Article
Biotechnology & Applied Microbiology
Dan Tang, Li Geng, Jing Ma
Summary: The study found elevated expression of PROX1-AS1 in PE patients' placental tissues and blood samples. Inhibiting PROX1-AS1 promoted cell migration and invasion, regulated apoptosis through interactions with miR-211-5p and caspase-9.
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Endocrinology & Metabolism
Wei Peng, Ying Liu, Hongbo Qi, Qingshu Li
Summary: The study suggests that ACTN4 may play a crucial role in regulating trophoblast proliferation and differentiation in the human placenta during early pregnancy, and dysregulation of this protein may contribute to the pathogenesis of preeclampsia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinxi Huang, Weiwei Yuan, Beibei Chen, Gaofeng Li, Xiaobing Chen
Summary: The study found that long noncoding RNA (lncRNA) extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense RNA 1 (ELFN1-AS1) is upregulated in various tumors. However, its role in gastric cancer (GC) is not well understood. The study showed that ELFN1-AS1 promotes GC cell proliferation, migration, invasion, and EMT, and inhibits apoptosis by acting as a sponge for miR-211-3p and upregulating TRIM29 expression. Thus, the ELFN1-AS1/miR-211-3p/TRIM29 axis may be a potential target for GC treatment in the future.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Orthopedics
Zhanhu Mi, Yanyun Dong, Zhibiao Wang, Peng Ye
Summary: The study identified that high expression of lncRNA GNAS-AS1 in OS is associated with malignancy and distant metastasis, serving as an independent prognostic predictor. Additionally, inhibition of lncRNA GNAS-AS1 can slow down the progression of OS.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Medicine, General & Internal
Yanjiao Ou, Yong Deng, Hong Wang, Qingyi Zhang, Huan Luo, Peng Hu
Summary: This study identified a novel lncRNA PRKAG2-AS1 as a potential therapeutic target in hepatocellular carcinoma, demonstrating its association with clinical implications and malignant behaviors. PRKAG2-AS1 may function through regulating the miR-502-3p/BICD2 axis.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoming Liu, Dandan Peng, Yixin Cao, Yuanzhe Zhu, Jianjun Yin, Guangxing Zhang, Xiaodong Peng, Yanqiu Meng
Summary: Recent studies have highlighted the crucial role of aberrant regulatory interactions in driving malignant phenotypes of hepatocellular carcinoma (HCC) cells. Specifically, the long noncoding RNA DLX6-AS1 was shown to promote HCC progression by modulating the miR-513c/Cul4A/ANXA10 axis, affecting cell viability, migration, invasion, and apoptosis. Silencing DLX6-AS1 could inhibit HCC development and provide potential therapeutic targets for HCC treatment.
CANCER GENE THERAPY
(2021)
Article
Behavioral Sciences
Xiaoming Wu, Tingting Jiang, Rui Huang, Xue Xiao
Summary: GAS8-AS1 is downregulated while lncRNA NEAT1 is upregulated in GBM patients. Alterations in the expression levels of GAS8-AS1 and NEAT1 can distinguish GBM patients from healthy controls. The expression of GAS8-AS1 and NEAT1 is inversely correlated in GBM patients.
BRAIN AND BEHAVIOR
(2021)
Article
Pediatrics
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Dong Pei, Devin C. Koestler, Ke Hao, Jia Chen, Diane Gilbert-Diamond, Usha Ramakrishnan, Margaret R. Karagas, Carmen J. Marsit
Summary: Placental microRNAs are associated with early childhood growth trajectory and play a role in regulating placental cellular dynamics, impacting infant growth beyond birth.
PEDIATRIC RESEARCH
(2023)
Article
Cell Biology
Yanling Tao, Jingjing Zhang, Lulu Chen, Xin Liu, Mingkang Yao, Hao Zhang
Summary: High expression of CD27-AS1 in AML is associated with shorter overall survival time, its downregulation can inhibit the proliferation and induce apoptosis of AML cells, while overexpression enhances the malignant phenotype. CD27-AS1 regulates the growth of AML cells through the miR-224-5p/PBX3/MAPK signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yongxiang Liu, Dawei Wang, Qinghui Ji, Jinglong Yan
Summary: The study revealed that lnc MATN1-AS1 is significantly elevated in osteosarcoma cells and tissues, associated with tumor staging, lung metastasis, and histologic type. Patients with high lnc MATN1-AS1 levels had shorter overall survival and recurrence-free survival. Knockdown of lnc MATN1-AS1 inhibited OS cell proliferation, migration, and invasion by sponging miR-1299, indicating its oncogenic features and prognostic significance in OS.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yetao Xu, Dan Wu, Bingqing Hui, Lijun Shu, Xiaotong Tang, Cong Wang, Jiaheng Xie, Yin Yin, Matthew Sagnelli, Nana Yang, Ziyan Jiang, Yuanyuan Zhang, Lizhou Sun
Summary: Preeclampsia (PE) is a serious complication associated with high morbidity and mortality rates for pregnant women and infants. The failure of uterine spiral artery remodeling is believed to contribute to the development of PE. This study investigated the role of long non-coding RNA (lncRNA) TUG1 in PE and found that it was regulated by miR-218 and FOXP1. Silencing TUG1 increased the expression of DNA demethylase TET3 and proliferation-related genes in the DUSP family, potentially through an epigenetic mechanism. These findings provide new insights into the pathogenesis of PE and suggest that TUG1 may play a crucial role in regulating cell growth and the development of other diseases.
