Article
Physiology
Ruiqin Hu, Genfang Li, Qianghua Xu, Liangbiao Chen
Summary: This study investigated the role of iron in the hypoxic responses of two zebrafish-derived cell lines. The results showed that iron homeostasis is important for maintaining mitochondrial integrity in hypoxic stress, and this effect is cell type-dependent.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yun Zhang, Fanhe Dong, Zihan Wang, Bingbing Xu, Tao Zhang, Qiqi Wang, Qiao Lin
Summary: The study aimed to investigate the effect of fluoride on osteocytes and explore the underlying mechanisms. Results showed that fluoride exposure caused apoptosis and mitophagy in osteocytes, suggesting a potential role in skeletal and dental fluorosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Cell Biology
Lulu Wo, Xin Zhang, Chengning Ma, Cixiang Zhou, Jingchi Li, Zhexuan Hu, Xiufeng Gong, Mengna Zhan, Ming He, Qian Zhao
Summary: The long non-coding RNA (lncRNA) HABON is found to inhibit hypoxia-induced necroptosis in liver cancer cells. Knockdown of HABON leads to programmed cell death and tumor growth inhibition.
CELL DEATH DISCOVERY
(2022)
Review
Cell & Tissue Engineering
Qingyin Lin, Jiaqi Chen, Lifang Gu, Xingang Dan, Cheng Zhang, Yanzhou Yang
Summary: Mitophagy is a crucial autophagic process that plays a key role in clearing damaged mitochondria and maintaining the health and longevity of stem cells. Decreased mitophagy can impact the regenerative capacity of stem cells, which is essential for preventing tissue aging.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xuan Li, Zheng Li, Yu-Qi Meng, Hui Qiao, Ke-Rong Zhai, Zhen-Qing Li, Shi-Lin Wei, Bin Li
Summary: The study demonstrates that melittin targets mitochondria, causing mitochondrial damage, and inhibits the autophagy-lysosomal degradation pathway. This process triggers mitoROS burst and ultimately activates the mitochondria-associated Bax/Bcl-2 apoptotic signaling pathways in A549 cells.
Article
Oncology
Guanghong Luo, Ruili Feng, Wengang Li, Yanlu Chen, Yangyang Sun, Junfeng Ma, Yanhong Duo, Tieqiao Wen
Summary: This study revealed that unmutated Dcf1 expression is negatively associated with the malignancy of glioblastoma, overexpression of Dcf1 causes nucleosome destabilization, mitochondria destruction and dysfunction to preferentially induce mitophagy, and blocks autophagy by impairing lysosomes to induce apoptosis in glioblastoma cells.
Article
Medicine, Research & Experimental
Chao Peng, Xi Li, Feng Ao, Ting Li, Jingpei Guo, Junfeng Liu, Xiaoting Zhang, Jinyan Gu, Junjie Mao, Bin Zhou
Summary: Incomplete radiofrequency ablation (iRFA) leads to the survival of cells that contribute to hepatocellular carcinoma (HCC) recurrence. This study investigated the role of reactive oxygen species (ROS) in HCC cells exposed to sublethal heat stress. It was found that sublethal heat stress induced a burst of ROS, which was initiated by upregulated NOX4 expression in mitochondria. The increased ROS triggered PINK1-dependent mitophagy to protect cells from apoptosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Massimo Bonora, Sonia Missiroli, Mariasole Perrone, Francesco Fiorica, Paolo Pinton, Carlotta Giorgi
Summary: Cancer cells display genomic instability, with mitochondria playing a key role in responding to DNA alterations and affecting cell survival and the accumulation of mutations. Mitochondrial alterations in cancer can impact cell death pathways and metabolic plasticity, contributing to the evolution of the disease. Mitochondria are involved in regulating cell death and metabolic adaptation in tumor cells, and their role in supporting genomic instability in cancer is an important aspect that warrants further exploration.
