Overcoming Challenges to Make Bacteriophage Therapy Standard Clinical Treatment Practice for Cystic Fibrosis

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

(2020) Matthias I. Gröschel et al.   Nature Communications

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

(2020) Fadi Soukarieh et al.   Frontiers in Chemistry

Phage Therapy in the Year 2035

(2020) Jean-Paul Pirnay   Frontiers in Microbiology

Identification and Characterization of New Bacteriophages to Control Multidrug-Resistant Pseudomonas aeruginosa Biofilm on Endotracheal Tubes

(2020) Viviane C. Oliveira et al.   Frontiers in Microbiology

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

(2019) Thaysa Leite Tagliaferri et al.   Frontiers in Cellular and Infection Microbiology

CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses

(2019) Audrey Bernut et al.   Cell Reports

Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study

(2019) Martin Wallin et al.   BMC Pulmonary Medicine

Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model

(2019) Marco Cafora et al.   Scientific Reports

Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

(2019) Nancy Law et al.   INFECTION

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Safety and Tolerability of Bacteriophage Therapy for Chronic Rhinosinusitis Due to Staphylococcus aureus

(2019) Mian Li Ooi et al.   JAMA Otolaryngology-Head & Neck Surgery

Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure

(2019) Rosanna C. T. Wright et al.   mBio

Antibiotic efficacy varies based on the infection model and treatment regimen for Pseudomonas aeruginosa

(2019) Cristina Cigana et al.   EUROPEAN RESPIRATORY JOURNAL

Phage therapy for severe bacterial infections: a narrative review

(2019) Aleksandra Petrovic Fabijan et al.   MEDICAL JOURNAL OF AUSTRALIA

Transplanting organs from pigs to humans

(2019) Megan Sykes et al.   Science Immunology

Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells

(2018) Alysia G. Buckley et al.   BIOLOGICAL PROCEDURES ONLINE

Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma

(2018) K. Looi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Phage Therapy: What Have We Learned?

(2018) Andrzej Górski et al.   Viruses-Basel

Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections

(2018) Rachit Agarwal et al.   Nature Biomedical Engineering

Defining antimicrobial resistance in cystic fibrosis

(2018) Timothy J. Kidd et al.   Journal of Cystic Fibrosis

Novel Iron-Chelator DIBI Inhibits Staphylococcus aureus Growth, Suppresses Experimental MRSA Infection in Mice and Enhances the Activities of Diverse Antibiotics in vitro

(2018) Maria del Carmen Parquet et al.   Frontiers in Microbiology

Ethics codes and use of new and innovative drugs

(2018) Jan Borysowski et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

(2018) Lucy L. Furfaro et al.   Frontiers in Cellular and Infection Microbiology

Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance

(2018) Varsha Shriram et al.   Frontiers in Microbiology

Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis

(2018) Stephanie Trend et al.   Frontiers in Pharmacology

Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection

(2017) Rachel Y. Chang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Pan-Genomic Approach to Understand the Basis of Host Adaptation in Achromobacter

(2017) Julie Jeukens et al.   Genome Biology and Evolution

The AREST CF experience in biobanking — More than just tissues, tubes and time

(2017) Luke W. Garratt et al.   Journal of Cystic Fibrosis

Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler

(2017) Nicholas B. Carrigy et al.   PHARMACEUTICAL RESEARCH

Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

(2017) Kelly M. Martinovich et al.   Scientific Reports

Overview of FDA’s Expanded Access Program for Investigational Drugs

(2017) Jonathan P. Jarow et al.   Therapeutic Innovation & Regulatory Science

The isolation and characterization of Stenotrophomonas maltophilia T4-like bacteriophage DLP6

(2017) Danielle L. Peters et al.   PLoS One

Biofilm Formation byMycobacterium abscessusin a Lung Cavity

(2016) Kevin P. Fennelly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of a genetically engineered bacteriophage on Enterococcus faecalis biofilms

(2016) Justine Monnerat Tinoco et al.   ARCHIVES OF ORAL BIOLOGY

Organogenesis of adult lung in a dish: Differentiation, disease and therapy

(2016) Jinwook Choi et al.   DEVELOPMENTAL BIOLOGY

Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

(2016) Kevin Looi et al.   EXPERIMENTAL LUNG RESEARCH

Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis

(2016) Tavs Qvist et al.   Journal of Cystic Fibrosis

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

(2016) Gudio Veit et al.   MOLECULAR BIOLOGY OF THE CELL

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriophages as Therapeutic and Prophylactic Means: Summary of the Soviet and Post Soviet Experiences

(2016) Nina Chanishvili   Current Drug Delivery

Antibody Production in Response to Staphylococcal MS-1 Phage Cocktail in Patients Undergoing Phage Therapy

(2016) Maciej Żaczek et al.   Frontiers in Microbiology

CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis

(2016) Miquéias Lopes-Pacheco   Frontiers in Pharmacology

Infection in cystic fibrosis: impact of the environment and climate

(2016) KA Ramsay et al.   Expert Review of Respiratory Medicine

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

An Optimised Human Cell Culture Model for Alveolar Epithelial Transport

(2016) Hui Ren et al.   PLoS One

Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections

(2016) Cristina Cigana et al.   Scientific Reports

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

A murine model of early Pseudomonas aeruginosa lung disease with transition to chronic infection

