期刊
CELLS
卷 10, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells10010147
关键词
porcine; TRPC1; myogenesis; muscle growth
类别
资金
- National Major Special Project on New Varieties Cultivation for Transgenic Organisms [2016ZX08009-003-006]
- China Agricultural University partner assistance on research cooperation [2020SF001]
- Central Government guides Local Science and Technology [YDZX20195400004426]
The translation above suggests that the TRPC1 gene may promote muscle growth and development through activating Wnt signaling pathways and play a key role in myogenesis.
In animals, muscle growth is a quantitative trait controlled by multiple genes. Previously, we showed that the transient receptor potential channel 1 (TRPC1) gene was differentially expressed in muscle tissues between pig breeds with divergent growth traits base on RNA-seq. Here, we characterized TRPC1 expression profiles in different tissues and pig breeds and showed that TRPC1 was highly expressed in the muscle. We found two single nucleotide polymorphisms (SNPs) (C-1763T and C-1604T) in TRPC1 that could affect the promoter region activity and regulate pig growth rate. Functionally, we used RNAi and overexpression to illustrate that TRPC1 promotes myoblast proliferation, migration, differentiation, fusion, and muscle hypertrophy while inhibiting muscle degradation. These processes may be mediated by the activation of Wnt signaling pathways. Altogether, our results revealed that TRPC1 might promote muscle growth and development and plays a key role in Wnt-mediated myogenesis.
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