Article
Medicine, General & Internal
Gerald W. Prager, Julien Taieb, Marwan Fakih, Fortunato Ciardiello, Eric Van Cutsem, Elena Elez, Felipe M. Cruz, Lucjan Wyrwicz, Daniil Stroyakovskiy, Zsuzsanna Papai, Pierre-Guillaume Poureau, Gabor Liposits, Chiara Cremolini, Igor Bondarenko, Dominik P. Modest, Karim A. Benhadji, Nadia Amellal, Catherine Leger, Loick Vidot, Josep Tabernero
Summary: In this study, researchers found that treatment with trifluridine-tipiracil plus bevacizumab could prolong overall survival in patients with metastatic colorectal cancer compared to trifluridine-tipiracil alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Nathalia D. de Moura Sperotto, Rodrigo Braccini Madeira Silva, Marcia Alberton Perello, Ana Flavia Borsoi, Adilio da Silva Dadda, Candida Deves Roth, Raquel Dal Sasso Freitas, Ana Paula Duarte de Souza, Deise do Nascimento de Freitas, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Debora Dreher Nabinger, Stefani Altenhofen, Carla Denise Bonan, Valnes S. Rodrigues-Junior, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Summary: The study investigated the effects of the hTP inhibitor CPBMF-223 in a xenograft tumor model induced by human colorectal carcinoma cells, showing significant inhibition of tumor growth, reduction in vessel number, and decrease in cell migration. Additionally, CPBMF-223 demonstrated a favorable toxicity profile and pharmacokinetic characteristics, highlighting its potential as a promising drug candidate for colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
I. Bijnsdorp, Godefridus J. Peters
Summary: The study found that resistance to rapamycin in TP-expressing cancer cells may be related to thymidine-mediated autophagy activation, and thymidine-induced mTOR signaling is correlated with TP expression levels.
CANCER DRUG RESISTANCE
(2021)
Article
Oncology
Hiroya Taniguchi, Kentaro Yamazaki, Toshiki Masuishi, Takeshi Kawakami, Yusuke Onozawa, Kazunori Honda, Shigenori Kadowaki, Yukiya Narita, Takahiro Tsushima, Satoshi Hamauchi, Akiko Todaka, Tomoya Yokota, Masashi Ando, Keita Mori, Hiromichi Shirasu, Hirofumi Yasui, Kei Muro
Summary: In this phase Ib study, trifluridine/tipiracil, irinotecan, and bevacizumab were tested in patients with metastatic colorectal cancer. The treatment showed moderate antitumor activity but had a high risk of severe myelotoxicity.
Article
Oncology
Muneyuki Koyama, Erika Osada, Nubutake Akiyama, Ken Eto, Yoshinobu Manome
Summary: This study indicates that demethylating agent alone does not enhance the cytotoxicity of 5-FU against colorectal cancer cells. To increase sensitivity to 5-FU, combination with adjuvant therapy focusing on metabolic pathways other than the TYMP pathway seems necessary.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Yosuke Kito, Hisato Kawakami, Seiichiro Mitani, Shinichi Nishina, Toshihiko Matsumoto, Takao Tsuzuki, Yudai Shinohara, Hozumi Shimokawa, Ryosuke Kumanishi, Takashi Ohta, Hiroo Katsuya, Takeshi Kawakami, Tomohiro Nishina, Hiroko Hasegawa, Kohei Akiyoshi, Yasutaka Chiba, Kentaro Yamazaki, Shuichi Hironaka, Kei Muro
Summary: The study evaluated the efficacy and safety of trifluridine/tipiracil plus bevacizumab for patients with previously treated metastatic colorectal cancer who were intolerant of intensive therapy.
Article
Biochemistry & Molecular Biology
Becka M. Warfield, Christopher J. Matheson, Debbie G. McArthur, Donald S. Backos, Philip Reigan
Summary: Studies have shown high levels of TP expression in glioblastoma, which can support tumor progression. Inhibiting TP can enhance the cytotoxicity of temozolomide, improving treatment efficacy.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Oncology
Shinnosuke Harata, Takuya Suzuki, Hiroki Takahashi, Takahisa Hirokawa, Akira Kato, Kaori Watanabe, Takeshi Yanagita, Hajime Ushigome, Kazuyoshi Shiga, Ryo Ogawa, Akira Mitsui, Masahiro Kimura, Yoichi Matsuo, Shuji Takiguchi
Summary: Combination therapy with ATR inhibitor AZD6738 and FTD enhanced the inhibition of tumor proliferation in vitro and in vivo, suggesting a potential treatment strategy for colorectal cancer.