(2016) H. K. Bayes et al.   Scientific Reports

NewIn VitroModel To Study the Effect of Human Simulated Antibiotic Concentrations on Bacterial Biofilms

(2015) Janus A. J. Haagensen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The isolation and characterization of two Stenotrophomonas maltophilia bacteriophages capable of cross-taxonomic order infectivity

(2015) Danielle L. Peters et al.   BMC GENOMICS

D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

(2015) César de la Fuente-Núñez et al.   CHEMISTRY & BIOLOGY

Chronic pulmonary disease withMycobacterium abscessuscomplex is a biofilm infection

(2015) Tavs Qvist et al.   EUROPEAN RESPIRATORY JOURNAL

Bacteriophage Delivery by Nebulization and Efficacy Against Phenotypically DiversePseudomonas aeruginosafrom Cystic Fibrosis Patients

(2015) Jaspreet Singh Sahota et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Pseudomonas aeruginosaantibiotic resistance in Australian cystic fibrosis centres

(2015) Daniel J. Smith et al.   RESPIROLOGY

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis

(2015) R Andres Floto et al.   THORAX

Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets

(2015) Iram J Haq et al.   THORAX

Bacteriophage Therapy: Advances in Formulation Strategies and Human Clinical Trials

(2015) Dieter Vandenheuvel et al.   Annual Review of Virology

Experience of the Eliava Institute in bacteriophage therapy

(2015) Mzia Kutateladze   VIROLOGICA SINICA

Burkholderia cepacia Complex Phage-Antibiotic Synergy (PAS): Antibiotics Stimulate Lytic Phage Activity

(2014) Fatima Kamal et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Twenty-Five-Year Outbreak of Pseudomonas aeruginosa Infecting Individuals with Cystic Fibrosis: Identification of the Prairie Epidemic Strain

(2014) M. D. Parkins et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats

(2014) Katherine L. Tuggle et al.   PLoS One

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

(2014) Marcella Facchini et al.   Jove-Journal of Visualized Experiments

Lung Phenotype of Juvenile and Adult Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferrets

(2013) Xingshen Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model

(2013) Andrew J. Sawyer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Factors influencing the acquisition of Stenotrophomonas maltophilia infection in cystic fibrosis patients

(2013) Sanja Stanojevic et al.   Journal of Cystic Fibrosis

Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo

(2013) B. L. Geller et al.   JOURNAL OF INFECTIOUS DISEASES

Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance

(2013) Stefano Sabatini et al.   JOURNAL OF MEDICINAL CHEMISTRY

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation

(2013) C. T. O'Loughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

(2013) S. Kalghatgi et al.   Science Translational Medicine

Bursting the bubble on bacterial biofilms: a flow cell methodology

(2012) Shanika A. Crusz et al.   BIOFOULING

SharedPseudomonas aeruginosagenotypes are common in Australian cystic fibrosis centres

(2012) Timothy J. Kidd et al.   EUROPEAN RESPIRATORY JOURNAL

Transmissible strains ofPseudomonas aeruginosain cystic fibrosis lung infections

(2012) Joanne L. Fothergill et al.   EUROPEAN RESPIRATORY JOURNAL

Synergistic Action of Gentamicin and Bacteriophage in a Continuous Culture Population of Staphylococcus aureus

(2012) Amy E. Kirby   PLoS One

Phage-antibiotic synergism: a possible approach to combatting Pseudomonas aeruginosa

(2012) Petar Knezevic et al.   RESEARCH IN MICROBIOLOGY

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Innate Inflammatory Responses of Pediatric Cystic Fibrosis Airway Epithelial Cells

(2011) Erika N. Sutanto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The  F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs

(2011) L. S. Ostedgaard et al.   Science Translational Medicine

Economic burden ofPseudomonas aeruginosainfection in patients with cystic fibrosis

(2011) Sujit S. Sansgiry et al.   JOURNAL OF MEDICAL ECONOMICS

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children

(2010) David K. Meyerholz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis

(2010) Xingshen Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis

(2010) Charles R. Esther et al.   Journal of Cystic Fibrosis

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Changes in cystic fibrosis sputum microbiology in the United States between 1995 and 2008

(2010) Julia Emerson et al.   PEDIATRIC PULMONOLOGY

Pseudomonas aeruginosaMicroevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence

(2009) Alessandra Bragonzi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tobramycin and FDA-Approved Iron Chelators EliminatePseudomonas aeruginosaBiofilms on Cystic Fibrosis Cells

(2009) Sophie Moreau-Marquis et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Respiratory Microbiology of Patients With Cystic Fibrosis in the United States, 1995 to 2005

(2009) Samiya Razvi et al.   CHEST

Pharmacokinetics and Pharmacodynamics of Antibacterial Agents

(2009) Matthew E. Levison et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985–2005

(2009) F.A. Millar et al.   Journal of Cystic Fibrosis

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation

(2008) J. Overhage et al.   INFECTION AND IMMUNITY

Adeno-associated virus–targeted disruption of the CFTR gene in cloned ferrets

(2008) Xingshen Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients

(2008) Helle Krogh Johansen et al.   Journal of Cystic Fibrosis

Phage therapy experience at the Eliava Institute

(2008) M. Kutateladze et al.   MEDECINE ET MALADIES INFECTIEUSES

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

(2008) C. S. Rogers et al.   SCIENCE

Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway

(2007) Sophie Moreau-Marquis et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS