Article
Immunology
Chiel van Geffen, Astrid Deissler, Sandra Beer-Hammer, Bernd Nuernberg, Rupert Handgretinger, Harald Renz, Dominik Hartl, Saeed Kolahian
Summary: The study suggests that MDSCs play a role in lung diseases like asthma through the EP4 pathway, showing that EP4-primed MDSCs can dampen airway inflammation by modulating arginase-1 and nitric oxide synthase-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ash Lee Manley, Jichun Chen, Wendy Fitzgerald, Xingmin Feng, Neal S. Young
Summary: This study demonstrates that G-MDSC-exos attenuate immune bone marrow failure by modulating the delivery of immunosuppressive miRNAs into activated T lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Jemma V. Milburn, Anna Hoog, Sonia Villanueva-Hernandez, Kerstin H. Mair, Wilhelm Gerner
Summary: Progress has been made in the study of regulatory B cells (IL-10 producing) in pigs, with the identification of a small subset of IL-10 competent cells within both porcine B1 and B2 cell subsets. The differentiation status of these cells varies across different tissues. These findings support the emerging paradigm that B cell IL-10 production is regulated by activation history and microenvironmental factors.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Immunology
Xueping Yu, Jian Sun, Feifei Yang, Richeng Mao, Zhiqing Shen, Lan Ren, Songhua Yuan, Qian He, Linxia Zhang, Yu Yang, Xiangqing Ding, Yongquan He, Haoxiang Zhu, Zhongliang Shen, Mengqi Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Summary: This study found that the proportion of granulocytic myeloid-derived suppressor cells (gMDSC) increased significantly in patients with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and this increase was associated with disease severity, prognosis, and infection. Further experiments revealed that TNF-alpha induced gMDSC expansion and inhibited T cell proliferation and interferon-gamma production through the IDO signaling pathway. These findings have important implications for understanding the pathogenesis of HBV-ACLF and developing potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Elham Shokati, Elahe Safari
Summary: MDSCs have been shown to play a role in tumor progression and metastasis in the tumor microenvironment by downregulating anti-tumor immune responses. Exosomal miRNAs released by MDSCs and tumor cells mediate the immunosuppressive characteristics of MDSCs, but their role in MDSCs differentiation and function in the tumor microenvironment requires further investigation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medical Laboratory Technology
Ari Ahn, Chan-Jeoung Park, Min-sun Kim, Young-Uk Cho, Seongsoo Jang, Mi Hyun Bae, Jung-Hee Lee, Je-Hwan Lee, Kyung-Nam Koh, Ho Joon Im
Summary: Myeloid-derived suppressor cells (MDSCs) are heterogeneous populations that suppress tumor-specific T-cell responses and are increased in several hematologic malignancies, including chronic myeloid leukemia (CML). In CML patients, differences in levels and prognostic significance of MDSCs are evaluated according to clinical status. High levels of peripheral blood granulocytic MDSCs (gMDSCs) are associated with better prognosis, while monocytic MDSCs (mMDSCs) may be related to malignant conditions and poor prognosis.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jin Kyeong Choi, Cheng-Rong Yu, So Jin Bing, Yingyos Jittayasothorn, Mary J. Mattapallil, Minkyung Kang, Seung Bum Park, Hyun-Su Lee, Lijin Dong, Guangpu Shi, Rachel R. Caspi, Charles E. Egwuagu
Summary: Natural regulatory B-1a cells producing IL-27 (i27-Bregs) have been identified in the peritoneal cavity and human umbilical cord blood, accumulating in the CNS during neuroinflammation to confer protection against autoimmune diseases. i27-Breg immunotherapy ameliorated encephalomyelitis and uveitis through up-regulating inhibitory receptors, suppressing immune responses, and converting conventional B cells to secrete IL-10 and/or IL-35.Mutation of irf4 in B cells resulted in increased i27-Bregs with few i35-Bregs, while loss of irf8 led to an abundance of i35-Bregs but impaired generation of i27-Bregs, suggesting the role of IRF8/BATF and IRF4/BATF axis in regulating B cell differentiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Alejandro Ogazon del Toro, Lidia Jimenez, Mauricio Serrano Rubi, Aida Castillo, Lorena Hinojosa, Jacqueline Martinez Rendon, Marcelino Cereijido, Arturo Ponce
Summary: Prostaglandin E2 (PGE2) significantly increases gap junctional intercellular communication in epithelial cells, with this effect not requiring synthesis of new RNA or proteins but rather trafficking of pre-synthesized subunits. Furthermore, this effect is mediated by the E2 receptor, which triggers a signaling pathway involving activation of adenylyl cyclase and protein kinase A (PKA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Qiying Xu, Huifang Liu, Muge Qile, Tana Wuren
Summary: This study investigates the dynamic changes of myeloid-derived suppressor cells (MDSCs) during the menstrual cycle under normal physiological conditions and finds that MDSCs have different functions in different stages of the cycle. These findings are important for understanding the pathogenesis of pregnancy-related complications and improving perinatal outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Kentaro Mizuhara, Yuji Shimura, Taku Tsukamoto, Akinori Kanai, Saeko Kuwahara-Ota, Junko Yamaguchi, Ayako Muramatsu, Haruya Okamoto, Yoko Taminishi-Katsuragawa, Yuka Kawaji-Kanayama, Reiko Isa, Shinsuke Mizutani, Toshiya Inaba, Junya Kuroda
Summary: In multiple myeloma, the shift of the tumour immune microenvironment to a suppressive state promotes disease development and resistance to immunotherapy. This study demonstrates that miR-106a-5p and miR-146a-5p delivered by tumour-derived exosomes play essential roles in inducing monocyte-derived suppressor cells in multiple myeloma. These miRNAs collaborate with CCL5 and MIF to promote the induction of suppressor cells. This finding may contribute to the development of novel therapeutic approaches to improve the efficacy of immunotherapy.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Rashi Sehgal, Navkiran Kaur, Gayatri Ramakrishna, Nirupma Trehanpati
Summary: This review focuses on understanding the key molecules involved in the expansion and regulation of MDSCs in liver diseases and their immunosuppressive mechanisms. The key message is that modulated MDSCs can be used for therapeutic purposes in inflammation, cancer, and sepsis.
