopra, Valerie Cormier-Daire, Boris Keren, Alexandra Afenjar, Marcello Niceta, Alessandra Terracciano, Nicola Specchio, Marco Tartaglia, Marlene Rio, Giulia Barcia, Sophie Rondeau, Cindy Colson, Jeroen Bakkers, Peter D. Mace, Louise S. Bicknell, Gijs van Haaften
Summary: This study reports a cohort of individuals with de novo missense variants in six H4 genes, which are associated with neurodevelopmental features such as intellectual disability and developmental delay. Functional consequences of these variants were confirmed in zebrafish embryos.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Review
Clinical Neurology
Renske Oegema, Tahsin Stefan Barakat, Martina Wilke, Katrien Stouffs, Dina Amrom, Eleonora Aronica, Nadia Bahi-Buisson, Valerio Conti, Andrew E. Fry, Tobias Geis, David Gomez Andres, Elena Parrini, Ivana Pogledic, Edith Said, Doriette Soler, Luis M. Valor, Maha S. Zaki, Ghayda Mirzaa, William B. Dobyns, Orly Reiner, Renzo Guerrini, Daniela T. Pilz, Ute Hehr, Richard J. Leventer, Anna C. Jansen, Grazia M. S. Mancini, Nataliya Di Donato
NATURE REVIEWS NEUROLOGY
(2020)
Article
Multidisciplinary Sciences
Raquel Romero-Garcia, Laura Gomez-Jaramillo, Rosa Maria Mateos, Gema Jimenez-Gomez, Nuria Pedreno-Horrillo, Esther Foncubierta, Juan Francisco Rodriguez-Gutierrez, Sebastian Garzon, Francisco Mora-Lopez, Carmen Rodriguez, Luis M. Valor, Antonio Campos-Caro
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Noelia Geribaldi-Doldan, Irati Hervas-Corpion, Ricardo Gomez-Oliva, Samuel Dominguez-Garcia, Felix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal, Ricardo Pardillo-Diaz, Jose L. Gil-Salu, Pedro Nunez-Abades, Luis M. Valor, Carmen Castro
Summary: GBM is a common and aggressive primary brain tumor with poor prognosis. GSCs, which are resistant to current treatments, have been identified as the origin of GBM. Targeting PKC may be an effective approach to treat recurrent GBM.
Review
Biochemistry & Molecular Biology
Luis M. Valor, Jorge C. Morales, Irati Hervas-Corpion, Rosario Marin
Summary: Abnormal trinucleotide expansions, particularly the CGG repeats in the FMR1 gene, lead to various Fragile X-associated syndromes affecting children, adult men, and adult women; tracking and monitoring these expand carriers using peripheral blood can help identify disease progression and specific pathological traits. The association between molecular pathogenesis and biomarker dynamics can improve prognosis and clinical management of CGG-expansion carriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Cristina Alenda, Estefania Rojas, Luis M. Valor
Summary: Researchers found substantial similarities in molecular diagnosis and gene expression profiles between fixed materials from cavitational ultrasonic surgical aspirators (CUSAs) and tumor core resections (TCRs), confirming the suitability of CUSA-derived biomaterials for downstream applications and biomarkers screening in glioma surgeries.
Article
Oncology
Irati Hervas-Corpion, Andrea Gallardo-Orihuela, Inmaculada Catalina-Fernandez, Irene Iglesias-Lozano, Olga Soto-Torres, Noelia Geribaldi-Doldan, Samuel Dominguez-Garcia, Nuria Luna-Garcia, Raquel Romero-Garcia, Francisco Mora-Lopez, Marianela Iriarte-Gahete, Jorge C. Morales, Antonio Campos-Caro, Carmen Castro, Jose L. Gil-Salu, Luis M. Valor
Summary: The study identified that high expression levels of H3.1/H3.2 are associated with glioblastomas, while high expression of H3.3 is linked to low-grade gliomas. There is a potential for further investigation on the association between H3 variants and glioma aggressiveness. Additionally, the reduced levels of H3.3 in glioblastomas compared to other gliomas suggest a potential diagnostic utility in distinguishing high-grade gliomas.
Review
Biochemistry & Molecular Biology
Silvia Marti-Martinez, Luis M. Valor
Summary: Huntington's disease is a neurodegenerative disorder caused by abnormal expansion of CAG repeats in the Huntingtin gene. It not only affects the central nervous system but also has a peripheral component. Precise diagnosis and evaluation of therapeutic response require the use of biomarkers with prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Michal Lipinski, Sergio Ninerola, Miguel Fuentes-Ramos, Luis M. Valor, Beatriz del Blanco, Jose P. Lopez-Atalaya, Angel Barco
Summary: Environmental factors and life experiences can affect brain circuits, triggering adaptive changes. Epigenetic regulators play a crucial role in this neuroadaptation. The elimination of CBP reduces the expression and chromatin acetylation of plasticity genes, weakens activity-driven transcription, and causes memory deficits.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jorge Navarro-Calvo, Gema Esquiva, Violeta Gomez-Vicente, Luis M. Valor
Summary: The retina, as one of the most highly organized tissues in the central nervous system, requires finely regulated developmental processes to form the specialized retinal layers and allow precise phototransduction. MicroRNAs have crucial roles in retinal development, including the rearrangement of microRNA expression program and the differentiation and maintenance of retinal cell subtypes. This review provides an overview of the important findings regarding the involvement of microRNAs in retinal development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Irati Hervas-Corpion, Jorge Navarro-Calvo, Paula Martin-Climent, Marianela Iriarte-Gahete, Noelia Geribaldi-Doldan, Carmen Castro, Luis M. Valor
Summary: By exploring the TCGA database, we identified alterations in histone/DNA modifications and chromatin remodeling factors at transcriptional and genetic levels in glioblastoma (GB) compared to lower-grade gliomas. We also found a significant reduction in the levels of acetylated lysines 9 and 14 of histone H3 in high-grade compared to low-grade tumors. The transcriptional changes associated with histone deacetylase (HDAC) inhibition in GB-derived cultures were consistent with our RNA-seq analysis, suggesting the potential use of HDAC inhibitors in therapy.
Editorial Material
Biochemistry & Molecular Biology
Luis M. M. Valor
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
