Article
Nutrition & Dietetics
Stacy Loeb, Benjamin C. Fu, Scott R. Bauer, Claire H. Pernar, June M. Chan, Erin L. Van Blarigan, Edward L. Giovannucci, Stacey A. Kenfield, Lorelei A. Mucci
Summary: This study suggests that consuming a greater amount of healthful plant-based foods is associated with a reduced risk of aggressive forms of prostate cancer, with a stronger effect observed among men under 65 years of age.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Jun Li, Yanping Li, Kerry L. Ivey, Dong D. Wang, Jeremy E. Wilkinson, Adrian Franke, Kyu Ha Lee, Andrew Chan, Curtis Huttenhower, Frank B. Hu, Eric B. Rimm, Qi Sun
Summary: This study found that high intake of red meat and choline was significantly associated with TMAO concentrations, especially among participants identified as microbial TMAO-producers. Alistipes shahii strengthened the positive association between red meat intake and HbA1c levels. The results underscore the interaction between diet and gut microbiome in producing potentially bioactive metabolites that may modulate cardiometabolic health.
Article
Nutrition & Dietetics
Dong D. Wang, Yanping Li, Xuan-Mai T. Nguyen, Rebecca J. Song, Yuk-Lam Ho, Frank B. Hu, Walter C. Willett, Peter W. F. Wilson, Kelly Cho, J. Michael Gaziano, Luc Djousse
Summary: High sodium intake and low potassium intake are associated with a higher risk of CVD.
Article
Nutrition & Dietetics
Gustavo G. Nascimento, Fabio R. M. Leite, David A. Gonzalez-Chica, Karen G. Peres, Marco A. Peres
Summary: This study found a protective association between dietary calcium intake and periodontitis among women, while no clear association was found between vitamin D and periodontitis.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Xiaoxia Fan, Lingling Zhao, Shuqiong Wang, Kang Song, Beibei Wang, Yanling Xie, Yanping Jiang, Lijun Lin, Weiping Teng, Chunmei Cai, Yongli Yao
Summary: This study investigated the iodine nutrition and prevalence of thyroid diseases in adults in Qinghai Province. The results showed that there is an excess of iodine in the province, with a high rate of subclinical hypothyroidism. Female adults had a higher prevalence of thyroid disorders, and urban areas had a higher proportion of iodine deficiency compared to rural areas.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Jialei Fu, Sangah Shin
Summary: This study aimed to investigate the association between dietary patterns and the risk of NAFLD. The findings showed that a prudent dietary pattern was associated with a lower risk of NAFLD, while a flour-based food and meat pattern was associated with a higher risk of NAFLD.
Review
Medicine, General & Internal
Katharina Beyer, Lisa Moris, Michael Lardas, Anna Haire, Francesco Barletta, Simone Scuderi, Megan Molnar, Ronald Herrera, Abdul Rauf, Riccardo Campi, Isabella Greco, Kirill Shiranov, Saeed Dabestani, Thomas van den Broeck, Sujenthiran Arun, Mauro Gacci, Giorgio Gandaglia, Muhammad Imran Omar, Steven MacLennan, Monique J. Roobol, Bahman Farahmand, Eleni Vradi, Zsuzsanna Devecseri, Alex Asiimwe, Jihong Zong, Sara J. Maclennan, Laurence Collette, James NDow, Alberto Briganti, Anders Bjartell, Mieke Van Hemelrijck
Summary: The study aims to explore diagnostic and prognostic factors related to prostate cancer and evaluate their reliability and applicability. The results indicate that most of the factors identified need further evaluation and validation before they can be recommended for use in clinical practice.
Editorial Material
Public, Environmental & Occupational Health
Lauren E. Mccullough, Doratha A. Byrd
Summary: In 1986, a commentary published by Willett and Stampfer propelled the field of nutritional epidemiology forward by emphasizing the importance of analyzing diet in relation to total energy intake in epidemiologic analyses of diet and disease. This publication has become highly influential, cited over 2,886 times, and has significantly advanced methodology in studying diet-disease associations.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Teresa Marsden, Derek J. Lomas, Neil McCartan, Joanna Hadley, Steve Tuck, Louise Brown, Anna Haire, Charlotte Louise Moss, Saran Green, Mieke Van Hemelrijck, Ton Coolen, Aida Santaolalla, Elizabeth Isaac, Giorgio Brembilla, Douglas Kopcke, Francesco Giganti, Harbir Sidhu, Shonit Punwani, Mark Emberton, Caroline M. Moore
Summary: The ReIMAGINE Prostate Cancer Screening Study aims to explore the uptake of prostate cancer screening using MRI in men aged 50-75 with no prior diagnosis or treatment history. The study will offer MRI and PSA blood tests to eligible men and assess the prevalence of cancer detected in MRI-screened individuals.
