Article
Endocrinology & Metabolism
Jie Wang, Fei Xing, Ning Sheng, Zhou Xiang
Summary: We utilized data from NHANES to examine the association between dietary oxidative balance score (DOBS) and femur bone mineral density (BMD) as well as the risk of osteoporosis in postmenopausal women. The findings demonstrated a positive correlation between DOBS and femur BMD, as well as a negative association between DOBS and the risk of osteoporosis in this population. These results suggest that a higher DOBS may provide a protective effect against femur osteoporosis in postmenopausal women, highlighting the importance of an antioxidant-rich diet for bone health. Furthermore, DOBS could serve as a valuable tool in identifying individuals with osteoporosis and guiding early intervention strategies.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ciro Menale, Gaia Tabacco, Anda Mihaela Naciu, Maria Lucia Schiavone, Francesca Cannata, Emanuela Morenghi, Cristina Sobacchi, Andrea Palermo
Summary: The study aimed to assess the association between Dpp3 activity and bone fragility in postmenopausal osteoporosis, as well as the impact of denosumab on the enzymatic activity. The results showed that serum Dpp3 activity was significantly reduced in patients with severe osteoporosis compared to controls and was associated with bone mass. Additionally, there was a negative correlation between Dpp3 activity and specific bone metabolism markers. Dpp3 activity did not change after denosumab injection.
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Orthopedics
Filippo Migliorini, Nicola Maffulli, Giorgia Colarossi, Joerg Eschweiler, Markus Tingart, Marcel Betsch
Summary: This study found that Denosumab has a higher impact on spine bone mineral density in selected postmenopausal women, and has the highest influence on hip and femur bone mineral density.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Plant Sciences
Usharani Pingali, Chandrasekhar Nutalapati
Summary: This study investigated the effects of dietary supplementation with a standardized aqueous extract of shilajit on bone loss in postmenopausal women with osteopenia. The results showed that supplementation with shilajit extract attenuated bone loss, decreased bone turnover and inflammation, and reduced oxidative stress. This supports the bone mineral density in postmenopausal women with osteopenia, who are at increased risk for osteoporosis and bone fractures.
Article
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Stergios A. Polyzos, Nikolaos E. Rodopaios, Polyzois Makras, Ajay Kumar, Bhanu Kalra, Christos S. Mantzoros
Summary: This study aimed to evaluate the effect of the activins-follistatins-inhibins (AFI) hormonal system on bone metabolism. The results showed that lower inhibin B concentrations and higher ratios of activins A, B, and AB to follistatin were independently associated with lumbar spine bone mineral density (BMD) and the presence of osteoporosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Immunology
Xueli Yang, Tian Chang, Qian Yuan, Wei Wei, Pingping Wang, Xiaojian Song, Huijuan Yuan
Summary: This study investigates the variations in gut microbiota (GM) and vaginal microbiota (VM) in postmenopausal women with osteoporosis. The results show that changes in bone mineral density are associated with changes in GM and VM, with GM being more closely correlated with postmenopausal osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Weibin Du, Zhenwei Wang, Yi Dong, Jintao Hu, Xiaoping Chen
Summary: This study aimed to examine the relationship between fibrinogen and bone mineral density (BMD) in postmenopausal women. The findings of this cross-sectional analysis showed a negative association between fibrinogen levels and total BMD in most postmenopausal women, with a lack of significant correlation in Non-Hispanic Blacks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
Zahra Shahriarpour, Bita Nasrabadi, Sudiyeh Hejri-Zarifi, Seyedeh-Elaheh Shariati-Bafghi, Mahboobe Yousefian-Sanny, Mohsen Karamati, Bahram Rashidkhani
Summary: This study is the first to investigate the association between oxidative balance score (OBS) and risk of osteoporosis. The results suggest that a higher OBS, indicating a predominance of anti-oxidant exposures, is associated with lower risk of lumbar spine osteoporosis among postmenopausal Iranian women.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Orthopedics
Yimei Yang, Shanshan Wang, Hui Cong
Summary: The study aimed to determine the association between age at menarche and lumbar spine bone mineral density (BMD) in postmenopausal women. The results showed that postmenopausal women with a menarche age ≥ 16 years had significantly lower lumbar spine BMD compared to those with a menarche age ≤ 12 years.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Nutrition & Dietetics
Raul Roncero-Martin, Ignacio Aliaga, Jose M. Moran, Luis M. Puerto-Parejo, Purificacion Rey-Sanchez, Maria de la Luz Canal-Macias, Antonio Sanchez-Fernandez, Juan D. Pedrera-Zamorano, Fidel Lopez-Espuela, Vicente Vera, Purificacion Cerrato-Carretero, Jesus M. Lavado-Garcia
Summary: The study found a significant positive association between plasma n-3 polyunsaturated fatty acid levels and bone density in Spanish postmenopausal women, independent of BMI and total plasma n-3 PUFAs.
Article
Endocrinology & Metabolism
E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak
Summary: This study evaluated the safety and efficacy of the abaloparatide microstructured transdermal system (abaloparatide-sMTS) as an alternative to subcutaneous injection. The results showed that the abaloparatide-sMTS was not noninferior to the subcutaneous injection in terms of lumbar spine bone density at 12 months, but both treatments significantly increased lumbar spine and total hip bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
