Article
Medicine, General & Internal
Bo Wang, Chongde Liu, Yanli Yao, Zhihui Lu, Rong Yu, Zhuoma CaiRen, Zhixiu Wang, Runwu Liu, Yazhen Wu, Zhangbin Yu
Summary: This study aims to establish the reference interval for pulse oxygen saturation in high altitudes and determine if there are variations between preductal and postductal measurements at the same altitude. The study will recruit approximately 2000 healthy newborns from six hospitals in Qinghai Province, China. The measurements will be recorded and input into a cloud database for analysis. The results of this study will be disseminated through academic conferences and peer-reviewed journals.
Article
Medicine, General & Internal
Grace J. Chan, Bezawit Mesfin Hunegnaw, Kimiko Van Wickle, Yahya Mohammed, Mesfin Hunegnaw, Chalachew Bekele, Frederick G. B. Goddard, Fisseha Tadesse, Delayehu Bekele
Summary: The study aims to collect health data on pregnant women and children to assess disease and mortality rates, providing evidence for prevention measures. The research follows an open prospective design, tracking the health status of pregnant women and newborns.
Review
Medicine, General & Internal
Shin Kato, Masato Ito, Makoto Saito, Naoyuki Miyahara, Fumihiko Namba, Erika Ota, Hidehiko Nakanishi
Summary: This scoping review aims to screen available evidence, identify perinatal risk factors associated with the development and severity of bronchopulmonary dysplasia (BPD), and devise a novel disease classification system that can predict long-term prognosis.
Review
Medicine, General & Internal
Sarah Sturrock, Shohaib Ali, Chris Gale, Cheryl Battersby, Kirsty Le Doare
Summary: This is a systematic review on the association between maternal SARS-CoV-2 infection in pregnancy and neonatal morbidities and outcomes. The study found limited evidence of an increased risk of certain neonatal diseases, such as respiratory diseases, following maternal SARS-CoV-2 infection. However, there is still limited understanding of the outcomes for infants born in low-income countries and following early pregnancy infections.
Article
Medicine, General & Internal
Stanley Mwita, Benjamin Anathory Kamala, Eveline Konje, Emmanuela Eusebio Ambrose, Angelina Izina, Elieza Chibwe, Gilbert Kongola, Deborah Dewey
Summary: The use of antenatal corticosteroids (ACS) between 24 weeks 0 days and 34 weeks 6 days of gestation in both singletons and twins in low-resource settings is associated with positive infant outcomes, particularly lower rates of perinatal mortality and respiratory distress syndrome (RDS). For twin infants, ACS may only be associated with a reduced risk of RDS.
Article
Medicine, General & Internal
Girma Teferi Mengistu, Bizunesh Kefale Mengistu
Summary: This study aimed to assess the practice of early initiation of breastfeeding (EIBF) and associated factors among mother-baby dyads who practiced immediate skin-to-skin contact in Ethiopia. The study found that 88.8% of mother-baby dyads practicing immediate skin-to-skin contact initiated EIBF. Factors associated with EIBF included wealth, education level, region, mode of delivery, place of delivery, and assistance by midwifery.
Article
Medicine, General & Internal
Francesca L. Cavallaro, Charles P. Kabore, Rachel Pearson, Ruth M. Blackburn, Soha Sobhy, Ana Pilar Betran, Carine Ronsmans, Alexandre Dumont
Summary: The study examined the variation in crude and risk-adjusted rates of intrapartum-related perinatal mortality among cesarean births in Burkina Faso. The results showed a high burden of perinatal deaths and significant variation in mortality rates between hospitals, indicating potential differences in the quality of cesarean care. Improving access to and quality of emergency obstetric and newborn care is crucial for improving survival rates.
Article
Medicine, General & Internal
Amit Ovental, Reut Doyev, Laurence Mangel, Jacky Herzlich, Amir Hadanny, Ronella Marom
Summary: Neonatal morbidity among African refugee infants in Israel was found to be similar to that of native Israeli infants. However, within the refugee group, significant differences were observed in factors such as birth weight, twin deliveries, small for gestational age neonates, and the use of human milk. Successful implementation of health policies for refugees may have improved their access to maternal and child health services.
