Review
Orthopedics
Duncan Angus McGrouther
Summary: Concepts of tissue damage from sepsis are rooted in the works of Pasteur and Lister. The pathogenic mechanisms have become more complex, with toxins being categorized as virulence factors. Neutrophils play a key role in immunological defense by attacking pathogens, but excessive host immune response can lead to tissue damage. In addition to traditional surgical methods, dilution of inflammatory mediators is now being focused on. This emerging knowledge has the potential to change the approach to hand infections.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2023)
Review
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Alvaro Tamayo-Velasco, Rocio Aller, Hugo Gonzalo-Benito, Pedro Martinez-Paz, Eduardo Tamayo
Summary: Sepsis is a major global health problem with a high mortality rate. Early diagnosis is crucial for reducing the mortality rate. Endothelial dysfunction and neutrophil dysregulation play important roles in the pathophysiology of sepsis, and the use of biomarkers may provide a fast and accurate diagnostic tool. New biomarkers and treatments related to endothelial dysfunction and neutrophil dysregulation should be further researched to improve the diagnosis, treatment, and prognosis of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Camilla Pecoraro, Daniela Carbone, Barbara Parrino, Stella Cascioferro, Patrizia Diana
Summary: Infectious diseases caused by antimicrobial-resistant strains have become a serious threat to global health, with a high social and economic impact. Strategies to fight antibiotic resistance, such as inhibiting bacterial adhesion to host surfaces, can effectively hamper bacterial virulence without affecting cell viability. Targeting structures and biomolecules involved in the adhesion of Gram-positive and Gram-negative pathogens can lead to the development of promising tools against pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Carla Cacciotto, Alberto Alberti
Summary: Neutrophils play a crucial role in the immune response against infection, but some microorganisms can evade their attacks. Mycoplasma, a reduced genome bacteria, induces the release of neutrophil extracellular traps (NETs), but can digest the DNA scaffold of NETs to escape entrapment and promote infection. This persistence of mycoplasma infection and prolonged NET release are associated with the onset of chronic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil, Cohen Idan
Summary: In this study, it was found that patients undergoing hemodialysis have impaired neutrophil functionality, leading to increased susceptibility to infections. Targeting NETosis may reduce the occurrence and mortality rate of infections in these patients.
Article
Biochemistry & Molecular Biology
Chia-Lun Liu, Yang-Hong Dai
Summary: This study compared the gene expression differences between non-chylomicronemia syndrome (CS)-associated acute pancreatitis (AP) and CS-associated AP, and found different gene expression patterns as well as lower estimated neutrophil infiltration in CS-associated AP.
Article
Cell Biology
Stacey A. Maskarinec, Margaret McKelvy, Kimberly Boyle, Halie Hotchkiss, Madelaine E. Duarte, Bechtler Addison, Nicholas Amato, Sanjay Khandelwal, Gowthami M. Arepally, Grace M. Lee
Summary: This study systematically characterized the functional heterogeneity of neutrophils in a cohort of healthy individuals, revealing that each individual has a fixed phenotype determined by gene expression patterns. These findings may have implications for disease states.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Environmental Sciences
Yanjun Wu, Hongmei Huang, Jiayun Wu, Yiru Qin, Na Zhao, Baowei Chen, Qiying Nong, Yongshun Huang, Ligang Hu
Summary: This study investigates the mechanism of lead-induced myocardial injury and finds that neutrophil degranulation plays a significant role in this process. The findings suggest that lead exposure can initiate early myocardial injury by promoting neutrophil degranulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Endocrinology & Metabolism
Chen Chen, Tingting Huang, Xiaozhu Zhai, Yezhi Ma, Lv Xie, Bingwei Lu, Yueman Zhang, Yan Li, Zengai Chen, Jiemin Yin, Peiying Li
Summary: After a stroke, the intricate immune response involving various immune cells, including neutrophils, plays a crucial role in ischemic brain damage. The heterogeneity of neutrophils and their diverse roles in different conditions are still being studied, with single-cell RNA sequencing providing new insights. Potential therapeutic strategies targeting neutrophils to limit brain damage following ischemic stroke are being explored.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Brice Korkmaz, Anne-Sophie Lamort, Roxane Domain, Celine Beauvillain, Artur Gieldon, Ali Oender Yildirim, Georgios T. Stathopoulos, Moez Rhimi, Dieter E. Jenne, Ralph Kettritz
Summary: Cathepsin C plays a crucial role in cancer development and metastasis, and is considered as a potential therapeutic target for various types of cancer. Recent studies have highlighted the important interaction between tumor-associated CatC, NSPs, and NETs in cancer progression, providing new insights for cancer treatment strategies.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dewei Ye, Jianyu Yao, Wenfa Du, Cuishan Chen, Yong Yang, Kaixuan Yan, Jufei Li, Ying Xu, Shufei Zang, Yuying Zhang, Xianglu Rong, Rongxin Zhang, Aimin Xu, Jiao Guo
Summary: The miR-223/NE axis was found to be a key regulator of NETs in acute liver failure (ALF), exacerbating oxidative stress and neutrophilic inflammation, and potentiating hepatocellular damage and liver necrosis during ALF development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Joseph J. Wanford, Abderrahman Hachani, Charlotte Odendall
Summary: The modulation of programmed cell death has a crucial role in the immunity against bacterial infections. Tight regulation of cell death is necessary to resolve infection and maintain immune homeostasis, as uncontrolled inflammation can worsen the damage caused by bacterial infections. Bacterial pathogens have evolved strategies to manipulate cell death pathways to promote infection.
