Review
Immunology
Nanxin Liu, Xiaoxiao Pang, Hua Zhang, Ping Ji
Summary: The cGAS-STING pathway is crucial in protecting the host against viral infections and has also been found to play a role in response to bacterial infections. However, its functions in bacterial infections are more complex and diverse compared to viral infections, as the effects on the host vary depending on the bacterial species and infection mode.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Quanjin Li, Pu Gao
Summary: Biomolecular condensates formed by phase separation play critical roles in cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. The regulation and activation mechanisms of these condensates are under investigation, offering new opportunities for drug discovery.
FRONTIERS OF MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
M. Petrovic, G. Borchard, O. Jordan
Summary: Studies have shown the significance of the cGAS-STING pathway in anticancer immunity, but issues exist with cGAMP as a ligand, such as susceptibility to degradation and difficulty in transfecting into negatively charged membrane cells. Therefore, a suitable carrier is needed to enhance transfection efficiency and protect cGAMP.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Yu Wang, Gui Qian, Lingyan Zhu, Zhuo Zhao, Yinan Liu, Wendong Han, Xiaokai Zhang, Yihua Zhang, Tingrong Xiong, Hao Zeng, Xianghui Yu, Xiaofang Yu, Xiaoyan Zhang, Jianqing Xu, Quanming Zou, Dapeng Yan
Summary: HIV-1 infection inhibits the production of type I interferon by using Vif to evade host immune response, providing insights into a novel mechanism for HIV-1 to escape antiviral immunity by interfering with STING posttranslational modification. These findings could offer a foundation for developing new therapeutic strategies for treating HIV-1 infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Lucia Amurri, Branka Horvat, Mathieu Iampietro
Summary: The function of cGAS/STING signalling in innate immunity to DNA viruses has been well understood, and growing evidence suggests its significant contribution in controlling RNA virus infections. This review summarizes the known cGAS/STING escape strategies and discusses the mechanisms of STING signalling activation by RNA viruses as well as possible therapeutic approaches. Further research on the interaction between RNA viruses and cGAS/STING-mediated immunity could lead to important discoveries for understanding immunopathogenesis and treating RNA viral infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Zi-Jie Long, Jun-Dan Wang, Jue-Qiong Xu, Xin-Xing Lei, Quentin Liu
Summary: The accurate duplication and transfer of genetic material is crucial for cell division. The interaction between cell cycle regulation and cGAS/STING signaling plays a significant role in cancer initiation, development, and treatment.
Article
Pharmacology & Pharmacy
Yuanxing Zhi, Jin Liu, Peihua Kuang, Xin Zhang, Ziwei Xu, Yanshan Chen, Xiuling Lin, Xiaoyan Wu, Pingzheng Zhou, Jianjun Chen
Summary: In this study, a series of novel DCPIB derivatives were synthesized and found to have dual inhibitory effects on VRAC/TREK1 channels. Compound 6u showed potential in inhibiting interferon production in the cGAS-cGAMP-STING pathway, without any cytotoxicity during HSV1 infection. This research provides a new strategy for the development of potent VRAC inhibitors and its potential applications in treating cGAS-STING related autoimmune and inflammatory diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mohamed Wehbe, Lihong Wang-Bishop, Kyle W. Becker, Daniel Shae, Jessalyn J. Baljon, Xinyi He, Plamen Christov, Kelli L. Boyd, Justin M. Balko, John T. Wilson
Summary: The STING pathway is crucial in cancer immunosurveillance and STING-NPs show promising potential in remodeling TME and enhancing immunotherapy responses. Nanocarrier delivery of cGAMP improves its accumulation in tumors and activation of STING pathway, resulting in reprogramming of TME towards an immunogenic milieu with increased T-cell infiltration and improved response to immunotherapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Microbiology
Samira Elmanfi, Mustafa Yilmaz, Wilson W. S. Ong, Kofi S. Yeboah, Herman O. Sintim, Mervi Gursoy, Eija Kononen, Ulvi K. Gursoy
Summary: In the study of periodontal disease, bacterial cyclic dinucleotides and the STING/TBK1/IRF3 pathway may play important roles in the pathogenesis of the disease and immune response regulation. Understanding the stimulation of the innate immune response by cyclic dinucleotides opens new approaches to host modulation therapies in periodontology.
Review
Immunology
Wei Xie, Dinshaw J. Patel
Summary: Upon dsDNA activation, cGAS synthesizes 2'3'-cGAMP, which binds to STING and triggers an inflammatory response. Recent studies highlight the intercellular transmission of 2'3'-cGAMP, facilitated by gap junctions and membrane-spanning channels. This review emphasizes the structural perspective of intercellular trafficking of 2'3'-cGAMP, focusing on the binding of importer SLC19A1 and the role of folate nutrients and antifolate therapeutics.
TRENDS IN IMMUNOLOGY
(2023)
Article
Immunology
Ismail Cem Yilmaz, Emre Dunuroglu, Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Muzaffer Yildirim, Nogay Girginkardesler, Yusuf Ozbel, Seray Toz, Ahmet Ozbilgin, Gamze Aykut, Ihsan Gursel, Mayda Gursel
Summary: This study reveals that Leishmania parasites can manipulate the cGAS-STING-TBK1 signaling pathway to evade the immune system. The TBK1 inhibitor Amlexanox shows potential as a candidate drug for the treatment of cutaneous leishmaniasis. These findings have important implications for the development of new therapies for leishmaniasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jinglin Zhou, Zhan Zhuang, Jiamian Li, Zhihua Feng
Summary: The cGAS-STING pathway is involved in regulating innate immunity, inflammation, and other cellular processes. It is linked to infectious, inflammatory, and autoimmune diseases, as well as tumorigenesis. Therefore, studying this pathway can provide insights for the development of clinical treatments for various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Vera E. Mekers, Vera M. Kho, Marleen Ansems, Gosse J. Adema
Summary: cGAS/STING signaling plays a significant role in the onco-immunology field. Radiotherapy treatment induces DNA damage, activating the cGAS/STING pathway and resulting in the production of type I interferons for antitumor defense. This review summarizes the mechanisms of cGAS/STING signal propagation in tumor cells and myeloid cells, revealing potential targets for combinatorial treatment approaches.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Immunology
Lishuang Deng, Zhiwen Xu, Fengqin Li, Jun Zhao, Zhijie Jian, Huidan Deng, Siyuan Lai, Xiangang Sun, Yi Geng, Ling Zhu
Summary: Herpesviruses are large DNA viruses that can establish lifelong infection in hosts, posing a burden on human and animal health. The cGAS-STING signaling pathway plays an important role in the innate immunity against herpesvirus infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Qinfu Dan, Yang Yang, Hong Ge
Summary: Immunotherapy has revolutionized lung cancer treatment and improved overall survival for advanced patients, but many are still resistant. The cGAS-STING pathway has shown potential in overcoming resistance and enhancing antitumor immunity, making it a promising target for new therapies.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Biology
Myra Hosmillo, Jia Lu, Michael R. McAllaster, James B. Eaglesham, Xinjie Wang, Edward Emmott, Patricia Domingues, Yasmin Chaudhry, Tim J. Fitzmaurice, Matthew K. H. Tung, Marc Dominik Panas, Gerald McInerney, Nicolas Locker, Craig B. Wilen, Ian G. Goodfellow
