Article
Nanoscience & Nanotechnology
Jia Ouyang, Yu Jiang, Chao Deng, Zhiyuan Zhong, Qing Lan
Summary: The study demonstrated that doxorubicin hydrochloride loaded in ApoE peptide-functionalized reduction-sensitive polymersomes induces potent and safe chemotherapy of orthotopic U-87 MG model in nude mice, effectively inhibiting glioblastoma invasion with minimal side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Meng Zheng, Qiuli Du, Xin Wang, Yuan Zhou, Jia Li, Xue Xia, Yiqing Lu, Jinlong Yin, Yan Zou, Jong Bae Park, Bingyang Shi
Summary: The study found that nanoformulations with different elasticity exhibit different effects in targeting brain tumors, with stiff polymersomes showing better performance in brain tumor cell uptake and penetration. However, stiff polymersomes have a relatively shorter blood circulation time, which together affect their in vivo performance.
Article
Nanoscience & Nanotechnology
Chen He, Huiyan Ding, Jing Chen, Yinan Ding, Rui Yang, Chunmei Hu, Yanli An, Dongfang Liu, Peidang Liu, Qiusha Tang, Zhiyuan Zhang
Summary: The novel pH-sensitive cargo-loaded polymersomes have been shown to effectively induce immunogenic cell death and synergize with radiotherapy, holding potential significance for cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Zhiming Zhang, Chenlu Huang, Li Zhang, Qing Guo, Yu Qin, Fan Fan, Boxuan Li, Bao Xiao, Dunwan Zhu, Linhua Zhang
Summary: The study developed a novel drug delivery system using multifunctional nanoparticles loaded with chemotherapeutic agent and photosensitizer for tumor combination therapy. The nanoparticles showed high targeting efficacy, pH-dependent drug release, and significant photothermal and photodynamic effects, providing a promising system for combination therapy.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Elena Kunadis, Eleftheria Lakiotaki, Penelope Korkolopoulou, Christina Piperi
Summary: Glioblastoma is the most common primary brain tumor in adults, characterized by variable histopathology, aggressiveness, and poor clinical outcomes. Epigenetic modifications play a crucial role in GBM research, providing a potential for tumor classification and prognosis, as well as for drug targeting. Recent advances in glioma epigenetic research focus on histone modifications and the use of epigenetic therapy as a valid treatment option for glioblastoma.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Leonardo Delello Di Filippo, Juliana Hofstatter Azambuja, Jessyca Aparecida Paes Dutra, Marcela Tavares Luiz, Jonatas Lobato Duarte, Luiza Ribeiro Nicoleti, Sara Teresinha Olalla Saad, Marlus Chorilli
Summary: Glioblastoma multiforme (GBM) is the most common primary brain cancer with aggressive development and increasing resistance to drugs like temozolomide (TMZ). Functionalized nanocarriers can serve as an efficient and safe strategy for delivering TMZ, improving its biopharmaceutical properties and potentially repurposing its use in anti-GBM therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Ling-Xiao Zhao, Zhi-Qiang Gong, Qi Zhang, Da-Long He, Ri-Le Ge, Jin Meng, Hang Ren, Yong-Gang Fan, Zhan-You Wang
Summary: Glioblastoma, a highly malignant tumor, can be treated by inducing ferroptosis using graphdiyne-based nanoplatforms. These nanoplatforms can penetrate the blood-brain barrier and release the therapeutic drug in the tumor tissue, leading to inhibition of tumor growth and prolonged survival.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, General & Internal
Jeremy Ariey-Bonnet, Raphael Berges, Marie-Pierre Montero, Baptiste Mouysset, Patricia Piris, Kevin Muller, Guillaume Pinna, Tim W. Failes, Greg M. Arndt, Philippe Morando, Nathalie Baeza-Kallee, Carole Colin, Olivier Chinot, Diane Braguer, Xavier Morelli, Nicolas Andre, Manon Carre, Emeline Tabouret, Dominique Figarella-Branger, Marion Le Grand, Eddy Pasquier
Summary: This study identified targetable vulnerabilities in glioblastoma using high-throughput screening, target deconvolution, and functional genomics. They validated the role of the top gene hit and discovered pharmacological synergisms through drug combination screens. The efficacy of the AURKA/BET inhibitor combination in glioblastoma was confirmed in pre-clinical models.
Article
Chemistry, Multidisciplinary
Babak Mamnoon, Li Feng, Jamie Froberg, Yongki Choi, Venkatachalem Sathish, Oleh Taratula, Olena Taratula, Sanku Mallik
Summary: Endoxifen is conjugated to polymeric nanoparticles for targeted delivery of doxorubicin to estrogen receptor-positive breast cancer cells. The developed polymersomes are hypoxia-responsive and demonstrate increased cytotoxicity and cell viability when compared to non-targeted counterparts. The use of endoxifen ligands in this novel nanoparticle design shows translational potential for ER+ breast cancer treatment.
Article
Pharmacology & Pharmacy
Guanxing Sun, Kai Sun, Jie Sun
Summary: A drug delivery system for the co-delivery of DOX and TAN to prostate cancer cells was constructed, showing the advantages of combining the two drugs in one system for better inhibition of tumor growth. The novel nanomedicine offers great promise for synergistic combination therapy for prostate cancer.
Article
Medicine, Research & Experimental
Ting Su, Shurong Zhou, Suling Yang, Nicholas Humble, Fuwu Zhang, Guocan Yu, Paula D. Bos, Furong Cheng, Kristoffer Valerie, Guizhi Zhu
Summary: This study reports a radioimmunotherapy for adult brain cancer that combines radiotherapy, immune checkpoint blockade, and lymph-node-targeting vaccines. The vaccines induced anti-cancer immune responses in mice and enhanced therapeutic efficacy in orthotopic brain cancer mice. However, radioimmunotherapy only showed a trend towards improved efficacy compared to radiotherapy alone.
