Article
Materials Science, Biomaterials
Lei Liang, Xi Li, Zhouying Tan, Min Liu, Yuwei Qiu, Qingyu Yu, Chaojie Yu, Mengmeng Yao, Bingyan Guo, Fanglian Yao, Pengcheng Che, Hong Zhang, Junjie Li
Summary: We propose an injectable hydrogel filler with asymmetric adhesion ability and removability, which is formed by the Schiff-base reaction between aldehyde-based sodium alginate and multi-amino crosslinkers, combined with the coordination interaction between Au nanoparticles and disulfide bond. The hydrogel exhibits high mechanical properties and injectable behaviors. It also has reversible coordination interaction and antibacterial ability, while maintaining favorable degradability and biocompatibility. This versatile wound filler can achieve a wide range of applications in the field of all-skin wound repair.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Article
Engineering, Biomedical
Afeng Yang, Yun Bai, Xia Dong, Teng Ma, Dunwan Zhu, Lin Mei, Feng Lv
Summary: The biomaterial-mediated combined cell vaccines provide an innovative strategy for cancer immunotherapy by combining tumor cell and DC vaccines with a hydrogel and nanoadjuvant. This approach enhances the immunogenicity of cell vaccines, promotes antigen presentation, and inhibits tumor growth effectively, showing promising potential for improving cancer immunotherapy.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Mohammad Ariful Islam, Jamie Rice, Emma Reesor, Harshal Zope, Wei Tao, Michael Lim, Jianxun Ding, Yunhan Chen, Dike Aduluso, Bruce R. Zetter, Omid C. Farokhzad, Jinjun Shi
Summary: The study demonstrated that using mRNA vaccine nanoparticles with C16-R848 adjuvant can effectively induce anti-tumor immune response, increase the number of OVA-specific CD8(+) T cells, and significantly inhibit tumor growth.
Article
Materials Science, Multidisciplinary
Yixuan Huang, Tsukuru Masuda, Madoka Takai
Summary: The modifiable polymer gel composed of phosphorylcholine and N-hydroxysuccinimide ester can be postmodified to obtain a redox zwitterionic gel, which demonstrates superior operational stability and resistance to biofouling compared to typical redox hydrogels. The gel can serve as an enzyme-immobilizing matrix for enzymatic bioelectrodes, showing potential applications in the field of implantable bioelectronic applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Immunology
Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle
Summary: The discovery of tumor antigens has led to the development of cancer vaccines, but many antigens lack immunogenicity. Adjuvants are added to vaccine formulations to trigger immune responses. Aging can lead to immunosenescence and chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yong Zuo, Xiaoning Liu, Enguang Fu, Shaodong Zhang
Summary: Without chiral induction, the emergence of homochirality from achiral molecules is accidental due to the ambiguity of the rationale. In this study, we propose a plausible solution: by forming a pair of interconverting cage conformers from achiral precursors, each conformer self-sorts into a homochiral crystal when their interconversion is hindered by intramolecular H-bonding. This self-assembly process is driven by a helical network of multivalent intermolecular interactions. Our findings provide insights for the rational design of homochirality emergence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Daniel Delitto, Daniel J. Zabransky, Fangluo Chen, Elizabeth D. Thompson, Jacquelyn W. Zimmerman, Todd D. Armstrong, James M. Leatherman, Reecha Suri, Tamara Y. Lopez-Vidal, Amanda L. Huff, Melissa R. Lyman, Samantha R. Guinn, Marina Baretti, Luciane T. Kagohara, Won Jin Ho, Nilofer S. Azad, William R. Burns, Jin He, Christopher L. Wolfgang, Richard A. Burkhart, Lei Zheng, Mark Yarchoan, Neeha Zaidi, Elizabeth M. Jaffee
Summary: Applying PancVax gel at a positive tumor margin effectively prevented local recurrence in PDAC by expanding neoantigen-specific T cells.
