Article
Health Care Sciences & Services
Jiang Li, Anshul Tiwari, Hooman Mirzakhani, Alberta L. Wang, Alvin T. Kho, Michael J. McGeachie, Augusto A. Litonjua, Scott T. Weiss, Kelan G. Tantisira
Summary: MicroRNAs show potential as biomarkers for incident asthma, particularly when considering vitamin D levels. Meta-analysis across cohorts and logistic regression models were used to predict asthma occurrence based on miRNA expression levels and vitamin D interactions. A specific miRNA, hsa-miR-574-5p, showed good prognostic ability for incident asthma.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Caitlin O'Mahony, Adam Clooney, Siobhan F. Clarke, Monica Aguilera, Aisling Gavin, Donjete Simnica, Mary Ahern, Aine Fanning, Maurice Stanley, Raul Cabrera Rubio, Elaine Patterson, Tatiana Marques, Rebecca Wall, Aileen Houston, Amr Mahmoud, Michael W. Bennett, Catherine Stanton, Marcus J. Claesson, Paul D. Cotter, Fergus Shanahan, Susan A. Joyce, Silvia Melgar
Summary: Environmental factors, such as westernised diets and alterations to the gut microbiota, are considered risk factors for inflammatory bowel diseases (IBD). This study found that feeding mice a high-fat diet protected them from developing colitis and colitis-associated cancer (CAC) by modulating gut microbiota and bile acid metabolism, which then influenced vitamin D targeting pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Yi Zhang, Jun Ding, Hongbin Guo, Ze Liu, Qi Liu, Yusheng Li, Dianzhong Zhang, Jieyu Liang
Summary: The results of this meta-analysis suggest that dietary vitamin E level is inversely associated with MetS, while the relationship between circulating vitamin E level and MetS remains inconclusive. Well-designed prospective cohort studies are needed for further investigation.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Sieglinde Zelzer, Florian Prueller, Pero Curcic, Zdenka Sloup, Magdalena Holter, Markus Herrmann, Harald Mangge
Summary: This study aimed to investigate vitamin D status markers and degradation products in 148 hospitalized COVID-19 patients with different clinical courses. The results did not show a significant role of vitamin D in the course and outcome of COVID-19. Non-survivors were older, had higher peak concentrations of IL-6 and CRP, and required mechanical ventilation more frequently.
Article
Nutrition & Dietetics
Fatema Habbash, Tariq Abdulkarim Alalwan, Simone Perna, Naila Ahmed, Omar Sharif, Adel Al Sayyad, Clara Gasparri, Cinzia Ferraris, Mariangela Rondanelli
Summary: This study investigated the prevalence of H. pylori infection among Bahraini adults and found that individuals with lower education levels, lower intake of green tea, coffee and honey, and vitamin D deficiency were more likely to have H. pylori infection. Higher education levels, consumption of honey, green tea, and coffee, as well as normal vitamin D levels were found to be protective factors against H. pylori infection.
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Wenting Luo, Yaping Dong, Tao Hu, Dan Liu, Xiaowei Wei, Wei Ma, Zhengwei Yuan, Qun Zhao
Summary: The study revealed that most orthopedic patients have vitamin D insufficiency, while patients with DDH are in the insufficiency range. MiR-140 was downregulated in both DDH patients' serum and rat hip joints. A combination of 25(OH)D and miR-140 showed strong performance in distinguishing DDH from controls.
Review
Food Science & Technology
Ankita Kumari, Shalaka Bhawal, Suman Kapila, Hariom Yadav, Rajeev Kapila
Summary: The epigenome, as important as the genome, plays a crucial role in the normal development and functioning of an organism. Environmental factors and bioactive compounds in the diet can influence epigenetic modifications, making these compounds potential therapeutic agents for treating inflammatory diseases and cancers while reducing the side effects of chemotherapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Laongthip Ruknarong, Chongchira Boonthongkaew, Nisa Chuangchot, Amonrat Jumnainsong, Naruemon Leelayuwat, Apinya Jusakul, Silvana Gaudieri, Chanvit Leelayuwat
Summary: The study found that vitamin C supplementation can alter the expression of circulating miR-451a in patients with T2DM, potentially serving as a biomarker for oxidative status and poor glycemic control, and leading to a novel molecular strategy to reduce oxidative stress in these patients.
