期刊
MOLECULAR THERAPY-ONCOLYTICS
卷 20, 期 -, 页码 342-351出版社
CELL PRESS
DOI: 10.1016/j.omto.2021.01.011
关键词
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资金
- National Natural Science Foundation of China [81872210, 81802948]
- Excellent Talent Science and Technology Innovation Project of Shanxi Province [201605D211029, 201705D211018, 201805D211007]
- Shanxi Province Scientific and Technological Achievements Transformation Guidance Foundation [201804D131043]
- Shanxi Province Science Foundation for Excellent Young Scholars [201901D211486]
- Youth Foundation of The First Hospital Affiliated with Shanxi Medical University [YQ1503]
- Fund of Shanxi 1331 Project
HNSCC is a common malignant tumor affecting the head and neck regions, with current treatments including surgery, radiotherapy, chemotherapy, and immunotherapy, but the overall survival rate remains low. Studies have shown that the tumor microenvironment plays a crucial role in the recurrence, metastasis, and drug resistance of HNSCC.
Head and neck squamous cell carcinomas (HNSCCs) are a type of common malignant tumor, mainlymanifesting as oropharyngeal, oral cavity, laryngopharyngeal, hypopharyngeal, and laryngeal cancers. These highly aggressive malignant tumors reportedly affect more than 830,000 patients worldwide every year. Currently, the main treatments for HNSCC include surgery, radiotherapy, chemotherapy, and immunotherapy, as well as combination therapy. However, the overall 5-year survival rate of HNSCC has remained 50%, and it has not significantly improved in the past 10 years. Previous studies have shown that the tumor microenvironment (TME) plays a crucial role in the recurrence, metastasis, and drug resistance of patients with HNSCC. In this review, we summarize the role of anti-tumor and pro-tumor immune cells, as well as extracellular components in the TME of HNSCC. We also discuss classical HNSCC immunotherapy and highlight examples of clinical trials using CTLA-4 inhibitors and programmed cell death 1 (PD1)/programmed cell death ligand 1 (PD-L1)-related combination therapies. We also outline somemolecules in the TME known to regulate immunosuppressive cells. Furthermore, the role and underlying mechanism of radiation therapy on the TME, immune cells, and immune response are discussed.
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