Article
Medicine, General & Internal
Alex Hincker, Jacob Nadler, Suzanne Karan, Ebony Carter, Shay Porat, Barbara Warner, Yo-El S. Ju, Arbi Ben Abdallah, Elizabeth Wilson, Ellen M. Lockhart, Yehuda Ginosar
Summary: This study aims to investigate the relationship between maternal obstructive sleep apnoea (OSA) and fetal growth restriction (FGR), hypothesizing that treating OSA patients with positive airway pressure (PAP) can improve birth weight and neonatal outcomes.
Article
Medicine, General & Internal
Mingyan Hei, Xiaoying Li, Yuan Shi, Yun Cao, Jianhua Sun, Hui Wu, Siyuan Jiang, Xiaolu Ma, Yanchen Wang, Huiqing Sun, Huayan Zhang, Li-Zhong Du, Wenhao Zhou, Shoo K. Lee, Chao Chen
Summary: The Chinese Neonatal Network (CHNN) aims to provide a platform for collaborative research and quality improvement for preterm infants in China. It collects and analyzes data from various medical institutions to improve outcomes for these infants. The network examines variations in outcomes among different institutions and uses this information to develop quality improvement measures. Additionally, it collects and analyzes information about environmental and human resource factors, as well as neonatal care processes, to determine their association with outcomes.
Article
Medicine, General & Internal
Basant Sharma, Suraj Bhattarai, Sabita Shrestha, Rakshya Joshi, Renuka Tamrakar, Prekshya Singh, Jully Chaudhary, Upendra Pandit
Summary: High stillbirth rate in Nepal may be attributed to inadequate quality of antenatal care. Strengthening the country's health systems is crucial in identifying pregnancy-related risks such as maternal hypertension and infections early on. Enhancing mothers' hygiene and health awareness is equally important in reducing fetal deaths in low-resource settings.
Article
Medicine, General & Internal
Victor Ogik, Mark Muyingo, Moses Musooko, Jolly Nankunda
Summary: This study found that about a fifth of babies born at Mulago National Referral Hospital had high umbilical artery lactate levels. Factors significantly associated with high lactate levels included the baby's sex, mother's gravidity, presence of meconium-stained amniotic fluid, and use of oxytocin during labor.
Review
Medicine, General & Internal
Jennifer Horwitz, Linda Mardiros, Ahmed Musa, Vivian A. Welch, Amanda Hodgson, Michael Narvey, Andrea Ghazzawi, Beverley Shea, Michael Saginur
Summary: This scoping review examined the existing empirical evidence on screening, treatment, and harm of exposure to neonatal hypoglycemia. The results showed the need for further research to define an optimal threshold for intervention and assess potential harms of screening.
Article
Pediatrics
Andre Kidszun, Anna Bruns, Daniel Schreiner, Susanne Tippmann, Julia Winter, Roman M. Pokora, Michael S. Urschitz, Eva Mildenberger
Summary: This two-year prospective nationwide surveillance study of neonatal HSV infections finds few cases in Germany. Most children had few symptoms and good outcomes, but five infants had significant sequelae. Orofacial HSV infection was present in one or more family members for 20/23 babies where data was available, but it is not clear if this was the mode of transmission.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Review
Medicine, General & Internal
Naima Nasir, Adeniyi Kolade Aderoba, Proochista Ariana
Summary: Through a systematic review, we found that most interventions aimed at improving maternal and newborn health in Nigeria were in line with WHO recommendations and focused on the intermediate social determinants of health within health facilities. However, there is a lack of research on interventions targeting structural social determinants and community-based approaches, as well as limited attention to pre-pregnancy interventions.
Article
Obstetrics & Gynecology
Yizhen Liu, Jim G. Thornton, Wentao Li, Madelon van Wely, Ben W. Mol
Summary: The analysis of 22 RCTs by Dr. Maged suggests potential data integrity issues, and it is recommended that journals investigate according to the guidelines of the Committee on Publication Ethics. The procedures demonstrated in this paper may help assess data integrity for future attempts to verify the authenticity of published RCTs.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Krystle Y. Chong, Sarah Solangon, Kurt Barnhart, Pamela Causa-Andrieu, Perrine Capmas, George Condous, Liesl de Waard, James M. N. Duffy, Andrew W. Horne, Maria Memtsa, Femke Mol, Munira Oza, Romina Pesce, Annika Strandell, Madelon van Wely, Janneke van't Hooft, Lan N. Vuong, Jian Zhang, Davor Jurkovic, Ben W. Mol
Summary: This study developed a core outcome set for ectopic pregnancy (EP) to address methodological deficiencies in published randomized controlled trials and systematic reviews. The core outcome set consists of 6 outcomes, including treatment success, resolution time, the number of additional interventions, adverse events, mortality and severe morbidity, and treatment satisfaction.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
E. M. Bordewijk, T. Jannink, N. S. Weiss, T. de Vries, M. Nahuis, A. Hoek, M. Goddijn, B. W. Mol, M. van Wely, M-Ovin Study Grp
Summary: This study aimed to investigate the long-term outcomes of using gonadotrophins versus clomiphene citrate (CC) in women with normogonadotropic anovulation and clomiphene failure. The results showed that about four in five women were able to have a live birth after experiencing clomiphene failure, with no significant difference in pregnancy outcomes among the allocated groups.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Vanessa Brizuela, Joy J. Chebet, Anna Thorson
Summary: Mentorship is crucial in enhancing research capacity among health researchers, particularly for women mentees. The UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction at the World Health Organization launched a mentorship programme specifically for early career women researchers in 2020. This paper explains the process and implementation of the mentorship programme, highlighting the importance of considering language and geographical distribution, involving mentees in the matching process, providing training and networking opportunities, and offering support for developing relationships. By equipping women researchers with the tools to navigate challenges and ensuring gender equality, mentorship can have a lasting impact on research capacity.
GLOBAL HEALTH ACTION
(2023)
Review
Obstetrics & Gynecology
Kelly Hughes, Heather Ford, Shakila Thangaratinam, Shaun Brennecke, Ben W. Mol, Rui Wang
Summary: This study conducted a systematic review of 14 papers and found that cervical length is associated with the risk of preterm birth. However, most of the systematic reviews analyzed the diagnostic test accuracy of cervical length rather than its predictive ability. It is recommended to perform individual participant data meta-analysis to better quantify the predictive capacity of transvaginal ultrasonographic cervical length for preterm birth.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Jitske Eliveld, Ilias van der Bles, Madelon van Wely, Andreas Meissner, Alexandre T. Soufan, Annemieke C. Heijboer, Sjoerd Repping, Fulco van der Veen, Ans M. M. van Pelt
Summary: This study investigates the risk of hypogonadism in men with obstructive azoospermia, non-obstructive azoospermia (NOA) or Klinefelter syndrome after testicular sperm extraction (TESE). The results show that 36% of men with Klinefelter syndrome, 4% of men with obstructive azoospermia, and 3% of men with NOA required testosterone replacement therapy (TRT). Klinefelter syndrome is strongly associated with the need for TRT, while no association is found for obstructive azoospermia or NOA. Additionally, higher testosterone concentrations before TESE are linked to a lower chance of needing TRT.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Public, Environmental & Occupational Health
Dena Javadi, Emma Sacks, Vanessa Brizuela, Kenneth Finlayson, Nicola Crossland, Etienne Langlois, Daniela Ziegler, Venkatraman Chandra-Mouli, Mercedes Bonet
Summary: Adolescent pregnancy is associated with increased risk of maternal and child morbidity and mortality globally. Access to safe, appropriate and affordable antenatal, childbirth and postnatal care (PNC) is essential in mitigating this risk. This qualitative evidence synthesis seeks to highlight the experiences and perspectives of adolescent girls and their partners in accessing and using routine PNC.