Article
Oncology
B. Doleschal, H. Taghizadeh, T. Lentner, J. M. Riedl, J. Granitzer, D. Morariu, J. Decker, K. J. Aichberger, G. Webersinke, P. Kirchweger, A. Petzer, H. Rumpold
Summary: This study aimed to investigate the efficacy of trifluridine/tipiracil (FTD/TPI) + bevacizumab in metastatic colorectal cancer (mCRC) based on RAS mutational status. The results showed that the efficacy of FTD/TPI + bevacizumab was independent of RAS mutational status.
Review
Oncology
Shiekhah M. Alzahrani, Huda A. Al Doghaither, Ayat B. Al-Ghafari, Peter N. Pushparaj
Summary: Although 5-FU-based chemotherapy is widely used for colorectal cancer, it has limitations. Capecitabine, a prodrug of 5-FU, was developed to overcome these drawbacks and achieve more convenient therapy. This review compares the properties and efficacy of 5-FU therapy and capecitabine therapy, including drug metabolism, cellular mechanisms, safety, and tolerability. Future research should explore the combination of capecitabine with novel drugs to inhibit tumor initiation, progression, and metastasis.
Article
Oncology
Mamoru Nukatsuka, Akio Fujioka, Hideki Nagase, Gotaro Tanaka, Hiroaki Hayashi
Summary: In this study, the antitumor activity of combination therapy with FTD/TPI and fruquintinib in colorectal cancer was evaluated. The results showed that the combined treatment had significantly better activity than monotherapy, and no greater than 20% body weight loss was observed.
Article
Oncology
Donia Kaidi, Louis Szeponik, Ulf Yrlid, Yvonne Wettergren, Elinor Bexe Lindskog
Summary: This study found that high TYMP expression in tumor epithelial cells is associated with shorter relapse-free survival in stage II CRC patients. Tissue microdissection is important for accurate analysis. Further research is needed to explore the clinical relevance of TYMP and CD163 in identifying high-risk stage II patients who may benefit from adjuvant chemotherapy.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Y. Kagawa, E. Shinozaki, R. Okude, T. Tone, Y. Kunitomi, M. Nakashima
Summary: This study evaluated the efficacy and safety of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) in refractory metastatic colorectal cancer (mCRC) compared to FTD/TPI or regorafenib (REG) monotherapy. The real-world data showed that FTD/TPI+BEV was associated with longer overall survival (OS) and time to treatment discontinuation (TTD) compared to FTD/TPI or REG. This suggests that FTD/TPI+BEV could be a favorable regimen for refractory mCRC in clinical practice.
Article
Polymer Science
Elisa Sturabotti, Vyali Georgian Moldoveanu, Alessandro Camilli, Andrea Martinelli, Giovanna Simonetti, Alessio Valletta, Ilaria Serangeli, Alessandro Giustini, Elena Miranda, Luisa Maria Migneco, Fabrizio Vetica, Francesca Leonelli
Summary: Hyaluronic acid (HA) is a natural biopolymer used in medicine, but it can promote microbial growth. Thymol (Thy) is a phenolic compound with antimycotic properties but has low water solubility and moderate cytotoxicity. The HA-Thy conjugate combines the benefits of both components to reduce cytotoxicity and show promising antibiofilm activity against Candida albicans, making it a potential preservative biomaterial.