Review
Medicine, Research & Experimental
Jason Miska, Navdeep S. Chandel
Summary: Glioblastoma (GBM) is a highly lethal brain tumor that is resistant to conventional therapies. Recent research has focused on understanding the metabolic processes involved in GBM, particularly fatty acid (FA) metabolism. These processes can be classified into four broad fates: synthesis, degradation, regulation of ferroptosis, and generation of signaling molecules. This Review provides insights into each of these fates and highlights the need for further understanding and untangling of the complex FA metabolism in GBM.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Physical
Eunyoung Park, Donghyun Lee, Yeeun Lee, Eunjin Jeong, Sehee Kim, Heebeom Koo
Summary: The study prepared pH-sensitive liposomes for successful combination therapy with high drug accumulation in tumor tissue and simultaneous attack on nucleus and cytosol through a double hit strategy. Effective tumor suppression in a mouse model demonstrated the synergistic effect of combination therapy enabled by the pH-lipo-Dox-Pba.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Oncology
Michael P. Castro, Bence Sipos, Saskia Biskup, Nina Kahn
Summary: The identification of a disease network characterized by multiple disease-specific synthetic lethal vulnerabilities involving DNA repair, REDOX homeostasis, and impaired autophagy provides a potential novel network-targeting combination therapy for relapsed leptomeningeal glioblastoma.
FRONTIERS IN ONCOLOGY
(2023)
Review
Neurosciences
Imran Khan, Sadaf Mahfooz, Elif Burce Elbasan, Busra Karacam, Mustafa Namik Oztanir, Mustafa Aziz Hatiboglu
Summary: Glioblastoma is one of the most deadly and aggressive cancers in the adult central nervous system, and current treatment approaches are limited in effectiveness. Therefore, novel strategies such as molecular therapies, immunotherapies, and nanotechnology are needed to improve patient outcomes.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Gang Jia, Yong Han, Yanli An, Yinan Ding, Chen He, Xihui Wang, Qiusha Tang
Article
Biotechnology & Applied Microbiology
Yinan Ding, Rui Yang, Weiping Yu, Chunmei Hu, Zhiyuan Zhang, Dongfang Liu, Yanli An, Xihui Wang, Chen He, Peidang Liu, Qiusha Tang, Daozhen Chen
Summary: A CO-coated liposome was designed for TNBC therapy, showing good biocompatibility and targeting capability in vitro and better fluorescence imaging capability in vivo. Liposomes loaded with HPPH and TH302 exhibited significantly better antitumor effects in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chen He, Huiyan Ding, Jing Chen, Yinan Ding, Rui Yang, Chunmei Hu, Yanli An, Dongfang Liu, Peidang Liu, Qiusha Tang, Zhiyuan Zhang
Summary: The novel pH-sensitive cargo-loaded polymersomes have been shown to effectively induce immunogenic cell death and synergize with radiotherapy, holding potential significance for cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Yinan Ding, Luhong Wang, Han Li, Fengqin Miao, Zhiyuan Zhang, Chunmei Hu, Weiping Yu, Qiusha Tang, Guoliang Shao
Summary: Immunotherapy has emerged as a promising anticancer therapy, with the ability to activate immune cells, regulate the tumor immune microenvironment, and deliver drugs. Lipid nanovesicles as a drug delivery system have important applications in cancer immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yi-Nan Ding, Ming Xue, Qiu-Sha Tang, Li-Jun Wang, Hui-Yan Ding, Han Li, Cheng-Cheng Gao, Wei-Ping Yu
Summary: Gastrointestinal cancer, with a poor prognosis, is commonly treated with surgery. However, the high rate of postoperative recurrence and low five-year survival rate have led to the exploration of immunotherapy and nanodrug delivery systems. Challenges include low immunogenicity and immunosuppressive microenvironment. The review summarizes recent advances in immunotherapy-based nanoparticles for gastrointestinal cancers and discusses existing challenges and future trends.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chen He, Huiyan Ding, Lubo Li, Jing Chen, Xiaofei Mo, Yinan Ding, Wenjing Chen, Qiusha Tang, Yuetao Wang
Summary: The combination of gold nanoparticles (AuNPs) with radiation therapy (RT) can enhance radiation-induced immunogenic cell death (ICD) in glioblastoma cells. AuNPs and RT treatment resulted in the release of crucial damage-associated molecular patterns (DAMPs) such as CRT, HMGB1, and ATP. Additionally, AuNPs and RT treatment promoted the maturation of bone marrow-derived dendritic cells (BMDCs). In a tumor prophylactic vaccination model, dying tumor cells treated with AuNPs and RT effectively inhibited the growth of living tumor cells in mice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Han Li, Yinan Ding, Jiayan Huang, Yanyan Zhao, Wei Chen, Qiusha Tang, Yanli An, Rong Chen, Chunmei Hu
Summary: In this study, we loaded rifampin (RIF) into exosomes and modified the exosomes with a brain-targeting peptide to improve the blood-brain barrier (BBB) permeability. The results showed that the modified exosomes exhibited high targeting capacity and permeability in vitro and in vivo, and had high anti-tuberculosis activity and biocompatibility, providing hope for an effective treatment of CNS-TB.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Luhong Wang, Yinan Ding, Chuanyong Zhang, Rong Chen
Summary: This study reveals the molecular link between COVID-19 and HCC and proposes potential drugs for HCC patients with COVID-19, providing clinicians with novel therapeutic ideas.