Review
Clinical Neurology
Jia Liu, Guojun Tan, Bin Li, Jingze Zhang, Ying Gao, Yuanbo Cao, Zhen Jia, Kazuo Sugimoto
Summary: This study systematically assessed the association between serum AQP4-IgG titer and NMOSD activity and severity, demonstrating that the serum AQP4-IgG titer was not associated with disease activity but indicated the disease severity in the attack phase. Further meta-analyses with standardized AQP4-IgG assays and detailed medication information are needed to confirm these findings and optimize clinical AQP4-IgG monitoring.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yuichi Hayashi, Natsuko Ueda, Hideaki Shibata, Tomonori Yaguchi, Nobuaki Yoshikura, Megumi Yamada, Akio Kimura, Takashi Inuzuka, Takayoshi Shimohata
Summary: This study aimed to compare the clinical characteristics of intractable or persistent hiccups and nausea associated with herpes zoster to those associated with neuromyelitis optica spectrum disorder. Patients with herpes zoster-related symptoms were older and more likely to have hemi-cranial nerve involvement compared to those with neuromyelitis optica spectrum disorder-related symptoms.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Immunology
Robert Kadish, Stacey L. Clardy, Minying Royston, Imran Tanvir, Tavan Parker, Joseph Biskupiak, Adrian Kielhorn
Summary: This retrospective observational analysis of 47 patients with AQP4-IgG+ NMOSD found that patients with a higher risk of relapse exhibited diminished visual acuity, worsening of neurological disability, and greater pain medication use. Therapies targeting relapse prevention should be considered in treatment decisions.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Mohamad Ali H. Tfaily, Boghuma Titanji, Matthew J. Schniederjan, Abigail Goodman, Neil S. Lava, Stephanie M. Pouch, Matthew H. Collins, Max W. Adelman
Summary: This case discusses a 34-year-old man admitted for fever and headache two weeks after a motor vehicle accident, ultimately diagnosed with neuromyelitis optica spectrum disorder (NMOSD). Despite an extensive workup, no infectious agent was identified, and during treatment, he developed acute transverse myelitis.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Immunology
Pakeeran Siriratnam, Saif Huda, Helmut Butzkueven, Anneke van der Walt, Vilija Jokubaitis, Mastura Monif
Summary: This article reviews the evolution of our understanding of NMOSD, including its pathogenesis, clinical features, disease course, treatment options, and associated symptoms. The article also addresses the gaps in current knowledge and areas for future research focus.
AUTOIMMUNITY REVIEWS
(2023)
Article
Clinical Neurology
Rui Li, Cong Li, Qiao Huang, Zifeng Liu, Jingjing Chen, Bingjun Zhang, Chunxin Liu, Yaqing Shu, Yuge Wang, Allan G. Kermode, Wei Qiu
Summary: The optimal duration of immunosuppressant treatment and the risk of discontinuation for neuromyelitis optica spectrum disorder (NMOSD) were explored in this study. Long-term use of immunosuppressant medication is generally suitable for NMOSD, but there is a higher risk of relapse after discontinuation, especially for patients with longitudinal extensive transverse myelitis.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Liang Wang, Lei Du, Qinying Li, Fang Li, Bei Wang, Yuanqi Zhao, Qiang Meng, Wenyu Li, Juyuan Pan, Junhui Xia, Shitao Wu, Jie Yang, Heng Li, Jianhua Ma, Jingzi ZhangBao, Wenjuan Huang, Xuechun Chang, Hongmei Tan, Jian Yu, Lei Zhou, Chuanzhen Lu, Min Wang, Qiang Dong, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study investigates the predictors of relapse, and severe visual or motor disability in patients with NMOSD and develops corresponding predictive models. Early identification of patients at risk of unfavorable outcomes is crucial for informing treatment decisions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaoyan Yang, Jing Peng, Xiaoxi Huang, Peidong Liu, Juan Li, Jiali Pan, Zhihua Wei, Ju Liu, Min Chen, Hongbo Liu