Article
Nutrition & Dietetics
Kristine K. Dennis, Fenglei Wang, Yanping Li, JoAnn E. Manson, Eric B. Rimm, Frank B. Hu, Walter C. Willett, Meir J. Stampfer, Dong D. Wang
Summary: This study investigated the associations between different dietary sugars and the risk of coronary heart disease (CHD). The results showed that higher intake of total glucose equivalents (TGE), total sugar, and added sugar were associated with increased CHD risk, while fructose equivalents (TFE) and fructose from fruits and vegetables were not.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Jorge Dominguez-Barragan, Alba Fernandez-Sanles, Alvaro Hernaez, Joana Llaurado-Pont, Jaume Marrugat, Oliver Robinson, Ioanna Tzoulaki, Roberto Elosua, Camille Lassale
Summary: This study suggests that diet quality in adults is associated with differential methylation at 18 CpG sites in blood, some of which are related to cardiometabolic health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Rachel A. Murphy, Prasad P. Devarshi, Shauna Ekimura, Keri Marshall, Susan Hazels Mitmesser
Summary: This study aimed to determine the reference ranges of circulating long-chain (LC) omega-3 fatty acids in a nationally representative population of Americans. The findings indicated that the majority of children and a portion of adults had lower LC omega-3 concentrations than recommended levels, highlighting the importance of emphasizing regular consumption of LC omega-3s among Americans.
Article
Medicine, General & Internal
Katherine M. Livingstone, Gavin Abbott, Steven J. Bowe, Joey Ward, Catherine Milte, Sarah A. McNaughton
Summary: The study found that higher diet quality predicted lower risk of all-cause mortality, independent of genetic risk. Higher Recommended Food Score (RFS) was also associated with lower risk of CVD mortality and MI. These findings demonstrate the benefit of following a healthy diet, regardless of genetic risk.
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Fisaha Haile Tesfay, Sara Javanparast, Hailay Gesesew, Lillian Mwanri, Anna Ziersch
Summary: This systematic review examines the characteristics and impact of nutritional programs on weight-related nutritional outcomes for people living with HIV in sub-Saharan Africa. The review includes sixteen studies and finds that while these programs have shown some improvements in weight-related nutritional outcomes, they also face issues such as high rates of default and non-response.
Article
Oncology
Feng Zhang, Shuang Gao, Yiqiao Zhao, Bin Wu, Xiaonan Chen
Summary: The study comparing sutureless and conventional laparoscopic partial nephrectomy found that sutureless approach can reduce operative time and warm ischemia time, with better postoperative renal function recovery and preservation of more renal parenchyma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shijie Li, Shiyang Lu, Xuefeng Liu, Xiaonan Chen
Summary: This study found that the serum albumin-to-alkaline phosphatase ratio (AAPR) is significantly associated with the prognosis of bladder cancer patients receiving radical cystectomy, providing insights for clinical decision-making and risk stratification. The AAPR-based nomograms showed good predictive accuracy for overall survival, cancer-specific survival, and recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shijie Li, Xuefeng Liu, Xiaonan Chen
Summary: This study compared the clinical and pathological characteristics and outcomes of different subtypes of papillary renal cell carcinoma (PRCC) and found that type 2 PRCC had significantly poorer survival rates. Smoking history and pathological characteristics were independent factors for predicting the oncological outcomes of PRCC patients.
Article
Oncology
Yiqiao Zhao, Zijia Tao, Lei Li, Jianyi Zheng, Xiaonan Chen
Summary: In this study, we developed a prognostic model based on gene expression profiles to predict biochemical recurrence (BCR) in prostate cancer patients. The model showed strong predictive ability and could be a valuable tool for clinical use and further research in understanding the mechanisms underlying prostate cancer.
Review
Medicine, Research & Experimental
Mingyang Li, Zijia Tao, Yiqiao Zhao, Lei Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: In recent years, m(5)C RNA modification has been found to play a crucial role in regulating RNA metabolism and function, affecting cell proliferation, differentiation, apoptosis, and other biological processes. m(5)C modification is associated with the pathogenesis and progression of cancers, and abnormal expression of related genes can be used to predict patient prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Lei Li, Zijia Tao, Yiqiao Zhao, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: This study investigated the relationship between N-6-methyladenosine and 5-methylcytosine regulators and clear cell renal cell carcinoma and identified five potential biomarkers for future research.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Jianyi Zheng, Shijie Li, Yiqiao Zhao, Zijia Tao, Lei Li, Zeyu Li, Mingyang Li, Xiaonan Chen
Summary: This study successfully constructed and validated nomograms to predict overall survival (OS) and cancer-specific survival (CSS) for patients with chromophobe renal cell carcinoma (chRCC) after nephrectomy. The nomograms showed accurate discrimination and were proven to be better in accuracy and efficacy ability compared to the seventh tumor, node, and metastasis stage. These nomograms can assist clinical doctors in choosing individual treatment strategies for chRCC patients.
