Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jan-Hendrik Schroeder, Katrin Meissl, Dominika Hromadova, Jonathan W. Lo, Joana F. Neves, Jane K. Howard, Helena Helmby, Nick Powell, Birgit Strobl, Graham M. Lord
Summary: T-bet deficient mice show an increase in ILC3 cellularity but do not have a greater risk of developing spontaneous colitis. T-bet appears to control the number of ILC3 cells, but does not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Maryam Ghaedi, Fumio Takei
Summary: Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and play a regulatory role in tissue homeostasis and immunity. They are divided into 3 groups based on similar effector programs to T cells, and their development from lymphoid progenitors in adult mouse bone marrow has been extensively studied.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Kathleen R. Bartemes, Hirohito Kita
Summary: ILC2, a type of innate lymphoid cell, responds rapidly to allergen exposure and environmental insults in mucosal organs by producing type 2 cytokines. In addition to being activated by epithelium-derived cytokines, ILC2s are regulated by other cytokines, eicosanoids, and neuropeptides.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Negar Sadeghi Hassanabadi, Bieke Broux, Sonja Marinovic, Dagmar Gotthardt
Summary: Multiple sclerosis (MS) is a debilitating autoimmune disease with millions of patients worldwide. Recent studies have shown that innate lymphoid cells (ILCs), in addition to T cells, play a role in the disease pathology. However, the exact role of ILCs in MS is still controversial.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Thuy T. Luu, Jonas Norskov Sondergaard, Lucia Pena-Perez, Shabnam Kharazi, Aleksandra Krstic, Stephan Meinke, Laurent Schmied, Nicolai Frengen, Yaser Heshmati, Marcin Kierczak, Thibault Bouderlique, Arnika Kathleen Wagner, Charlotte Gustafsson, Benedict J. Chambers, Adnane Achour, Claudia Kutter, Petter Hoglund, Robert Mansson, Nadir Kadri
Summary: FOXO1 and FOXO3 coordinately regulate essential developmental genes at multiple stages during murine NK cell and ILC lineage commitment through orchestrating distinct molecular mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaodong Yuan, Faiz Rasul, Bjoern Nashan, Cheng Sun
Summary: ILCs, including NK cells, ILC1s, ILC2s, ILC3s, and LTi cells, have been identified as important players in tumor progression and inhibition. While NK cells and ILC1s are primarily involved in antitumor activities, the roles of ILC2s and ILC3s in tumors are still unclear and influenced by various factors. Understanding the mechanisms that shape the phenotypes and responses of ILCs in the tumor microenvironment is crucial for potential cancer immunotherapy strategies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amrita Kumar, Weiping Cao, Kedan Endrias, Suresh V. Kuchipudi, Suresh K. Mittal, Suryaprakash Sambhara
Summary: Innate Lymphoid Cells play a critical role in clearing pathogens in mammalian hosts and are particularly important in response to viral infections.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Immunology
Oceane Paris, Franck J. D. Mennechet, E. J. Kremer
Summary: This study investigated the interaction between ILCs and adaptive immune response. The researchers found that ILCs uptake HAdVs, leading to phenotypic maturation and cytokine secretion. Moreover, the complex of neutralizing antibodies and host defense proteins altered the cytokine profile generated by ILCs, potentially impacting the efficacy of adenovirus-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Noha Mousaad Elemam, Rakhee K. Ramakrishnan, Jennifer E. Hundt, Rabih Halwani, Azzam A. Maghazachi, Qutayba Hamid
Summary: Infectious diseases, particularly bacterial infections, pose a significant global medical challenge, with the innate lymphoid cells (ILCs) playing a crucial role in defense against these infections. However, bacteria have evolved methods to evade the host immune system, leading to infection spread and tissue damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Guoquan Yin, Chen Zhao, Weiya Pei
Summary: Innate lymphoid cells (ILCs) and macrophages are important components of tissue-immune homeostasis and regulation. They have complex interactions and can quickly respond to disturbances in environmental conditions and organ homeostasis. More research is needed to understand the crosstalk between ILCs and macrophages in different tissues and their impact on inflammation and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hobin Seo, Amisha Verma, Megan Kinzel, Qiutong Huang, Douglas J. J. Mahoney, Nicolas Jacquelot
Summary: Reinvigorating the killing function of tumor-infiltrating immune cells through targeting regulatory molecules has improved the prognosis of cancer patients. Recent investigations suggest that tissue-resident innate lymphoid cells (ILCs), in addition to T lymphocytes, can benefit from immunotherapy. This article discusses the expression of immune checkpoint on ILCs and how their effector function is modulated by checkpoint blockade-based therapies, exploring potential to impede tumor growth and disease progression.
Review
Immunology
Aurelie S. Clottu, Morgane Humbel, Natalia Fluder, Maria P. Karampetsou, Denis Comte
Summary: Innate lymphoid cells (ILC) are a group of immune cells similar to T cells in morphology and cytokine profile, but they lack clonally distributed diverse antigen receptors. ILC, especially ILC1, ILC2, and ILC3, express transcription factors and cytokines similar to T helper cells, and play an important role in innate immunity by responding rapidly to pathogens. Recent studies have shown that alterations in the number and function of ILC are associated with autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Laura Kiekens, Sigrid Wahlen, Eva Persyn, Zenzi De Vos, Tom Taghon, Bart Vandekerckhove, Georges Leclercq
Summary: The study demonstrates that human ILC3s can convert into functional NK cells, with T-BET being the main driver.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
William Narinyan, Nicole Poladian, Davit Orujyan, Areg Gargaloyan, Vishwanath Venketaraman
Summary: This article discusses the major causes and immune response of tuberculosis and focuses on the role of innate lymphoid cells (ILCs) in combating tuberculosis infection. By reviewing recent literature and current evidence, the authors summarize the characteristics of the three major groups of ILCs (including NK cells) and analyze the role of each group in the tuberculosis infection process to provide a more comprehensive understanding of the host immune response.
Article
Oncology
Alessandra Gennari, Mariapia Sormani, Matteo Puntoni, Veronica Martini, Adriana Amaro, Paolo Bruzzi, Ulrich Pfeffer
Summary: Insulin signaling plays a key role in breast cancer prognosis, with potential implications for preventive and treatment strategies.
Article
Oncology
Francesca Piaggio, Michela Croce, Francesco Reggiani, Paola Monti, Cinzia Bernardi, Marianna Ambrosio, Barbara Banelli, Mehmet Dogrusoez, Ralf Jockers, Domenico Bordo, Roberto Puzone, Silvia Viaggi, Domenico Coviello, Francesco B. Lanza, Martina Bartolucci, Andrea Petretto, Carlo Mosci, Rosaria Gangemi, Pieter A. van der Velden, Martine J. Jager, Ulrich Pfeffer, Adriana Amaro
Summary: This study investigated the impact of GNAQ and GNA11 gene mutations on the characteristics and prognosis of uveal melanoma. The results showed that GNA11 mutation was associated with worse prognosis and high-risk cytogenetic, mutational, and molecular tumor characteristics. Additionally, G-proteins encoded by GNAQ and GNA11 had different protein interaction partners, and differential DNA methylation might contribute to different progression risks.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Allergy
Arinna Bertoni, Federica Penco, Hilaria Mollica, Paola Bocca, Ignazia Prigione, Anna Corcione, Davide Cangelosi, Francesca Schena, Genny Del Zotto, Adriana Amaro, Noemi Paladino, Emanuele Pontali, Marcello Feasi, Sara Signa, Marta Bustaffa, Roberta Caorsi, Serena Palmeri, Paola Contini, Raffaele De Palma, Ulrich Pfeffer, Paolo Uva, Anna Rubartelli, Marco Gattorno, Stefano Volpi
Summary: This study reveals the crucial role of IL-1 beta in driving inflammatory phenotypes in severe COVID-19 patients, whose maturation and secretion are regulated by inflammasomes. The findings suggest that targeting IL-1 beta could be an effective strategy for treating COVID-19 and provide a mechanistic explanation for the strong inflammatory manifestations associated with the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Melania Grottoli, Paolo Carrega, Lodovica Zullo, Chiara Dellepiane, Giovanni Rossi, Francesca Parisi, Giulia Barletta, Linda Zinoli, Simona Coco, Angela Alama, Silvia Marconi, Monica Parodi, Paola Orecchia, Sara Bassi, Massimo Vitale, Maria Cristina Mingari, Ulrich Pfeffer, Carlo Genova, Gabriella Pietra
Summary: This review provides an overview of NK cell-based checkpoint therapy approaches, including their rationale, mechanisms of action, and clinical efficacy. The article also discusses the future directions and planned enhancements in this field. Compared to T cell-based checkpoint immunotherapies, NK cells have higher potential in anti-tumor activity, making them a promising target for tumors that escape T-cell-mediated control.
