Review
Medicine, Research & Experimental
Yu Du, Haitong Wan, Ping Huang, Jiehong Yang, Yu He
Summary: Astragalus polysaccharides (APs), as important active ingredients of Astragali Radix, have therapeutic potential for multiple diseases. However, their low bioavailability limits their clinical application. Nanocrystals and structural modification of APs have been shown to improve bioavailability, potentially expanding their application.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Ming Cai, Chao Wu, Chen Jing, Xunzhang Shen, Mian He, Liyan Wang, Qi Guo, Yan Yan, Xu Yan, Ruoyu Yang
Summary: This study aimed to explore novel metabolite biomarkers in professional swimmers with different competition levels using nuclear magnetic resonance (NMR) metabolomics. The researchers identified ten metabolite biomarkers with differentially expressed levels between elite and sub-elite swimmers, and established a model using four metabolites (HDL, glutamine, methanol, and alpha-glucose) to predict athletic status. The model achieved a high accuracy in differentiating professional swimmers with different competitive levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuwei Tan, Xiaosong Liu, Yinping Yang, Baoying Li, Fei Yu, Wenqian Zhao, Chunli Fu, Xin Yu, Zhenxia Han, Mei Cheng
Summary: Diabetic sarcopenia (DS) is a disease characterized by muscle atrophy, slower nerve conduction, reduced muscle contraction capacity, and slower contraction rate. Serum metabolomics analysis identified potential biomarkers and revealed the underlying pathophysiological mechanism of DS. These findings provide new insights for the treatment of DS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Zeqi Liao, Xu Han, Yuhe Wang, Jingru Shi, Yuanyue Zhang, Hongyan Zhao, Lei Zhang, Miao Jiang, Meijie Liu
Summary: This study conducted a systematic review and meta-analysis on the differential small molecule metabolites between OA patients and healthy individuals, identifying potential biomarkers for the early detection of osteoarthritis.
Article
Biochemistry & Molecular Biology
Shaojie Zhang, Lijun An, Zhengguo Li, Xuelian Wang, Honglin Wang, Lijuan Shi, Jiahe Bao, Xiaozhong Lan, Erhao Zhang, Namrita Lall, Anna-Mari Reid, Yuhao Li, Da-Qing Jin, Jing Xu, Yuanqiang Guo
Summary: In this study, an immunological arabinan, LCP70-2A, was isolated from Ligusticum chuanxiong for the first time. Physicochemical characterization revealed its homogeneous polysaccharide nature and potential as an immunological enhancement supplement by activating macrophages and promoting the secretion of immunoregulatory factors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yingying Qiao, Yongpeng Guo, Wei Zhang, Weibing Guo, Kyselov Oleksandr, Nataliia Bozhko, Zhixiang Wang, Changzhong Liu
Summary: This study evaluated the effects of dietary supplementation of compound polysaccharides derived from Astragalus and Glycyrrhiza on broilers. The results showed that the supplementation improved the growth performance, antioxidant function and meat quality of the broilers, and also altered the microbial composition and metabolites.
Article
Biochemistry & Molecular Biology
Guangming Chen, Nan Jiang, Junping Zheng, Haiming Hu, Huabing Yang, Aizhen Lin, Baifei Hu, Hongtao Liu
Summary: In this study, two homogeneous polysaccharides (APS-A1 and APS-B1) were isolated from Astragalus membranaceus and their chemical structures were characterized. APS-A1 had a 1,4-alpha-D-Glcp backbone with a 1,4,6-alpha-D-Glcp branch every ten residues, while APS-B1 was a heteropolysaccharide composed of glucose, galactose, and arabinose. Bioactivity assays showed that both APS-A1 and APS-B1 exhibited potential anti-inflammatory activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Multidisciplinary
Bingbing Li, Ying Hong, Yu Gu, Shengjie Ye, Kaili Hu, Jian Yao, Kan Ding, Aihua Zhao, Wei Jia, Houkai Li
Summary: This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides (APS) using a functional metabolomics strategy. The study found that APS supplementation reversed the metabolic changes induced by a high-fat diet and identified 2-hydroxybutyric acid (2-HB) as a potential functional metabolite for APS activity. Further research indicated that 2-HB inhibited triglyceride accumulation and regulated proteins involved in lipid degradation.
