Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

(2020) Eslam Mohamed et al.   IMMUNITY

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

(2019) Chuan-xia Zhang et al.   CELL DEATH AND DIFFERENTIATION

Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy

(2019) Charlie Gourley et al.   JOURNAL OF CLINICAL ONCOLOGY

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

(2019) Pia-Katharina Tegtmeyer et al.   Nature Communications

Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations

(2019) Jennifer Taylor Veneris et al.   GYNECOLOGIC ONCOLOGY

Tracking the fate of adoptively transferred myeloid-derived suppressor cells in the primary breast tumor microenvironment

(2018) Jaclyn Sceneay et al.   PLoS One

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression

(2018) Bastian Dörsam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microsatellite Instability in Mouse Models of Colorectal Cancer

(2018) Nicola Currey et al.   Canadian Journal of Gastroenterology and Hepatology

PD-1/PD-L1 pathway: an adaptive immune resistance mechanism to immunogenic chemotherapy in colorectal cancer

(2018) Magalie Dosset et al.   OncoImmunology

PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

(2018) Jianfeng Shen et al.   CANCER RESEARCH

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

(2018) Todd A. Hopkins et al.   MOLECULAR CANCER RESEARCH

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

(2018) Liya Ding et al.   Cell Reports

Role of PARP activity in lung cancer-induced cachexia: Effects on muscle oxidative stress, proteolysis, anabolic markers, and phenotype

(2017) Alba Chacon-Cabrera et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chasing the thermodynamical noise limit in whispering-gallery-mode resonators for ultrastable laser frequency stabilization

(2017) Jinkang Lim et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Why anti-PD1/PDL1 therapy is so effective? Another piece in the puzzle

(2017) Antonio Marchetti et al.   Journal of Thoracic Disease

The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression

(2017) Julia M. Weiss et al.   OncoImmunology

Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice

(2016) Claire B. Larmonier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice

(2015) M. A. Ghonim et al.   CLINICAL SCIENCE

Transcriptional regulation of myeloid-derived suppressor cells

(2015) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function

(2015) Mohamed A Ghonim et al.   Journal of Translational Medicine

Poly(ADP-Ribose) Polymerase-1 Is a Determining Factor in Crm1-Mediated Nuclear Export and Retention of p65 NF- B upon TLR4 Stimulation

(2010) M. Zerfaoui et al.   JOURNAL OF IMMUNOLOGY

PARP1 suppresses homologous recombination events in mice in vivo

(2010) A. Claybon et al.   NUCLEIC ACIDS RESEARCH

Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines

(2009) Mourad Zerfaoui et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia

(2008) A. S. Naura et al.   EUROPEAN RESPIRATORY JOURNAL

Nuclear translocation of p65 NF-κB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction

(2007) Mourad Zerfaoui et al.   CELLULAR SIGNALLING