4.7 Article

Thioredoxin Delays Photoreceptor Degeneration, Oxidative and Inflammation Alterations in Retinitis Pigmentosa

期刊

FRONTIERS IN PHARMACOLOGY
卷 11, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.590572

关键词

retina; thioredoxin; glutathione; vascular endothelial growth factor; glia; hepatic growth factor

资金

  1. Cardenal Herrera CEU [INDI 19/35]
  2. San Pablo CEU Foundation University [INDI 19/35]
  3. Generalitat Valenciana [ACIF/2019/199, GV/2019/125, GV/2019/034]

向作者/读者索取更多资源

Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study was to study if thioredoxin (TRX) administration is able to decrease photoreceptor death in an animal model of RP (rd1 mouse), but also if it is able to modulate the retinal oxidative stress, glial and vascular changes that can be observed as the disease progresses. Wild type and rd1 mice received several doses of TRX. After treatment, animals were euthanized at postnatals days 11, 17, or 28. Glutathione (GSH) and other thiol compounds were determined by high performance liquid chromatography (HPLC). Glial fibrilary acidic protein (GFAP) and anti-ionized calcium binding adaptor molecule 1 (Iba1) were studied by immunohistochemistry. Vascular endothelial growth factor (VEGF) and hepatic growth factor (HGF) expression were determined by western blot. TRX administration significantly diminished cell death in rd1 mouse retinas and increased GSH retinal concentrations at postnatal day 11 (PN11). TRX was also able to reverse glial alterations at PN11 and PN17. No alterations were observed in retinal VEGF and HGF expression in rd1 mice. In conclusion, TRX treatment decreases photoreceptor death in the first stages of RP and this protective effect may be due in part to the GSH system activation and to a partially decrease in inflammation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Biochemistry & Molecular Biology

Neuroprotection of Brain Cells by Lipoic Acid Treatment after Cellular Stress

Sara Paradells-Navarro, Maria Soledad Benlloch-Navarro, Maria Inmaculada Almansa Frias, Ma Angeles Garcia-Esparza, Vania Broccoli, Maria Miranda, Jose Miguel Soria

ACS CHEMICAL NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models

Violeta Sanchez-Vallejo, Soledad Benlloch-Navarro, Laura Trachsel-Moncho, Rosa Lopez-Pedrajas, Inmaculada Almansa, Francisco Javier Romero, Maria Miranda

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Multidisciplinary Sciences

Serum Malondialdehyde Concentration and Glutathione Peroxidase Activity in a Longitudinal Study of Gestational Diabetes

Luis Arribas, Inmaculada Almansa, Maria Miranda, Maria Muriach, Francisco J. Romero, Vincent M. Villar

PLOS ONE (2016)

Article Pharmacology & Pharmacy

Bevacizumab Diminishes Inflammation in an Acute Endotoxin-Induced Uveitis Model

Salvador Merida, Maria Sancho-Tello, Inmaculada Almansa, Carmen Desco, Cristina Peris, Mari-Luz Moreno, Vincent M. Villar, Amparo Navea, Francisco Bosch-Morell

FRONTIERS IN PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

An Anti-Interleukin-2 Receptor Drug Attenuates T-Helper 1 Lymphocytes-Mediated Inflammation in an Acute Model of Endotoxin-Induced Uveitis

Salvador Merida, Maria Sancho-Tello, Amparo Navea, Inmaculada Almansa, Maria Muriach, Francisco Bosch-Morell

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Progesterone anti-inflammatory properties in hereditary retinal degeneration

Soledad Benlloch-Navarro, Laura Trachsel-Moncho, Angel Fernandez-Carbonell, Teresa Olivar, Jose Miguel Soria, Inmaculada Almansa, Maria Miranda

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Article Multidisciplinary Sciences

Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats

Rosa Lopez-Pedrajas, Inmaculada Almansa, Maria V. Sanchez-Villarejo, Borja Muriach, Jorge M. Barcia, Francisco J. Romero, Maria Muriach

Summary: The study found that chronic cocaine administration impairs memory acquisition, increases GluN2B expression in the hippocampus, decreases NF-kappa B activity, and reduces expression of the active form of CREB, highlighting the roles of these transcription factors in cocaine-induced memory impairment.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Sulforaphane Modulates the Inflammation and Delays Neurodegeneration on a Retinitis Pigmentosa Mice Model

Antolin Canto, Javier Martinez-Gonzalez, Maria Miranda, Teresa Olivar, Inma Almansa, Vicente Hernandez-Rabaza

Summary: Retinitis pigmentosa (RP) is a type of hereditary retinal disease, and inflammation is an important factor. This study found that sulforaphane (SFN) has anti-inflammatory properties and regulates retinal degeneration and inflammation in an RP mouse model. SFN may have neuroprotective effects in clinical settings.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Time-Course Changes in Oxidative Stress and Inflammation in the Retinas of rds Mice: A Retinitis Pigmentosa Model

Antolin Canto, Javier Martinez-Gonzalez, Inmaculada Almansa, Rosa Lopez-Pedrajas, Vicente Hernandez-Rabaza, Teresa Olivar, Maria Miranda

Summary: The study found that in rds mice, the time sequence of oxidative stress and inflammation changes as follows: at PN11, there is a small increase in photoreceptor death and microglial cells; at PN17, damage to macromolecules is observed; at PN21, the maximum photoreceptor death rate is detected, along with an increase in GSH-GSSG and GFAP; at PN21, microglial cells are activated; and at PN28, there is a decrease in GSH synthesis enzymes. These findings contribute to understanding the pathophysiology of RP and suggest that oxidative stress and inflammation may be therapeutic targets in this disease.

ANTIOXIDANTS (2022)

Meeting Abstract Ophthalmology

Dutasteride: possible new treatment in retinal degenerations

Maria Miranda, Antolin Canto, Javier Martinez, Vicente Hernandez-Rabaza, Teresa Olivar, Inmaculada Almansa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

Review Biochemistry & Molecular Biology

Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review

Vicente Hernandez-Rabaza, Rosa Lopez-Pedrajas, Inmaculada Almansa

ANTIOXIDANTS (2019)

Meeting Abstract Ophthalmology

Benefitial effects of thioredoxin administration in experimental retinal degeneration

Maria Miranda, Roberto Gimeno-Hernandez, Angel Fernandez-Carbonell, Teresa Olivar, Vicente Hernandez-Rabaza, Rosa Lopez-Pedrajas, Inmaculada Almansa

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Meeting Abstract Ophthalmology

Rescue of photoreceptor degeneration by progesterone in an animal model of retinitis pigmentosa

M. Miranda, S. Benlloch-Navarro, L. C. Trachsel-Moncho, D. T. Ramirez, R. Lopez-Pedrajas, I. Almansa, D. Silvestre

ACTA OPHTHALMOLOGICA (2015)

Article Neurosciences

Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum

Rosa Lopez-Pedrajas, Dolores T. Ramirez-Lamelas, Borja Muriach, Maria V. Sanchez-Villarejo, Inmaculada Almansa, Lorena Vidal-Gil, Francisco J. Romero, Jorge M. Barcia, Maria Muriach

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

暂无数据