Article
Biotechnology & Applied Microbiology
Qingqin Tan, Lingjie He, Xiaojun Meng, Wei Wang, Hudan Pan, Weiguo Yin, Tianchuan Zhu, Xi Huang, Hong Shan
Summary: The study developed a drug delivery system based on macrophage biomimetic nanocarriers for anti-inflammation and antiviral treatment against COVID-19, showing promising results in neutralizing inflammatory cytokines and reducing viral loads in tissues.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Immunology
Laurent Calvier, Aleksandra Drelich, Jason Hsu, Chien-Te Tseng, Yair Mina, Avindra Nath, Maria Z. Kounnas, Joachim Herz
Summary: Thromboembolic complications and excessive inflammation in severe COVID-19 can lead to long COVID. This study found that Reelin is involved in endothelial dysfunction and hyperinflammation during COVID-19. Increased levels of Reelin in COVID-19 patients were correlated with disease activity. A hyperinflammatory state was observed in severe COVID-19 patients, with Reelin levels correlated with several inflammatory markers. Inhibiting Reelin with an anti-Reelin antibody reduced mortality and severity of disease in a mouse model infected with SARS-CoV-2, suggesting Reelin as a potential therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Khalid Omer Alfarouk, Sari T. S. Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S. Alqahtani, Samrein B. M. Ahmed, Ali M. Alqahtani, Saad S. Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H. H. Bashir, Muntaser E. Ibrahim, Maria Raffaella Greco, Rosa A. Cardone, Salvador Harguindey, Stephan Joel Reshkin
Summary: COVID-19, caused by viral infection, is a pandemic disease with high mortality rate, with most symptoms related to mitochondrial dysfunction. Targeting mitochondrion may offer a more rational treatment approach, and understanding the underlying causes could enhance the opportunity to treat COVID-19 effectively.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Vincent Zhang, Molly Fisher, Wei Hou, Lili Zhang, Tim Q. Duong
Summary: The incidence of new-onset persistent hypertension in patients with COVID-19 is higher than those with influenza, indicating a significant health burden associated with COVID-19.
Review
Endocrinology & Metabolism
Lili Yu, Xiaoying Zhang, Sarah Ye, Hongkai Lian, Hui Wang, Jianping Ye
Summary: Obesity is associated with increased risk of morbidity and mortality from COVID-19, which is related to the cytokine storm. Energy metabolism disorders in adipose tissue contribute to the development of cytokine storm. Adipose tissue in obesity restricts pulmonary function, provides a base for virus entry, impairs antiviral responses, and contributes to chronic inflammation, all of which contribute to the cytokine storm.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Aldo Bonaventura, Alessandra Vecchie, Lorenzo Dagna, Kimberly Martinod, Dave L. Dixon, Benjamin W. Van Tassell, Francesco Dentali, Fabrizio Montecucco, Steffen Massberg, Marcel Levi, Antonio Abbate
Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Immunology
Yaoyun Niu, Yang Chen, Pengbo Sun, Yangyang Wang, Jingyi Luo, Yipei Ding, Weidong Xie
Summary: The study found that canagliflozin significantly reduced the production of inflammatory cytokines in lung tissues of mice induced with lipopolysaccharides, and improved inflammatory pathological changes. It may attenuate cytokine storm in critical cases of COVID-19 by regulating hypoxia inducible factor 1 alpha and glycolysis, but further clinical application and mechanism analysis are needed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Jingya Wang, Yinyin Xu, Xiaoli Zhang, Sheng Wang, Ziyi Peng, Jing Guo, Hongmei Jiang, Jing Liu, Ying Xie, Jingjing Wang, Xin Li, Juan Liao, Chao Wan, Lihua Yu, Jinsong Hu, Beizhong Liu, Zhiqiang Liu
Summary: Leptin, a cytokine found in significantly altered profiles in severe COVID-19 patients, correlates with disease severity and may exacerbate or dysregulate immune responses through activating monocytes. This study suggests a possible mechanism by which overweight COVID-19 patients have a greater tendency to develop severe conditions, providing insights into potential therapeutic strategies.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Immunology
Nicole Paland, Antonina Pechkovsky, Miran Aswad, Haya Hamza, Tania Popov, Eduardo Shahar, Igal Louria-Hayon
Summary: COVID-19, caused by the novel RNA betacoronavirus SARS-CoV2, originated in Wuhan, China and has become a global pandemic with over 99 million cases and 2.1 million deaths. Severe cases require respiratory support due to respiratory failure, with most symptoms related to hyperinflammation. Treatments are still under clinical trials, highlighting the need for new anti-inflammatory therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Justin Y. Lu, Jack Wilson, Wei Hou, Roman Fleysher, Betsy C. Herold, Kevan C. Herold, Tim Q. Duong
Summary: This study compared the incidences and risk factors of new-onset persistent type-2 diabetes in COVID-19 patients to those in influenza patients. It was found that the incidence of type-2 diabetes was higher in COVID-19 patients compared to influenza patients. The risk of developing persistent type-2 diabetes was also higher in hospitalized COVID-19 patients compared to non-hospitalized COVID-19 patients and hospitalized influenza patients.
Article
Immunology
Mark W. Hall, Ila Joshi, Luis Leal, Eng Eong Ooi
Summary: The host response to SARS-CoV-2 infection is complex and dynamic, with effective initial defense associated with mild symptoms. The immune response in patients varies greatly, with systemic inflammation or immune suppression. A personalized immunomodulation approach based on immunophenotype is crucial for successful treatment of critically ill patients with COVID-19.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Urology & Nephrology
Diego Sandoval, Ines Rama, Maria Quero, Miguel Hueso, Francisco Gomez, Josep M. Cruzado
Summary: Haemodialysis patients have higher morbidity and mortality risks in COVID-19, and treatment with Seraph 100 device may improve their symptoms.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Medicine, Research & Experimental
Ajaikumar B. Kunnumakkara, Varsha Rana, Dey Parama, Kishore Banik, Sosmitha Girisa, Sahu Henamayee, Krishan Kumar Thakur, Uma Dutta, Prachi Garodia, Subash C. Gupta, Bharat B. Aggarwal
Summary: Spices with potent antioxidant and anti-inflammatory properties may help reduce COVID-19-associated complications and suppress cytokine storm. By regulating key molecular targets in inflammation, spices show potential for anti-inflammatory effects.
Article
Virology
Oleksandr Oliynyk, Wojciech Barg, Anna Slifirczyk, Yanina Oliynyk, Vitaliy Gurianov, Marta Rorat
Summary: The study identified three subtypes of cytokine storm in COVID-19 patients: CRS, MAS, and sepsis. Tocilizumab therapy was associated with reduced mortality in MAS patients but increased mortality in CRS patients.
Article
Mathematics, Applied
Siddhartha Mishra, Roberto Molinaro
Summary: Physics-informed neural networks (PINNs) have gained popularity for accurately approximating solutions of partial differential equations (PDEs). This paper provides upper bounds for the generalization error of PINNs in solving the forward problem of PDEs. By introducing an abstract formalism and utilizing the stability properties of the underlying PDE, an estimate for the generalization error is derived in terms of the training error and number of training samples. The proposed theory is validated through numerical experiments on various nonlinear PDEs.
IMA JOURNAL OF NUMERICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Francesca Paradiso, Marcos Quintela, Stefania Lenna, Stefano Serpelloni, David James, Sergio Caserta, Steve Conlan, Lewis Francis, Francesca Taraballi
Summary: Fibrosis and solid tumor progression are closely related, and both involve pathways associated with chronic wound dysregulation. This study investigates the biophysical evolution of remodeling regulation during the development and progression of matrix-related diseases. The results reveal the impact of mechanical changes in the microenvironment on fibroblast migration and gene expression.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Nazila Kamaly, Omid C. Farokhzad, Claudia Corbo
Summary: This review discusses the significance of protein corona in proteomic profiling and highlights the importance of understanding nano-bio interactions for the clinical translation of nanomedicines and the identification of disease-specific biomarkers. The analysis of the protein corona of nanoparticles on a case-by-case basis can provide valuable nano-bio interface information to improve their clinical translation.
Review
Chemistry, Physical
Joana Lopes, Daniela Lopes, Miguel Pereira-Silva, Diana Peixoto, Francisco Veiga, Michael R. Hamblin, Joao Conde, Claudia Corbo, Ehsan Nazarzadeh Zare, Milad Ashrafizadeh, Franklin R. Tay, Chengshui Chen, Ryan F. Donnelly, Xiangdong Wang, Pooyan Makvandi, Ana Claudia Paiva-Santos
Summary: Biomimetic nanotechnology utilizes natural cell membrane-derived nanovesicles to camouflage nanoparticles, improving therapeutic efficacy and safety. Macrophage cell membrane-functionalized nanosystems combine the advantages of macrophages and nanomaterials, enabling targeted delivery of drugs and imaging agents.
