Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection

(2020) Mélanie Foulon et al.   Science Advances

Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis

(2020) Michael S. Avumegah et al.   PLoS Neglected Tropical Diseases

Mechanism of Mycolactone Toxin Membrane Permeation: Atomistic vs Coarse-Grained MARTINI Simulations

(2019) Fikret Aydin et al.   BIOPHYSICAL JOURNAL

Mycolactone as Analgesic: Subcutaneous Bioavailability Parameters

(2019) Jérémie Babonneau et al.   Frontiers in Pharmacology

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

(2018) Joy Ogbechi et al.   Cell Death & Disease

The potent effect of mycolactone on lipid membranes

(2018) Milène Nitenberg et al.   PLoS Pathogens

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

(2018) Caroline Demangel et al.   BIOLOGY OF THE CELL

Cutaneous Mycobacterial Infections

(2018) Carlos Franco-Paredes et al.   CLINICAL MICROBIOLOGY REVIEWS

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria

(2017) Marie-Thérèse Ruf et al.   Virulence

Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation

(2017) Jérémy Manry et al.   PLoS Genetics

IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells

(2017) Jieliang Shen et al.   Scientific Reports

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced byMycobacterium ulceransand SwitchM. ulceransinto a Low Mycolactone Producer

(2016) Estelle Marion et al.   JOURNAL OF IMMUNOLOGY

Autoinflammatory Skin Disorders: The Inflammasome in Focus

(2016) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

GOplot: an R package for visually combining expression data with functional analysis: Fig. 1.

(2015) Wencke Walter et al.   BIOINFORMATICS

Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival

(2015) B. Hube et al.   JOURNAL DE MYCOLOGIE MEDICALE

The Cyclopentenone Prostaglandin 15d-PGJ2Inhibits the NLRP1 and NLRP3 Inflammasomes

(2015) Nolan K. Maier et al.   JOURNAL OF IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide Induces Pro-Inflammatory Cytokines and MMP Production via TLR4 in Nasal Polyp-Derived Fibroblast and Organ Culture

(2014) Jung-Sun Cho et al.   PLoS One

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

Clinical epidemiology of laboratory-confirmed Buruli ulcer in Benin: a cohort study

(2014) Quentin B Vincent et al.   Lancet Global Health

Exogenous Administration of 15d-PGJ2-Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model

(2012) M. H. Napimoga et al.   JOURNAL OF IMMUNOLOGY

Photodegradation of the Mycobacterium ulcerans Toxin, Mycolactones: Considerations for Handling and Storage

(2012) Estelle Marion et al.   PLoS One

Analyzing Illumina Gene Expression Microarray Data from Different Tissues: Methodological Aspects of Data Analysis in the MetaXpress Consortium

(2012) Claudia Schurmann et al.   PLoS One

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

(2011) Rafael Prados-Rosales et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of 15d-PGJ2-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation

(2010) CF Alves et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity

(2010) Alvar Grönberg et al.   PLoS One

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Buruli ulcer

(2009) Françoise Portaels et al.   CLINICS IN DERMATOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Mycobacterium marinum infection acts as a tumor promoter in Japanese Medaka (Oryzias latipes)

(2008) Gregory W. Broussard et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Mycolactone Is Responsible for the Painlessness of Mycobacterium ulcerans Infection (Buruli Ulcer) in a Murine Study

(2008) J. En et al.   INFECTION AND IMMUNITY