DIGESTIVE DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Minjie Luo, Hao Wang, Ke Liu, Meidong Liu, Sipin Tan, Yaxi Zhu, Huali Zhang
Summary: This study demonstrates that blockade of IL-1R1 has a protective effect on liver injury in septic mice. Anakinra treatment and IL-1R1 deficiency inhibit the migration of MDSCs to the liver in sepsis, attenuating the immune suppression of MDSCs on effector T cells. Furthermore, IL-1R1 blockade promotes the switch from pro-inflammatory M1 macrophage to anti-inflammatory M2 phenotype and enhances bacterial clearance in the liver, contributing to the attenuation of liver injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Kenta Murata, Manami Oyama, Misaki Ogata, Nina Fujita, Ryuji Takahashi
Summary: This study demonstrated that Jumihaidokuto (JHT) can effectively prevent UVB-induced skin damage by inhibiting the production of proinflammatory mediators.
JOURNAL OF NATURAL MEDICINES
(2021)
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yaotang Ji, Hongli Suo, ZiLi Zhang, Lin Ma, Jiazhi Li, Chengxi Zhang, Xingyu Wu, Shaheen Kausar, Jin Cui, Min Liu, Yi Wang, Qiuliang Wang
Summary: By heavy cold rolling and annealing processes, three types of Ni8W/Ni12W/Ni8W composite substrates with strong cube texture, high yield strength, and low magnetization were successfully produced. The presence of Ni alloys with higher W content in the Ni-12 at%W layer enhanced the mechanical properties and decreased the ferromagnetic behavior of the substrates. Additionally, an area that enhances cubic nucleation and growth in the Ni8W layer of composite substrates was identified.
METALS AND MATERIALS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Yaotang Ji, Hongli Suo, ZiLi Zhang, Lin Ma, Xinyu Wu, Chenxi Zhang, Jiazhi Li, Jin Cui, Chunyan Li, Shaheen Kausar, Min Liu, Yi Wang, Qiuliang Wang
JOURNAL OF ALLOYS AND COMPOUNDS
(2020)
Article
Materials Science, Multidisciplinary
Xinyu Wu, Hongli Suo, Jiazhi Li, Yaotang Ji, Lin Ma, Min Liu, Yinming Dai, Jianhua Liu, Zili Zhang
Summary: The research investigated the microstructure and texture evolution of Ni-5 at%W alloy substrates during in situ tensile testing in different directions. Results showed that the tensile stress direction significantly influenced the texture evolution, with the cubic texture showing severe degradation at 45 degrees-RD.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Biotechnology & Applied Microbiology
Xinyu Wu, Daoyan Liu, Shuzhen Wang, Jie Liu
Summary: This study revealed that circ_0007444 is down-regulated in ovarian cancer patients and inhibits the progression of ovarian cancer by regulating the miR-570-3p/PTEN pathway. circ_0007444 has the potential to be a candidate for targeted therapy of ovarian cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Metallurgy & Metallurgical Engineering
Yaotang Ji, Hongli Suo, Yichen Meng, Xinyu Wu, Kausar Shaheen, Lin Ma, Min Liu, Lei Wang, Zili Zhang
Summary: The study shows that the microstructure, cold-rolling texture, and recrystallization texture of Ni-8 at % W alloy are significantly influenced by the initial grain size. The cold-rolled tape mainly consists of S, brass, and a weak {110} <118> texture. Large-scale twinning is exhibited in the cold-rolled microstructure at a high annealing temperature, and cube orientation and RD-cube orientation grains grow faster than other orientation grains.