Summary: The percentage of circulating CD4+CXCR5+PD-1+ Tfh cells and serum CXCL13 levels are significantly higher in patients with NMOSD during the acute and recovery phases compared to patients with other noninflammatory neurological diseases and healthy controls. The levels of Tfh cells and CXCL13 are positively correlated with disease severity indicators such as EDSS scores and cerebrospinal fluid protein levels in patients with acute NMOSD, suggesting the potential of Tfh cells as a biomarker for disease severity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Shu Umezawa, Katsura Ioka, Satoshi Aizawa, Yuichi Tashiro, Kazuo Yoshizawa
Summary: This case report presents a 52-year-old female who developed AQP4-IgG-positive NMOSD 14 days after receiving the first dose of BNT162b2 vaccine. MRI results showed enhanced lesions in the cervical cord, predominantly on the left side. The researchers suspected that immune responses following vaccination led to a breakdown of the blood-brain barrier, allowing plasma cells producing AQP4Abs to enter the central nervous system.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Orhan Aktas, Michael A. Smith, William A. Rees, Jeffrey L. Bennett, Dewei She, Eliezer Katz, Bruce A. C. Cree
Summary: High serum GFAP concentration may be associated with NMOSD activity and attack risk, and may reflect treatment effects.
ANNALS OF NEUROLOGY
(2021)
Article
Immunology
Patrick Schindler, Ulrike Grittner, Johanna Oechtering, David Leppert, Nadja Siebert, Ankelien S. Duchow, Frederike C. Oertel, Susanna Asseyer, Joseph Kuchling, Hanna G. Zimmermann, Alexander U. Brandt, Pascal Benkert, Markus Reindl, Sven Jarius, Friedemann Paul, Judith Bellmann-Strobl, Jens Kuhle, Klemens Ruprecht
Summary: This study suggests a potential role for sGFAP as a biomarker for disease severity and future disease activity in patients with AQP4-IgG(+) NMOSD during phases of clinical remission, while sNfL does not show significant associations in this aspect.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biology
Michela Ada Noris Ferilli, Roberto Paparella, Ilaria Morandini, Laura Papetti, Lorenzo Figa Talamanca, Claudia Ruscitto, Fabiana Ursitti, Romina Moavero, Giorgia Sforza, Samuela Tarantino, Martina Proietti Checchi, Federico Vigevano, Massimiliano Valeriani
Summary: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare inflammatory disease in children characterized by recurrent inflammation in the optic nerves and spinal cord, and can also affect other regions of the central nervous system. Early diagnosis is crucial for initiating appropriate treatment.
Review
Neurosciences
Emanuela Claudia Turco, Erica Curti, Francesco Pisani, Franco Granella
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is characterized by recurrent inflammatory events primarily involving optic nerves and the spinal cord. Varicella zoster virus (VZV) infection may trigger NMOSD attacks, especially in female patients.
