Article
Engineering, Environmental
Peng Zhang, Liyang Zheng, Yitao Duan, Yuting Gao, Huihui Gao, Daqing Mao, Yi Luo
Summary: The study revealed that TCS can cause liver injury by disturbing lipid metabolism and dysbiosis of gut microbiota. TCS also increases intestinal permeability, contributing to liver damage. The research provides new insights into the health impact of TCS on the human body.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Tongtong Liu, Haitao Yu, Zeming Zhang, Yunfei Xie, Long Yang, Fuping You
Summary: Intestinal ELF4 plays a critical role in maintaining gut barrier and homeostasis, and is beneficial in alleviating alcohol-induced hepatic steatosis and injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Haixia Liu, Xing Kang, Xiaodan Yang, Hao Yang, Xiaoyu Kuang, Peng Ren, Huan Yan, Xiaorong Shen, Yongbo Kang, Lin Li, Xiaohui Wang, Linzhi Guo, Mingwei Tong, Weiping Fan
Summary: This study demonstrates the protective effects of a compound probiotic against acute alcohol-induced liver injury. The compound probiotic ameliorated liver injury, maintained intestinal barrier integrity, reduced inflammation and oxidative stress, and regulated fatty acid metabolism. Fecal microbiota transplantation showed comparable protective effects. These findings provide potential strategies for the treatment of alcoholic liver disease.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Agriculture, Multidisciplinary
Qi Xu, Renshuai Zhang, Yan Mu, Yue Song, Na Hao, Yunbo Wei, Quanbo Wang, Charles R. Mackay
Summary: Propionate supplementation has a promising beneficial effect on alcoholic liver injury by improving gut-liver axis homeostasis, reducing intestinal permeability, and alleviating inflammation and dysbiosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Huizhen Li, Jialu Shi, Li Zhao, Jiaqi Guan, Fei Liu, Guicheng Huo, Bailiang Li
Summary: The Lactobacillus mixture improved intestinal permeability, reduced serum levels of lipopolysaccharides (LPS), and inhibited liver lipid accumulation, oxidative stress, and inflammation by regulating key pathways. Additionally, the Lactobacillus mixture modulated the gut microbiota, increasing SCFA producers and decreasing Gram-negative bacteria, thereby protecting the liver from alcohol-induced damage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
Meng-Yang Xu, Can-Can Guo, Meng-Ying Li, Yu-Han Lou, Zhuo-Ran Chen, Bo-Wei Liu, Ling Lan
Summary: This study investigated the effect and mechanism of chronic psychological stress in promoting liver injury and fibrosis through the gut. The results showed that chronic psychological stress can lead to changes in gut microbiota and increased intestinal permeability, which in turn promote liver damage and fibrosis. The findings suggest the existence of a brain-gut-liver axis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Grace T. Patterson, Elvia Y. Osorio, Alex Peniche, Sara M. Dann, Erika Cordova, Geoffrey A. Preidis, Ji Ho Suh, Ichiaki Ito, Omar A. Saldarriaga, Michael Loeffelholz, Nadim J. Ajami, Bruno L. Travi, Peter C. Melby
Summary: Acute malnutrition is associated with abnormal development of the intestinal microbiota and dysfunction of the intestinal barrier, resulting in systemic inflammation and endotoxemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Lin Ye, Huodai Chen, Karl Wah Keung Tsim, Xing Shen, Xiangmei Li, Xueling Li, Hongtao Lei, Yunle Liu
Summary: Through mouse experiments, it was found that the gut microbiota plays a crucial role in AFB(1)-induced liver injury, as alterations in gut microbiota lead to colonic barrier dysfunction and liver pyroptosis, resulting in hepatic inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Yang Wang, Yifan Zhang, Yun Liu, Jun Xu, Yulan Liu
Summary: The study found that LSEC is a crucial barrier in the gut-liver axis, defending the liver against colitis-induced injury. When LSECs are damaged, they can turn into a pro-inflammatory pattern under the stimulation of LPS. LSEC injury and colitis-derived LPS synergistically contribute to the recruitment and activation of hepatic neutrophils. Neutrophils play a pivotal role as a downstream effector in colitis-induced liver injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Zhiyuan Meng, Shiran Huang, Wei Sun, Sen Yan, Xiaojun Chen, Jinling Diao, Zhiqiang Zhou, Wentao Zhu
Summary: This study systematically investigated the adverse effects of PTC and PTCd on liver function in mice from the perspective of gut microbiota, revealing that exposure to these compounds can cause liver damage by changing gut microbiota, disrupting intestinal barrier function, and promoting bacterial translocation. Additionally, exposure to PTC and PTCd also affects lipid metabolism in the liver tissue and gene expression related to inflammation and barrier function in colon tissue, leading to liver and intestinal dysfunction in mice. The findings highlight the key role of gut microbiota in liver damage induced by pesticides, offering new insights into the mechanisms of liver toxicity through the gut-liver axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xi Shu, Jing Wang, Liang Zhao, Jian Wang, Pengjie Wang, Feng Zhang, Ran Wang
Summary: This study investigates the preventive effect of Bifidobacterium lactis TY-S01 on alcohol-induced liver injury in mice. The results show that TY-S01 pretreatment effectively protects mice against alcohol-induced liver injury by maintaining the levels of liver enzymes and inflammatory cytokines, preserving the integrity of the intestinal barrier, and preventing gut microbiota dysbiosis. Spearman's correlation analysis reveals a clear correlation among serum indicators, inflammatory cytokines, and gut microbiota. Overall, TY-S01 attenuates alcohol-induced liver injury by preserving intestinal barrier integrity and maintaining gut microbiota balance.