Article
Oncology
Daisaku Kamiimabeppu, Hiroki Osumi, Eiji Shinozaki, Akira Ooki, Takeru Wakatsuki, Koichiro Yoshino, Taro Sato, Izuma Nakayama, Mariko Ogura, Daisuke Takahari, Keisho Chin, Kensei Yamaguchi
Summary: This study investigated the clinical outcomes of trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer and found that grade 3 or 4 chemotherapy-induced neutropenia in the first cycle of treatment is an early predictor of efficacy, associated with longer progression-free survival and higher disease control rate. Multivariate analysis revealed that this neutropenia is an independent predictor for longer progression-free survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuke Nishimuta, Daisuke Tsurumaru, Satohiro Kai, Junki Maehara, Yoshiki Asayama, Eiji Oki, Kousei Ishigami
Summary: This study aims to assess the correlation between histopathological features of gastric cancer and the extracellular volume fraction (ECV) measured by preoperative equilibrium contrast-enhanced computed tomography (CECT). The results showed that the values of venous invasion and tumor infiltration pattern were significantly correlated with tumor ECV. Linear regression and receiver operating characteristic (ROC) curve analyses further confirmed the correlation between tumor ECV and pathological infiltration. The tumor ECV demonstrated high diagnostic accuracy for predicting infiltration.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Oncology
Claire Gallois, Qian Shi, Jeffrey P. Meyers, Timothy Iveson, Steven R. Alberts, Aimery de Gramont, Alberto F. Sobrero, Daniel G. Haller, Eiji Oki, Anthony Frank Shields, Richard M. Goldberg, Rachel Kerr, Sara Lonardi, Greg Yothers, Caroline Kelly, Ioannis Boukovinas, Roberto Labianca, Frank A. Sinicrope, Ioannis Souglakos, Takayuki Yoshino, Jeffrey A. Meyerhardt, Thierry Andre, Demetris Papamichael, Julien Taieb
Summary: Whether early discontinuation of all treatment or early discontinuation of oxaliplatin could worsen the prognosis in patients with stage III CC remains unknown.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Eiji Shinto, Eiji Oki, Mototsugu Shimokawa, Shigeki Yamaguchi, Megumi Ishiguro, Seiji Hasegawa, Yasumasa Takii, Hideyuki Ishida, Tetsuya Kusumoto, Masaru Morita, Naohiro Tomita, Manabu Shiozawa, Masafumi Tanaka, Heita Ozawa, Yojiro Hashiguchi, Shinobu Ohnuma, Sachiyo Tada, Tomoko Matsushima, Keisuke Yamagishi, Kazuo Hase
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Eiji Shinto, Eiji Oki, Mototsugu Shimokawa, Shigeki Yamaguchi, Megumi Ishiguro, Seiji Hasegawa, Yasumasa Takii, Hideyuki Ishida, Tetsuya Kusumoto, Masaru Morita, Naohiro Tomita, Manabu Shiozawa, Masafumi Tanaka, Heita Ozawa, Yojiro Hashiguchi, Shinobu Ohnuma, Sachiyo Tada, Tomoko Matsushima, Keisuke Yamagishi, Kazuo Hase
Summary: This study confirmed the predictive power of the MBS for recurrence risk in stage II/III CC patients by using FFPE materials. The MBS-low group demonstrated better relapse-free survival compared with the MBS-high group, and the MBS score was found to be an independent prognostic factor.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Sachie Omori, Tomoko Shigechi, Kana Kawaguchi, Hideki Ijichi, Eiji Oki, Tomoharu Yoshizumi
Summary: TLS in solid tumors is a life-threatening condition that can be complicated by DIC. Early recognition and treatment of patients at risk of TLS is crucial to prevent fatal situations. This case report and literature review focuses on identifying the distinctive features and hazards of TLS in breast cancer.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Yasutoshi Kuboki, Tetsuji Terazawa, Toshiki Masuishi, Masato Nakamura, Jun Watanabe, Hitoshi Ojima, Akitaka Makiyama, Masahito Kotaka, Hiroki Hara, Yoshinori Kagawa, Naotoshi Sugimoto, Hisato Kawakami, Atsuo Takashima, Takeshi Kajiwara, Eiji Oki, Yu Sunakawa, Soichiro Ishihara, Hiroya Taniguchi, Takako Eguchi Nakajima, Satoshi Morita, Kuniaki Shirao, Naruhito Takenaka, Daisuke Ozawa, Takayuki Yoshino
Summary: This study assessed the noninferiority of trifluridine/tipiracil (FTD/TPI) plus bevacizumab as second-line treatment for metastatic colorectal cancer (mCRC) compared to fluoropyrimidine and irinotecan plus bevacizumab. The results showed that FTD/TPI plus bevacizumab did not demonstrate superiority over the control group in mCRC second-line treatment.
BRITISH JOURNAL OF CANCER
(2023)
Article
Surgery
Eiji Oki, Mitsuhiko Ota, Tomonori Nakanoko, Yasushi Tanaka, Satoshi Toyota, Qingjiang Hu, Yu Nakaji, Ryota Nakanishi, Koji Ando, Yasue Kimura, Yuichi Hisamatsu, Koshi Mimori, Yoshiya Takahashi, Hajime Morohashi, Takahiro Kanno, Kotaro Tadano, Kenji Kawashima, Hironobu Takano, Yuma Ebihara, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto, Tomoharu Yoshizumi, Kenichi Hakamada, Satoshi Hirano, Masaki Mori
Summary: This study describes the first application of a double-surgeon cockpit system to telesurgery. Non-specialized surgeons were able to safely perform cholecystectomy and renal vein ligation with remote assistance using the system, and the system also received higher technical scores compared to telesurgery performed by specialized surgeons.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Kentaro Yamazaki, Satoshi Yuki, Eiji Oki, Fumikazu Sano, Misako Makishima, Kenichi Aoki, Tetsutaro Hamano, Kouji Yamamoto
Summary: In this study, the baseline characteristics and efficacies of intensive and less intensive therapies for metastatic colorectal cancer were compared. Patient age and daily activity levels were found to be important factors in determining treatment intensity.