JOURNAL OF NEUROVIROLOGY
(2022)
Article
Immunology
Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qin
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). TREM2, expressed by microglia, plays a crucial role in microglial activation and function during NMOSD demyelination.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Eleonora Virgilio, Domizia Vecchio, Marco Vercellino, Paola Naldi, Fabiana Tesser, Roberto Cantello, Paola Cavalla, Cristoforo Comi
Summary: AQP4-IgG neuromyelitis optica spectrum disorders are rare idiopathic autoimmune diseases with a potential association with tumors, and there is currently no consensus on treatment for paraneoplastic syndrome.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Yutaka Ikenouchi, Koji Kamagata, Christina Andica, Taku Hatano, Takashi Ogawa, Haruka Takeshige-Amano, Kouhei Kamiya, Akihiko Wada, Michimasa Suzuki, Shohei Fujita, Akifumi Hagiwara, Ryusuke Irie, Masaaki Hori, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Nobutaka Hattori, Shigeki Aoki
Article
Neurosciences
Christina Andica, Koji Kamagata, Taku Hatano, Yuya Saito, Wataru Uchida, Takashi Ogawa, Haruka Takeshige-Amano, Akifumi Hagiwara, Syo Murata, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Toshiaki Akashi, Akihiko Wada, Kanako K. Kumamaru, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Rheumatology
Tatou Iseki, Yuri Yamashita, Yuji Ueno, Kenichiro Hira, Nobukazu Miyamoto, Kazuo Yamashiro, Taiji Tsunemi, Kosuke Teranishi, Kenji Yatomi, Sho Nakajima, Chikage Kijima, Hidenori Oishi, Nobutaka Hattori
Summary: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thromboembolic events, including ischemic stroke or complications in pregnancy. Cervical artery dissection (CAD) is a common cause of stroke in young adults, and the concomitant presence of APS and CAD is extremely rare. Two rare cases of ischemic stroke caused by CAD secondary to APS were described in this report, along with a review of the literature indicating specific mechanisms for cerebral artery disorders secondary to APS.
Article
Clinical Neurology
Koichiro Yasaka, Koji Kamagata, Takashi Ogawa, Taku Hatano, Haruka Takeshige-Amano, Kotaro Ogaki, Christina Andica, Hiroyuki Akai, Akira Kunimatsu, Wataru Uchida, Nobutaka Hattori, Shigeki Aoki, Osamu Abe
Summary: Deep learning techniques applied to parameter-weighted structural matrices can differentiate patients with Parkinson's disease from healthy controls. Neural circuit disorders, such as alterations in connections between the basal ganglia and cerebellum, can be visualized using gradient-weighted class activation mapping.
Review
Biochemistry & Molecular Biology
Koji Kamagata, Christina Andica, Ayumi Kato, Yuya Saito, Wataru Uchida, Taku Hatano, Matthew Lukies, Takashi Ogawa, Haruka Takeshige-Amano, Toshiaki Akashi, Akifumi Hagiwara, Shohei Fujita, Shigeki Aoki
Summary: With the rapid increase in aging societies worldwide, there has been a growing prevalence of neurodegenerative diseases, highlighting the urgent need for biomarkers to enable early intervention. Diffusion MRI is a promising tool for inferring microstructural characteristics of the brain, and new technologies are being developed to overcome the limitations of diffusion tensor imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Takahiro Koinuma, Taku Hatano, Koji Kamagata, Christina Andica, Akio Mori, Takashi Ogawa, Haruka Takeshige-Amano, Wataru Uchida, Shinji Saiki, Ayami Okuzumi, Shin-Ichi Ueno, Yutaka Oji, Yuya Saito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
Summary: The study revealed white matter microstructural abnormalities in patients with parkin (PRKN) mutations, which are associated with disease duration and oxidative stress.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Sho Nakajima, Ryota Tanaka, Kazuo Yamashiro, Asako Chiba, Daisuke Noto, Toshiki Inaba, Naohide Kurita, Nobukazu Miyamoto, Takuma Kuroki, Hideki Shimura, Yuji Ueno, Takao Urabe, Sachiko Miyake, Nobutaka Hattori
Summary: The study revealed that mucosal-associated invariant T (MAIT) cells play a significant role in neuroinflammation following focal cerebral ischemia, and regulating them may offer a novel approach for the treatment of acute ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Takashi Ogawa, Taku Hatano, Koji Kamagata, Christina Andica, Haruka Takeshige-Amano, Wataru Uchida, Yuya Saito, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Hirokazu Iwamuro, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