Article
Biochemistry & Molecular Biology
Yilong Cui, Miao Song, Bonan Xiao, Menglin Liu, Pengli Liu, Yanfei Han, Bing Shao, Yanfei Li
Summary: The study showed that NAC inhibited mitophagy and apoptosis, alleviated growth inhibition, mineral metabolism imbalance, structural damage, decreased bone mineral density and decreased bone formation factor expressions in the femora of mice treated with aluminum, suggesting that ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice, and exogenous ROS clearance is a potential strategy for the treatment of aluminum-induced bone impairment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Pharmacology & Pharmacy
Junqi Huang, Rundong Wu, Linyi Chen, Ziqiang Yang, Daoguang Yan, Mingchuan Li
Summary: This review summarizes the recent findings on the mitochondrial mechanisms during anthracycline cardiotoxicity, including the production of ROS and mitochondrial damage, mitochondrial iron overload and ferroptosis, autophagy, mitophagy, and disruption of cardiac metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Taeyeon Hong, Jiyeon Ham, Jisoo Song, Gwonhwa Song, Whasun Lim
Summary: Brassinin exerts antiproliferative effects on HCC cells by reducing PCNA activity and inducing cell cycle arrest, increasing mitochondrial Ca2+ levels, generating ROS, and regulating AKT and MAPK signaling pathways. Co-administration with pharmacological inhibitors enhances its antiproliferative effects.
Article
Food Science & Technology
Menglin Liu, Xia Wu, Yilong Cui, Pengli Liu, Bonan Xiao, Xuliang Zhang, Jian Zhang, Zhuo Sun, Miao Song, Bing Shao, Yanfei Li
Summary: Aluminum as an environmental pollutant can cause dysfunction in osteoblasts leading to bone diseases, with oxidative stress being one of the mechanisms. Research indicates that mitochondrial dysfunction and apoptosis mediated by ROS are involved in aluminum-induced cell dysfunction.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Qiqi Zhu, Shanshan Zhu, Qiyao Li, Yun Wang, Dongxu Zheng, Chunjiang Chen, Naqi Ruan, Haiqiong Chen, Haoni Yan, Han Lin, Ren-Shan Ge
Summary: Exposure to MTBE during late puberty compromises the development of Leydig cells in male rats by inhibiting cell proliferation, inducing mitochondrial autophagy and apoptosis, and indirectly stimulating Sertoli cells to secrete anti-Mullerian hormones, resulting in a reduced number of Leydig cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Cell Biology
Asli E. Atici, Timothy R. Crother, Magali Noval Rivas
Summary: Cardiovascular diseases are a leading cause of death worldwide, and optimal mitochondrial function is crucial for the cardiovascular system. Mitochondrial quality control ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis, playing a role in cell survival and adaptation to environmental stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Bo Wang, Xiaoqin Yin, Weidong Gan, Fan Pan, Shiyuan Li, Zou Xiang, Xiaodong Han, Dongmei Li
Summary: The study revealed that PRCC-TFE3 fusion protein activates specific genes leading to rapid mitophagy, promoting cell survival and proliferation, as well as accelerating mitochondrial turnover. However, nuclear translocation of TFE3 fusions escapes from this process.
Review
Biochemistry & Molecular Biology
Mikhail V. Dubinin, Konstantin N. Belosludtsev
Summary: Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin protein and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells, which leads to significant changes in ion channel functioning and ion homeostasis regulation. This review analyzes current data on the structure, functioning, and regulation of ion channels in striated muscles in DMD, and discusses their contribution to muscle dysfunction and pathology. The review also explores the potential of therapy targeting sarcolemma and organelle channels for correcting and alleviating DMD pathology, as well as the challenges in interpreting data from dystrophin-deficient models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Mikhail A. Kaplan, Artem D. Gorbenko, Alexander Y. Ivannikov, Bakhyt B. Kartabaeva, Sergey V. Konushkin, Konstantin Y. Demin, Alexander S. Baikin, Konstantin V. Sergienko, Elena O. Nasakina, Igor O. Bannykh, Irina V. Gorudko, Alexey G. Kolmakov, Alexander V. Simakin, Sergey V. Gudkov, Alexey P. Glinushkin, Mikhail A. Sevostyanov
Summary: This article focuses on the study of melted ingots, rolled plates, and spherical powder made of corrosion-resistant 316L steel with the addition of 0.2 wt.% and 0.5 wt.% Ag. The research includes the analysis of antibacterial properties, microstructure, silver distribution, and qualitative silver analysis. The results show that the addition of silver does not affect the structure and distribution of silver in both ingots and rolled plates. It is also found that the addition of silver does not significantly reduce the strength of the steel. The study confirms the chemical composition of the corrosion-resistant steels through X-ray fluorescence analysis. The antibacterial activity of plates and powder with silver addition is observed against specific bacteria species.
