Article
Immunology
Rehab M. El-Sayed, Mohamed N. Fawzy, Hala F. Zaki, Enas A. Abd El-Haleim
Summary: Recurrent seizures are a hallmark of epilepsy, a complex neurological disorder. This study investigated the potential anti-epileptic effects of biochanin A in a PTZ-induced kindling model in mice. The results showed that biochanin A pretreatment significantly reduced the severity of epileptogenesis, downregulated histological changes in the hippocampus, and exhibited antioxidant and anti-inflammatory properties. Biochanin A also suppressed neuronal damage and attenuated PTZ-induced activation of astrocytes. Molecular docking findings suggested that biochanin A may have neuroprotective and anti-epileptic characteristics by interacting with specific proteins involved in neuronal signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Bo Hui, Yantao Shu, Dandan Yang, Zhidong Wang, Li Zhang, Nina Lei, Zhengan Yang
Summary: In this study, the impact of sinomenine (SIN) on hepatic ischemia-reperfusion (IR) injury and the related signaling pathway was investigated. The results showed that SIN pretreatment significantly prevented IR-induced liver injury, including decreased levels of liver enzymes, reduced oxidative stress, suppressed inflammatory responses, and attenuated apoptosis. The histopathological changes in the livers of IR rats were also alleviated by SIN pretreatment, and Nrf-2/HO-1 activation was induced. The use of a selective inhibitor for Nrf-2 effectively reversed the effects induced by SIN. These findings suggest that SIN may be a useful therapeutic drug for preventing hepatic IR-induced injury during clinical liver transplantation.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Immunology
Xiaodan Guan, Liang Jin, Daojun Yu, Yu He, Yida Bao, Huifen Zhou, Haitong Wan
Summary: This study found that glycyrrhetinic acid (GA) can protect pulmonary epithelial cells from CRKP-induced damage by regulating mitochondrial damage and antioxidative stress.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Manisha J. Oza, Yogesh A. Kulkarni
Summary: This study found that Biochanin A may reduce myocardial structure abnormalities in patients with type 2 diabetic cardiomyopathy and decrease the morbidity rate of heart diseases. Oral administration of Biochanin A can lower hyperglycemia, hyperlipidemia, and oxidative stress in cardiac tissue, and improve cardiac function parameters. Furthermore, Biochanin A can stimulate the expression of SIRT1 in cardiac tissue, thereby reducing cardiac hypertrophy and providing cardiac protection.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Mustafa Cellat, Cafer Tayer Isler, Ahmet Uyar, Muslum Kuzu, Tuba Aydin, Muhammed Etyemez, Erdinc Turk, Ilker Yavas, Mehmet Guvenc
Summary: The protective effects of ethanol extract of Smilax excelsa L. leaves on testicular tissue of rats with a torsion model were investigated. The extract improved sperm quality, oxidative stress, and inflammation markers, and activated the Nrf-2/HO-1 pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Zunaira Syed, Bushra Shal, Aqsa Azhar, Safa Amanat, Adnan Khan, Hussain Ali, Yun-Seo Kil, Eun Kyoung Seo, Salman Khan
Summary: The present study investigated the effect of xanthoangelol on Alzheimer's disease (AD). Xanthoangelol showed neuroprotective effects and reduced the symptoms of AD by improving signaling pathways, activating antioxidants, attenuating apoptotic pathways, and reducing neuroinflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Tong Jin, Cheng Chen
Summary: The findings suggest that umbelliferone has a protective effect on diabetic nephropathy by activating the Nrf2/HO-1 pathway and attenuating high glucose-induced ferroptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Vadivukkarasi Sasikumar, Ganapathy Saravanan
Summary: This study demonstrated that the polyherbal formulation (PHF) successfully attenuated inflammation and oxidative stress in diabetic cardiomyopathy rats by regulating the NF-kappa B/Nrf-2/HO-1 pathway. The results suggest that PHF may be a potential therapeutic agent for DCM.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Vadivukkarasi Sasikumar, Ganapathy Saravanan
Summary: The study demonstrates that the polyherbal formulation successfully alleviates inflammation and oxidative stress in DCM rats by regulating the NF-κB/Nrf-2/HO-1 pathway and protecting against cardiac damage. Therefore, PHF may be a prospective therapeutic agent for DCM.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Qiang Li, Qifei Xu, Jun Tan, Linfeng Hu, Chenxu Ge, Minxuan Xu
Summary: Carminic acid (CA) significantly reduced inflammation and oxidative stress in the kidneys by regulating NF- κ B and Nrf-2 signaling pathways, alleviating the progression of chronic kidney injury induced by excessive fructose (Fru).
Review
Medicine, Research & Experimental
Seyyedeh Mina Hejazian, Seyed Mahdi Hosseiniyan Khatibi, Abolfazl Barzegari, Graciela Pavon-Djavid, Saiedeh Razi Soofiyani, Sina Hassannejhad, Elham Ahmadian, Mohammadreza Ardalan, Sepideh Zununi Vahed
Summary: Nrf-2 plays a crucial protective role in the kidneys, helping to alleviate acute kidney injury triggered by inflammation and oxidative stress. Understanding the molecular mechanisms of AKI is essential for balancing renal adaptation and dysfunction, reducing disease progression.
