Type 2 Diabetes, Obesity, and Cancer Share Some Common and Critical Pathways

The anticancer potential of metformin on prostate cancer

(2019) Saher Zaidi et al.   PROSTATE CANCER AND PROSTATIC DISEASES

LC–MS and docking profiling reveals potential difference between the pure and crude fucoidan metabolites

(2019) Saad Mustafa et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies

(2018) Shreyasi Asthana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glyoxalases in Urological Malignancies

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control

(2018) Cinzia Antognelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role and Cytotoxicity of Amylin and Protection of Pancreatic Islet β-Cells from Amylin Cytotoxicity

(2018) Yoshimitsu Kiriyama et al.   Cells

Glyoxalase 2 drives tumorigenesis in human prostate cells in a mechanism involving androgen receptor and p53-p21 axis

(2017) Cinzia Antognelli et al.   MOLECULAR CARCINOGENESIS

Type 2 Diabetes Mellitus and Cancer: The Role of Pharmacotherapy

(2016) Gadi Shlomai et al.   JOURNAL OF CLINICAL ONCOLOGY

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

Cancer, obesity, diabetes and antidiabetic drugs: is the fog clearing?

(2016) Adi J. Klil-Drori et al.   Nature Reviews Clinical Oncology

Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα

(2016) Vincenzo N. Talesa et al.   PROSTATE

Rosiglitazone reduces breast cancer risk in Taiwanese female patients with type 2 diabetes mellitus

(2016) Chin-Hsiao Tseng   Oncotarget

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

(2016) Rosa Divella et al.   Journal of Cancer

Insulin, insulin receptors, and cancer

(2016) R. Vigneri et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant

(2015) Eric R. Gross et al.   Annual Review of Pharmacology and Toxicology

Associations of pre-diagnostic body mass index with overall and cancer-specific mortality in a large Austrian cohort

(2015) Katharina Reichle et al.   CANCER CAUSES & CONTROL

Unmasking Determinants of Specificity in the Human Kinome

(2015) Pau Creixell et al.   CELL

Review of natural product databases

(2015) Tao Xie et al.   CELL PROLIFERATION

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells

(2015) M. Breinig et al.   Molecular Systems Biology

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

(2015) Matthew T Chang et al.   NATURE BIOTECHNOLOGY

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

(2015) Tzung-Ju Wu et al.   Cell Reports

Altered Fibroblast Growth Factor Receptor 4 Stability Promotes Prostate Cancer Progression

(2015) Jianghua Wang et al.   NEOPLASIA

Molecular Pathways: Preclinical Models and Clinical Trials with Metformin in Breast Cancer

(2014) A. M. Thompson   CLINICAL CANCER RESEARCH

Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

(2014) Jacqueline F. Rivera et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

Origin and Pathogenesis of Pelvic (Ovarian, Tubal, and Primary Peritoneal) Serous Carcinoma

(2013) Niloofar N. Nik et al.   Annual Review of Pathology-Mechanisms of Disease

The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes

(2013) Shereen Ezzat et al.   Cell Metabolism

Preclinical Rationale for PI3K/Akt/mTOR Pathway Inhibitors as Therapy for Epidermal Growth Factor Receptor Inhibitor-Resistant Non–Small-Cell Lung Cancer

(2013) Shirish M. Gadgeel et al.   Clinical Lung Cancer

Computational Drug Repositioning: From Data to Therapeutics

(2013) M R Hurle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

(2013) Shane R. Horman et al.   MOLECULAR CELL

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

mTORC1 Status Dictates Tumor Response to Targeted Therapeutics

(2013) I. Kelsey et al.   Science Signaling

Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases

(2013) G. Zhuang et al.   Science Signaling

Insulin/IGF-1 Signaling Regulates Proteasome Activity through the Deubiquitinating Enzyme UBH-4

(2013) Olli Matilainen et al.   Cell Reports

A 12-Gene Expression Signature Is Associated with Aggressive Histological in Prostate Cancer

(2012) Laia Agell et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Abiraterone and Novel Antiandrogens: Overcoming Castration Resistance in Prostate Cancer

(2012) R. Ferraldeschi et al.   Annual Review of Medicine

Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

(2012) Edita Aksamitiene et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

Exploiting the Cancer Genome: Strategies for the Discovery and Clinical Development of Targeted Molecular Therapeutics

(2011) Timothy A. Yap et al.   Annual Review of Pharmacology and Toxicology

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Diabetes mellitus type 2 through oncology lens

(2011) Khalid Omer Alfarouk et al.   MEDICAL HYPOTHESES

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

(2011) Markus K Muellner et al.   Nature Chemical Biology

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)

(2011) Khalid O. Alfarouk et al.   Cancers

Diabetes and Cancer: A Consensus Report

(2010) E. Giovannucci et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Diabetes and Cancer

(2010) T. A. Chowdhury   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Amyloid inhibitors enhance survival of cultured human islets

(2009) Kathryn J. Potter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

Oncogenes and Cancer

(2008) Carlo M. Croce   NEW ENGLAND JOURNAL OF MEDICINE