Article
Nutrition & Dietetics
Filippo Vernia, Giorgia Burrelli Scotti, Noemi Sara Bertetti, Giuseppe Donato, Stefano Necozione, Piero Vernia, Nadia Pallotta
Summary: The inadequate intake of Vitamin D and Vitamin K in the diet is a reversible factor for IBD-associated bone loss, but there is a lack of data on Vitamin K. A study found that both IBD patients and control patients had inadequate intake of Vitamin D, while the intake of Vitamin K was inadequate in IBD patients and high in controls. The study suggests that proactive nutritional intervention is needed to address Vitamin K shortages in IBD patients.
Article
Public, Environmental & Occupational Health
Su H. Chu, Mengna Huang, Rachel S. Kelly, Priyadarshini Kachroo, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su
Summary: This study found that higher levels of maternal vitamin D in the third trimester are associated with a lower risk of ADHD in offspring, with a stronger effect observed in male offspring.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Dermatology
Naotaka Serizawa, Shizuka Okazaki, Yohei Otsuka, Mototaka Koto, Kyochika Okabe, Michiko Ito, Takashi Morita, Toshihiko Hoashi, Hidehisa Saeki, Namiko Abe, Miho Mori, Yukari Okubo, Yumiko Yano, Hiroshi Mitsui, Naoko Kanda
Summary: PPP is a chronic dermatitis characterized by pustules on the palms and soles. The inflammatory pathway involving TNF-α/IL-23/IL-17 may play a role in its pathogenesis. Dietary habits in Japanese PPP patients include higher BMI, pulses and sugar intake, and lower vitamin A intake, with high BMI and pulse intake associated with PPP. Sodium intake and BMI were correlated with PPPASI. Age and sodium intake may be lower in PPP patients with PAO, suggesting a potential association with the disease. Further studies are needed to investigate the impact of dietary intervention on PPP progression.
JOURNAL OF DERMATOLOGY
(2021)
Article
Nutrition & Dietetics
Chwan-Li Shen, Sivapriya Ramamoorthy, Gurvinder Kaur, Jannette M. Dufour, Rui Wang, Huanbiao Mo, Bruce A. Watkins
Summary: This study investigated the effects of dietary tocotrienols (TT) on obese mice and found that TT supplementation could reduce inflammation and oxidative stress levels, increase levels of key metabolites, and help to reduce obesity-related complications.
Article
Nutrition & Dietetics
Malgorzata Starek, Pawel Gumulka, Monika Dabrowska
Summary: Nowadays, the quality of dietary supplements is of utmost importance due to reports of insufficient content or absence of ingredients. This study developed optimal conditions for analyzing the content of vitamins D-2, D-3, and K-2 in various dietary supplements. The results showed that the methodology developed was reliable and met analytical requirements. The amount of vitamin D-3 in the analyzed products matched the manufacturer's declaration, while the content of vitamin K-2 varied.
Article
Medicine, Research & Experimental
Daniela Gabbia, Sara Carpi, Samantha Sarcognato, Ilaria Zanotto, Katia Sayaf, Martina Colognesi, Beatrice Polini, Maria Digiacomo, Marco Macchia, Paola Nieri, Maria Carrara, Nora Cazzagon, Francesco Paolo Russo, Maria Guido, Sara De Martin
Summary: Liver fibrosis is a chronic condition resulting from the activation of hepatic stellate cells and excessive extracellular matrix deposition. Phenolic compounds tyrosol and hydroxytyrosol have been found to exhibit antifibrotic and antioxidant effects. In vitro and in vivo experiments showed that these compounds can reduce fibrogenesis and modulate oxidative stress, making them promising candidates for liver fibrosis treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Amedeo Gagliardi, Giulia Francescato, Giulio Ferrero, Giovanni Birolo, Sonia Tarallo, Antonio Francavilla, Giulia Piaggeschi, Carla Di Battista, Gaetano Gallo, Alberto Realis Luc, Carlotta Sacerdote, Giuseppe Matullo, Paolo Vineis, Alessio Naccarati, Barbara Pardini
Summary: This study investigates the expression changes of miRNAs located in the 8q24 region in colorectal cancer (CRC) and bladder cancer (BC). The findings suggest that altered expression of certain miRNAs may be associated with the initiation and progression of cancer. This study provides valuable insights into the relationship between the 8q24 region and cancer, as well as the understanding of transcriptomic regulation.