Article
Oncology
Weitao Yao, Jingyu Hou, Guoqing Liu, Fangxing Wu, Qiang Yan, Liangyu Guo, Chuchu Wang
Summary: The study found that CBR3-AS1 is highly expressed in osteosarcoma cells and promotes the stemness and EMT of these cells, as well as tumor growth.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biotechnology & Applied Microbiology
Yang Bai, Chenchen Ren, Baojin Wang, Jingge Xue, Feiyan Li, Jiaxi Liu, Li Yang
Summary: Recent studies have shown that MAFG-AS1 stimulates the malignant progression of OC by upregulating NFKB1-mediated IGF1 via miR-339-5p, highlighting a potential novel therapeutic target against OC.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Xudong Zhao, Fengyun Su, Qing Guo, Xiuhong Tao, Huifeng Wang, Hongling Wang, Qinwen Li, Wangmeng Zhang
Summary: In this study, the downregulation of FEZF1-AS1 and NOC2L in placental tissues of PE patients was observed. Overexpression of FEZF1-AS1 or NOC2L promoted cell proliferation and inhibited apoptosis, while knockdown of FEZF1-AS1 or NOC2L had the opposite effect. Furthermore, FEZF1-AS1 was found to stabilize NOC2L mRNA expression by interacting with ELAVL1. This study demonstrates that PE-related FEZF1-AS1 regulates trophoblast cell proliferation and apoptosis through the ELAVL1/NOC2L axis.
Article
Biochemistry & Molecular Biology
Yanhui Hu, Aram Comjean, Jonathan Rodiger, Yifang Liu, Yue Gao, Verena Chung, Jonathan Zirin, Norbert Perrimon, Stephanie E. Mohr
Summary: The FlyRNAi database at DRSC/TRiP provides online resources for functional genomics studies, focusing on Drosophila melanogaster. It includes gene-centric, reagent-centric, and data-centric resources to aid in ortholog mapping, identifying RNAi and CRISPR sgRNA reagents, and visualizing transcriptomics data and protein interactions. These features help biological and biomedical researchers efficiently integrate and analyze information for Drosophila and other species in functional genomics workflows.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Xin Luo, Yuyan Xu, Yilei Li, Guiming Zhang, Sisi Huang, Xiaolian Liu, Zhonglu Ren, Shuwen Liu, Le Yu
Summary: The study revealed an unexpected role of BAP1 in suppressing CM growth and metastasis through regulating gene expression and cellular functions. Deletion of BAP1 compromised colony-forming capability of CM cell lines and inhibited tumor growth and metastasis in animal models. BAP1 may serve as a potential therapeutic target for CM treatment.
Article
Chemistry, Multidisciplinary
Xiao-lian Liu, Gui-ming Zhang, Si-si Huang, Wen-hui Shi, Lin-xuan Ye, Zhong-lu Ren, Jia-jie Zhang, Shu-wen Liu, Le Yu, Yi-lei Li
Summary: PTEN loss correlates with hypersensitivity to rapalogs in ccRCC cells and could be a marker for rapalog therapy selection in ccRCC patients.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Yu-yan Xu, Zhong-lu Ren, Xiao-lian Liu, Gui-ming Zhang, Si-si Huang, Wen-hui Shi, Lin-xuan Ye, Xin Luo, Shu-wen Liu, Yi-lei Li, Le Yu
Summary: The study reveals that BAP1 loss makes cells more vulnerable to BET inhibitors, leading to a more potent suppressive effect on the transcription of various proliferation-related genes, especially MYC.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Oncology
Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun-Liang Guan
Summary: The combined BAP1 deficiency and SF3B1 hotspot mutation in uveal melanoma lead to cell senescence, growth arrest, increased sensitivity to chemotherapeutic drugs, decreased DNA damage response, and reduced invasion capabilities. The co-occurrence of these mutations explains their mutual exclusivity in human UM.