Article
Optics
Alexey F. Bunkin, Sergey M. Pershin, Diana G. Artemova, Sergey V. Gudkov, Alexey V. Gomankov, Pavel A. Sdvizhenskii, Mikhail Ya. Grishin, Vasily N. Lednev
Summary: Researchers have studied fossilized plant remains using laser-induced fluorescence and Raman spectroscopies, exploring the potential methods for onsite or laser remote sensing in future extraterrestrial missions. By utilizing a multiwavelength instrument, they have found that fluorescence spectroscopy can easily detect plant fossils at rock surfaces due to the difference in luminosity caused by chlorophyll derivatives. Raman spectroscopy, on the other hand, alters the fossilized graphitic material, providing insights into the detection of samples with biogenicity indicators. The method of laser remote sensing can also be valuable in geological exploration for organic matter-rich rocks.
Article
Biochemistry & Molecular Biology
Mikhail V. Dubinin, Vlada S. Starinets, Yuliya A. Chelyadnikova, Natalia V. Belosludtseva, Irina B. Mikheeva, Daria K. Penkina, Anastasia D. Igoshkina, Eugeny Yu. Talanov, Igor I. Kireev, Dmitry B. Zorov, Konstantin N. Belosludtsev
Summary: In this study, NS1619 was found to improve potassium ion transport and content in the heart mitochondria of DMD mice. This led to a decrease in oxidative stress and fibrosis level. The findings suggest that NS1619 could be a potential approach for correcting the pathology in DMD.
BIOCHEMISTRY-MOSCOW
(2023)
Article
Cell Biology
V. N. Samartsev, A. A. Semenova, K. N. Belosludtsev, M. V. Dubinin
Summary: Stimulation of mitochondrial respiration in state 4 by TMPD and HDA effectively switches off complex III, resulting in a decrease in the H+/O ratio during succinate oxidation. This study provides evidence that TMPD and HDA do not affect oxidative ATP synthesis and energy transformation by complex IV but selectively inhibit complex III during succinate oxidation.
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2023)
Article
Cell Biology
M. V. Dubinin, A. D. Igoshkina, A. A. Semenova, N. V. Mikina, E. I. Khoroshavina, K. N. Belosludtsev
Summary: The study investigated the effect of NS1619, an activator of the BKCa channel, on the function of mouse skeletal muscle mitochondria. NS1619 was found to inhibit respiration and oxidative phosphorylation, as well as the activity of complexes I, III, and IV of the respiratory chain and ATP synthase. It also decreased the membrane potential and calcium uptake of the mitochondria, while exhibiting antioxidant effects by reducing hydrogen peroxide production.
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2023)
Article
Chemistry, Physical
Sergey V. Gudkov, Maxim E. Astashev, Ilya V. Baymler, Polina N. Bolotskova, Valery A. Kozlov, Alexander V. Simakin, Minh T. Khuong, Polina A. Fomina, Nikolai F. Bunkin
Summary: Photoluminescence from the surface of Nafion polymer membrane upon swelling in water under irradiation by electromagnetic waves at a frequency of 100 MHz was investigated. The effects of natural deionized (DI) water and deuterium-depleted water (DDW) with different deuterium content were studied. The influence of linearly and randomly polarized low-frequency electromagnetic radiation on luminescence excitation was examined for the first time. Anisotropic submicron-sized particles were used to obtain low-frequency electromagnetic radiation with random polarizations.
Article
Chemistry, Multidisciplinary
Elena G. Varlamova, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky
Summary: The anti-cancer effects of selenium sources, particularly selenium nanoparticles, have been found to induce apoptosis in glioblastoma cells with high efficiency and without causing necrosis. The shape and size of nanoparticles also influence their cytotoxic effects and calcium signaling in glioblastoma cells. This study provides insights into the potential use of selenium nanoparticles as a targeted therapy for aggressive brain tumors.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Mikhail V. Dubinin, Anna I. Ilzorkina, Elena V. Salimova, Manish S. Landage, Ekaterina I. Khoroshavina, Sergey V. Gudkov, Konstantin N. Belosludtsev, Lyudmila V. Parfenova
Summary: This paper assesses the membranotropic action of fusidic acid and its derivatives. The authors found that a derivative with ethylenediamine moiety can increase the mobility of lipid bilayer and induce permeabilization of liposome membranes. A similar effect was observed in rat liver mitochondrial membranes. Moreover, the derivatives reduced mitochondrial Delta psi and OXPHOS efficiency, leading to a decrease in mitochondrial calcium retention capacity.
Article
Optics
Aleksander V. Simakin, Ilya V. Baimler, Alexey S. Baryshev, Anastasiya O. Dikovskaya, Sergey V. Gudkov
Summary: This paper investigates the physicochemical processes during laser-induced breakdown in colloids of gadolinium oxide nanoparticles with different concentrations. The study demonstrates a monotonic change in various parameters, including the number of optical breakdowns, average distance between breakdowns, average plasma size, integral luminosity, acoustic signal intensity, and the rate of formation of dissociation products. It is shown that gadolinium oxide nanoparticles have the highest rate of chemical product formation compared to other materials. The rates of formation of H-2, O-2, and hydrogen peroxide during laser-induced breakdown of gadolinium oxide nanoparticles are 13.13 nmol/pulse, 5.41 nmol/pulse, and 6.98 nmol/pulse, respectively.
Article
Horticulture
Mark O. Paskhin, Denis V. Yanykin, Alexander V. Popov, Roman V. Pobedonostsev, Dina V. Kazantseva, Alexey S. Dorokhov, Andrey Yu. Izmailov, Alexey A. Vyatchinov, Elena O. Orlovskaya, Artem T. Shaidulin, Yurii V. Orlovskii, Vladimir A. Vodeneev, Sergey V. Gudkov
Summary: The effect of light conversion using europium (Eu(III))-based photoconversion covers on the cultivation of agricultural plants and their resistance to stress conditions was investigated. Two types of europium nanoparticles were used: europium oxide (Eu2O3) and Eu3+:LaF3 nanocrystals. Tomatoes and cucumbers were used as model plants. It was found that plants grown under Eu2O3 cover had higher growth, yield, and faster activation of gas exchange and photosynthesis, while plants grown under Eu3+:LaF3 cover showed slower biomass accumulation and decreased gas exchange activation, but increased resistance to high and low temperatures.
Review
Mathematics
Maxim E. Astashev, Dmitriy A. Serov, Sergey V. Gudkov
Summary: Biological rhythms are a characteristic of all living organisms, and scientists have accumulated a vast amount of data on these rhythms at various levels. However, these rhythms are often studied in isolation from each other, and more advanced mathematical methods are needed to further understand their nature and purpose.
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Egor Y. Plotnikov, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky
Summary: This study demonstrates the cytoprotective properties of the trace element selenium, its nanoparticles, and selenium nanocomplexes with active compounds. It shows that spherical selenium nanoparticles can protect brain cells during ischemia/reoxygenation, and their effectiveness is dependent on factors such as diameter and pathways of penetration into astrocytes. The research also highlights the potential advantages of studying and utilizing nanorods as nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
V. N. Samartsev, A. A. Semenova, K. N. Belosludtsev, M. V. Dubinin
Summary: In this study, it was found that TMPD and HDA effectively stimulate respiration in state 4 during the oxidation of succinate by liver mitochondria, and their action is not caused by an increase in the proton conductivity of the inner membrane. TMPD and HDA selectively disable ETC complex III from energy transformation without significantly affecting oxidative ATP synthesis. The H+/O ratio can be determined based on the ratio of respiratory rates in the absence and presence of TMPD and HDA.
BIOLOGICHESKIE MEMBRANY
(2023)
Article
Biochemistry & Molecular Biology
Elena G. G. Varlamova, Venera V. V. Khabatova, Sergey V. V. Gudkov, Egor A. A. Turovsky
Summary: Despite its recommended use for treating various cancers, sorafenib faces significant obstacles to widespread and effective use, such as the blood-brain barrier, high doses required, mechanisms of redistribution and release in brain tissue, and resistance of gliomas and glioblastomas. Therefore, new methods are needed to deliver sorafenib to brain tumors, enhance its therapeutic potential, and minimize cytotoxic effects on healthy cells. The selenium-sorafenib nanocomplex shows promising results in bypassing chemoresistance and inducing apoptosis in glioblastoma cells, while selenium nanoparticles demonstrate high anticancer efficacy but lack selectivity in cortical astrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)