Article
Oncology
Shijie Li, Zeyu Li, Jianyi Zheng, Xiaonan Chen
Summary: This study aimed to investigate risk factors for intraoperative hemodynamic instability (HDI) and construct a clinical model for predicting intraoperative HDI for large pheochromocytomas and paragangliomas (PPGLs) patients. Independent risk factors were identified and a predictive model was constructed, which showed good predictive power in the training and validation cohorts. This model can help in individualized pre-treatment decision-making.
Review
Biochemistry & Molecular Biology
Mingyang Li, Lei Li, Jianyi Zheng, Zeyu Li, Shijie Li, Kefeng Wang, Xiaonan Chen
Summary: Renal cell carcinoma (RCC) is a common type of kidney cancer with unremarkable symptoms in early stages and low sensitivity to radiotherapy and chemotherapy. Liquid biopsy, an emerging non-invasive test, can measure patient biomarkers for diagnosis, prognostic assessment, treatment monitoring, and response evaluation. With rapid development and iteration of extraction and analysis technologies, liquid biopsy has become a low cost, high efficiency, and high accuracy clinical detection method. In this review, we comprehensively discuss the components, clinical applications, limitations, and future prospects of liquid biopsy in the past 5 years.
Article
Medicine, General & Internal
Zeyu Li, Lei Li, Jianyi Zheng, Mingyang Li, Siyu Wu, Kerong Xin, Rong Li, Song Bai, Xiaonan Chen
Summary: This study aimed to investigate the relationship between kidney stone history and human bone health. Results showed a negative correlation between lumbar bone mineral density and kidney stone history, and an interaction between serum 25-hydroxyvitamin D and lumbar BMD regarding kidney stone formation. Therefore, maintaining high lumbar BMD and serum 25-hydroxyvitamin D levels may help prevent the occurrence of kidney stones.
Review
Medicine, Research & Experimental
Siyu Wu, Rong Li, Yuanhong Jiang, Jiazheng Yu, Jianyi Zheng, Zeyu Li, Mingyang Li, Kerong Xin, Yang Wang, Zhenqun Xu, Shijie Li, Xiaonan Chen
Summary: Liquid biopsy is an accurate method for determining molecular profiles in urothelial carcinoma (UC). It has the potential to play a crucial role in early diagnosis, treatment monitoring, and prognosis prediction, thereby contributing to precision medicine in UC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Lei Li, Mingyang Li, Jianyi Zheng, Zeyu Li, Xiaonan Chen
Summary: This study reveals that NSUN5 is highly expressed in ccRCC and is associated with tumor immunity. The high-risk group responds poorly to immunosuppressive treatment and has lower stromal scores compared to the low-risk group. NSUN5 knockout reduces ccRCC cell proliferation and migration, while increasing apoptosis.
Review
Biochemistry & Molecular Biology
Shijie Li, Kerong Xin, Shen Pan, Yang Wang, Jianyi Zheng, Zeyu Li, Xuefeng Liu, Bitian Liu, Zhenqun Xu, Xiaonan Chen
Summary: Bladder cancer is a global clinical challenge characterized by late presentation, poor prognosis, and low survival rates. Traditional methods for diagnosis and monitoring, such as cystoscopy and tissue biopsy, have limitations and high costs. In recent years, liquid biopsies, specifically blood-based ones, have emerged as highly efficient methods for discovering biomarkers and monitoring tumor progression. Several liquid biopsy biomarkers have shown promising results in clinical applications, including early detection, residual disease detection, recurrence prediction, and therapy response.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Zijia Tao, Enchong Zhang, Lei Li, Jianyi Zheng, Yiqiao Zhao, Xiaonan Chen
Summary: The study successfully established a unified prognostic risk model, incorporating clinical stage and immune-related gene pairs, to effectively assess the overall survival of ccRCC patients. The model showed high accuracy in predicting survival outcomes across multiple validation cohorts, demonstrating better performance than individual IRGP signatures. Immune infiltration analysis revealed higher abundance of certain immune cells in ccRCC patients with poor prognosis.