Article
Gastroenterology & Hepatology
Barbara Pardini, Giulio Ferrero, Sonia Tarallo, Gaetano Gallo, Antonio Francavilla, Nicola Licheri, Mario Trompetto, Giuseppe Clerico, Carlo Senore, Sergio Peyre, Veronika Vymetalkova, Ludmila Vodickova, Vaclav Liska, Ondrej Vycital, Miroslav Levy, Peter Macinga, Tomas Hucl, Eva Budinska, Pavel Vodicka, Francesca Cordero, Alessio Naccarati
Summary: This study comprehensively evaluated stool microRNA (miRNA) profiles as biomarkers for noninvasive colorectal cancer (CRC) diagnosis. A 5-miRNA signature accurately distinguished patients from control individuals and showed good correlation with tissue miRNA profiles and fecal profiles of different gastrointestinal diseases. These findings have the potential to improve noninvasive diagnosis and screening strategies for CRC.
Article
Gastroenterology & Hepatology
Antonio Francavilla, Giulio Ferrero, Barbara Pardini, Sonia Tarallo, Laura Zanatto, Gian Paolo Caviglia, Sabina Sieri, Sara Grioni, Giulia Francescato, Francesco Stalla, Cristina Guiotto, Lucia Crocella, Marco Astegiano, Mauro Bruno, Pier Luigi Calvo, Paolo Vineis, Davide Giuseppe Ribaldone, Alessio Naccarati
Summary: Current treatment for celiac disease is adhering to a gluten-free diet, but its long-term molecular effects are still unknown. This study explored fecal small non-coding RNAs and gut microbiome profiles in celiac disease subjects and found altered miRNA and microbial profiles in treated celiac disease subjects.
Article
Biochemistry & Molecular Biology
Beatrice Polini, Caterina Ricardi, Andrea Bertolini, Vittoria Carnicelli, Grazia Rutigliano, Federica Saponaro, Riccardo Zucchi, Grazia Chiellini
Summary: Microglial dysfunction is a hallmark and leading cause of common neurodegenerative diseases (NDDs). Inhibition of glial activation may be a therapeutic target. T1AM, an endogenous derivative of thyroid hormone, has shown potential neuroprotective effects, but its effects on microglial dysfunction remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Biochemistry & Molecular Biology
Einar Birkeland, Giulio Ferrero, Barbara Pardini, Sinan U. Umu, Sonia Tarallo, Sara Bulfamante, Geir Hoff, Carlo Senore, Trine B. Rounge, Alessio Naccarati
Summary: Fecal microRNAs have potential clinical interest as non-invasive diagnostic and prognostic biomarkers in colorectal cancer (CRC) screening. This study assessed the feasibility of using small RNA sequencing to measure human miRNAs in FIT samples and demonstrated the stability and consistency of this method for detecting CRC and advanced adenoma in large scale screening.
Article
Biochemistry & Molecular Biology
Sara Carpi, Stefano Quarta, Stefano Doccini, Anella Saviano, Noemi Marigliano, Beatrice Polini, Marika Massaro, Maria Annunziata Carluccio, Nadia Calabriso, Martin Wabitsch, Filippo Maria Santorelli, Marco Cecchini, Francesco Maione, Paola Nieri, Egeria Scoditti
Summary: The two compounds TIIA and CRY found in Danshen were found to reduce inflammation in adipocytes and prevent inflammatory response through modulation of gene and miRNA expression. This offers a new approach for preventing and treating obesity-related diseases.
Article
Medicine, General & Internal
Marino Paroli, Andrea Becciolini, Elena Bravi, Romina Andracco, Valeria Nucera, Simone Parisi, Francesca Ometto, Federica Lumetti, Antonella Farina, Patrizia Del Medico, Matteo Colina, Alberto Lo Gullo, Viviana Ravagnani, Palma Scolieri, Maddalena Larosa, Marta Priora, Elisa Visalli, Olga Addimanda, Rosetta Vitetta, Alessandro Volpe, Alessandra Bezzi, Francesco Girelli, Aldo Biagio Molica Colella, Rosalba Caccavale, Eleonora Di Donato, Giuditta Adorni, Daniele Santilli, Gianluca Lucchini, Eugenio Arrigoni, Ilaria Plate, Natalia Mansueto, Aurora Ianniello, Enrico Fusaro, Maria Chiara Ditto, Vincenzo Bruzzese, Dario Camellino, Gerolamo Bianchi, Francesca Serale, Rosario Foti, Giorgio Amato, Francesco De Lucia, Ylenia Dal Bosco, Roberta Foti, Massimo Reta, Alessia Fiorenza, Guido Rovera, Antonio Marchetta, Maria Cristina Focherini, Fabio Mascella, Simone Bernardi, Gilda Sandri, Dilia Giuggioli, Carlo Salvarani, Veronica Franchina, Francesco Molica Colella, Giulio Ferrero, Alarico Ariani
Summary: This study aimed to provide new real-world data on the retention rate of Tofacitinib in rheumatoid arthritis patients through long-term observation. The results showed that Tofacitinib demonstrated a long retention rate in real-world settings, with comparable safety to previous registration studies. This indicates that Tofacitinib is a viable alternative for patients who have failed treatment with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or biologic DMARDs (bDMARDs).
