期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 3, 页码 1065-1073出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c01705
关键词
posterior capsular opacification; intraocular lens; surface modification; polydopamine; drug-loading coating
资金
- National Key RD Program [2017YFC1104602]
- National Natural Science Foundation of China [81771984]
- National Innovation and Entrepreneurship Training Program for College Students [201910343023, 201910343033]
- Xinmiao Talents Program of Zhejiang Province [2019R413019]
A synergistic coating with drug-eluting and hydrophilic properties was designed and applied to IOLs to prevent posterior capsular opacification effectively. In vitro and in vivo studies demonstrated the coating's ability to induce cell apoptosis, thereby preventing PCO development while ensuring safety and biocompatibility to surrounding tissues.
Posterior capsular opacification (PCO) is the most important complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from the adhesion, proliferation, and transdifferentiation of the postsurgically residual lens epithelial cells (LECs). Previous investigations mainly focused on the hydrophilic surface modification of the IOLs for PCO prevention, such as heparinization. However, the long-term clinical investigations show that there is no significant difference between pristine and heparinized IOLs. In the present study, a synergetic coating with properties of drug-eluting and hydrophilicity was designed and modified onto the IOL surface via facile dopamine self-polymerization. The antiproliferative drug doxorubicin (DOX) was loaded when a polydopamine (PDA) coating was formed on the IOL surface. The hydrophilic 2-methacryloyloxyethyl phosphorylcholine (MPC) could be subsequently grafted onto the drug-loaded PDA coating surface easily. The hydrophilic outer layer could slow down drug-eluting from underneath the drug-incorporated coating. In vitro and in vivo investigations demonstrated that such multifunctionalized coating-modified IOLs could not only thoroughly and effectively prevent PCO development by induced cell apoptosis but also render safety and biocompatibility to the surrounding tissues.
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