Review
Immunology
Nasser Hashemi Goradel, Mahnaz Nemati, Azam Bakhshandeh, Arash Arashkia, Babak Negahdari
Summary: Cancer vaccines have been developed as an interesting cancer immunotherapy approach to deliver tumor antigens and adjuvants to antigen-presenting cells (APCs). Nanotechnology-based vaccines, known as nanovaccines, address the limitations of traditional vaccines by co-delivering antigens and adjuvants to lymphoid organs and APCs, leading to potent anti-tumor immune responses. The formation of nanocomplexes between antigens and adjuvants based on electrostatic interactions has shown promising results in enhancing immune responses. This article summarizes the various platforms for developing cancer vaccines, discusses the advantages of using delivery systems, and focuses on the potential of nanocomplexes formation as cancer nanovaccine platforms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Roberta Liberato Pagni, Patricia da Cruz Souza, Rafael Pegoraro, Bruna Felicio Milazzotto Maldonado Porchia, Jamile Ramos da Silva, Luana Raposo de Melo Moraes Aps, Mariangela de Oliveira Silva, Karine Bitencourt Rodrigues, Natiely Silva Sales, Luis Carlos de Souza Ferreira, Ana Carolina Ramos Moreno
Summary: The study demonstrated that IL-6 and IDO negatively contribute to the activation of immune cells, particularly dendritic cells, reducing protective immune responses induced by the gDE7 vaccine. Therefore, combined strategies based on inhibition of IL-6 and IDO offer new perspectives for immunotherapy against HPV-related tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physics, Multidisciplinary
Keisuke Fukutani, Roland Stania, Chang Il Kwon, Jun Sung Kim, Ki Jeong Kong, Jaeyoung Kim, Han Woong Yeom
Summary: Low-temperature ARPES measurements on Ta2NiSe5 provide evidence for the spontaneous formation of excitons, shedding light on their important roles in optoelectronics, photovoltaics, and photosynthesis. The study also reveals the potential for excitons to form spontaneously in small-gap semiconductors or semimetals, leading to Bose-Einstein condensation at low temperatures. This detection of spontaneously formed excitons in a debated excitonic insulator candidate, Ta2NiSe5, guarantees the excitonic insulator nature of the material at low temperature.
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Medicine, Research & Experimental
Mingliang Lin, Alexander Marin, Beverly Ellis, Lisa M. Eubanks, Alexander K. Andrianov, Kim D. Janda
Summary: This study demonstrates the potential of using a polyphosphazene macromolecule to enhance the delivery of a cocaine conjugate vaccine, resulting in higher antibody titers and successful sequestration of cocaine in the blood. The intranasal administration of the vaccine also proved to be effective in reducing cocaine's effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Medicine, General & Internal
Sapna P. Patel, Megan Othus, Yuanbin Chen, G. Paul Wright, Kathleen J. Yost, John R. Hyngstrom, Siwen Hu-Lieskovan, Christopher D. Lao, Leslie A. Fecher, Thach-Giao Truong, Jennifer L. Eisenstein, Sunandana Chandra, Jeffrey A. Sosman, Kari L. Kendra, Richard C. Wu, Craig E. Devoe, Gary B. Deutsch, Aparna Hegde, Maya Khalil, Ankit Mangla, Amy M. Reese, Merrick I. Ross, Andrew S. Poklepovic, Giao Q. Phan, Adedayo A. Onitilo, Demet G. Yasar, Benjamin C. Powers, Gary C. Doolittle, Gino K. In, Niels Kokot, Geoffrey T. Gibney, Michael B. Atkins, Montaser Shaheen, James A. Warneke, Alexandra Ikeguchi, Jose E. Najera, Bartosz Chmielowski, Joseph G. Crompton, Justin D. Floyd, Eddy Hsueh, Kim A. Margolin, Warren A. Chow, Kenneth F. Grossmann, Eliana Dietrich, Victor G. Prieto, Michael C. Lowe, Elizabeth I. Buchbinder, John M. Kirkwood, Larissa Korde, James Moon, Elad Sharon, Vernon K. Sondak, Antoni Ribas
Summary: This study aimed to investigate whether giving pembrolizumab both before and after surgery would improve event-free survival in patients with resectable stage III or IV melanoma. Results showed that patients who received pembrolizumab both before and after surgery had significantly longer event-free survival. Overall rating: 9 out of 10.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Shukun Li, Wenjia Zhang, Ruirui Xing, Chengqian Yuan, Huadan Xue, Xuehai Yan
Summary: A biocompatible therapeutic paradigm that can inhibit pancreatic tumor growth and eliminate tumor metastasis is urgently needed. The use of supramolecular nanofibrils created from clinically approved molecules for photothermal immunotherapy shows promise in improving treatment outcomes for pancreatic cancer. The integration of rapid photothermal therapy and moderate immunomodulation enhances the complementary effects of the components and creates opportunities for clinical translation.
ADVANCED MATERIALS
(2021)