Summary: This study aimed to investigate white matter alterations in Parkinson's disease patients with and without levodopa-induced dyskinesia using advanced diffusion magnetic resonance imaging techniques. The results showed significant differences in white matter microstructural disruption, especially in temporal lobe fibers, between patients with and without levodopa-induced dyskinesia. The tracts in temporal lobe fibers had a more than 2-fold odds ratio for the presence of levodopa-induced dyskinesia, suggesting a potential association with the pathogenesis of the sequela.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Yuya Uehara, Shin-Ichi Ueno, Haruka Amano-Takeshige, Shuji Suzuki, Yoko Imamichi, Motoki Fujimaki, Noriyasu Ota, Takatoshi Murase, Takayoshi Inoue, Shinji Saiki, Nobutaka Hattori
Summary: This study utilized RNA in skin surface lipids for transcriptome analysis and demonstrated the potential of these expression profiles with machine learning as diagnostic biomarkers for Parkinson's disease. Differential gene expression analysis identified more than 100 differentially expressed genes between PD patients and healthy controls, with several genes related to oxidative phosphorylation being upregulated. Machine learning using gene expression information from skin surface lipids could efficiently discriminate PD patients from healthy controls, with an area under the receiver operating characteristic curve of 0.806.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Taku Hatano, Genko Oyama, Yasushi Shimo, Kotaro Ogaki, Noriko Nishikawa, Jiro Fukae, Ryota Nakamura, Naohide Kurita, Taiji Tsunemi, Yutaka Oji, Shinji Saiki, Kenya Nishioka, Haruka Takeshige-Amano, Daisuke Taniguchi, Takashi Ogawa, Hikaru Kamo, Hiroto Eguchi, Atsuhito Fuse, Asuka Nakajima, Masayoshi Kano, Sho Nakajima, Naotake Yanagisawa, Nobutaka Hattori
Summary: This study aims to investigate the efficacy and safety of elobixibat in treating chronic constipation in patients with Parkinson's disease (PD). The study will consist of a 2-week observation period and a 4-week treatment period, during which data will be collected through bowel movement diaries and questionnaires. The study adheres to ethical guidelines and the results will be disseminated through various channels.
Article
Neurosciences
Takashi Ogawa, Taku Hatano, Koji Kamagata, Christina Andica, Haruka Takeshige-Amano, Wataru Uchida, Daiki Kamiyama, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Hirokazu Iwamuro, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
Summary: This study investigated microstructural alterations in the brains of patients with MSA-P using various imaging techniques, revealing significant differences in white matter and SNc compared to healthy controls and Parkinson's disease patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Kenichiro Hira, Yuji Ueno, Nobukazu Miyamoto, Sho Nakajima, Chikage Kijima, Nobutaka Hattori
Summary: This study investigated the association between serum omega-3 polyunsaturated fatty acids and intracerebral hemorrhage during the COVID-19 pandemic. The results showed that patients with intracerebral hemorrhage during the pandemic had significantly lower levels of serum eicosapentaenoic acid compared to before. Low levels of eicosapentaenoic acid might serve as an endogenous surrogate marker for intracerebral hemorrhage during the COVID-19 pandemic.
Article
Clinical Neurology
Sho Nakajima, Hiroyuki Kawano, Kazuo Yamashiro, Ryota Tanaka, Tomoaki Kameda, Naohide Kurita, Kenichiro Hira, Nobukazu Miyamoto, Yuji Ueno, Masao Watanabe, Teruyuki Hirano, Shigeru Fujimoto, Takao Urabe, Nobutaka Hattori
Summary: This study investigated the relationship between plasma D-dimer levels after stroke treatment and short-term outcomes in patients with cancer-associated stroke. The results showed that high plasma D-dimer levels after treatment were associated with poor outcomes and mortality.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cell Biology
Koji Kamagata, Christina Andica, Taku Hatano, Takashi Ogawa, Haruka Takeshige-Amano, Kotaro Ogaki, Toshiaki Akashi, Akifumi Hagiwara, Shohei Fujita, Shigeki Aoki
NEURAL REGENERATION RESEARCH
(2020)