Article
Chemistry, Analytical
Ya Zhang, Qian Zhou, Xin Ding, Haibo Wang, Guangguo Tan
Summary: This study found that Astragalus polysaccharides (ASP) could alleviate doxorubicin (DOX)-induced cardiomyopathy by regulating sphingolipid and glycerophospholipid metabolism, as shown through a metabolomics approach.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Immunology
Yuze Yuan, Chao Wang, Guoqiang Wang, Xiaoping Guo, Shengyu Jiang, Xu Zuo, Xinlei Wang, Alan Chen-Yu Hsu, Mingran Qi, Fang Wang
Summary: Allergic rhinitis is a common chronic disease influenced by genetic and environmental factors. Analyzing the microbiome and serum composition, we found potential biomarkers and disrupted metabolic pathways that may be used for the diagnosis of allergic rhinitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Renyuan Gao, Chunyan Wu, Yefei Zhu, Cheng Kong, Yin Zhu, Yaohui Gao, Xiaohui Zhang, Rong Yang, Hui Zhong, Xiao Xiong, Chunqiu Chen, Qian Xu, Huanlong Qin
Summary: This study identified microbial and metabolic signatures of colorectal cancer (CRC) with broad population relevance, developed a diagnostic panel for CRC and adenoma, and linked many CRC-associated metabolites with gut microbiome signatures of the disease, providing new insights for exploring CRC-related features.
Article
Immunology
Shaobing Xie, Sijie Jiang, Hua Zhang, Fengjun Wang, Yongzhen Liu, Yongchuan She, Qiancheng Jing, Kelei Gao, Ruohao Fan, Shumin Xie, Zhihai Xie, Weihong Jiang
Summary: This study identified several serum biomarkers through metabolomics analysis that can reliably predict the efficacy of ASIT in AR patients, with these biomarkers mainly involving glycolysis, fatty acid metabolism, and other metabolic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yong Lai, Hailun Yu, Huiling Deng, Qi Fang, Hui Lei, Li Liu, Nannan Wu, Xiurong Guo, Can Song
Summary: Wolfiporia cocos, also known as Poria cocos, is an ancient edible and medicinal mushroom valued for its tranquilizing, diuretic, and spleen-enhancing properties. This study investigated the effects of three main metabolites of P. cocos on gut microbiota. The results showed that water-insoluble polysaccharides (PCY) had the strongest effect in regulating gut microbiota and increasing the number of Lactobacillus. Metabolomics analysis revealed significant changes in the content of short-chain peptides in intestinal metabolites caused by the three main active metabolites of P. cocos.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Mengyin Chen, Xuefeng Chen, Ketang Wang, Luyang Cai, Nannan Liu, Duan Zhou, Wei Jia, Pin Gong, Ning Liu, Yujiao Sun
Summary: This study investigated the protective effects of kiwifruit polysaccharides against acrylamide-induced disorders of gut microbiota and systemic metabolism. The results showed that kiwifruit polysaccharides improved the body features, liver histopathologic morphology, and liver function enzymes in mice. It also restored the healthy gut microbiota and positively affected amino and bile acid-related metabolism pathways.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Gabriel A. Kurokawa, Pedro T. Hamamoto Filho, Jeany Delafiori, Aline F. Galvani, Arthur N. de Oliveira, Flavia L. Dias-Audibert, Rodrigo R. Catharino, Maria Ines M. C. Pardini, Marco A. Zanini, Estela de O. Lima, Adriana C. Ferrasi
Summary: This study identified plasma metabolic alterations that can differentiate between low-grade and high-grade meningiomas, providing valuable information for surgeons to determine the ideal surgical strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)