Article
Biochemistry & Molecular Biology
Yiyang Wang, Jia Liao, Yuanliang Luo, Mengsi Li, Xingyu Su, Bo Yu, Jiashuo Teng, Huadong Wang, Xiuxiu Lv
Summary: This study aimed to determine the therapeutic effect of berberine (Ber) on DOX-induced cardiomyopathy and explore the underlying mechanism. The results showed that Ber effectively prevented cardiac dysfunction and fibrosis, reduced oxidative stress, and restored mitochondrial function in DOX-treated rats and cells. The protective effect of Ber was mediated by the activation of the Nrf2 pathway. These findings suggest that Ber is a potential therapeutic agent for DOX-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Soudabeh Balarastaghi, Samira Barangi, Hossein Hosseinzadeh, Mohsen Imenshahidi, Zahra Moosavi, Bibi Marjan Razavi, Gholamreza Karimi
Summary: Arsenic is a heavy metal that can cause vascular toxicity. Melatonin, a hormone, has been shown to have protective effects against oxidative stress and apoptosis, as well as modulating autophagy. This study found that melatonin can protect against arsenic-induced vascular toxicity by inhibiting apoptosis and regulating the Sirt1/autophagy pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Pengzhan Zhao, Yutian Wei, Guangchi Sun, Lei Xu, Tian Wang, Yufei Tian, Honglu Chao, Yiming Tu, Jing Ji
Summary: The study found that Fetuin-A can attenuate the abnormal inflammatory response following traumatic brain injury (TBI) by activating the Nrf-2/HO-1 pathway, suppressing oxidative stress and necroptosis levels. This provides a potential therapeutic strategy for TBI treatment.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Lei Li, Shu-Qi Cheng, Wei Guo, Zhen-Yu Cai, Yu-Qin Sun, Xin-Xin Huang, Jin Yang, Juan Ji, Ya-Yun Chen, Yin-Feng Dong, Hong Cheng, Xiu-Lan Sun
Summary: Oridonin, a natural compound extracted from a Chinese herb, has been shown to protect against oxidative stress-induced endothelial injury by promoting nuclear translocation of Nrf-2. It repairs the blood-brain barrier and reduces infarct volume in ischemic stroke mice by activating signaling pathways. These findings suggest the potential therapeutic effect of oridonin in ischemic stroke treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Ravindarnaik Ramavat, Suresh Pothani, S. Vadivukkarasi, P. Ponmurugan, P. Chandrasekaran, Saravanan Ganapathy
Summary: The study evaluated the ameliorative effect of SAC on diabetic nephropathy and found that SAC can protect the kidney by regulating the MEK1/2-ERK1/2-RSK2 signaling pathway.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sangeethadevi Govindasami, V. V. Sathibabu Uddandrao, Jansy Isabella Rani Antony Rathinasamy, Saravanan Ganapathy, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Sengottuvelu Singaravel, Vadivukkarasi Sasikumar
Summary: The study showed that Biochanin-A could significantly improve lipid metabolic abnormalities and reduce inflammation in isoproterenol-induced myocardial infarction in rats. By inhibiting the expressions of proinflammatory cytokines and matrix metalloproteinases, BCA has a positive effect on the pathological processes of myocardial infarction.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Chandrasekaran Ponnusamy, Vadivukkarasi Sasikumar, Ganapathy Saravanan
Summary: This study demonstrated that the polyherbal formulation (PHF) successfully attenuated inflammation and oxidative stress in diabetic cardiomyopathy rats by regulating the NF-kappa B/Nrf-2/HO-1 pathway. The results suggest that PHF may be a potential therapeutic agent for DCM.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seshathri Eraniappan, Prathap Balasubramaniyan, V. V. Sathibabu Uddandrao, Anitha Roy, Sengottuvelu Singaravel
Summary: The study examined the therapeutic potential of beta-glucan (BG) found in mushrooms and cereals against high-fat-diet-induced obesity. Rats were fed a high-fat diet with BG supplementation for 6 weeks, resulting in reduced body weight gain and improved hyperglycemia. BG also mitigated dyslipidemia by regulating the expressions of key markers associated with obesity. The study concluded that BG is a potential candidate for treating high-fat-diet-induced obesity by modulating obesogenic marker expressions, specifically the master regulator PPAR-gamma.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Tamilmani Periyasamy, V. V. Sathibabu Uddandrao, Chandrasekaran Ponnusamy, Saravanan Ganapathy, Sethumathi Ponnusamy Pudhupalayam, Sengottuvelu Singaravel, Ponmurugan Ponnusamy, Jagadeesan Ramasamy, Kalaivani Aiyasamy, Vadivukkarasi Sasikumar
Summary: Linalool may prevent high-fat diet-induced non-alcoholic fatty liver disease by regulating the intestinal-hepatic axis, alleviating insulin resistance, and anomalies in lipid homeostasis.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Gastroenterology & Hepatology
P. Tamilmani, V. V. Sathibabu Uddandrao, P. Chandrasekaran, G. Saravanan, Parim Brahma Naidu, S. Sengottuvelu, S. Vadivukkarasi
Summary: In a high-fat diet-induced liver disease with lipid accumulation, linalool attenuates lipid accumulation in the liver by inhibiting de novo lipogenesis, promoting fatty acid oxidation, and attenuating oxidative stress through regulating the Sirt1/Akt/PPRA-alpha/AMPK and Nrf-2/HO-1 signaling pathways.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Chemistry, Medicinal
Sethumathi Ponnusamy Pudhupalayam, V. V. Sathibabu Uddandrao, Chandrasekaran Ponnusamy, Sengottuvelu Singaravel, Tamilmani Periyasamy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar, Mustapha Shabana Begum, Saravanan Ganapathy
Summary: This study evaluated the antihyperglycemic effects of biochanin A in a high-fat diet-streptozotocin-induced type 2 diabetes rat model. The results showed that biochanin A significantly reduced glucose levels, insulin resistance, hemoglobin levels, and the activity of certain enzymes, while increasing the activity of hexokinase and glycogen synthase and hepatic levels of glycogen in hyperglycemic rats.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)