Article
Biochemistry & Molecular Biology
Yan Wang, Jiahui Ni, Aiyu Wang, Run Zhang, Linjie Wang
Summary: This study found that VEGFA regulates glycolipid metabolism in Schizothorax prenanti through AMPK alpha, contributing to a better understanding of the functions of VEGFA in fish glycolipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lei Xi
Summary: Ocular ischemia is a vision-threatening disease associated with various ocular diseases. This study investigated the effects of pigment epithelium derived factor (PEDF) and anti-vascular endothelial growth factor (anti-VEGF) therapy, as well as their combined use, on an ex vivo ischemic rat eye model. The results showed that the combination of PEDF and anti-VEGF significantly reduced the staining intensity of VEGF and GFAP, and decreased the number of TUNEL-positive nuclei, indicating its potential as a therapeutic strategy for ischemic retinal and choroidal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Akiyoshi Uemura, Yoko Fukushima
Summary: Rho GTPases, especially RhoJ, play essential roles in regulating cell migration and junctions in vascular endothelial cells, affecting vascular formation and permeability. RhoJ, enriched in angiogenic ECs, induces actin depolymerization by competing with Cdc42 for common effector proteins, thus influencing cytoskeletal rearrangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Elisabeth C. Kugler, John Greenwood, Ryan B. MacDonald
Summary: The neurovascular unit is a complex multi-cellular structure consisting of various cell types such as endothelial cells, neurons, glia, smooth muscle cells, and pericytes. While neurovascular coupling is a key function of the NVU, the unit's functionality extends beyond this coupling to include signaling, metabolism, and homeostasis across different components. Glial cells have gained increased attention within the NVU and play central roles in its functionality and disease pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Summary: While ascorbate supplementation did not protect against liver failure in TrxR1/Gsr-null livers, it unexpectedly increased the death rate. However, it was found that ascorbate treatment reduced basal DNA damage and oxidative stress markers despite depleting GSH in the stressed livers.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Pharmacology & Pharmacy
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: VEGF reduces PV arrhythmogenesis by modulating sodium/calcium homeostasis through VEGFR-1/NOS signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Biochemistry & Molecular Biology
Tami Livnat, Yehonatan Weinberger, Jose A. Fernandez, Alaa Bashir, Gil Ben-David, Dahlia Palevski, Sarina Levy-Mendelovich, Gili Kenet, Ivan Budnik, Yael Nisgav, John H. Griffin, Dov Weinberger
Summary: The study demonstrated that 3K3A-APC induced regression of pre-existing CNV and reduced VEGF levels, highlighting its potential as a novel treatment for CNV and other ocular pathologies. The results suggest that the anticoagulant properties of APC are not necessary for its activities in the retina, and that VEGF reduction may contribute to the protective effects of APC and 3K3A-APC.
Article
Neurosciences
Joseph M. Holden, Lauren K. Wareham, David J. Calkins
Summary: Astrocytes in the retina have been mischaracterized as stellate in morphology, underestimating their complexity and their role in neurovascular regulation. By analyzing the membranous morphology of over fifteen hundred individual astrocytes in the mouse retina, we found recurring morphological motifs that predict the underlying neurovascular architecture and suggest function. Our data also reveals a higher degree of astrocyte participation in neurovascular interactions than previously reported, with 100% of cells contacting the vasculature and neuronal elements.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Ersilia Lucenteforte, Marco Finocchietti, Antonio Addis, Mauro Tettamanti, Monica Varano, Mariacristina Parravano, Gianni Virgili
Summary: This study aimed to describe the polytherapy and multimorbidity pattern of patients receiving anti-VEGF and dexamethasone drugs for the treatment of retinal conditions. The results revealed that patients receiving intravitreal injections have a high prevalence of multimorbidity and polytherapy, leading to a significant burden of care.