Review
Oncology
Laura Damele, Grazia Maria Spaggiari, Monica Parodi, Maria Cristina Mingari, Massimo Vitale, Chiara Vitale
Summary: NK cells have established anti-tumor activity against hematological malignancies and their role in controlling solid tumor growth and metastasis generation is supported by many studies. However, the tumor microenvironment may influence NK cell function. In this context, umbilical cord blood (UCB) is an important source of NK cells and CD34(+) HSPCs, which can generate NK cells. UCB-derived NK cells are valuable for in vitro and preclinical analyses and have been used in clinical settings against hematological malignancies. This review summarizes the characteristics of UCB-derived NK cells and the in vitro models for their expansion, highlighting their importance in cancer immunotherapy protocols.
Article
Oncology
Adriana Agnese Amaro, Rosaria Gangemi, Laura Emionite, Patrizio Castagnola, Gilberto Filaci, Martine. J. J. Jager, Enrica Teresa Tanda, Francesco Spagnolo, Matteo Mascherini, Ulrich Pfeffer, Michela Croce
Summary: It has been found that driver mutations GNAQ and GNA11 activate MAP kinase and YAP/TAZ pathways, and MEK inhibitors do not effectively block UM progression. Combined treatment of trametinib and different drugs targeting YAP/TAZ can overcome resistance. The combined treatment of trametinib and cerivastatin can inhibit the growth of BAP1 mutated and chromosome 3 monosomic uveal melanoma cell lines in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Adriana Amaro, Max Pfeffer, Ulrich Pfeffer, Francesco Reggiani
Summary: This article introduces a data fusion technique for multi-domain genomic datasets to improve tumor classification results. The study shows that data fusion methods do not generate superior classification results compared to single-domain data. However, these methods might be better suited for predicting treatment response and identifying domain-independent predictive features.
Editorial Material
Oncology
Adriana Amaro, Ulrich Pfeffer
Article
Biochemistry & Molecular Biology
Francesco Reggiani, Marianna Ambrosio, Michela Croce, Enrica Teresa Tanda, Francesco Spagnolo, Edoardo Raposio, Mariangela Petito, Zeinab El Rashed, Alessandra Forlani, Ulrich Pfeffer, Adriana Agnese Amaro
Summary: The metastatic risk of uveal melanoma (UM) is determined by limited molecular lesions, somatic mutations, and copy number alterations. BAP1 mutations are always associated with M3 in high-risk patients, while other features such as 6p, 8q, M3, and SF3B1 mutation are present independently. Chr8q gain is frequently associated with chr3 disomy. Gene expression data analysis reveals two clusters, one enriched in metastatic samples with 8q|M3, BAP1|M3, and the other mainly containing low-risk samples with 6p combined with either 8q or SF3B1. Some gene expression events become significant when considering combinations of risk features, indicating additive action. The independence of risk factors supports a random risk model of UM metastasis without an obligatory sequence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)