Article
Public, Environmental & Occupational Health
Kenneth Finlayson, Emma Sacks, Vanessa Brizuela, Nicola Crossland, Sarah Cordey, Daniela Ziegler, Etienne Langlois, Dena Javadi, Liz Comrie-Thomson, Soo Downe, Mercedes Bonet
Summary: Postnatal care is crucial for the health and well-being of women and newborns, but it is often undervalued. A study found that fathers and family members play an important role in the utilization and support of postnatal care. To improve access to postnatal care, healthcare providers should adopt a more inclusive approach and provide flexible contact opportunities, "family-friendly" information, and psychosocial support services.
Article
Obstetrics & Gynecology
Aafke Bruinsma, Judit K. J. Keulen, Rik Van Eekelen, Madelon Van Wely, Joep C. Kortekaas, Jeroen Van Dillen, Joris A. M. Van de Post, Ben W. Mol, Esteriek de Miranda
Summary: This study assessed the cost-effectiveness of elective induction of labour (IOL) at 41 weeks compared to expectant management (EM) until 42 weeks for late-term pregnancies. The results showed that IOL has an 80% chance of being cost-effective for preventing adverse perinatal outcomes at a certain willingness-to-pay threshold. Subgroup analysis suggested that IOL may be cost-effective for nulliparous women, but unlikely to be cost-effective for multiparous women. The cost-effectiveness in other settings will depend on the baseline characteristics of the population and the organization and funding of the healthcare system.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X
(2023)
Article
Medicine, General & Internal
Siang Ing Lee, Stephanie Hanley, Zoe Vowles, Rachel Plachcinski, Ngawai Moss, Megha Singh, Chris Gale, Adeniyi Francis Fagbamigbe, Amaya Azcoaga-Lorenzo, Anuradhaa Subramanian, Beck Taylor, Catherine Nelson-Piercy, Christine Damase-Michel, Christopher Yau, Colin McCowan, Dermot O'Reilly, Gillian Santorelli, Helen Dolk, Holly Hope, Katherine M. Phillips, Kathryn Abel, Kelly-Ann Eastwood, Lisa Kent, Louise Locock, Maria Loane, Mohamed Mhereeg, Peter Brocklehurst, Sharon McCann, Sinead Brophy, Steven Wambua, Sudasing Pathirannehelage Buddhika Hemali Sudasinghe, Shakila Thangaratinam, Krishnarajah Nirantharakumar, Mairead Black, MuM PreDiCT Grp
Summary: This study developed a core outcome set for pregnant women with multimorbidity, aiming to address the heterogeneity in reported outcomes and improve the synthesis of research evidence. The core outcome set was developed through a systematic literature search, focus groups, Delphi surveys, and consensus meetings. It includes 11 outcomes, covering maternal and child outcomes.
Article
Medicine, General & Internal
Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Utkarsh Agrawal, Mairead Black, Muhammad Usman, Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Sinead Brophy, Dermot O'Reilly, Krishnarajah Nirantharakumar, Colin Mccowan
Summary: This study aims to estimate the prevalence of multimorbidity in pregnant women and examine the association between maternal multimorbidity and preterm birth. The results showed that multimorbidity was present in one in six women and was associated with an increased risk of preterm birth. Routine and comprehensive evaluation of women with multimorbidity before and during pregnancy is urgently needed to address the significant health burden it imposes.
Review
Obstetrics & Gynecology
Janneke A. C. van Baar, Elena B. Kostova, John Allotey, Shakila Thangaratinam, Javier R. Zamora, Mercedes Bonet, Caron Rahn Kim, Lynne M. Mofenson, Heinke Kunst, Asma Khalil, Elisabeth van Leeuwen, Julia Keijzer, Marije Strikwerda, Bethany Clark, Maxime Verschuuren, Arri Coomarasamy, Mariette Goddijn, Madelon van Wely
Summary: This systematic review aims to determine the prevalence of early pregnancy loss in women with SARS-Cov-2 infection and compare the risk to pregnant women without SARS-CoV-2 infection.
HUMAN REPRODUCTION UPDATE
(2023)