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara Paradells-Navarro, Maria Soledad Benlloch-Navarro, Maria Inmaculada Almansa Frias, Ma Angeles Garcia-Esparza, Vania Broccoli, Maria Miranda, Jose Miguel Soria
ACS CHEMICAL NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Violeta Sanchez-Vallejo, Soledad Benlloch-Navarro, Laura Trachsel-Moncho, Rosa Lopez-Pedrajas, Inmaculada Almansa, Francisco Javier Romero, Maria Miranda
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Multidisciplinary Sciences
Luis Arribas, Inmaculada Almansa, Maria Miranda, Maria Muriach, Francisco J. Romero, Vincent M. Villar
Article
Pharmacology & Pharmacy
Salvador Merida, Maria Sancho-Tello, Inmaculada Almansa, Carmen Desco, Cristina Peris, Mari-Luz Moreno, Vincent M. Villar, Amparo Navea, Francisco Bosch-Morell
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Salvador Merida, Maria Sancho-Tello, Amparo Navea, Inmaculada Almansa, Maria Muriach, Francisco Bosch-Morell
Article
Biochemistry & Molecular Biology
Soledad Benlloch-Navarro, Laura Trachsel-Moncho, Angel Fernandez-Carbonell, Teresa Olivar, Jose Miguel Soria, Inmaculada Almansa, Maria Miranda
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Rosa Lopez-Pedrajas, Inmaculada Almansa, Maria V. Sanchez-Villarejo, Borja Muriach, Jorge M. Barcia, Francisco J. Romero, Maria Muriach
Summary: The study found that chronic cocaine administration impairs memory acquisition, increases GluN2B expression in the hippocampus, decreases NF-kappa B activity, and reduces expression of the active form of CREB, highlighting the roles of these transcription factors in cocaine-induced memory impairment.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Antolin Canto, Javier Martinez-Gonzalez, Maria Miranda, Teresa Olivar, Inma Almansa, Vicente Hernandez-Rabaza
Summary: Retinitis pigmentosa (RP) is a type of hereditary retinal disease, and inflammation is an important factor. This study found that sulforaphane (SFN) has anti-inflammatory properties and regulates retinal degeneration and inflammation in an RP mouse model. SFN may have neuroprotective effects in clinical settings.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antolin Canto, Javier Martinez-Gonzalez, Inmaculada Almansa, Rosa Lopez-Pedrajas, Vicente Hernandez-Rabaza, Teresa Olivar, Maria Miranda
Summary: The study found that in rds mice, the time sequence of oxidative stress and inflammation changes as follows: at PN11, there is a small increase in photoreceptor death and microglial cells; at PN17, damage to macromolecules is observed; at PN21, the maximum photoreceptor death rate is detected, along with an increase in GSH-GSSG and GFAP; at PN21, microglial cells are activated; and at PN28, there is a decrease in GSH synthesis enzymes. These findings contribute to understanding the pathophysiology of RP and suggest that oxidative stress and inflammation may be therapeutic targets in this disease.
Meeting Abstract
Ophthalmology
Maria Miranda, Antolin Canto, Javier Martinez, Vicente Hernandez-Rabaza, Teresa Olivar, Inmaculada Almansa
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Vicente Hernandez-Rabaza, Rosa Lopez-Pedrajas, Inmaculada Almansa
Meeting Abstract
Ophthalmology
Maria Miranda, Roberto Gimeno-Hernandez, Angel Fernandez-Carbonell, Teresa Olivar, Vicente Hernandez-Rabaza, Rosa Lopez-Pedrajas, Inmaculada Almansa
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Ophthalmology
M. Miranda, S. Benlloch-Navarro, L. C. Trachsel-Moncho, D. T. Ramirez, R. Lopez-Pedrajas, I. Almansa, D. Silvestre
ACTA OPHTHALMOLOGICA
(2015)
Article
Neurosciences
Rosa Lopez-Pedrajas, Dolores T. Ramirez-Lamelas, Borja Muriach, Maria V. Sanchez-Villarejo, Inmaculada Almansa, Lorena Vidal-Gil, Francisco J. Romero, Jorge M. Barcia, Maria Muriach
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)