PHYSICS OF METALS AND METALLOGRAPHY
(2021)
Article
Oncology
Nan Jin, Chunxiao Sun, Yijia Hua, Xinyu Wu, Wei Li, Yongmei Yin
Summary: We report the first case of significant radiographic response in a patient with multiple recurrent lumbar and sacral cord HBs treated with anlotinib. This finding suggests a potential novel therapeutic approach for patients with multiple recurrent HB or those with multiple lesions such as in VHL disease which are difficult to surgically resect.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Xizi Du, Lin Yuan, Ye Yao, Yu Yang, Kai Zhou, Xinyu Wu, Leyuan Wang, Ling Qin, Wenkai Li, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Ming Yang, Chi Liu
Summary: In this study, the involvement of ITGB4 in RSV infection and its effect on airway epithelial anti-RSV responses were investigated. The results showed that ITGB4 expression decreased during RSV infection, and ITGB4 deficiency worsened RSV infection and increased sensitivity to allergens in later life. Furthermore, it was found that IFN-λ suppression during RSV infection in ITGB4 deficient airway epithelial cells was regulated by IRF-1 through the phosphorylation of EGFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Kun-Chan Lan, Chang-Yin Lee, Shu-Chen Chang, Xin-Yu Wu, Gerhard Litscher, Chih-Yu Wang
Summary: The developed laser acupuncture system can stimulate multiple acupoints simultaneously, improving therapeutic efficacy. The system utilizes a 2D galvo mirror for fast scanning and uses a single laser beam to stimulate multiple acupoints. It offers a low-cost and noncontact approach for laser acupuncture stimulation.
MEDICAL ACUPUNCTURE
(2022)
Review
Medicine, Research & Experimental
Ye Yao, Huijun Liu, Lin Yuan, Xizi Du, Yu Yang, Kai Zhou, Xinyu Wu, Ling Qin, Ming Yang, Yang Xiang, Xiangping Qu, Xiaoqun Qin, Chi Liu
Summary: Integrins play a dual role in pulmonary infectious diseases, promoting pathogen clearance while potentially causing tissue damage. Innovative therapeutic strategies targeting integrins offer promising approaches for the treatment of these diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Allergy
Lin Yuan, Huijun Liu, Xizi Du, Ye Yao, Ling Qin, Zhenkun Xia, Kai Zhou, Xinyu Wu, Yunchang Yuan, Bei Qing, Yang Xiang, Xiangping Qu, Xiaoqun Qin, Ming Yang, Chi Liu
Summary: This study investigates the impact of ITGB4 deficiency on airway remodeling in asthma and identifies the molecular mechanisms involved. The results show that ITGB4 deficiency enhances asthma susceptibility and airway remodeling through the activation of EMTU via the SHP2/JNK/c-Jun/FGF2 pathway.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Pathology
Amir Momeni Boroujeni, Elizabeth Kertowidjojo, Xinyu Wu, Robert A. Soslow, Sarah Chiang, Edaise M. Da Silva, Britta Weigelt, M. Herman Chui
Summary: This study reveals that high-grade adenosarcomas are molecularly heterogeneous, characterized by genomic instability and TP53 mutations; ATRX loss may contribute to the progression to high-grade adenosarcoma from low-grade lesions; and BAP1 inactivation appears to play a specific pathogenic role in certain adenosarcomas.
Article
Allergy
Kun Xu, Ye Yao, Huijun Liu, Ming Yang, Lin Yuan, Xizi Du, Yu Yang, Ling Qin, Weijie Wang, Kai Zhou, Xinyu Wu, Chi Liu
Summary: This study confirms the involvement of ITGB4 in the regulation of DNA damage through mediating HDAC1 in airway epithelial cells under exogenous stress, providing potential targets for early prediction and intervention of pulmonary diseases.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tian-rong He, Xiu-yu Tang, Qi Yan, Xin-yu Wu, Bin Shi, Yi Lin
Summary: The study shows that retinoic acid-incorporated glycol chitosan nanoparticles can promote the polarization of macrophages in an inflammatory environment, thereby regulating the expression of inflammatory factors. This finding has potential value for the clinical treatment of Pg-LPS-related diseases.
CURRENT MEDICAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Hongli Suo, Lanjin Wang, Xinyu Wu, Yaotang Ji, Xufeng Wang, Lin Ma, Min Liu, Lei Wang, Qiuliang Wang, Zili Zhang
Summary: Multiple factors, such as crystallographic orientation, twins, dislocation, and grain size, significantly affect the tensile properties of alloys, but identifying the dominant factor is difficult. To overcome this limitation, a combination of in situ tensile technique and electron backscattering diffraction (EBSD) was used to analyze the dominant factors affecting the tensile properties of pure nickel. This study confirmed that the grain size of pure nickel is the most significant factor influencing its tensile properties.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Oncology
Yijia Hua, Wei Li, Nan Jin, Dongyan Cai, Jie Sun, Chunxiao Sun, Fan Yang, Xinyu Wu, Xiang Huang, Biyun Wang, Yongmei Yin
Summary: This study evaluated the efficacy of pyrotinib-based therapy in lapatinib-resistant HER2-positive metastatic breast cancer. The results showed that pyrotinib has the potential to improve survival in these patients. Additionally, patients who benefited from lapatinib prior to treatment may experience a longer progression-free survival with pyrotinib.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)