Article
Biochemistry & Molecular Biology
Xiaobin Wen, Ruqing Zhong, Guoqi Dang, Bing Xia, Weida Wu, Shanlong Tang, Lixin Tang, Lei Liu, Zhengqun Liu, Liang Chen, Hongfu Zhang
Summary: The study suggests that pectin enhances intestinal integrity and barrier function by altering intestinal microbiota composition and their metabolites, which subsequently alleviates intestinal injury and improves the growth performance of piglets.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Bowei Zhang, Yingchuan Xu, Huan Lv, Wenwen Pang, Jin Wang, Hui Ma, Shuo Wang
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Article
Immunology
Xiaogang Chen, Wenjing Sun, Baichang Xu, Enyun Wu, Yao Cui, Kaiyuan Hao, Geyin Zhang, Congcong Zhou, Yanping Xu, Jiang Li, Hongbin Si
Summary: The polysaccharides from the roots of Millettia Speciosa Champ exhibit immunomodulatory effects in cyclophosphamide-induced mice by improving immune organ indices, cytokine secretion, intestinal morphology, and microbial diversity. These findings suggest that Millettia Speciosa Champ polysaccharide holds promise as an immunostimulant in functional foods and drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Pawel Liskiewicz, Mariusz Kaczmarczyk, Blazej Misiak, Michal Wronski, Agata Baba-Kubis, Karolina Skonieczna-Zydecka, Wojciech Marlicz, Przemyslaw Bienkowski, Agata Misera, Justyna Pelka-Wysiecka, Jolanta Kucharska-Mazur, Anna Konopka, Igor Loniewski, Jerzy Samochowiec
Summary: The study found a significant correlation between gut microbiota and the severity of depressive symptoms, but they do not serve as predictors of symptomatic improvement during antidepressant treatment. Intestinal integrity and inflammation markers were associated with the response to treatment and symptom severity in patients with MDD. Additional studies are needed to confirm and expand on these findings.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Cell Biology
Huinan Chen, Biqiang Zhu, Lei Zhao, Yang Liu, Fuya Zhao, Jing Feng, Ye Jin, Jiayu Sun, Rui Geng, Yunwei Wei
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Microbiology
Ye Jin, Yang Liu, Lei Zhao, Fuya Zhao, Jing Feng, Shengda Li, Huinan Chen, Jiayu Sun, Biqiang Zhu, Rui Geng, Yunwei Wei
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Oncology
Jing Feng, Fuya Zhao, Jiayu Sun, Baiqiang Lin, Lei Zhao, Yang Liu, Ye Jin, Shengda Li, Aidong Li, Yunwei Wei
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Biqiang Zhu, Lei Zhao, Yang Liu, Ye Jin, Jing Feng, Fuya Zhao, Jiayu Sun, Rui Geng, Yunwei Wei
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)
Article
Oncology
Lei Zhao, Yang Liu, Fuya Zhao, Ye Jin, Jing Feng, Rui Geng, Jiayu Sun, Liqing Kang, Lei Yu, Yunwei Wei
MOLECULAR THERAPY-ONCOLYTICS
(2020)