MEDICINA-LITHUANIA
(2023)
Article
Public, Environmental & Occupational Health
Lorenzo Mangone, Carlotta Sacerdote, Jessica Laine, Giovanna Masala, Benedetta Bendinelli, Salvatore Panico, Paolo Chiodini, Sara Grioni, Valeria Pala, Rosario Tumino, Luca Petiti, Paolo Vineis
Summary: This cohort study provides evidence on the impact of diet on health, greenhouse gas emissions, and land use. The study analyzed data from the EPIC Italy cohort and found that sustainable diets with lower associated emissions and land use were associated with lower mortality and cancer incidence. The results suggest that promoting diets with low environmental impact can have important health benefits.
EPIDEMIOLOGIA & PREVENZIONE
(2023)
Article
Oncology
Elisabetta Casalone, Giovanni Birolo, Barbara Pardini, Alessandra Allione, Alessia Russo, Chiara Catalano, Manlio Mencoboni, Daniela Ferrante, Corrado Magnani, Marika Sculco, Irma Dianzani, Federica Grosso, Dario Mirabelli, Rosa Angela Filiberti, Ottavio Rena, Carlotta Sacerdote, Miguel Rodriguez-Barranco, Karl Smith-Byrne, Salvatore Panico, Claudia Agnoli, Theron Johnson, Rudolf Kaaks, Rosario Tumino, Jose Maria Huerta, Elio Riboli, Alicia K. Heath, Camino Trobajo-Sanmartin, Matthias B. Schulze, Calogero Saieva, Pilar Amiano, Antonio Agudo, Elisabete Weiderpass, Paolo Vineis, Giuseppe Matullo
Summary: This study identified a miRNA signature in preclinical MPM patients, which can be detected up to five years before diagnosis, providing potential non-invasive markers for early detection and intervention.
Article
Biochemistry & Molecular Biology
Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A. A. Mohamed, Giovanna Baron, Salvatore Faiella, Giulio Poli, Simona Rapposelli, Giuseppe Saccomanni, Giancarlo Aldini, Grazia Chiellini, Robert B. B. Laprairie, Clementina Manera, Gabriella Ortore
Summary: We have developed a new generation of ligands (JR compounds) that target the CB2R. These compounds combine the pharmacophoric portion of CB2R positive allosteric modulator (EC21a) with that of CB2R selective orthosteric agonist (LV62). Among the tested compounds, JR22a showed dualsteric behavior as a CB2R ligand. Computational studies confirmed the binding mode of JR22a at CB2R, and its potential to prevent neuroinflammation was investigated using a human microglial cell model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Vittorio Picchio, Giulio Ferrero, Claudia Cozzolino, Barbara Pardini, Erica Floris, Sonia Tarallo, Xhulio Dhori, Cristina Nocella, Lorenzo Loffredo, Giuseppe Biondi-Zoccai, Roberto Carnevale, Giacomo Frati, Isotta Chimenti, Francesca Pagano
Summary: This study defines for the first time the miRNA profile in the serum of chronic exclusive heat-not-burn cigarette smokers and suggests a significant impact of heat-not-burn cigarettes on circulating miRNAs.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Medicine, General & Internal
Rebecca Ferrisi, Francesca Gado, Caterina Ricardi, Beatrice Polini, Clementina Manera, Grazia Chiellini
Summary: Alzheimer's disease (AD) is characterized by neuronal death, brain atrophy, and cognitive decline. Neuroinflammation, with microglia as key players, has been identified as a major cause of AD progression. Cannabinoids show potential as a preventive treatment for AD, with altered expression of endocannabinoids and their receptors reported in neurodegenerative disorders including AD. Modulation of cannabinoid receptors has been shown to have neuroprotective effects in reducing protein deposition, suggesting their therapeutic potential for neurodegenerative diseases. This review provides an overview of the involvement of cannabinoid receptors in microglia activation and highlights the role of neuroinflammation in AD pathogenesis. It also discusses recently developed candidate drugs targeting cannabinoid receptors as an innovative strategy for AD treatment and management.
JOURNAL OF CLINICAL MEDICINE
(2023)