MOLECULAR ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yue Gao, Yanjun Li, ShuangYan Li, Xiaozhen Liang, Zhonglu Ren, Xiaoxue Yang, Bin Zhang, Yanhui Hu, Xinping Yang
Summary: Immune activation plays a critical role in the development of schizophrenia, with specific vulnerability during mid-to-late gestation and adolescence. By inducing immune activation in mice at these stages, researchers identified potential molecular pathways and key regulators correlating maternal immune activation during gestation and an increased risk for schizophrenia after a second immune activation at puberty. This study not only provides valuable resources for understanding the molecular mechanisms underlying schizophrenia, but also offers a systematic strategy for uncovering molecular pathways of complex mental disorders.
Article
Medicine, Research & Experimental
Han Zhang, Wei Li, Qian Zhang, Renxing Zhong, Chuanqiu Li, Ying Chen, Tianyi Xia, Mingming Peng, Zhonglu Ren, Hong Zhao, Yi Wang, Zunpeng Shu
Summary: This study explored the effects, active compounds, and molecular mechanisms of Dalbergia tsoi Merr.et Chun (JZX) in wound healing. The results showed that JZX accelerated wound healing, improved tissue quality, and inhibited inflammation and oxidative stress. The active compounds butin, eriodyctiol, and formononetin were identified as the key compounds in facilitating wound treatment. JZX accelerated wound healing by regulating the PI3K/Akt signaling pathway and inducing the expression of growth factors.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Gui-Ming Zhang, Si-Si Huang, Lin-Xuan Ye, Xiao-Lian Liu, Wen-Hui Shi, Zhong-Lu Ren, Run-Hua Zhou, Jia-Jie Zhang, Jing-Xuan Pan, Shu-Wen Liu, Le Yu, Yi-Lei Li
Summary: This study identifies a causal link between Gq activating mutations and hypersensitivity to BET inhibitors, suggesting BRD4 as a potential therapeutic target for Gq-driven Uveal melanoma.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemical Research Methods
Lingzhi Hu, Chengzhou Fu, Zhonglu Ren, Yongming Cai, Jin Yang, Siwen Xu, Wenhua Xu, Deyu Tang
Summary: In order to efficiently and effectively predict drug-target interactions (DTIs), this study proposed a framework called SSELM-neg, which uses a screening approach and a spherical search approach to optimize prediction. The experimental results demonstrated that this method outperformed other state-of-the-art methods in terms of accuracy.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, Istvan A. Kovacs, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Cote, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr
Summary: This study uses advanced methods to identify protein-protein interactions in Drosophila, generating widely useful physical and data resources for the identification of new components in pathways, complexes, and processes. The generation of reference maps of interactome networks provides a protein-centric approach to discover new components in existing pathways, complexes, and processes, which is helpful for genetic studies. The results include the FlyBi dataset and the DroRI reference interaction network, which provide a foundation for building new hypotheses about protein networks and function.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Ruquan Liu, Biaojie Huang, Yongzhao Shao, Yongming Cai, Xi Liu, Zhonglu Ren
Summary: In this study, memory B-cell-associated miRNA prognostic features were identified and a novel risk model was constructed for gastric adenocarcinoma (STAD) based on single-cell RNA sequencing (scRNA-seq) data and bulk RNA-seq data. The high-risk group showed poor prognosis and high sensitivity to a specific drug, providing prognostic insights for personalized treatment of STAD patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qian Chen, Jiexing He, Haihua Liu, Qiuyu Huang, Shuoshi Wang, Ailan Yin, Shuying Chen, Xinyang Shen, Yanxuan Xiao, Haoyue Hu, Jiayi Jiang, Wenqian Chen, Song Wang, Zhenqin Huang, Jiaqi Li, You Peng, Xiaocong Wang, Xinping Yang, Zhijian Wang, Mei Zhong
Summary: In this study, the researchers found that TDRKH-AS1 is a novel biomarker that induces inflammatory responses and impairs endothelial function by interacting with PDIA4. The expression of TDRKH-AS1 was significantly increased in patients with preeclampsia, and it was positively correlated with the severity of the disease. Further experiments in mice confirmed the role of TDRKH-AS1 in the development of preeclampsia. These findings highlight the importance of TDRKH-AS1 in the pathogenesis of preeclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jing Wang, Yue Gao, Liuyan Xiao, Yanmei Lin, Lang Huang, Jinfa Chen, Guanmei Liang, Weiming Li, Wenjuan Yi, Jianpei Lao, Bin Zhang, Tian-Ming Gao, Mei Zhong, Xinping Yang
Summary: Mutations of GABRB1 gene are associated with autism. In this study, a Gabrb1(-/-) mouse model was generated, and the involvement of the glutamatergic pathway in autism-like behaviors was investigated through various experiments.
Article
Medicine, Research & Experimental
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Summary: The study found that early-onset severe preeclampsia and late-onset severe preeclampsia have different molecular mechanisms, with the former associated with metabolism-related pathways and the latter with immune-related pathways. Some key transcription factors may be driving the widespread gene dysregulation in both early-onset and late-onset patients.