Article
Surgery
Mitsuhiko Ota, Eiji Oki, Tomonori Nakanoko, Yasushi Tanaka, Satoshi Toyota, Qingjiang Hu, Yu Nakaji, Ryota Nakanishi, Koji Ando, Yasue Kimura, Yuichi Hisamatsu, Koshi Mimori, Yoshiya Takahashi, Hajime Morohashi, Takahiro Kanno, Kotaro Tadano, Kenji Kawashima, Hironobu Takano, Yuma Ebihara, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto, Tomoharu Yoshizumi, Kenichi Hakamada, Satoshi Hirano, Masaki Mori
Summary: The study aimed to validate the effectiveness of haptic feedback in telesurgery and enhance the safety of telerobotic surgery.
Article
Oncology
Tomonori Nakanoko, Yasue Kimura, Keita Natsugoe, Kentaro Nonaka, Sho Nambara, Qingjiang Hu, Ryota Nakanishi, Mitsuhiko Ota, Eiji Oki, Tomoharu Yoshizumi
Summary: Due to the interference of the robotic arm, the dissection of the left recurrent nerve lymph nodes during robotic surgery is difficult. In this study, we developed a method of LRLN dissection with natural space creation and evaluated its short-term results.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Akio Kawabata, Bijoy Chand Chatterjee, Eiji Oki
Summary: This paper proposes a multi-homing network design model named MHND, which balances low delay and high availability for distributed processing applications. MHND maintains event occurrence order using conservative synchronization and formulates an integer linear programming problem to minimize delay. Numerical results show that increasing the number of multi-homing servers improves availability but also increases delay. Two or more multi-homing can achieve approximately 10 times higher availability compared to single-homing at the cost of a 1.25 times delay increase. MHND enables flexible network design based on required availability and acceptable delay.
2023 IEEE 20TH CONSUMER COMMUNICATIONS & NETWORKING CONFERENCE, CCNC
(2023)
Article
Biochemistry & Molecular Biology
Eiji Oki, Takayuki Yoshino
Summary: The ongoing CIRCULATE-Japan trial is investigating the role of ctDNA-based molecular residual disease testing in patients with resectable colorectal cancer after surgery. An interim analysis of GALAXY, a prospective observational arm, confirms ctDNA as a prognostic and predictive biomarker.
Article
Surgery
Yuma Ebihara, Satoshi Hirano, Hironobu Takano, Takahiro Kanno, Kenji Kawashima, Hajime Morohashi, Eiji Oki, Kenichi Hakamada, Shigeo Urushidani, Masaki Mori
Summary: This study evaluated the performance of robotic tele-cholecystectomy using the Saroa(TM) system. The results showed that there was no significant difference in completion time, technical assessment, and fatigue between tele-cholecystectomy and local surgery, but the total path length of the forceps was longer in tele-cholecystectomy.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Surgery
Tomonori Nakanoko, Eiji Oki, Mitsuhiko Ota, Naoki Ikenaga, Yuichi Hisamatsu, Takeo Toshima, Takahiro Kanno, Kotaro Tadano, Kenji Kawashima, Kenoki Ohuchida, Hajime Morohashi, Yuma Ebihara, Koshi Mimori, Masafumi Nakamura, Tomoharu Yoshizumi, Kenichi Hakamada, Satoshi Hirano, Norihiko Ikeda, Masaki Mori
Summary: In this study, the usefulness of telementoring using 3D drawing annotations in robotic surgery was examined. The results showed that the 3D annotation group had a shorter working time, fewer retries, and higher scores on the evaluation of robot skills compared to the control group.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Yuho Ebata, Yasue Kimura, Kentaro Nonaka, Sho Nambara, Qingjiang Hu, Ryota Nakanishi, Tomonori Nakanoko, Mitsuhiko Ota, Eiji Oki, Tomoharu Yoshizumi
Summary: Esophagectomy is a valuable option for treating esophageal strictures in patients with SSc. Therefore, surgical approaches should be established for SSc patients.
SURGICAL CASE REPORTS
(2023)