INFECTION AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Salma A. Rizo-Tellez, Meriem Sekheri, Janos G. Filep
Summary: This article explores the multifaceted roles of the neutrophil protein MPO in immunity, focusing on its impact on host defense, tissue damage, repair, and autoimmunity. Novel therapeutic approaches targeting MPO activity, expression, or signaling for the treatment of inflammatory and autoimmune diseases are also discussed.
Article
Multidisciplinary Sciences
Renuka Bankar, Kruthi Suvarna, Saicharan Ghantasala, Arghya Banerjee, Deeptarup Biswas, Manisha Choudhury, Viswanthram Palanivel, Akanksha Salkar, Ayushi Verma, Avinash Singh, Amrita Mukherjee, Medha Gayathri J. Pai, Jyotirmoy Roy, Alisha Srivastava, Apoorva Badaya, Sachee Agrawal, Om Shrivastav, Jayanthi Shastri, Sanjeeva Srivastava
Summary: This study conducted a comprehensive proteomics-based investigation of nasopharyngeal swab samples from patients with COVID-19, identifying some host proteins that were upregulated in COVID-19-positive patients, and important pathways that provide detailed insights into the host response in COVID-19 infection. Additionally, the docking of potential drugs with host proteins involved in the interleukin-12 signaling pathway may aid in COVID-19 therapeutic interventions.
Review
Microbiology
M. Mozammel Hoque, Gustavo Espinoza-Vergara, Diane McDougald
Summary: Protozoan predation on biofilms leads to generation of diversity in bacteria, resulting in adaptation to eukaryotic hosts and changes in virulence. Protozoa play an important role in nutrient cycling and maintaining balance in the food web. Predation, symbiosis, and parasitism are three types of interactions between protozoa and bacteria. Not all bacterial species are equally susceptible to protozoan predation, as they can defend against predation and establish symbiotic or parasitic lifestyles. Biofilm formation enhances resistance to predation compared to planktonic bacteria. Predation on biofilms creates phenotypic and genetic heterogeneity in prey, leading to trade-offs in virulence. Recent advances in molecular and genomics techniques provide new insights into protozoan predation on biofilms.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Microbiology
Roger D. Pechous, Christopher A. Broberg, Nikolas M. Stasulli, Virginia L. Miller, William E. Goldman
Article
Microbiology
Nikolas M. Stasulli, Kara R. Eichelberger, Paul A. Price, Roger D. Pechous, Stephanie A. Montgomery, Joel S. Parker, William E. Goldman
Article
Genetics & Heredity
Jose F. Munoz, Gregory M. Gauthier, Christopher A. Desjardins, Juan E. Gallo, Jason Holder, Thomas D. Sullivan, Amber J. Marty, John C. Carmen, Zehua Chen, Li Ding, Sharvari Gujja, Vincent Magrini, Elizabeth Misas, Makedonka Mitreva, Margaret Priest, Sakina Saif, Emily A. Whiston, Sarah Young, Qiandong Zeng, William E. Goldman, Elaine R. Mardis, John W. Taylor, Juan G. McEwen, Oliver K. Clay, Bruce S. Klein, Christina A. Cuomo
Article
Microbiology
Vijay Sivaraman, Roger D. Pechous, Nikolas M. Stasulli, Edward A. Miao, William E. Goldman
Article
Immunology
Donggi Paik, Amanda Monahan, Daniel R. Caffrey, Roland Elling, William E. Goldman, Neal Silverman
JOURNAL OF IMMUNOLOGY
(2017)
Article
Microbiology
Victoria E. Sepulveda, Roberto Marquez, David A. Turissini, William E. Goldman, Daniel R. Matute
Article
Microbiology
Kara R. Eichelberger, Grant S. Jones, William E. Goldman
Article
Microbiology
Tara Essock-Burns, Clotilde Bongrand, William E. Goldman, Edward G. Ruby, Margaret J. McFall-Ngai
Article
Microbiology
Kara R. Eichelberger, Victoria E. Sepulveda, John Ford, Sara R. Selitsky, Piotr A. Mieczkowski, Joel S. Parker, William E. Goldman
Article
Microbiology
Grant S. Jones, Victoria E. Sepulveda, William E. Goldman
Article
Immunology
Philip M. Roper, Kara R. Eichelberger, Linda Cox, Luke O'Connor, Christine Shao, Caleb A. Ford, Stephanie A. Fritz, James E. Cassat, Deborah J. Veis
Summary: This study investigated the pathogenesis of hematogenous osteomyelitis (HOM) in pediatric patients by inoculating mice with various strains of Staphylococcus aureus. The results showed differences in disease manifestation among the different strains, laying the groundwork for future studies on strain-dependent differences in musculoskeletal infection in children.
INFECTION AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Kara R. Eichelberger, Saikat Paul, Brian M. Peters, James E. Cassat
Summary: This review highlights the impact of Candida albicans-bacteria interactions on healthy polymicrobial community structure, host immune responses, and microbial pathogenesis, and discusses the significance of these interactions in discovering novel antivirulence compounds for fungal infections.
TRENDS IN MICROBIOLOGY
(2023)
Article
Microbiology
Ching-On Wong, Steven Gregory, Hongxiang Hu, Yufang Chao, Victoria E. Sepulveda, Yuchun He, David Li-Kroeger, William E. Goldman, Hugo J. Bellen, Kartik Venkatachalam
CELL HOST & MICROBE
(2017)