Review
Biochemistry & Molecular Biology
Madeline Franke, Chiara Mancino, Francesca Taraballi
Summary: Osteoarthritis is a common degenerative disease of articular cartilage. The causes of this disease are still unknown, but there is increasing interest in investigating biological sex as a risk factor. Clinical studies have shown that female patients have a higher prevalence and worse clinical outcomes, but most research has focused on male subjects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrew Speidell, Sofia Walton, Lee A. Campbell, Francesco Tomassoni-Ardori, Lino Tessarollo, Claudia Corbo, Francesca Taraballi, Italo Mocchetti
Summary: There are G-protein-coupled receptors (GPCRs) with incomplete ligand information that need to be characterized for potential new therapies. GPR75 has been found to play a role in regulating insulin secretion and obesity by binding to CCL5 and 20-Hydroxyeicosatetraenoic acid. However, its function in the brain is still not well understood.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Engineering, Biomedical
M. D. Hadiur Rahman Khan, Md Tauhidul Islam, Francesca Taraballi, Raffaella Righetti
Summary: In this study, a new non-invasive imaging method was proposed to assess the mechanical parameters and fluid dynamics of cancer. The results showed that stress relaxation experiments can accurately determine solid stress, fluid pressure, and their spatio-temporal distribution parameters with an error below 10%.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Esther Imperlini, Claudia Corbo
Summary: The eradication of cancer stem cells (CSCs) is a major challenge in cancer research. These cells are crucial for tumor initiation, growth, and maintenance. This study aimed to identify specific biomarkers for osteosarcoma (OS) stem cells by comparing their proteomic profile to non-stem counterparts. Using the cell lines 3AB-OS (stem-like) and MG63 (parental), 63 proteins exclusively expressed in 3AB-OS cells were discovered. Analyzing their functions, we found a potential correlation between the IGF2BPs signaling pathway and the tumorigenic and stemness features of 3AB-OS cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Gha Young Lee, Andrew A. Li, Intae Moon, Demos Katritsis, Yoannis Pantos, Francesco Stingo, Davide Fabbrico, Roberto Molinaro, Francesca Taraballi, Wei Tao, Claudia Corbo
Summary: Coronary artery disease (CAD) is a common and serious heart disease. Early detection is crucial and this study introduces a non-invasive diagnostic technology using nanotechnology to detect CAD. By forming disease-specific protein coronas on nanoparticles, a sensor array is developed for CAD detection. The results show high accuracy and sensitivity in detecting CAD using this method.
Article
Multidisciplinary Sciences
Chiara Mancino, Anna Pasto, Enrica De Rosa, Luigi Dolcetti, Marco Rasponi, Patrick McCulloch, Francesca Taraballi
Summary: Post-traumatic osteoarthritis (PTOA) is a major cause of disability in developed countries, accounting for 12% of all osteoarthritis cases in the United States. Current therapeutic strategies are ineffective, and PTOA remains a clinical challenge. This study evaluates the targeting potential of liposome-based nanoparticles (NPs) in a PTOA mouse model during the acute phase of inflammation. The results show preferential accumulation of NPs within the injured joint, as well as an immunomodulatory effect reducing immune cell infiltration.
Article
Cell & Tissue Engineering
Ava A. Brozovich, Stefania Lenna, Francesca Paradiso, Stefano Serpelloni, Patrick McCulloch, Bradley Weiner, Jason T. Yustein, Francesca Taraballi
Summary: This study utilized a biomimetic MHA/Coll composite material to promote bone regeneration in the presence of chemotherapy. It was found that human mesenchymal stem cells (hMSCs) seeded on the MHA/Coll scaffold migrated less toward osteosarcoma (OS) cells, indicating its potential oncologic safety. Furthermore, hMSCs on the MHA/Coll scaffold showed increased expression of osteogenic genes compared to hMSCs in 2D condition, even under the influence of chemotherapeutics.
JOURNAL OF TISSUE ENGINEERING
(2022)
Review
Materials Science, Multidisciplinary
Emma He, Stefano Serpelloni, Phillip Alvear, Maham Rahimi, Francesca Taraballi
Summary: Vascular disease in elderly patients is a growing health concern, and nanotechnology has the potential to provide more efficient vascular grafts to prevent postoperative infections.
Review
Chemistry, Multidisciplinary
Zhongyang Zhang, Jun Zhou, Chuang Liu, Jiaming Zhang, Yo Shibata, Na Kong, Claudia Corbo, Mitchel B. Harris, Wei Tao
Summary: Biomimetic nanotechnology plays an important role in the treatment of orthopedic diseases by restoring the structure and function of bone tissue and improving therapeutic efficacy. Understanding the pathogenesis can optimize treatment strategies. However, there are still challenges and unmet needs that hinder the clinical implementation of biomimetic nanotechnology.
TRENDS IN CHEMISTRY
(2022)
Article
Rheumatology
Ava Brozovich, Terry Clyburn, Kevin Park, Katharine D. Harper, Thomas Sullivan, Stephen Incavo, Francesca Taraballi
Summary: Implant-related hypersensitivity, mediated by Th2 cells and M1 macrophages, may be a potential cause of failure in total knee arthroplasty (TKA). Current screening methods for metal hypersensitivity in TKA patients are not accurate enough, highlighting the need for a more sensitive test to identify patients with allergic reactions.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2022)
Correction
Nanoscience & Nanotechnology
Steven Zanganeh, Petrina Georgala, Claudia Corbo, Leila Arabi, Jim Q. Ho, Najme Javdani, Mohammad R. Sepand, Kiara Cruickshank, Luis F. Campesato, Chien-Huan Weng, Saeed Hemayat, Chrysafis Andreou, Ricardo Alvim, Gregor Hutter, Marjan Rafat, Morteza Mahmoudi
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
